Article
Pharmacology & Pharmacy
Rifika Jain, Mohamed Ali Hussein, Shannon Pierce, Chad Martens, Preksha Shahagadkar, Gnanasekar Munirathinam
Summary: Licorice, a natural herb used for centuries, contains compounds like glycyrrhizin and glycyrrhetinic acid which have various pharmacological effects, including anti-inflammatory, anticancer, antiviral properties. Studies show that licorice is effective against the replication of SARS-CoV-2 and has potential in cancer prevention and treatment.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Bastian Haberkorn, Dennis Loewen, Lukas Meier, Martin F. F. Fromm, Joerg Koenig
Summary: Due to alternative splicing, the SLCO1B3 gene encodes two protein variants, Lt-OATP1B3 and Ct-OATP1B3, expressed in different tissues. The transcriptional regulation and transcription factors controlling the expression of these variants are not well understood. In this study, we cloned DNA fragments from the promoter regions of the Lt-SLCO1B3 and Ct-SLCO1B3 genes and investigated their activity in different cell lines. We identified potential binding sites for transcription factors and found that ZKSCAN3 and SOX9 are important for the cell type-specific regulation of the Ct-SLCO1B3 gene.
Article
Immunology
Fabiolla Rocha Santos Passos, Luana Heimfarth, Brenda Souza Monteiro, Cristiane Bani Correa, Tatiana Rodrigues de Moura, Adriano Antunes de Souza Araujo, Paulo Ricardo Martins-Filho, Lucindo Jose Quintans-Junior, Jullyana de Souza Siqueira Quintans
Summary: This study evaluated the role of oxidative stress-related molecules in COVID-19 and found that GFAP, RAGE, HMGB1, and COX-2 were upregulated in patients with the most severe forms of the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Yanlai Sun, Zhen Cao, Junqi Shan, Yang Gao, Xin Liu, Dejian Ma, Zengjun Li
Summary: The study revealed that circ_0020095 is highly expressed in colorectal cancer tissues and cells, promoting cancer cell proliferation, invasion, migration, and cisplatin resistance through the miR-487a-3p/SOX9 axis. This indicates that circ_0020095 could be a promising therapeutic target for colorectal cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Omer Uslukaya, Zeynep Yegin, Fatih Taskesen, Ibrahim Halil Yildirim
Summary: There is a connection between inflammation and tumor development, with NF-kappa B playing a crucial role. COX-2, IL-8, VEGF, MMP-2, and MMP-9 are key genes involved in angiogenesis and extracellular matrix disruption. COX-2, IL-8, and VEGF are upregulated in colon tumors, while MMP-2 and MMP-9 expression remains unchanged.
CELLULAR AND MOLECULAR BIOLOGY
(2023)
Article
Oncology
Erik Lizarraga-Verdugo, Tatiana Galicia Carmona, Rosalio Ramos-Payan, Mariana Avendano-Felix, Mercedes Bermudez, Maryelv Parra-Niebla, Cesar Lopez-Camarillo, Edith Fernandez-Figueroa, Leonardo Lino-Silva, Herminia Arvelo Saavedra, Itzel Vela-Sarmiento, Roberto Cardenas Ovando, Erika Ruiz-Garcia, Maribel Aguilar-Medina
Summary: Colorectal cancer is a common malignancy, with a need for novel biomarkers for accurate diagnosis and treatment. SOX9 expression in early-stage CRC patients was evaluated in this study, with findings indicating a potential role in tumorigenesis and association with advanced T-stages in clinical-stage II patients, though not linked to relapse-free survival.
Article
Cell Biology
Chenlong Li, Hongshan Zheng, Jinsheng Xiong, Yuxin Huang, Haoyang Li, Hua Jin, Siqi Ai, Yingjie Wang, Tianqi Su, Guiyin Sun, Xu Xiao, Tianjiao Fu, Yujie Wang, Xin Gao, Peng Liang
Summary: This study investigates the role of miR-596-3p in brain metastasis of NSCLC. The results reveal that miR-596-3p inhibits the invasion of cancer cells and permeability of the blood brain barrier by modulating the YAP1-IL8 network. The findings suggest that miR-596-3p may serve as a potential therapeutic target for brain metastasis in NSCLC.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Shazhou Ye, Mingjun Xu, Tingwei Zhu, Jiayi Chen, Shanping Shi, Haizhong Jiang, Qingfang Zheng, Qi Liao, Xiaoyun Ding, Yang Xi
Summary: CYGB plays a crucial role in ferroptosis by regulating ROS accumulation and impacting mitochondrial function. Overexpression of CYGB increases sensitivity of cancer cells to ferroptotic cell death, which is mediated through the p53-YAP1 axis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Polymer Science
Zi-yi Han, Xue-feng Bai, Yu-zhang Wang, Qi-wen Chen, Xian-zheng Zhang
Summary: Gut microbial glucuronidase-responsive glycyrrhizin micelles are a type of micelle system that can deliver chemotherapeutic drugs and inhibit P-gp protein, overcoming colon cancer chemotherapy resistance and enhancing its efficacy.
ACTA POLYMERICA SINICA
(2022)
Article
Oncology
Sara Shayan, Arash Arashkia, Golnaz Bahramali, Asghar Abdoli, Mohammad Sadegh Shams Nosrati, Kayhan Azadmanesh
Summary: This study demonstrates that HSV-HMGB1 enhances the viability of colorectal cancer cells under hypoxic conditions by inducing autophagy. Understanding the characteristics of cancer cells, microenvironment, and cell signaling is crucial to improving therapeutic strategies.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Jiaxin Liang, Qiang Liu, Longzheng Xia, Jinguan Lin, Linda Oyang, Shiming Tan, Qiu Peng, Xianjie Jiang, Xuemeng Xu, Nayiyuan Wu, Yanyan Tang, Min Su, Xia Luo, Yiqing Yang, Qianjin Liao, Yujuan Zhou
Summary: This study found that Rac1 is highly expressed in colon cancer tissues and cells, and promotes the proliferation, migration, and invasion of colon cancer cells by upregulating SOX9. Rac1 also activates glycolysis and the pentose phosphate pathway in colon cancer cells by mediating the axis of SOX9/HK2/G6PD.
Article
Chemistry, Multidisciplinary
Huan Liu, Rui Deng, Cheng-wei Zhu, Hong-kuan Han, Gang-fan Zong, Lang Ren, Peng Cheng, Zhong-hong Wei, Yang Zhao, Su-yun Yu, Yin Lu
Summary: The combination of rosmarinic acid and ginsenoside Rg1 can suppress the metastasis of colorectal cancer, providing potential therapeutic effects.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Oncology
Chao Gao, Mei-Yu Quan, Qian-Jie Chen, Ruo Yang, Yuanyuan Wu, Jia-Yu Liu, Zhong-Yuan Lin, Xue Li, Jue-Ting Cai, Tian-Fang Jiang, Le Xu, Majid Mossahebi-Mohammadi, Qiang Guo, Jin-San Zhang
Summary: Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive and resistant to traditional therapies. The alternative splicing of YAP1 mRNA results in 8 protein isoforms, with YAP1-2 being more crucial in mediating TGF-beta-induced EMT in PDAC cells and depending on AKT signaling.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Antonino Di Lorenzo, Elisabetta Bolli, Roberto Ruiu, Giuseppe Ferrauto, Enza Di Gregorio, Lidia Avalle, Aurora Savino, Pietro Poggio, Irene Fiore Merighi, Federica Riccardo, Mara Brancaccio, Elena Quaglino, Federica Cavallo, Laura Conti
Summary: High expression of TLR2 is associated with poor prognosis in breast cancer patients. Using a mouse model, we demonstrate the importance of TLR2 in maintaining breast cancer stem cells and inducing regulatory T cells. TLR2 inhibitors can reduce tumor growth and enhance the efficacy of chemotherapy.
Article
Pharmacology & Pharmacy
Xiaoyong Dai, Yibo Hou, Ting Deng, Gaoyang Lin, Yuanxiong Cao, Guiyuan Yu, Wei Wei, Qing Zheng, Laiqiang Huang, Shaohua Ma
Summary: TNBC is an aggressive cancer lacking clinical targets, and the RAGE antagonist peptide RP7 shows potential as a therapeutic option. RP7 selectively binds to RAGE-overexpressing TNBC cells, inhibiting cell proliferation, migration, and invasion, and suppressing tumor growth in mice models. Mechanistically, RP7 inhibits phosphorylation of ERK1/2, IKKα/β, IKBα, and p65, blocking the NF-xB pathway, decreasing Bcl-2 and HMGB1 protein expression, promoting cytochrome C release, activating apoptosis, and inhibiting EMT.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Shigeru Murakami, Chihiro Hirazawa, Takuma Ohya, Rina Yoshikawa, Toshiki Mizutani, Ning Ma, Mitsuru Moriyama, Takashi Ito, Chiaki Matsuzaki
Summary: The study demonstrated that Sargassum horneri can effectively suppress obesity, diabetes, and other metabolic disorders induced by a high-fat diet, as well as improve insulin resistance. The inhibitory effect of Sargassum horneri on intestinal fat absorption may be one of the key mechanisms for its beneficial effects.
