CD200:CD200R Interactions and Their Importance in Immunoregulation

CD200 promotes immunosuppression in the pancreatic tumor microenvironment

(2020) Fouad Choueiry et al.   Journal for ImmunoTherapy of Cancer

CD200-CD200R1 inhibitory signaling prevents spontaneous bacterial infection and promotes resolution of neuroinflammation and recovery after stroke

(2019) Rodney M. Ritzel et al.   Journal of Neuroinflammation

Phase I study of samalizumab in chronic lymphocytic leukemia and multiple myeloma: blockade of the immune checkpoint CD200

(2019) Daruka Mahadevan et al.   Journal for ImmunoTherapy of Cancer

CD200 modulates spinal cord injury neuroinflammation and outcome through CD200R1

(2018) Natalia Lago et al.   BRAIN BEHAVIOR AND IMMUNITY

Up-regulation of regulatory T cells, CD200 and TIM3 expression in cytogenetically normal acute myeloid leukemia

(2018) Asmaa M. Zahran et al.   Cancer Biomarkers

An autologous tumor vaccine for CLL

(2018) Fang Zhu et al.   LEUKEMIA RESEARCH

CD200fc enhances anti-tumoral immune response and inhibits visceral metastasis of breast carcinoma

(2018) Nuray Erin et al.   Oncotarget

Prognostic impact of CD200 and CD56 expression in adult acute lymphoblastic leukemia patients

(2017) Salah Aref et al.   Hematology

High CD200 expression is associated with poor prognosis in cytogenetically normal acute myeloid leukemia, even in FlT3-ITD-/NPM1+ patients

(2017) Mario Tiribelli et al.   LEUKEMIA RESEARCH

On the origin of myeloid-derived suppressor cells

(2016) Camilla Rydberg Millrud et al.   Oncotarget

CD200 Inhibits Inflammatory Response by Promoting KATP Channel Opening in Microglia Cells in Parkinson’s Disease

(2016) Yi Ren et al.   MEDICAL SCIENCE MONITOR

The immunosuppressive ligands PD-L1 and CD200 are linked in AML T-cell immunosuppression: identification of a new immunotherapeutic synapse

(2015) S J Coles et al.   LEUKEMIA

Clinical impact of CD200 expression in patients with acute myeloid leukemia and correlation with other molecular prognostic factors

(2015) Daniela Damiani et al.   Oncotarget

An Interaction between CD200 and Monoclonal Antibody Agonists to CD200R2 in Development of Dendritic Cells That Preferentially Induce Populations of CD4 + CD25 + T Regulatory Cells

(2014) Reg Gorczynski et al.   JOURNAL OF IMMUNOLOGY

Blockade of CD200 in the Presence or Absence of Antibody Effector Function: Implications for Anti-CD200 Therapy

(2014) A. Kretz-Rommel et al.   JOURNAL OF IMMUNOLOGY

CD200 in CNS tumor-induced immunosuppression: the role for CD200 pathway blockade in targeted immunotherapy

(2014) Christopher L Moertel et al.   Journal for ImmunoTherapy of Cancer

Expression of CD200 on AML blasts directly suppresses memory T-cell function

(2012) S J Coles et al.   LEUKEMIA

Aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity

(2012) Yang Li et al.   ARTHRITIS RESEARCH & THERAPY

Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice

(2011) B. L. Mundy-Bosse et al.   CANCER RESEARCH

Immune Inhibitory Ligand CD200 Induction by TLRs and NLRs Limits Macrophage Activation to Protect the Host from Meningococcal Septicemia

(2010) Subhankar Mukhopadhyay et al.   Cell Host & Microbe

Tumor expression of CD200 inhibits IL-10 production by tumor-associated myeloid cells and prevents tumor immune evasion of CTL therapy

(2010) Lixin Wang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Downstream of Tyrosine Kinase 1 and 2 Play Opposing Roles in CD200 Receptor Signaling

