HPV Meets APOBEC: New Players in Head and Neck Cancer

HPV induction of APOBEC3 enzymes mediate overall survival and response to cisplatin in head and neck cancer

(2020) Kayla L. Conner et al.   DNA REPAIR

Distinct immune evasion in APOBEC ‐enriched, HPV ‐negative HNSCC

(2020) Clemens Messerschmidt et al.   INTERNATIONAL JOURNAL OF CANCER

The mutational landscape of normal human endometrial epithelium

(2020) Luiza Moore et al.   NATURE

Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2

(2020) Salvatore Di Giorgio et al.   Science Advances

Endogenous APOBEC3B overexpression characterizes HPV-positive and HPV-negative oral epithelial dysplasias and head and neck cancers

(2020) Prokopios P. Argyris et al.   MODERN PATHOLOGY

Activation of DNA damage repair factors in HPV positive oropharyngeal cancers

(2020) Takeyuki Kono et al.   VIROLOGY

Association between APOBEC3H-Mediated Demethylation and Immune Landscape in Head and Neck Squamous Carcinoma

(2020) Qin Liu et al.   Biomed Research International

Detection of Viral Infections by Innate Immunity

(2020) Michael Carty et al.   BIOCHEMICAL PHARMACOLOGY

APOBEC: A molecular driver in cervical cancer pathogenesis

(2020) Sundaramoorthy Revathidevi et al.   CANCER LETTERS

APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma

(2019) Vincent L. Cannataro et al.   ONCOGENE

Novel genetic alterations and their impact on target therapy response in head and neck squamous cell carcinoma

(2019) Xiaohua Jiang et al.   Cancer Management and Research

The APOBEC3 genes and their role in cancer: insights from human papillomavirus

(2019) Nicola J Smith et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Epidemiology of Head and Neck Squamous Cell Carcinomas: Impact on Staging and Prevention Strategies

(2019) Jessica D. McDermott et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

PYHIN genes as potential biomarkers for prognosis of human papillomavirus-positive or -negative head and neck squamous cell carcinomas

(2019) Giuseppe Riva et al.   MOLECULAR BIOLOGY REPORTS

Expression of estrogen receptor alpha is associated with pathogenesis and prognosis of human papillomavirus‐positive oropharyngeal cancer

(2019) Makoto Kano et al.   INTERNATIONAL JOURNAL OF CANCER

A Conserved Mechanism of APOBEC3 Relocalization by Herpesviral Ribonucleotide Reductase Large Subunits

(2019) Adam Z. Cheng et al.   JOURNAL OF VIROLOGY

APOBEC mutagenesis is tightly linked to the immune landscape and immunotherapy biomarkers in head and neck squamous cell carcinoma

(2019) Daniel L. Faden et al.   ORAL ONCOLOGY

HPV33+ HNSCC is associated with poor prognosis and has unique genomic and immunologic landscapes

(2019) Kate Chatfield-Reed et al.   ORAL ONCOLOGY

PYHIN Proteins and HPV: Role in the Pathogenesis of Head and Neck Squamous Cell Carcinoma

(2019) Giuseppe Riva et al.   Microorganisms

Characterization of BK Polyomaviruses from Kidney Transplant Recipients Suggests a Role for APOBEC3 in Driving In-Host Virus Evolution

(2018) Alberto Peretti et al.   Cell Host & Microbe

NCCN Guidelines Insights: Head and Neck Cancers, Version 1.2018

(2018) A. Dimitrios Colevas et al.   Journal of the National Comprehensive Cancer Network

Within-Host Variations of Human Papillomavirus Reveal APOBEC Signature Mutagenesis in the Viral Genome

(2018) Yusuke Hirose et al.   JOURNAL OF VIROLOGY

Human Papillomavirus 16 E7 Stabilizes APOBEC3A Protein by Inhibiting Cullin 2-Dependent Protein Degradation

(2018) Joseph A. Westrich et al.   JOURNAL OF VIROLOGY

Strategy of Human Cytomegalovirus To Escape Interferon Beta-Induced APOBEC3G Editing Activity

