Human Placenta Exosomes: Biogenesis, Isolation, Composition, and Prospects for Use in Diagnostics

Visualization of SARS-CoV-2 virus invading the human placenta using electron microscopy

(2020) Gabriela N. Algarroba et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Placental exosomes isolated from urine of patients with gestational diabetes exhibit a differential profile expression of microRNAs across gestation

(2020) Ana Herrera-Van Oostdam et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Development of Novel High-Resolution Size-Guided Turbidimetry-Enabled Particle Purification Liquid Chromatography (PPLC): Extracellular Vesicles and Membraneless Condensates in Focus

(2020) Hussein Kaddour et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomes as Messengers between Mother and Fetus in Pregnancy

(2020) Liliana Czernek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Message from the Human Placenta: Structural and Immunomodulatory Defense against SARS-CoV-2

(2020) Nina-Naomi Kreis et al.   Cells

A Review of Exosomal Isolation Methods: Is Size Exclusion Chromatography the Best Option?

(2020) Karim Sidhom et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tetraspanins, More than Markers of Extracellular Vesicles in Reproduction

(2020) Jana Jankovičová et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SARS–CoV-2 infection of the placenta

(2020) Hillary Hosier et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating exosomal and Argonaute-bound microRNAs in preeclampsia

(2019) Orsolya Biró et al.   GENE

Preeclampsia

(2019) Sarosh Rana et al.   CIRCULATION RESEARCH

Comparison of six commercial serum exosome isolation methods suitable for clinical laboratories. Effect in cytokine analysis

(2019) Mónica Macías et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Extra Purified Exosomes from Human Placenta Contain An Unpredictable Small Number of Different Major Proteins

(2019) Burkova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomal microRNA profiling in early and late onset preeclamptic pregnant women reflects pathophysiology

(2019) Preenan Pillay et al.   International Journal of Nanomedicine

Placental extracellular vesicles express active dipeptidyl peptidase IV; levels are increased in gestational diabetes mellitus

(2019) Neva Kandzija et al.   Journal of Extracellular Vesicles

Proteomics profiling of autologous blood and semen exosomes from HIV-infected and uninfected individuals reveals compositional and functional variabilities

(2019) Hussein Kaddour et al.   MOLECULAR & CELLULAR PROTEOMICS

Preeclampsia: Risk Factors, Diagnosis, Management, and the Cardiovascular Impact on the Offspring

(2019) Rachael Fox et al.   Journal of Clinical Medicine

Placenta-derived mesenchymal stromal cells and their exosomes exert therapeutic effects in Duchenne muscular dystrophy

(2018) Ariel Bier et al.   BIOMATERIALS

Is the DNA of placental origin packaged in exosomes isolated from plasma and serum of pregnant women?

(2018) Gabriela Repiská et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Maternal and umbilical cord serum–derived exosomes enhance endothelial cell proliferation and migration

(2018) Linyan Jia et al.   FASEB JOURNAL

Placenta‑associated serum exosomal miR‑155 derived from patients with preeclampsia inhibits eNOS expression in human umbilical vein endothelial cells

(2018) Li Shen et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Placental exosomes profile in maternal and fetal circulation in intrauterine growth restriction - Liquid biopsies to monitoring fetal growth

(2018) Jezid Miranda et al.   PLACENTA

Role of mesenchymal stem cells exosomes derived microRNAs; miR-136, miR-494 and miR-495 in pre-eclampsia diagnosis and evaluation

(2018) Tarek M.k. Motawi et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Human Placental Exosomes in Gestational Diabetes Mellitus Carry a Specific Set of miRNAs Associated with Skeletal Muscle Insulin Sensitivity

(2018) Soumyalekshmi Nair et al.   CLINICAL SCIENCE

Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology

(2018) Tore Skotland et al.   JOURNAL OF LIPID RESEARCH

Exosomes From Women With Preeclampsia Induced Vascular Dysfunction by Delivering sFlt (Soluble Fms-Like Tyrosine Kinase)-1 and sEng (Soluble Endoglin) to Endothelial Cells

(2018) Xinwen Chang et al.   HYPERTENSION

Exosomes from human placenta purified by affinity chromatography on sepharose bearing immobilized antibodies against CD81 tetraspanin contain many peptides and small proteins

(2018) Evgeniya E. Burkova et al.   IUBMB LIFE

Quantitative Proteomics by SWATH‐MS Suggest an Association Between Circulating Exosomes and Maternal Metabolic Changes in Gestational Diabetes Mellitus

(2018) Nanthini Jayabalan et al.   PROTEOMICS

Placental Exosomes as Early Biomarker of Preeclampsia: Potential Role of Exosomal MicroRNAs Across Gestation

(2017) Carlos Salomon et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Gestational Diabetes

(2017) Lynn R. Mack et al.   OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA

Influence of maternal BMI on the exosomal profile during gestation and their role on maternal systemic inflammation

(2017) Omar Elfeky et al.   PLACENTA

Isolation of exosomes from whole blood by integrating acoustics and microfluidics

(2017) Mengxi Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipids in exosomes: Current knowledge and the way forward

(2017) Tore Skotland et al.   PROGRESS IN LIPID RESEARCH

Placenta-derived extracellular vesicles: their cargo and possible functions

(2017) Mary Familari et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Exosomes of human placenta-derived mesenchymal stem cells stimulate angiogenesis

(2017) Motohiro Komaki et al.   Stem Cell Research & Therapy

Secretome of in vitro cultured human embryos contains extracellular vesicles that are uptaken by the maternal side

(2017) Elisa Giacomini et al.   Scientific Reports

A Single Sphingomyelin Species Promotes Exosomal Release of Endoglin into the Maternal Circulation in Preeclampsia

(2017) Leonardo Ermini et al.   Scientific Reports

Human vaginal fluid contains exosomes that have an inhibitory effect on an early step of the HIV-1 life cycle

(2016) Johanna A. Smith et al.   AIDS

Proteomic characterization of macro-, micro- and nano-extracellular vesicles derived from the same first trimester placenta: relevance for feto-maternal communication

(2016) Mancy Tong et al.   HUMAN REPRODUCTION

Isolation of human trophoblastic extracellular vesicles and characterization of their cargo and antiviral activity

(2016) Yingshi Ouyang et al.   PLACENTA

Placental exosomes and pre-eclampsia: Maternal circulating levels in normal pregnancies and, early and late onset pre-eclamptic pregnancies

(2016) Preenan Pillay et al.   PLACENTA

MicroRNA-141 is upregulated in preeclamptic placentae and regulates trophoblast invasion and intercellular communication

(2016) Stephanie Ospina-Prieto et al.   Translational Research

Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification

(2016) Danielle L. Michell et al.   Jove-Journal of Visualized Experiments

Hypoxia-inducible miR-210 contributes to preeclampsia via targeting thrombospondin type I domain containing 7A

(2016) Rongcan Luo et al.   Scientific Reports

Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection

(2016) Barbara W Sódar et al.   Scientific Reports

Preeclampsia and Diabetes

(2015) Tracey L. Weissgerber et al.   Current Diabetes Reports

Gestational Diabetes Mellitus Is Associated With Changes in the Concentration and Bioactivity of Placenta-Derived Exosomes in Maternal Circulation Across Gestation

(2015) Carlos Salomon et al.   DIABETES

Mechanisms of RNA loading into exosomes

(2015) Teresa Janas et al.   FEBS LETTERS

The Effect of Glucose on the Release and Bioactivity of Exosomes From First Trimester Trophoblast Cells

(2015) Gregory E. Rice et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Isolation of syncytiotrophoblast microvesicles and exosomes and their characterisation by multicolour flow cytometry and fluorescence Nanoparticle Tracking Analysis

(2015) R.A. Dragovic et al.   METHODS

Oxygen tension regulates glucose-induced biogenesis and release of different subpopulations of exosome vesicles from trophoblast cells: A gestational age profile of placental exosomes in maternal plasma with gestational diabetes mellitus

(2015) Carlos Salomon et al.   PLACENTA

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Human Exosomal Placenta-Associated miR-517a-3p Modulates the Expression of PRKG1 mRNA in Jurkat Cells1

(2014) Saori Kambe et al.   BIOLOGY OF REPRODUCTION

Improvement of Cloned Embryos Development by Co-Culturing with Parthenotes: A Possible Role of Exosomes/Microvesicles for Embryos Paracrine Communication

(2014) Islam M. Saadeldin et al.   Cellular Reprogramming

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

Syncytin proteins incorporated in placenta exosomes are important for cell uptake and show variation in abundance in serum exosomes from patients with preeclampsia

(2014) Amandine Vargas et al.   FASEB JOURNAL

The role of trophoblastic microRNAs in placental viral infection

(2014) Jean-Francois Mouillet et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy

(2014) Suchismita Sarker et al.   Journal of Translational Medicine

Intercellular communication by exosomes in placenta: A possible role in cell fusion?

(2014) M. Record   PLACENTA

A Gestational Profile of Placental Exosomes in Maternal Plasma and Their Effects on Endothelial Cell Migration

(2014) Carlos Salomon et al.   PLoS One

Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2

(2014) Rania Ghossoub et al.   Nature Communications

The Possible Role of Extravillous Trophoblast-Derived Exosomes on the Uterine Spiral Arterial Remodeling under Both Normal and Pathological Conditions

(2014) Carlos Salomon et al.   Biomed Research International

Extravillous trophoblast cells-derived exosomes promote vascular smooth muscle cell migration

(2014) Carlos Salomon et al.   Frontiers in Pharmacology

Exosomes Secreted by Human Placenta Carry Functional Fas Ligand and TRAIL Molecules and Convey Apoptosis in Activated Immune Cells, Suggesting Exosome-Mediated Immune Privilege of the Fetus

(2013) A.-C. Stenqvist et al.   JOURNAL OF IMMUNOLOGY

Homeobox genes and down-stream transcription factor PPARγ in normal and pathological human placental development

(2013) P. Murthi et al.   PLACENTA

Lipidomic analysis of human placental Syncytiotrophoblast microvesicles in adverse pregnancy outcomes

(2013) S. Baig et al.   PLACENTA

Optimising sample collection for placental research

(2013) G.J. Burton et al.   PLACENTA

Exosomal Signaling during Hypoxia Mediates Microvascular Endothelial Cell Migration and Vasculogenesis

(2013) Carlos Salomon et al.   PLoS One

Hypoxia-Induced Changes in the Bioactivity of Cytotrophoblast-Derived Exosomes

(2013) Carlos Salomon et al.   PLoS One

Human placental trophoblasts confer viral resistance to recipient cells

(2013) E. Delorme-Axford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hijacking Multivesicular Bodies Enables Long-Term and Exosome-Mediated Long-Distance Action of Anthrax Toxin

(2013) Laurence Abrami et al.   Cell Reports

Amedeo Avogadro's cry: What is 1 µg of exosomes?

(2012) Eugene D. Sverdlov   BIOESSAYS

The expression profile of C19MC microRNAs in primary human trophoblast cells and exosomes

(2012) R. B. Donker et al.   MOLECULAR HUMAN REPRODUCTION

Immunomodulatory molecules are released from the first trimester and term placenta via exosomes

(2012) S.K. Kshirsagar et al.   PLACENTA

Multivesicular Body Morphogenesis

(2011) Phyllis I. Hanson et al.   Annual Review of Cell and Developmental Biology

Interaction and uptake of exosomes by ovarian cancer cells

(2011) Cristina Escrevente et al.   BMC CANCER

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Morphologic and proteomic characterization of exosomes released by cultured extravillous trophoblast cells

(2011) Safinur Atay et al.   EXPERIMENTAL CELL RESEARCH

Trophoblast-Derived Exosomes Mediate Monocyte Recruitment and Differentiation

(2010) Safinur Atay et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The Role of Placental Exosomes in Reproduction

(2010) Lucia Mincheva-Nilsson et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Lipidomics as a Tool for the Study of Lipoprotein Metabolism

(2010) Anatol Kontush et al.   Current Atherosclerosis Reports

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins

(2010) Caroline Subra et al.   JOURNAL OF LIPID RESEARCH

Human Villous Trophoblasts Express and Secrete Placenta-Specific MicroRNAs into Maternal Circulation via Exosomes1

(2009) Shan-Shun Luo et al.   BIOLOGY OF REPRODUCTION

Human Placenta Expresses and Secretes NKG2D Ligands via Exosomes that Down-Modulate the Cognate Receptor Expression: Evidence for Immunosuppressive Function

(2009) M. Hedlund et al.   JOURNAL OF IMMUNOLOGY

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

VAMP-8 segregates mast cell-preformed mediator exocytosis from cytokine trafficking pathways

(2008) N. Tiwari et al.   BLOOD

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY