Amino Acid Transporter LAT1 (SLC7A5) Mediates MeHg-Induced Oxidative Stress Defense in the Human Placental Cell Line HTR-8/SVneo

Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis

(2020) Magdalena Markowicz-Piasecka et al.   APOPTOSIS

Uptake, efflux, and toxicity of inorganic and methyl mercury in the endothelial cells (EA.hy926)

(2020) Songnian Liu et al.   Scientific Reports

Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death

(2020) Boutaina Daher et al.   Frontiers in Oncology

In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP)1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta

(2020) Sebastian Granitzer et al.   ARCHIVES OF TOXICOLOGY

ATP modulates SLC7A5 (LAT1) synergistically with cholesterol

(2020) Jessica Cosco et al.   Scientific Reports

Glutathione antioxidant system and methylmercury-induced neurotoxicity: An intriguing interplay

(2019) Marcelo Farina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Characterization of the expression of LAT1 as a prognostic indicator and a therapeutic target in renal cell carcinoma

(2019) Kosuke Higuchi et al.   Scientific Reports

Toxicity of mercury: Molecular evidence

(2019) Lixin Yang et al.   CHEMOSPHERE

Methylmercury alters proliferation, migration, and antioxidant capacity in human HTR8/SV-neo trophoblast cells

(2018) Emily K. Tucker et al.   REPRODUCTIVE TOXICOLOGY

Methylmercury Uptake into BeWo Cells Depends on LAT2-4F2hc, a System L Amino Acid Transporter

(2017) Christina Balthasar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Essential Roles of L-Type Amino Acid Transporter 1 in Syncytiotrophoblast Development by Presenting Fusogenic 4F2hc

(2017) Ryuichi Ohgaki et al.   MOLECULAR AND CELLULAR BIOLOGY

Increase in L-type amino acid transporter 1 expression during cholangiocarcinogenesis caused by liver fluke infection and its prognostic significance

(2017) Supak Yothaisong et al.   PARASITOLOGY INTERNATIONAL

Endoplasmic reticulum stress preconditioning modifies intracellular mercury content by upregulating membrane transporters

(2017) Fusako Usuki et al.   Scientific Reports

Genetics of the human placenta: implications for toxicokinetics

(2016) Claudia Gundacker et al.   ARCHIVES OF TOXICOLOGY

Mechanisms involved in the transport of mercuric ions in target tissues

(2016) Christy C. Bridges et al.   ARCHIVES OF TOXICOLOGY

Is Low Non-Lethal Concentration of Methylmercury Really Safe? A Report on Genotoxicity with Delayed Cell Proliferation

(2016) María Elena Crespo-Lopez et al.   PLoS One

Mercury toxicokinetics of the healthy human term placenta involve amino acid transporters and ABC transporters

(2016) Elisabeth Straka et al.   TOXICOLOGY

Trace elements as paradigms of developmental neurotoxicants: Lead, methylmercury and arsenic

(2015) Philippe Grandjean et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Oxidative stress in preeclampsia and the role of free fetal hemoglobin

(2015) Stefan R. Hansson et al.   Frontiers in Physiology

Global methylmercury exposure from seafood consumption and risk of developmental neurotoxicity: a systematic review

(2014) Mary C Sheehan et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Associations of methylmercury and inorganic mercury between human cord blood and maternal blood: A meta-analysis and its application

(2014) Langbo Ou et al.   ENVIRONMENTAL POLLUTION

Mechanisms of Hg species induced toxicity in cultured human astrocytes: genotoxicity and DNA-damage response

(2014) Imke Pieper et al.   Metallomics

The Catalytic Subunit of the System L1 Amino Acid Transporter (Slc7a5) Facilitates Nutrient Signalling in Mouse Skeletal Muscle

(2014) Nadège Poncet et al.   PLoS One

Differential levels of amino acid transporters System L and ASCT2, and the mTOR protein in placenta of preeclampsia and IUGR

(2014) Yukiyo Aiko et al.   BMC Pregnancy and Childbirth

Glutathione: new roles in redox signaling for an old antioxidant

(2014) Katia Aquilano et al.   Frontiers in Pharmacology

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mercury, Cadmium, and Lead Levels in Human Placenta: A Systematic Review

(2012) María D. Esteban-Vasallo et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Proliferation potential of human amniotic fluid stem cells differently responds to mercury and lead exposure

(2011) C. Gundacker et al.   AMINO ACIDS

Methylmercury and Brain Development: Imprecision and Underestimation of Developmental Neurotoxicity in Humans

(2011) Philippe Grandjean et al.   MOUNT SINAI JOURNAL OF MEDICINE

Modulation of methylmercury uptake by methionine: Prevention of mitochondrial dysfunction in rat liver slices by a mimicry mechanism

(2011) Daniel Henrique Roos et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Role of oxidative stress markers and antioxidants in the placenta of preeclamptic patients

(2010) Neerja Rani et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Efficient siRNA-mediated prolonged gene silencing in human amniotic fluid stem cells

(2010) Margit Rosner et al.   Nature Protocols

Role of the l-amino Acid Transporter-1 (LAT-1) in Mouse Trophoblast Cell Invasion

(2010) M.K. Chrostowski et al.   PLACENTA

Review: Reactive oxygen and nitrogen species and functional adaptation of the placenta

(2010) L. Myatt   PLACENTA

Transport of amino acids through the placenta and their role

(2008) M. A. Grillo et al.   AMINO ACIDS

The anatomy of the normal placenta

(2008) B Huppertz   JOURNAL OF CLINICAL PATHOLOGY

The methylmercury-l-cysteine conjugate is a substrate for the L-type large neutral amino acid transporter

(2008) Zhaobao Yin et al.   JOURNAL OF NEUROCHEMISTRY

A mathematical model of glutathione metabolism

(2008) Michael C Reed et al.   Theoretical Biology and Medical Modelling

Molecular mechanisms triggered by mercury

(2007) GianPaolo Guzzi et al.   TOXICOLOGY