(2010) R. Mihrshahi et al.   JOURNAL OF IMMUNOLOGY

The role of CD200 in immunity to B cell lymphoma

(2010) K. K. Wong et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Alternative splicing of CD200 is regulated by an exonic splicing enhancer and SF2/ASF

(2010) Zhiqi Chen et al.   NUCLEIC ACIDS RESEARCH

Potent Immunosuppression by a Bivalent Molecule Binding to CD200R and TGF-βR

(2010) Reginald M. Gorczynski et al.   TRANSPLANTATION

Breast cancer cell CD200 expression regulates immune response to EMT6 tumor cells in mice

(2009) Reginald M. Gorczynski et al.   BREAST CANCER RESEARCH AND TREATMENT

CD200/OX2, a cell surface molecule with immuno-regulatory function, is consistently expressed on hairy cell leukaemia neoplastic cells

(2009) Lorenzo Brunetti et al.   BRITISH JOURNAL OF HAEMATOLOGY

Expression profiling of genes related to asthma exacerbations

(2009) T. Aoki et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Gene expression signature of chronic lymphocytic leukaemia with Trisomy 12

(2009) E. Porpaczy et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

New assay to detect low-affinity interactions and characterization of leukocyte receptors for collagen including leukocyte-associated Ig-like receptor-1 (LAIR-1)

(2009) Lei Jiang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

Th2 cell hyporesponsiveness during chronic murine schistosomiasis is cell intrinsic and linked to GRAIL expression

(2009) Justin J. Taylor et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of a CD200 Transgene Is Necessary for Induction but Not Maintenance of Tolerance to Cardiac and Skin Allografts

(2009) R. M. Gorczynski et al.   JOURNAL OF IMMUNOLOGY

Lack of CD200 Enhances Pathological T Cell Responses during Influenza Infection

(2009) T. P. Rygiel et al.   JOURNAL OF IMMUNOLOGY

IDO Activates Regulatory T Cells and Blocks Their Conversion into Th17-Like T Cells

(2009) B. Baban et al.   JOURNAL OF IMMUNOLOGY

Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation

(2009) Nathalie Koning et al.   Journal of Innate Immunity

Role of a distal enhancer in the transcriptional responsiveness of the human CD200 gene to interferon-γ and tumor necrosis factor-α

(2009) Zhiqi Chen et al.   MOLECULAR IMMUNOLOGY

P120-Ras GTPase activating protein (RasGAP): A multi-interacting protein in downstream signaling

(2008) Perayot Pamonsinlapatham et al.   BIOCHIMIE

Prospective of Ras signaling in stem cells

(2008) Koushik Chakrabarty et al.   BIOLOGICAL CHEMISTRY

Control of viral immunoinflammatory lesions by manipulating CD200:CD200 receptor interaction

(2008) Pranita P. Sarangi et al.   CLINICAL IMMUNOLOGY

Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: A potential mechanism leading to chronic inflammation

(2008) Douglas G. Walker et al.   EXPERIMENTAL NEUROLOGY

CD200-dependent and nonCD200-dependant pathways of NK cell suppression by human IVIG

(2008) David A. Clark et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Disruption of T cell suppression in chronic lymphocytic leukemia by CD200 blockade

(2008) Christian P. Pallasch et al.   LEUKEMIA RESEARCH

A critical function for CD200 in lung immune homeostasis and the severity of influenza infection

(2008) Robert J Snelgrove et al.   NATURE IMMUNOLOGY

Identification of an Expressed Truncated Form of CD200, CD200tr, which is a Physiologic Antagonist of CD200-Induced Suppression

(2008) Zhiqi Chen et al.   TRANSPLANTATION

Cancer stem cells, CD200 and immunoevasion

(2008) Brian T. Kawasaki et al.   TRENDS IN IMMUNOLOGY

CD200: A putative therapeutic target in cancer

(2007) Jérôme Moreaux et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The inhibitory CD200R is differentially expressed on human and mouse T and B lymphocytes

(2007) Eva S.K. Rijkers et al.   MOLECULAR IMMUNOLOGY