The Central Role of Fibrinolytic Response in COVID-19—A Hematologist’s Perspective

Haemostasis in coronavirus disease 2019 - lesson from viscoelastic methods: a systematic review

(2021) Artur Slomka et al.   THROMBOSIS AND HAEMOSTASIS

Does Complement-Mediated Hemostatic Disturbance Occur in Traumatic Brain Injury? A Literature Review and Observational Study Protocol

(2020) Alexander Fletcher-Sandersjöö et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS

(2020) Yushun Wan et al.   JOURNAL OF VIROLOGY

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

COVID-19 Autopsies, Oklahoma, USA

(2020) Lisa M Barton et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Covid-19 infection and mortality: a physiologist’s perspective enlightening clinical features and plausible interventional strategies

(2020) Zaid A. Abassi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Expression of the SARS-CoV-2 ACE2 Receptor in the Human Airway Epithelium

(2020) Haijun Zhang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary Embolism in COVID-19 Patients: Awareness of an Increased Prevalence

(2020) Julien Poissy et al.   CIRCULATION

Prominent changes in blood coagulation of patients with SARS-CoV-2 infection

(2020) Huan Han et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment

(2020) Mehmet Soy et al.   CLINICAL RHEUMATOLOGY

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

(2020) Paolo Verdecchia et al.   European Journal of Internal Medicine

Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis

(2020) Wei-jie Guan et al.   EUROPEAN RESPIRATORY JOURNAL

Post‐mortem examination of COVID19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings of lungs and other organs suggesting vascular dysfunction

(2020) T. Menter et al.   HISTOPATHOLOGY

Contrast-enhanced ultrasound (CEUS) of the lung reveals multiple areas of microthrombi in a COVID-19 patient

(2020) Alice Tee et al.   INTENSIVE CARE MEDICINE

COVID-19 and Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers

(2020) Ankit B. Patel et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Autopsy in suspected COVID-19 cases

(2020) Brian Hanley et al.   JOURNAL OF CLINICAL PATHOLOGY

Fibrinolysis Shutdown Correlates to Thromboembolic Events in Severe COVID-19 Infection

(2020) Franklin L. Wright et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct Pathophysiology

(2020) Daniel Batlle et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tissue plasminogen activator (tPA) treatment for COVID‐19 associated acute respiratory distress syndrome (ARDS): A case series

(2020) Janice Wang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Hypercoagulability of COVID‐19 patients in Intensive Care Unit. A Report of Thromboelastography Findings and other Parameters of Hemostasis

(2020) Mauro Panigada et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Incidence of venous thromboembolism in hospitalized patients with COVID‐19

(2020) Saskia Middeldorp et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Evaluation of coagulation function by rotation thromboelastometry in critically ill patients with severe COVID-19 pneumonia

(2020) Vittorio Pavoni et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China

(2020) Hua Su et al.   KIDNEY INTERNATIONAL

Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies

(2020) Sufang Tian et al.   MODERN PATHOLOGY

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19

(2020) Louise Bowles et al.   NEW ENGLAND JOURNAL OF MEDICINE

Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young

(2020) Thomas J. Oxley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prediction of severe illness due to COVID-19 based on an analysis of initial Fibrinogen to Albumin Ratio and Platelet count

(2020) Xiaojie Bi et al.   PLATELETS

Plasminogen improves lung lesions and hypoxemia in patients with COVID-19

(2020) Yuanyuan Wu et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases

(2020) Cynthia Magro et al.   Translational Research

Salvage use of tissue plasminogen activator (tPA) in the setting of acute respiratory distress syndrome (ARDS) due to COVID-19 in the USA: a Markov decision analysis

(2020) Rashikh Choudhury et al.   World Journal of Emergency Surgery

Coronavirus disease 2019 (COVID-19): a clinical update

(2020) Min Zhou et al.   Frontiers of Medicine

H3K27M-mutant diffuse midline glioma with extensive intratumoral microthrombi in a young adult with COVID-19-associated coagulopathy

