Aldsulfin, a novel unusual anti-mannheimiosis epithiodiketopiperazine antibiotic produced by Lasiodiplodia pseudotheobromae FKI-4499

An anti-mannheimiosis agent, aldsulfin, was isolated from a culture broth of the fungus Lasiodiplodia pseudotheobromae FKI-4499, together with a known compound, lasiodipline C, using bioassay-guided fractionation. Spectroscopic analysis of aldsulfin, using NMR, mass spectrometry, and CD analyses revealed it to be an epithiodiketopiperazine with an unstable and unusual hemithioaminal moiety. Aldsulfin showed antibacterial activity against Mannheimia haemolytica and Pasteurella multocida.

Automated summary

Aldsulfin, an anti-mannheimiosis agent, isolated from a culture broth of the fungus Lasiodiplodia pseudotheobromae FKI-4499, showed antibacterial activity against Mannheimia haemolytica and Pasteurella multocida. Spectroscopic analysis revealed it to be an epithiodiketopiperazine with an unstable and unusual hemithioaminal moiety.