(2018) Sara Pautasso et al.   JOURNAL OF VIROLOGY

APOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa

(2018) Raymond J. Cho et al.   Science Translational Medicine

Expressed HNSCC variants by HPV-status in a well-characterized Michigan cohort

(2018) Tingting Qin et al.   Scientific Reports

Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium

(2018) Kazuaki Suda et al.   Cell Reports

Human papillomavirus and the landscape of secondary genetic alterations in oral cancers

(2018) Maura L. Gillison et al.   GENOME RESEARCH

Epstein–Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity

(2018) Adam Z. Cheng et al.   Nature Microbiology

APOBEC3A Is Upregulated by Human Cytomegalovirus (HCMV) in the Maternal-Fetal Interface, Acting as an Innate Anti-HCMV Effector

(2017) Yiska Weisblum et al.   JOURNAL OF VIROLOGY

Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor

(2017) Seiichiro Mori et al.   JOURNAL OF VIROLOGY

p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells

(2017) Manikandan Periyasamy et al.   NUCLEIC ACIDS RESEARCH

Multi-modality analysis supports APOBEC as a major source of mutations in head and neck squamous cell carcinoma

(2017) Daniel L. Faden et al.   ORAL ONCOLOGY

Roles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression

(2017) Cody Warren et al.   Viruses-Basel

APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism

(2017) Ting-Wen Chen et al.   Nature Communications

Functions and Malfunctions of Mammalian DNA-Cytosine Deaminases

(2016) Sachini U. Siriwardena et al.   CHEMICAL REVIEWS

Evidence for APOBEC3B mRNA and protein expression in oral squamous cell carcinomas

(2016) Galinos Fanourakis et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Human Papillomavirus Drives Tumor Development Throughout the Head and Neck: Improved Prognosis Is Associated With an Immune Response Largely Restricted to the Oropharynx

(2016) Ankur Chakravarthy et al.   JOURNAL OF CLINICAL ONCOLOGY

HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients

(2016) Xavier Castellsagué et al.   JNCI-Journal of the National Cancer Institute

Functional Upregulation of the DNA Cytosine Deaminase APOBEC3B by Polyomaviruses

(2016) Brandy Verhalen et al.   JOURNAL OF VIROLOGY

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

(2016) Serena Nik-Zainal et al.   NATURE

APOBEC3A associates with human papillomavirus genome integration in oropharyngeal cancers

(2016) S Kondo et al.   ONCOGENE

The APOBEC Protein Family: United by Structure, Divergent in Function

(2016) Jason D. Salter et al.   TRENDS IN BIOCHEMICAL SCIENCES

HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients

(2016) Xavier Castellsagué et al.   JNCI-Journal of the National Cancer Institute

Identification of APOBEC3B promoter elements responsible for activation by human papillomavirus type 16 E6

(2015) Seiichiro Mori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

APOBEC3A and 3C decrease human papillomavirus 16 pseudovirion infectivity

(2015) Md Monjurul Ahasan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Frequency and prognostic significance of p16INK4A protein overexpression and transcriptionally active human papillomavirus infection in laryngeal squamous cell carcinoma

(2015) R J Young et al.   BRITISH JOURNAL OF CANCER

Integrating genomics in head and neck cancer treatment: Promises and pitfalls

(2015) Juliette Thariat et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Genetic Landscape of Human Papillomavirus–Associated Head and Neck Cancer and Comparison to Tobacco-Related Tumors

(2015) D. Neil Hayes et al.   JOURNAL OF CLINICAL ONCOLOGY

APOBEC3 Proteins in Viral Immunity

(2015) Spyridon Stavrou et al.   JOURNAL OF IMMUNOLOGY

Hypermutation in theE2gene of human papillomavirus type 16 in cervical intraepithelial neoplasia

(2015) Iwao Kukimoto et al.   JOURNAL OF MEDICAL VIROLOGY

Comprehensive genomic characterization of head and neck squamous cell carcinomas

(2015)   NATURE

APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages

(2015) Shraddha Sharma et al.   Nature Communications

The transcription factor p53: Not a repressor, solely an activator

(2014) Martin Fischer et al.   CELL CYCLE

APOBEC3A Functions as a Restriction Factor of Human Papillomavirus

(2014) Cody J. Warren et al.   JOURNAL OF VIROLOGY

HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis

(2014) Cathy Ndiaye et al.   LANCET ONCOLOGY

Emerging biomarkers in head and neck cancer in the era of genomics

(2014) Hyunseok Kang et al.   Nature Reviews Clinical Oncology

Human Papillomavirus E6 Triggers Upregulation of the Antiviral and Cancer Genomic DNA Deaminase APOBEC3B

(2014) Valdimara C. Vieira et al.   mBio

APOBEC-Mediated Cytosine Deamination Links PIK3CA Helical Domain Mutations to Human Papillomavirus-Driven Tumor Development

(2014) Stephen Henderson et al.   Cell Reports

Endogenous APOBEC3A DNA Cytosine Deaminase Is Cytoplasmic and Nongenotoxic

(2013) Allison M. Land et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

APOBEC3 Multimerization Correlates with HIV-1 Packaging and Restriction Activity in Living Cells

(2013) Jinhui Li et al.   JOURNAL OF MOLECULAR BIOLOGY

APOBEC3 Deaminases Induce Hypermutation in Human Papillomavirus 16 DNA upon Beta Interferon Stimulation

(2013) Z. Wang et al.   JOURNAL OF VIROLOGY

APOBEC3B is an enzymatic source of mutation in breast cancer

(2013) Michael B. Burns et al.   NATURE

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

APOBEC3B mutagenesis in cancer

(2013) Kawai J Kuong et al.   NATURE GENETICS

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

(2013) Steven A Roberts et al.   NATURE GENETICS

Human APOBEC3A Isoforms Translocate to the Nucleus and Induce DNA Double Strand Breaks Leading to Cell Stress and Death

(2013) Bianka Mussil et al.   PLoS One

Correction: Role of Activation-Induced Cytidine Deaminase in the Development of Oral Squamous Cell Carcinoma

(2013) Yosuke Nakanishi et al.   PLoS One

The Role of Cytidine Deaminases on Innate Immune Responses against Human Viral Infections

(2013) Valdimara C. Vieira et al.   Biomed Research International

APOBEC3A can activate the DNA damage response and cause cell-cycle arrest

(2011) Sébastien Landry et al.   EMBO REPORTS

Human Papillomavirus and Rising Oropharyngeal Cancer Incidence in the United States

(2011) Anil K. Chaturvedi et al.   JOURNAL OF CLINICAL ONCOLOGY

Genetic Editing of Herpes Simplex Virus 1 and Epstein-Barr Herpesvirus Genomes by Human APOBEC3 Cytidine Deaminases in Culture and In Vivo

(2011) R. Suspene et al.   JOURNAL OF VIROLOGY

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

(2011) N. Agrawal et al.   SCIENCE

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

(2011) N. Stransky et al.   SCIENCE

Deaminase-Independent Inhibition of Parvoviruses by the APOBEC3A Cytidine Deaminase

(2009) Iñigo Narvaiza et al.   PLoS Pathogens

EGFR, p16, HPV Titer, Bcl-xL and p53, Sex, and Smoking As Indicators of Response to Therapy and Survival in Oropharyngeal Cancer

(2008) Bhavna Kumar et al.   JOURNAL OF CLINICAL ONCOLOGY

Evidence for Editing of Human Papillomavirus DNA by APOBEC3 in Benign and Precancerous Lesions

(2008) J.-P. Vartanian et al.   SCIENCE

The AID/APOBEC family of nucleic acid mutators

(2008) Silvestro G Conticello   GENOME BIOLOGY

Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA

(2007) Sukhdev S. Brar et al.   DNA REPAIR