(2020) Matthew Pun et al.   ACTA NEUROPATHOLOGICA

COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection

(2020) Hanny Al-Samkari et al.   BLOOD

Platelet Gene Expression and Function in COVID-19 Patients

(2020) Bhanu Kanth Manne et al.   BLOOD

Microthrombi and ST-Segment Elevation Myocardial Infarction in COVID-19

(2020) Giulio Guagliumi et al.   CIRCULATION

Insights into pathogenesis of fatal COVID‐19 pneumonia from histopathology with immunohistochemical and viral RNA studies

(2020) Jennifer L. Sauter et al.   HISTOPATHOLOGY

Specific ACE2 expression in small intestinal enterocytes may cause gastrointestinal symptoms and injury after 2019-nCoV infection

(2020) Hui Zhang et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Dying with SARS-CoV-2 infection—an autopsy study of the first consecutive 80 cases in Hamburg, Germany

(2020) Carolin Edler et al.   INTERNATIONAL JOURNAL OF LEGAL MEDICINE

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

(2020) Qing Ye et al.   JOURNAL OF INFECTION

Fibrinolysis and COVID‐19: A plasmin paradox

(2020) Robert L. Medcalf et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

In vitro hypercoagulability and ongoing in vivo activation of coagulation and fibrinolysis in COVID‐19 patients on anticoagulation

(2020) Annabel Blasi et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Profile of natural anticoagulant, coagulant factor and anti-phospholipid antibody in critically ill COVID-19 patients

(2020) Yan Zhang et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

High D dimers and low global fibrinolysis coexist in COVID19 patients: what is going on in there?

(2020) C. Ibañez et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study

(2020) Luca Carsana et al.   LANCET INFECTIOUS DISEASES

Fibrinogen and D-dimer variances and anticoagulation recommendations in Covid-19: current literature review

(2020) Mert İlker Hayıroğlu et al.   Revista da Associacao Medica Brasileira

Different Hypercoagulable Profiles in Patients with COVID-19 Admitted to the Internal Medicine Ward and the Intensive Care Unit

(2020) Luca Spiezia et al.   THROMBOSIS AND HAEMOSTASIS

Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis

(2020) F.A. Klok et al.   THROMBOSIS RESEARCH

Coagulation abnormalities and thrombosis in patients with COVID-19

(2020) Marcel Levi et al.   Lancet Haematology

Vascular occlusion by neutrophil extracellular traps in COVID-19

(2020) Moritz Leppkes et al.   EBioMedicine

Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19

(2020) Eugenio D. Hottz et al.   BLOOD

Is COVID-19 associated thrombosis caused by overactivation of the complement cascade? A literature review

(2020) Alexander Fletcher-Sandersjöö et al.   THROMBOSIS RESEARCH

Image-proven thromboembolism in patients with severe COVID-19 in a tertiary critical care unit in the United Kingdom

(2020) Michael J.R. Desborough et al.   THROMBOSIS RESEARCH

Rotational thromboelastometry to assess hypercoagulability in COVID-19 patients

(2020) Nadine van Veenendaal et al.   THROMBOSIS RESEARCH

Anticoagulation and bleeding risk in patients with COVID-19

(2020) Nancy Musoke et al.   THROMBOSIS RESEARCH

Anaphylatoxin Receptor C3aR Contributes to Platelet Function, Thrombus Formation and In Vivo Haemostasis

(2019) Reinhard Sauter et al.   THROMBOSIS AND HAEMOSTASIS

Fibrinolysis Shutdown in Trauma

(2019) Hunter B. Moore et al.   ANESTHESIA AND ANALGESIA

PAI-1 contributes to homocysteine-induced cellular senescence

(2019) Tianjiao Sun et al.   CELLULAR SIGNALLING

A Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis

(2018) Reinhard J. Sauter et al.   CIRCULATION

Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV

(2018) Yuting Jiang et al.   Emerging Microbes & Infections

Inflammatory and Fibrinolytic System in Acute Respiratory Distress Syndrome

(2018) Mahesh Manjunath Gouda et al.   LUNG

Meta-Analysis of Preclinical Studies of Fibrinolytic Therapy for Acute Lung Injury

