Journal
JOURNAL OF ANTIBIOTICS
Volume 74, Issue 6, Pages 363-369Publisher
SPRINGERNATURE
DOI: 10.1038/s41429-021-00411-8
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Funding
- Japan Agency for Medical Research and Development (AMED) [JP19am0101096]
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Aldsulfin, an anti-mannheimiosis agent, isolated from a culture broth of the fungus Lasiodiplodia pseudotheobromae FKI-4499, showed antibacterial activity against Mannheimia haemolytica and Pasteurella multocida. Spectroscopic analysis revealed it to be an epithiodiketopiperazine with an unstable and unusual hemithioaminal moiety.
An anti-mannheimiosis agent, aldsulfin, was isolated from a culture broth of the fungus Lasiodiplodia pseudotheobromae FKI-4499, together with a known compound, lasiodipline C, using bioassay-guided fractionation. Spectroscopic analysis of aldsulfin, using NMR, mass spectrometry, and CD analyses revealed it to be an epithiodiketopiperazine with an unstable and unusual hemithioaminal moiety. Aldsulfin showed antibacterial activity against Mannheimia haemolytica and Pasteurella multocida.
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