Article
Environmental Sciences
Hai Qin, Yaqin Yuan, Manqin Yuan, Haiyan Wang, Yonghong Yang
Summary: This study found that AZGP1 was highly expressed in breast cancer and negatively correlated with patient survival. Functional experiments showed that AZGP1 can promote the proliferation, migration, and invasion ability of breast cancer cells. Mechanistically, it was found that AZGP1 interacted with TRIM25 and was degraded through ubiquitination.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chunyan Liu, Yangyang Li, Changyan Dong, Luyun Qu, Ying Zuo
Summary: This study found that the oncogene E6E7 activates the transcription of GSK3B, which in turn reduces the level of FTO protein and inhibits the maturation and translation of HK2 mRNA.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Apoorvi Tyagi, Janardhan Keshav Karapurkar, Jencia Carminha Colaco, Neha Sarodaya, Ainsley Mike Antao, Kamini Kaushal, Saba Haq, Arun Pandian Chandrasekaran, Soumyadip Das, Vijai Singh, Seok-Ho Hong, Bharathi Suresh, Kye-Seong Kim, Suresh Ramakrishna
Summary: In this study, USP19 is identified as a negative regulator of p53 protein level in cervical cancer progression. The direct interaction between USP19 and p53 is demonstrated by pull down assay. Overexpression of USP19 promotes ubiquitination of p53 and reduces its protein half-life. CRISPR/Cas9-mediated knockout of USP19 elevates p53 protein levels, resulting in reduced colony formation, cell migration, and cell invasion in cervical cancer cells.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Cell Biology
Qianhui Li, Bumin Xie, Xi Chen, Bingfeng Lu, Shuo Chen, Xiujie Sheng, Yang Zhao
Summary: Small nucleolar RNAs (snoRNAs) have been found to participate in the occurrence and development of malignant tumors. In this study, SNORD6 was identified as a snoRNA that affects the pathogenesis and prognosis of cervical cancer. Knockdown of SNORD6 inhibited cell proliferation and clone formation, induced G1-S phase cell cycle arrest, decreased DNA synthesis, reduced cell migration and invasion, and increased apoptosis. Mechanistically, SNORD6 promoted the formation of the tumor suppressor protein p53 degradation complex E6-E6AP-p53, leading to p53 ubiquitination and degradation, and influencing its regulation of cell cycle and apoptosis. This study elucidated the biological role and specific mechanism of SNORD6 in cervical cancer, contributing to the basic theoretical research and potential diagnosis and treatment strategies.
CELL DEATH DISCOVERY
(2023)
Article
Biochemistry & Molecular Biology
Yuan Zhang, Jing-bo Liu, Jing Liu, Mengjun Liu, Hong-li Liu, Jing Zhang
Summary: In cervical cancer, the overexpression of UCHL3 is associated with poor prognosis, and it promotes cell growth, migration, and invasion. UCHL3 stabilizes NRF2 through deubiquitination, and overexpression of NRF2 can counteract the inhibitory effect of UCHL3 knockdown. These findings suggest that UCHL3 may serve as a novel therapeutic target for cervical cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cell Biology
Longxiang Wu, Zhenyu Ou, Peihua Liu, Cheng Zhao, Shiyu Tong, Ruizhe Wang, Yangle Li, Junbin Yuan, Minfeng Chen, Benyi Fan, Xiongbing Zu, Yongjie Wang, Jianing Tang
Summary: In this study, ATXN3 was identified as a deubiquitinating enzyme of YAP in prostate cancer. It interacted with YAP and inhibited the K48-specific poly-ubiquitination of YAP, thus stabilizing YAP protein and promoting the proliferation, invasion, and stem-like properties of prostate cancer cells. These findings provide a potential target for the therapy of prostate cancer.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Yongwen Luo, Jun Zhou, Jianing Tang, Fengfang Zhou, Zhiwen He, Tongzu Liu, Tao Liu
Summary: This study identified MINDY1 as a deubiquitinating enzyme of YAP in bladder cancer, demonstrating its role in interacting with, deubiquitinating, and stabilizing YAP. Depletion of MINDY1 led to decreased cell proliferation in bladder cancer, which could be rescued by YAP overexpression, affecting the expression of YAP and its target genes.
CANCER CELL INTERNATIONAL
(2021)
Article
Chemistry, Multidisciplinary
Tuan M. Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K. Tiwari, Katherine A. Donovan, Veronika Shoba, Santosh K. Chaudhary, Jaron A. M. Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S. Fischer, David R. Liu, Benjamin L. Ebert, Amit Choudhary
Summary: Proteolysis-targeting chimeras (PROTACs) are capable of inducing the degradation of target proteins by bringing them close to E3 ligases. However, the widely used E3 ligase recruiter, pomalidomide, can also cause the degradation of other proteins, resulting in off-target effects. This study developed a high-throughput platform to investigate off-target degradation and identified several zinc-finger (ZF) proteins as off-targets of pomalidomide-based PROTACs. By modifying the pomalidomide analogues at the appropriate position, off-target degradation of ZF proteins was reduced. Applying this design principle, anaplastic lymphoma kinase oncoprotein-targeting PROTACs with enhanced potency and minimal off-target degradation were developed.
Article
Gastroenterology & Hepatology
Jingsheng Ma, Yajun Wu, Shibao Cheng, Wentao Yang, Lin Zhong, Qigen Li, Lu Fang
Summary: This study investigates the role of FBXO22 in promoting pancreatic cancer growth. The researchers found that FBXO22 is upregulated in pancreatic cancer tissues and is associated with poor prognosis. Knockdown of FBXO22 inhibits pancreatic cancer cell growth, while overexpression accelerates it. Mechanistically, FBXO22 deactivates the Hippo pathway by directly interacting with and destabilizing LATS2. These findings shed light on the regulation of the Hippo pathway in pancreatic cancer growth and identify FBXO22 as a potential therapeutic target.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Zili Zhang, Yu Xing, Wenqing Gao, Liping Yang, Junzhong Shi, Weiliang Song, Tong Li
Summary: This study confirmed the high expression of IGF2BP2 in gastric cancer cell lines and tumor tissues, and identified its role in regulating the proliferation and migration of gastric cancer through recognition of the m(6)A modification sites of SIRT1 mRNA.
Article
Cell Biology
Tingting Lv, Dongwei He, Xiaokuan Zhang, Xiaojin Guo, Zijie Li, Aili Zhang, Bo Fan, Zhiyu Wang
Summary: Prostate cancer is the most common genitourinary malignant cancer in men worldwide, and effective treatment strategies for advanced prostate cancer are still lacking. The expression and interaction of SGOL2 and RAB1A in prostate cancer cells play important roles in tumor development and migration. These findings contribute to a better understanding and treatment of prostate cancer.
Article
Oncology
Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen
Summary: In this study, it was found that FBXO22 is highly expressed in MLLr AML and promotes AML progression by targeting BACH1 for degradation. Knockdown of FBXO22 leads to increased apoptosis in MLLr leukemia cells and reduced LSCs in serial transplantations. Targeting FBXO22 could be an ideal strategy to eradicate LSCs without affecting normal hematopoiesis.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Article
Oncology
Yinglan Liu, Ying Xiong
Summary: This study investigates the functional roles and pathogenic mechanisms of HADHA in ovarian cancer. The results reveal significant HADHA overexpression in ovarian cancer tissues and cell lines, which correlates with poor survival outcomes and various pathological parameters. Loss-of-function experiments targeting HADHA demonstrate its inhibitory effects on cell growth and migration, and its promotion of apoptosis in ovarian cancer cells. Additionally, HADHA is found to upregulate CDK1 expression by inhibiting its degradation, and CDK1 overexpression reverses the impaired cell development caused by HADHA depletion.
CANCER CELL INTERNATIONAL
(2023)
Article
Cell Biology
Mengling Ye, Lu Zhao, Lu Zhang, Siyi Wu, Zhao Li, Yi Qin, Fei Lin, Linghui Pan
Summary: Colorectal cancer is a common tumor worldwide, and long non-coding RNAs play important roles in its development. This study reveals that NALT1 promotes the proliferation and migration of colorectal cancer cells by competitively regulating the expression of miRNA-574-5p and PEG10. These findings suggest the potential of NALT1 as a biomarker and therapeutic target for colorectal cancer.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Zi-Mei Peng, Yi-Yue Zhang, Dan Wei, Xiao-Jie Zhang, Bin Liu, Jun Peng, Xiu-Ju Luo
Summary: This study demonstrates that MALT1 upregulation promotes necroptosis in ischemic stroke by enhancing the degradation of A20. Inhibition of MALT1 can alleviate brain injury and restore the expression of A20, leading to the inhibition of necroptosis.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Computer Science, Cybernetics
Renata Wachowiak-Smolikova, Haibin Zhu
Summary: This article presents an adaptive computational methodology called Role-based Collaboration (RBC) that uses roles to facilitate and analyze system behavior in collaborative entities. The use of visualization provides insights into complex system behaviors in dynamic environments. The results show that time-varying systems can be optimized and assessed using visual analytics (VA) dashboards.
IEEE TRANSACTIONS ON COMPUTATIONAL SOCIAL SYSTEMS
(2023)
Article
Obstetrics & Gynecology
Miaomiao Ye, Wenbin Huang, Fengyun Chen, Weinan Chen, Xueqiong Zhu
Summary: This study investigated the volume change of uterine leiomyomas during pregnancy and explored factors affecting their growth trends. The results showed that the growth rate of uterine leiomyomas was higher from the first to second trimester compared to the second to third trimester. Smaller leiomyomas were more likely to increase in size during pregnancy, and retroplacental leiomyomas were more likely to increase in volume compared to those located away from the placenta.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Editorial Material
Computer Science, Cybernetics
Haibin Zhu
Summary: In this issue, four articles are introduced, while the other three articles for the special section Next-Generation Networks for Industry 4.0 will be outlined in the special session editorial by guest editors Haisheng Yu, Jiehan Zhou, Zhixiong Chen, Yongzhi Wang, and Madhusanka Liyanage. They are highly appreciated for their effective work in collecting high-quality submissions.
IEEE SYSTEMS MAN AND CYBERNETICS MAGAZINE
(2023)
Article
Computer Science, Cybernetics
Qian Jiang, Haibin Zhu, Yan Qiao, Dongning Liu, Baoying Huang
Summary: This article introduces a method for group role assignment that considers cooperation and conflict factors to maximize team performance. It addresses two bottlenecks in practical applications and proposes a team evaluation method to help decision-makers establish sustainable teams. Large-scale simulation experiments demonstrate the feasibility and robustness of the proposed solution.
IEEE TRANSACTIONS ON COMPUTATIONAL SOCIAL SYSTEMS
(2023)
Article
Computer Science, Cybernetics
Peiyun Zhang, Xiaoqi Hua, Haibin Zhu
Summary: Blockchain as a ledger technology offers decentralization without the need for central servers. Cross-chain technology can connect different blockchains and enable interoperability and information sharing. This work designs a cross-chain digital asset system that includes two parallel chains and a relay chain. The proposed system ensures secure trading and payment through the transmission of cross-chain messages. Testing and analysis show that the system provides more secure trading and payment compared to its peers.
IEEE TRANSACTIONS ON COMPUTATIONAL SOCIAL SYSTEMS
(2023)
Article
Oncology
Han Wang, Xin Chen, Yanshan Jin, Tingxian Liu, Yizuo Song, Xuejie Zhu, Xueqiong Zhu
Summary: This study aims to clarify the role and underlying molecular pathways of DYNLT3 in breast cancer tumorigenesis. Differential expression of DYNLT3 was detected in breast cancer tissues and cells, showing that DYNLT3 may act as a tumor-promoter in age-associated breast cancer. Knockdown of DYNLT3 suppressed cell growth, migration, and invasion, and induced cell apoptosis, highlighting its potential as a therapeutic target for breast cancer.
Article
Oncology
Xin Chen, Mengying Jiang, Shengjie Zhou, Hong Chen, Gendi Song, Yichen Wu, Xueqiong Zhu
Summary: Preferentially expressed antigen in melanoma (PRAME), a member of the CTA gene family, was found to be highly expressed in cervical cancer tissues and cells compared with control groups. PRAME promoted cell proliferation, migration, and invasion while reducing cell apoptosis and G0/G1 arrest by activating the Wnt/beta-catenin pathway. These findings may have implications for future cervical cancer treatments.
Article
Computer Science, Cybernetics
Lu Liang, Jingdong Fu, Haibin Zhu, Dongning Liu
Summary: This article studies the team allocation problem in mass crowdsourcing. To ensure the rapid completion of tasks and maintain the enthusiasm and income of workers, tasks are assigned to multiple teams with limitations on worker participation. The article proposes a formalized problem based on extending GMRA and presents a solution. Simulation experiments demonstrate the efficiency and feasibility of the proposed approach.
IEEE TRANSACTIONS ON COMPUTATIONAL SOCIAL SYSTEMS
(2023)
Article
Computer Science, Cybernetics
Haibin Zhu
Summary: This article presents a model for simulating resource/benefit distribution and checks for Pareto improvements using a revised GRA model. The study shows that Pareto improvements are not possible when resources are insufficient, and can only be achieved when there are sufficient resources and manpower.
IEEE TRANSACTIONS ON COMPUTATIONAL SOCIAL SYSTEMS
(2023)
Article
Engineering, Biomedical
Shuya Pan, Zhengwei Sun, Bo Zhao, Liqing Miao, Qingfeng Zhou, Tianfeng Chen, Xueqiong Zhu
Summary: This review focuses on the application of Mn-based nanomaterials in radiotherapy. These nanomaterials can enhance the efficacy of radiotherapy by alleviating tumor hypoxia, increasing reactive oxygen species production, increasing GSH conversion, and promoting antitumor immunity. Furthermore, they can also serve as contrast agents for precision therapy.
Article
Oncology
Bo Sheng, Bo Zhao, Yue Dong, Jiamin Zhang, Suni Wu, Huihui Ji, Xueqiong Zhu
Summary: This study investigated the expression and function of CPNE1 in ovarian cancer. The results showed that CPNE1 overexpression was associated with poor prognosis in ovarian cancer and promoted tumor cell proliferation, invasion, and migration. Furthermore, CPNE1 was found to mediate M2 macrophage polarization and upregulate CD163, CD206, and interleukin-10, suggesting a potential therapeutic target for ovarian cancer.
Article
Cell Biology
Yi Liu, Hejing Liu, Miaomiao Ye, Mengying Jiang, Xin Chen, Gendi Song, Huihui Ji, Zhi-wei Wang, Xueqiong Zhu
Summary: This study reveals that BRD4, a member of the BET protein family, is asymmetrically methylated by PRMT1 in ovarian cancer. The overexpression of PRMT1 is associated with poor prognosis in ovarian cancer patients. Silencing PRMT1 inhibits ovarian cancer proliferation, migration, and invasion. PRMT1-mediated BRD4 methylation promotes BRD4 phosphorylation and is involved in ovarian cancer metastasis.
CELL DEATH & DISEASE
(2023)
Article
Computer Science, Cybernetics
Qian Jiang, Dongning Liu, Haibin Zhu, Yan Qiao, Baoying Huang
Summary: This article explores the team allocation problem from a dynamic perspective, proposing the revised group role assignment problem to achieve balance in resources and abilities within teams. Through large-scale simulation experiments, it reveals the paradox of equilibrium.
IEEE TRANSACTIONS ON COMPUTATIONAL SOCIAL SYSTEMS
(2023)
Article
Oncology
Miaomiao Ye, Tingxian Liu, Liqing Miao, Shuangwei Zou, Huihui Ji, Jian'an Zhang, Xueqiong Zhu
Summary: Zinc finger protein 275 (ZNF275) has been found to be highly expressed in cervical cancer tissues and downregulation of ZNF275 can inhibit tumor growth and weaken the AKT/Bcl-2 signaling pathway. Additionally, the AKT inhibitor triciribine synergizes with cisplatin to enhance the therapeutic effect on cervical cancer cells expressing high ZNF275. The combination treatment of triciribine and cisplatin is more effective in inducing tumor regression than single agents in cervical cancer PDX models expressing high ZNF275.
Review
Cell & Tissue Engineering
Yizuo Song, Hejing Liu, Shuya Pan, Xinli Xiang, Miaomiao Ye, Xueqiong Zhu
Summary: Mesenchymal stromal cells (MSCs) have shown great promise in various fields such as regenerative medicine and cancer therapy. However, their role as important components within the tumor microenvironment poses potential tumorigenic risks, hindering their clinical translation.
STEM CELL RESEARCH & THERAPY
(2023)