Letter
Gastroenterology & Hepatology
Rungtiwa Dangtakot, Kitti Intuyod, Yaovalux Chamgramol, Chawalit Pairojkul, Somchai Pinlaor, Chanakan Jantawong, Thatsanapong Pongking, Ornuma Haonon, Ning Ma, Porntip Pinlaor
Article
Gastroenterology & Hepatology
Rungtiwa Dangtakot, Kitti Intuyod, Yaovalux Chamgramol, Chawalit Pairojkul, Somchai Pinlaor, Chanakan Jantawong, Thatsanapong Pongking, Ornuma Haonon, Ning Ma, Porntip Pinlaor
Summary: The study found that H. pylori infection and exposure to carcinogens can induce the development of cholangiocarcinoma (CCA) with slow progression.
Article
Behavioral Sciences
Jun Kawanokuchi, Ken Takagi, Nobuyuki Tanahashi, Teruhisa Yamamoto, Nobuyuki Nagaoka, Torao Ishida, Ning Ma
Summary: The study examined the preventive and therapeutic effects of acupuncture on depression model mice, revealing that acupuncture can restore reduced expression of neurotrophic factors induced by stress and that this effect occurs earlier than that of antidepressants.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Oncology
Feng He, Guofei Feng, Ning Ma, Kaoru Midorikawa, Shinji Oikawa, Hatasu Kobayashi, Zhe Zhang, Guangwu Huang, Kazuhiko Takeuchi, Mariko Murata
Summary: This study found that GDF10 is downregulated in nasopharyngeal carcinoma (NPC) due to aberrant promoter methylation. Treatment with 5-aza-2'-deoxycytidine can reverse the expression of GDF10. Overexpression of GDF10 inhibits cell proliferation, tumor growth, migration and invasion, and attenuates epithelial-to-mesenchymal transition through regulation of Smad2 and NF-kappa B signaling pathways.
Article
Nutrition & Dietetics
Shigeru Murakami, Chihiro Hirazawa, Rina Yoshikawa, Toshiki Mizutani, Takuma Ohya, Ning Ma, Takahiko Ikemori, Takashi Ito, Chiaki Matsuzaki
Summary: This study investigated the effects of the edible seaweed Campylaephora hypnaeoides on high-fat diet-induced obesity and metabolic diseases in mice. The results showed that C. hypnaeoides could alleviate obesity, hyperglycemia, hepatic steatosis, and hypercholesterolemia by improving antioxidant capacity and reducing inflammation.
NUTRITION & METABOLISM
(2022)
Article
Integrative & Complementary Medicine
Teruhisa Yamamoto, Jun Kawanokuchi, Nobuyuki Nagaoka, Ken Takagi, Torao Ishida, Tomoya Hayashi, Ning Ma
Summary: This study suggests that simultaneous acupuncture stimulation at GV20 and Yintang is effective for the prevention and treatment of depression, and this effect may involve the modulation of multiple neurotrophic factors.
ACUPUNCTURE IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Shigeru Murakami, Kohei Funahashi, Natsuki Tamagawa, Ma Ning, Takashi Ito
Summary: Taurine ameliorated diabetes and its complications by improving hepatic glucose metabolism and reducing oxidative stress.
Article
Food Science & Technology
Shigeru Murakami, Chihiro Hirazawa, Toshiki Mizutani, Rina Yoshikawa, Takuma Ohya, Ning Ma, Yutaka Owaki, Toyohiro Owaki, Takashi Ito, Chiaki Matsuzaki
Summary: This study found that the polysaccharides from Gloiopeltis furcata can alleviate obesity, diabetes, and metabolic diseases by inhibiting intestinal fat absorption and reducing inflammation and oxidative stress.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Nattawan Suwannakul, Napat Armartmuntree, Raynoo Thanan, Kaoru Midorikawa, Tetsuo Kon, Shinji Oikawa, Hatasu Kobayashi, Ning Ma, Shosuke Kawanishi, Mariko Murata
Summary: Elevated expression of GLUT5 in human cholangiocarcinoma is associated with poor prognosis and contributes to tumor proliferation and survival through modulation of cellular metabolism.
Review
Biology
Torao Ishida, Ken Takagi, Guifeng Wang, Nobuyuki Tanahashi, Jun Kawanokuchi, Hisayo Takagi, Yi Guo, Ning Ma
Summary: This study aims to compare the differences in C5aR1 levels at onset and IgG levels after recovery between COVID-19 and non-COVID-19 patients. Using a novel statistical method, the study found that COVID-19 patients had a greater increase in C5aR1 levels at onset and a smaller decrease in IgG levels after recovery.
Article
Biochemistry & Molecular Biology
Toshihiro Kato, Ning Ma, Takashi Ito, Akinobu Nishimura, Akihiro Sudo, Takenori Yamashita
TAURINE 12: A Conditionally Essential Amino Acid
(2022)