(2018) Cong Liu et al.   Frontiers in Immunology

A Test in Context: D-Dimer

(2017) Jeffrey I. Weitz et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

MERS, SARS and other coronaviruses as causes of pneumonia

(2017) Yudong Yin et al.   RESPIROLOGY

Thrombin Provokes Degranulation of Platelet α-Granules Leading to the Release of Active Plasminogen Activator Inhibitor-1 (PAI-1)

(2017) Benjamin R. Huebner et al.   SHOCK

The lectin complement pathway serine proteases (MASPs) represent a possible crossroad between the coagulation and complement systems in thromboinflammation

(2016) H. Kozarcanin et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The Role of Plasminogen Activator Inhibitor Type-1 in Fibrosis

(2016) Panagiotis Flevaris et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

A small molecule inhibitor of PAI-1 protects against doxorubicin-induced cellular senescence

(2016) Asish K. Ghosh et al.   Oncotarget

Complement Activation in Arterial and Venous Thrombosis is Mediated by Plasmin

(2016) Jonathan H. Foley et al.   EBioMedicine

Role of the Urokinase-Fibrinolytic System in Epithelial–Mesenchymal Transition during Lung Injury

(2015) Amarnath Satheesh Marudamuthu et al.   AMERICAN JOURNAL OF PATHOLOGY

Natural heterogeneity of  2-antiplasmin: functional and clinical consequences

(2015) S. Abdul et al.   BLOOD

The role of activated coagulation factor XII in overall clot stability and fibrinolysis

(2015) Joke Konings et al.   THROMBOSIS RESEARCH

Complement System Part II: Role in Immunity

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

From Fibrinolysis to the Plasminogen–Plasmin System and Beyond: A Remarkable Growth of Knowledge, with Personal Observations on the History of Fibrinolysis

(2014) Hau Kwaan   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Regulation of Lung Injury and Fibrosis by p53-Mediated Changes in Urokinase and Plasminogen Activator Inhibitor-1

(2013) Yashodhar P. Bhandary et al.   AMERICAN JOURNAL OF PATHOLOGY

Angiotensin-(1–9) enhances stasis-induced venous thrombosis in the rat because of the impairment of fibrinolysis

(2013) A Mogielnicki et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Three Decades of Research on Plasminogen Activator Inhibitor-1: A Multifaceted Serpin

(2013) Ann Gils et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Mechanisms of Severe Acute Respiratory Syndrome Coronavirus-Induced Acute Lung Injury

(2013) L. E. Gralinski et al.   mBio

Replication-dependent downregulation of cellular angiotensin-converting enzyme 2 protein expression by human coronavirus NL63

(2012) R. Dijkman et al.   JOURNAL OF GENERAL VIROLOGY

Effects of MASP-1 of the Complement System on Activation of Coagulation Factors and Plasma Clot Formation

(2012) Katharina Hess et al.   PLoS One

The Biochemistry, Physiology and Pathological roles of PAI-1 and the requirements for PAI-1 inhibition in vivo

(2012) Britt Van De Craen et al.   THROMBOSIS RESEARCH

Regulation of fibrinolysis by S100A10 in vivo

(2011) A. P. Surette et al.   BLOOD

Surfactant Therapy for Acute Lung Injury and Acute Respiratory Distress Syndrome

(2011) Krishnan Raghavendran et al.   CRITICAL CARE CLINICS

PAI-1 in tissue fibrosis

(2011) Asish K. Ghosh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Single Asparagine-Linked Glycosylation Site of the Severe Acute Respiratory Syndrome Coronavirus Spike Glycoprotein Facilitates Inhibition by Mannose-Binding Lectin through Multiple Mechanisms

(2010) Y. Zhou et al.   JOURNAL OF VIROLOGY

C1 inhibitor, a multi-functional serine protease inhibitor

(2010) Fengxin Lu et al.   THROMBOSIS AND HAEMOSTASIS

Cleavage of the SARS Coronavirus Spike Glycoprotein by Airway Proteases Enhances Virus Entry into Human Bronchial Epithelial Cells In Vitro

(2009) Yiu-Wing Kam et al.   PLoS One

The fibrinolytic system and the regulation of lung epithelial cell proteolysis, signaling, and cellular viability

(2008) Sreerama Shetty et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY