Replacement of L-amino acid peptides with D-amino acid peptides mitigates anti-PEG antibody generation against polymer-peptide conjugates in mice

Melittin-lipid nanoparticles target to lymph nodes and elicit a systemic anti-tumor immune response

(2020) Xiang Yu et al.   Nature Communications

Impact of Pre-Existing or Induced Anti-PEG IgM on the Pharmacokinetics of Peginterferon Alfa-2a (Pegasys) in Mice

(2020) Nehal E. Elsadek et al.   MOLECULAR PHARMACEUTICS

Immune modulation of liver sinusoidal endothelial cells by melittin nanoparticles suppresses liver metastasis

(2019) Xiang Yu et al.   Nature Communications

Toxicity and immunogenicity concerns related to PEGylated-micelle carrier systems: a review

(2019) Kouichi Shiraishi et al.   SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS

Antibodies Predict Pegaspargase Allergic Reactions and Failure of Rechallenge

(2019) Yiwei Liu et al.   JOURNAL OF CLINICAL ONCOLOGY

Overcoming anti-PEG antibody mediated accelerated blood clearance of PEGylated liposomes by pre-infusion with high molecular weight free PEG

(2019) Morgan D. McSweeney et al.   JOURNAL OF CONTROLLED RELEASE

Understanding the Role of Anti-PEG Antibodies in the Complement Activation by Doxil in Vitro

(2018) Barry Neun et al.   MOLECULES

Pre-existing anti-polyethylene glycol antibody reduces the therapeutic efficacy and pharmacokinetics of PEGylated liposomes

(2018) Yuan-Chin Hsieh et al.   Theranostics

Polymer–drug conjugate therapeutics: advances, insights and prospects

(2018) Iriny Ekladious et al.   NATURE REVIEWS DRUG DISCOVERY

pH-sensitive polymer micelles provide selective and potentiated lytic capacity to venom peptides for effective intracellular delivery

(2018) David J. Peeler et al.   BIOMATERIALS

Analysis of Pre-existing IgG and IgM Antibodies against Polyethylene Glycol (PEG) in the General Population

(2016) Qi Yang et al.   ANALYTICAL CHEMISTRY

Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals

(2016) Bing-Mae Chen et al.   ANALYTICAL CHEMISTRY

Virus-Inspired Polymer for Efficient In Vitro and In Vivo Gene Delivery

(2016) Yilong Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exploring the relationship between anti-PEG IgM behaviors and PEGylated nanoparticles and its significance for accelerated blood clearance

(2016) Kouichi Shiraishi et al.   JOURNAL OF CONTROLLED RELEASE

Anti-PEG antibodies in the clinic: Current issues and beyond PEGylation

(2016) Peng Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Melittin-MIL-2 fusion protein as a candidate for cancer immunotherapy

(2016) Mingjun Liu et al.   Journal of Translational Medicine

Platelets in the immune response: Revisiting platelet-activating factor in anaphylaxis

(2015) Parwinder Gill et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Anti-PEG IgM Is a Major Contributor to the Accelerated Blood Clearance of Polyethylene Glycol-Conjugated Protein

(2015) Yu Mima et al.   MOLECULAR PHARMACEUTICS

Anti-PEG immunity: emergence, characteristics, and unaddressed questions

(2015) Qi Yang et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Therapeutic Protein–Polymer Conjugates: Advancing Beyond PEGylation

(2014) Emma M. Pelegri-O’Day et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

pH-Responsive Nanoparticle Vaccines for Dual-Delivery of Antigens and Immunostimulatory Oligonucleotides

(2013) John T. Wilson et al.   ACS Nano

The accelerated blood clearance (ABC) phenomenon: Clinical challenge and approaches to manage

(2013) Amr S. Abu Lila et al.   JOURNAL OF CONTROLLED RELEASE

Selectivity of binding of PEGs and PEG-like oligomers to anti-PEG antibodies induced by methoxyPEG-proteins

(2013) Mark G.P. Saifer et al.   MOLECULAR IMMUNOLOGY

Ex Vivo Red Blood Cell Hemolysis Assay for the Evaluation of pH-responsive Endosomolytic Agents for Cytosolic Delivery of Biomacromolecular Drugs

(2013) Brian C. Evans et al.   Jove-Journal of Visualized Experiments

Role of the Methoxy Group in Immune Responses to mPEG-Protein Conjugates

(2012) Merry R. Sherman et al.   BIOCONJUGATE CHEMISTRY

Bee venom in cancer therapy

(2011) Nada Oršolić   CANCER AND METASTASIS REVIEWS

Cytolytic peptide nanoparticles (‘NanoBees’) for cancer therapy

(2011) Hua Pan et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Sensitive Quantification of PEGylated Compounds by Second-Generation Anti-Poly(ethylene glycol) Monoclonal Antibodies

(2010) Yu-Cheng Su et al.   BIOCONJUGATE CHEMISTRY

Anti-PEG IgM Response against PEGylated Liposomes in Mice and Rats

(2010) Masako Ichihara et al.   Pharmaceutics

Minireview: Nanoparticles and the Immune System

(2009) Banu S. Zolnik et al.   ENDOCRINOLOGY

Emerging PEGylated drugs

(2009) Jung Seok Kang et al.   EXPERT OPINION ON EMERGING DRUGS

Molecularly targeted nanocarriers deliver the cytolytic peptide melittin specifically to tumor cells in mice, reducing tumor growth

(2009) Neelesh R. Soman et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting the cancer stroma with a fibroblast activation protein-activated promelittin protoxin

(2009) A. M. LeBeau et al.   MOLECULAR CANCER THERAPEUTICS

Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes

(2007) Tatsuhiro Ishida et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS