Partitioning of surfactant into drug-rich nanodroplets and its impact on drug thermodynamic activity and droplet size

Polymer Type Impacts Amorphous Solubility and Drug-Rich Phase Colloidal Stability: A Mechanistic Study Using Nuclear Magnetic Resonance Spectroscopy

(2020) Keisuke Ueda et al.   MOLECULAR PHARMACEUTICS

Impact of Hypromellose Acetate Succinate Grade on Drug Amorphous Solubility and In Vitro Membrane Transport

(2020) Keisuke Ueda et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Insights into the Dissolution Mechanism of Ritonavir–Copovidone Amorphous Solid Dispersions: Importance of Congruent Release for Enhanced Performance

(2019) Anura S. Indulkar et al.   MOLECULAR PHARMACEUTICS

Mechanistic elucidation of formation of drug-rich amorphous nanodroplets by dissolution of the solid dispersion formulation

(2019) Keisuke Ueda et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Effect of Amorphous Nanoparticle Size on Bioavailability of Anacetrapib in Dogs

(2019) Filippos Kesisoglou et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Cryo-TEM and AFM Observation of the Time-Dependent Evolution of Amorphous Probucol Nanoparticles Formed by the Aqueous Dispersion of Ternary Solid Dispersions

(2019) Zhijing Zhao et al.   MOLECULAR PHARMACEUTICS

Interplay of Supersaturation and Solubilization: Lack of Correlation between Concentration-Based Supersaturation Measurements and Membrane Transport Rates in Simulated and Aspirated Human Fluids

(2019) Ahmed Elkhabaz et al.   MOLECULAR PHARMACEUTICS

Molecular Mobility Suppression of Ibuprofen-Rich Amorphous Nanodroplets by HPMC Revealed by NMR Relaxometry and Its Significance with Respect to Crystallization Inhibition

(2019) Keisuke Ueda et al.   MOLECULAR PHARMACEUTICS

Impact of Monomeric versus Micellar Surfactant and Surfactant–Polymer Interactions on Nucleation–Induction Times of Atazanavir from Supersaturated Solutions

(2019) Anura S. Indulkar et al.   CRYSTAL GROWTH & DESIGN

Practical Approach to Modeling the Impact of Amorphous Drug Nanoparticles on the Oral Absorption of Poorly Soluble Drugs

(2019) Aaron M. Stewart et al.   MOLECULAR PHARMACEUTICS

Influence of Polymer and Drug Loading on the Release Profile and Membrane Transport of Telaprevir

(2018) Laura I. Mosquera-Giraldo et al.   MOLECULAR PHARMACEUTICS

Relationship between amorphous solid dispersion in vivo absorption and in vitro dissolution: phase behavior during dissolution, speciation, and membrane mass transport

(2018) Venecia Wilson et al.   JOURNAL OF CONTROLLED RELEASE

Direct NMR Monitoring of Phase Separation Behavior of Highly Supersaturated Nifedipine Solution Stabilized with Hypromellose Derivatives

(2017) Keisuke Ueda et al.   MOLECULAR PHARMACEUTICS

In Vivo Mechanisms of Intestinal Drug Absorption from Aprepitant Nanoformulations

(2017) Carl Roos et al.   MOLECULAR PHARMACEUTICS

Impact of Micellar Surfactant on Supersaturation and Insight into Solubilization Mechanisms in Supersaturated Solutions of Atazanavir

(2017) Anura S. Indulkar et al.   PHARMACEUTICAL RESEARCH

Amorphous solid dispersions: Rational selection of a manufacturing process

(2016) Teófilo Vasconcelos et al.   ADVANCED DRUG DELIVERY REVIEWS

Spray drying formulation of amorphous solid dispersions

(2016) Abhishek Singh et al.   ADVANCED DRUG DELIVERY REVIEWS

Physicochemical properties of direct compression tablets with spray dried and ball milled solid dispersions of tadalafil in PVP-VA

(2016) K. Wlodarski et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Polymeric Amorphous Solid Dispersions: A Review of Amorphization, Crystallization, Stabilization, Solid-State Characterization, and Aqueous Solubilization of Biopharmaceutical Classification System Class II Drugs

(2016) Shrawan Baghel et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Mechanism of Dissolution-Induced Nanoparticle Formation from a Copovidone-Based Amorphous Solid Dispersion

(2016) Paul Harmon et al.   MOLECULAR PHARMACEUTICS

Exploiting the Phenomenon of Liquid–Liquid Phase Separation for Enhanced and Sustained Membrane Transport of a Poorly Water-Soluble Drug

(2016) Anura S. Indulkar et al.   MOLECULAR PHARMACEUTICS

Nanoemulsions: formation, properties and applications

(2016) Ankur Gupta et al.   Soft Matter

Physicochemical properties of tadalafil solid dispersions – Impact of polymer on the apparent solubility and dissolution rate of tadalafil

(2015) K. Wlodarski et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The effect of drug and EUDRAGIT ® S 100 miscibility in solid dispersions on the drug and polymer dissolution rate

(2015) Kenjirou Higashi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Size selectivity of intestinal mucus to diffusing particulates is dependent on surface chemistry and exposure to lipids

(2015) Hasan M. Yildiz et al.   JOURNAL OF DRUG TARGETING

An Insight into Different Stabilization Mechanisms of Phenytoin Derivatives Supersaturation by HPMC and PVP

(2015) Naoya Otsuka et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Trends in the Precipitation and Crystallization Behavior of Supersaturated Aqueous Solutions of Poorly Water-Soluble Drugs Assessed Using Synchrotron Radiation

(2015) Shweta A. Raina et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Systematic Screening of Different Surface Modifiers for the Production of Physically Stable Nanosuspensions

(2015) Maria L.A.D. Lestari et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Mechanistic insight into the dramatic improvement of probucol dissolution in neutral solutions by solid dispersion in Eudragit E PO with saccharin

(2015) Kenjirou Higashi et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Crystallization of Probucol in Nanoparticles Revealed by AFM Analysis in Aqueous Solution

(2015) Kiichi Egami et al.   MOLECULAR PHARMACEUTICS

Glass–Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Telaprevir

(2015) Laura I. Mosquera-Giraldo et al.   MOLECULAR PHARMACEUTICS

Impact of Surfactants on the Crystallization of Aqueous Suspensions of Celecoxib Amorphous Solid Dispersion Spray Dried Particles

(2015) Jie Chen et al.   MOLECULAR PHARMACEUTICS

Drug–Polymer–Water Interaction and Its Implication for the Dissolution Performance of Amorphous Solid Dispersions

(2015) Yuejie Chen et al.   MOLECULAR PHARMACEUTICS

Dissolution Performance of High Drug Loading Celecoxib Amorphous Solid Dispersions Formulated with Polymer Combinations

(2015) Tian Xie et al.   PHARMACEUTICAL RESEARCH

Visualizing transient dark states by NMR spectroscopy

(2015) Nicholas J. Anthis et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Inhibition mechanism of hydroxypropyl methylcellulose acetate succinate on drug crystallization in gastrointestinal fluid and drug permeability from a supersaturated solution

(2014) Keisuke Ueda et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The effect of HPMCAS functional groups on drug crystallization from the supersaturated state and dissolution improvement

(2014) Keisuke Ueda et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Glass transition dynamics of anti-inflammatory ketoprofen studied by Raman scattering and terahertz time-domain spectroscopy

(2014) Tomohiko Shibata et al.   JOURNAL OF MOLECULAR STRUCTURE

Assessment of the Amorphous “Solubility” of a Group of Diverse Drugs Using New Experimental and Theoretical Approaches

(2014) Luis Almeida e Sousa et al.   MOLECULAR PHARMACEUTICS

Liquid–Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Poorly Water-Soluble Drugs: Implications for Solubility Enhancing Formulations

(2013) Grace A. Ilevbare et al.   CRYSTAL GROWTH & DESIGN

Influence of Additives on the Properties of Nanodroplets Formed in Highly Supersaturated Aqueous Solutions of Ritonavir

(2013) Grace A. Ilevbare et al.   MOLECULAR PHARMACEUTICS

Inhibitory Effect of Hydroxypropyl Methylcellulose Acetate Succinate on Drug Recrystallization from a Supersaturated Solution Assessed Using Nuclear Magnetic Resonance Measurements

(2013) Keisuke Ueda et al.   MOLECULAR PHARMACEUTICS

Understanding Polymer Properties Important for Crystal Growth Inhibition—Impact of Chemically Diverse Polymers on Solution Crystal Growth of Ritonavir

(2012) Grace A. Ilevbare et al.   CRYSTAL GROWTH & DESIGN

Maintaining Supersaturation in Aqueous Drug Solutions: Impact of Different Polymers on Induction Times

(2012) Grace A. Ilevbare et al.   CRYSTAL GROWTH & DESIGN

Mechanistic Differences in Permeation Behavior of Supersaturated and Solubilized Solutions of Carbamazepine Revealed by Nuclear Magnetic Resonance Measurements

(2012) Keisuke Ueda et al.   MOLECULAR PHARMACEUTICS

Insights into the Role of Polymer-Surfactant Complexes in Drug Solubilisation/Stabilisation During Drug Release from Solid Dispersions

(2012) Sheng Qi et al.   PHARMACEUTICAL RESEARCH

Application of Dissolution/Permeation System for Evaluation of Formulation Effect on Oral Absorption of Poorly Water-Soluble Drugs in Drug Development

(2011) Makoto Kataoka et al.   PHARMACEUTICAL RESEARCH

Improved dissolution and pharmacokinetic behavior of cyclosporine A using high-energy amorphous solid dispersion approach

(2010) Satomi Onoue et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Solubility Advantage of Amorphous Pharmaceuticals: II. Application of Quantitative Thermodynamic Relationships for Prediction of Solubility Enhancement in Structurally Diverse Insoluble Pharmaceuticals

(2010) Sharad B. Murdande et al.   PHARMACEUTICAL RESEARCH

Understanding the Behavior of Amorphous Pharmaceutical Systems during Dissolution

(2010) David E. Alonzo et al.   PHARMACEUTICAL RESEARCH

Tailoring the Release Rates of Fluconazole Using Solid Dispersions in Polymer Blends

(2008) George Z. Papageorgiou et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Rationalizing the selection of oral lipid based drug delivery systems by an in vitro dynamic lipolysis model for improved oral bioavailability of poorly water soluble drugs

(2008) Arik Dahan et al.   JOURNAL OF CONTROLLED RELEASE