Integrin-Linked Kinase Links Integrin Activation to Invadopodia Function and Invasion via the p(T567)-Ezrin/NHERF1/NHE1 Pathway

Acidosis and proteolysis in the tumor microenvironment

(2019) Kyungmin Ji et al.   CANCER AND METASTASIS REVIEWS

Defining the Hallmarks of Metastasis

(2019) Danny R. Welch et al.   CANCER RESEARCH

Integrins: Moonlighting Proteins in Invadosome Formation

(2019) Peláez et al.   Cancers

Targeting invadopodia for blocking breast cancer metastasis

(2018) Tomer Meirson et al.   DRUG RESISTANCE UPDATES

Integrin and microtubule crosstalk in the regulation of cellular processes

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Phosphorylation of NHERF1 S279 and S301 differentially regulates breast cancer cell phenotype and metastatic organotropism

(2018) Maria Raffaella Greco et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Invadosomes are coming: new insights into function and disease relevance

(2017) Elyse K. Paterson et al.   FEBS Journal

Tumor Cell Invadopodia: Invasive Protrusions that Orchestrate Metastasis

(2017) Robert J. Eddy et al.   TRENDS IN CELL BIOLOGY

Tetraspanin 8 is a novel regulator of ILK-driven β1 integrin adhesion and signaling in invasive melanoma cells

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The challenge of targeting metastasis

(2015) Isaiah J. Fidler et al.   CANCER AND METASTASIS REVIEWS

Podosomes and invadopodia: tools to breach vascular basement membrane

(2015) Giorgio Seano et al.   CELL CYCLE

Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network

(2015) Vira V. Artym et al.   JOURNAL OF CELL BIOLOGY

Looking at the whole picture

(2015) Michael J. Zellweger   JOURNAL OF NUCLEAR CARDIOLOGY

A Novel NHE1-Centered Signaling Cassette Drives Epidermal Growth Factor Receptor–Dependent Pancreatic Tumor Metastasis and Is a Target for Combination Therapy

(2015) Rosa Angela Cardone et al.   NEOPLASIA

Targeting invadopodia to block breast cancer metastasis

(2015) Mark A Eckert et al.   Oncotarget

EMT and EGFR in CTCs cytokeratin negative non-metastatic breast cancer

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Digging a little deeper: The stages of invadopodium formation and maturation

(2014) Brian T. Beaty et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The scaffolding protein NHERF1 sensitizes EGFR-dependent tumor growth, motility and invadopodia function to gefitinib treatment in breast cancer cells

(2014) ANTONIA BELIZZI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

MS/MS-based strategies for proteomic profiling of invasive cell structures

(2014) Serhiy Havrylov et al.   PROTEOMICS

β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation

(2013) Brian T. Beaty et al.   MOLECULAR BIOLOGY OF THE CELL

Invading one step at a time: the role of invadopodia in tumor metastasis

(2013) H Paz et al.   ONCOGENE

Protease activity at invadopodial focal digestive areas is dependent on NHE1-driven acidic pHe

(2013) MARIA RAFFAELLA GRECO et al.   ONCOLOGY REPORTS

ß1 Integrin Binding Phosphorylates Ezrin at T567 to Activate a Lipid Raft Signalsome Driving Invadopodia Activity and Invasion

(2013) Ester Antelmi et al.   PLoS One

Exosome Secretion Is Enhanced by Invadopodia and Drives Invasive Behavior

(2013) Daisuke Hoshino et al.   Cell Reports

Pathological roles of invadopodia in cancer invasion and metastasis

(2012) Hideki Yamaguchi   EUROPEAN JOURNAL OF CELL BIOLOGY

pH regulators in invadosomal functioning: Proton delivery for matrix tasting

(2012) Lucie Brisson et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

NHERF1 acts as a molecular switch to program metastatic behavior and organotropism via its PDZ domains

(2012) Rosa Angela Cardone et al.   MOLECULAR BIOLOGY OF THE CELL

Metastatic disease: A drug discovery perspective

(2012) François Lehembre et al.   SEMINARS IN CANCER BIOLOGY

Adhesion rings surround invadopodia and promote maturation

(2012) K. M. Branch et al.   Biology Open

Degrading Devices: Invadosomes in Proteolytic Cell Invasion

(2011) Stefan Linder et al.   Annual Review of Cell and Developmental Biology

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms

(2011) Qian Qin et al.   CELL RESEARCH

Directed cell invasion and migration during metastasis

(2011) Jose Javier Bravo-Cordero et al.   CURRENT OPINION IN CELL BIOLOGY

Na+/H+ exchanger regulatory factor 1 expression levels in blood and tissue predict breast tumour clinical behaviour

(2011) Antonia Bellizzi et al.   HISTOPATHOLOGY

Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway

(2011) Marco A. O. Magalhaes et al.   JOURNAL OF CELL BIOLOGY

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

(2011) Danielle A. Murphy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hypoxia-Induced Invadopodia Formation Involves Activation of NHE-1 by the p90 Ribosomal S6 Kinase (p90RSK)

(2011) Fabrice Lucien et al.   PLoS One

NHE1 promotes invadopodial ECM proteolysis through acidification of the peri-invadopodial space

(2010) Giovanni Busco et al.   FASEB JOURNAL

Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay

(2008) Ola Söderberg et al.   METHODS