Article
Medicine, Research & Experimental
Elham Fakhr, Fatemeh Zare, Kayhan Azadmanesh, Ladan Teimoori-Toolabi
Summary: LEF1 plays an important role in the chemo-resistance of colorectal cancer cells, with downregulation of the long isoform making cells more sensitive to chemotherapy through reduced proliferation, increased apoptosis, or cell cycle arrest. Balancing the expression of long and short isoforms of LEF1 is crucial in overcoming chemo-resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Jingui Wang, Xiaoqian Zhang, Junling Zhang, Shangwen Chen, Jing Zhu, Xin Wang
Summary: The study revealed that high expression of CRART16 promotes resistance to 5-FU in CRC cells by suppressing miR-193b-5p, leading to the modulation of HMGA2 expression and activation of the MAPK signaling pathway.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Gui-Li Zheng, Yu-Lin Liu, Ze-Xuan Yan, Xiao-Ye Xie, Zhuo Xiang, Li Yin, Qing-Qing Wang, Dao-Chen Chong, Guo-Liang Xue, Li-Li Xu, Kai Zhou, Qiang Wang
Summary: Elevated expression of LINC01347 is associated with disease progression and poor prognosis in colorectal cancer (CRC) patients undergoing chemotherapy. LINC01347 may play a role in promoting cell proliferation and resistance to 5-FU in CRC cells, potentially through regulation of LOXL2 via miR-328-5p. Identification of LINC01347 as a prognostic biomarker and therapeutic target highlights its potential in overcoming chemotherapy resistance in CRC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yueli Zhang, Xinchun Wang, Shuyun Wang, Jia Liu, Ruijia Li, Xiaoxia Li, Rui Zhang
Summary: In this study, researchers found that upregulation of circ-ERBB2 promoted the malignancy of colorectal cancer (CRC) cells and reduced their resistance to 5-FU. They identified miR-181a-5p as the target of circ-ERBB2 and verified phosphatase and tensin homolog (PTEN) as miR-181a-5p's downstream target. Circ-ERBB2 activated the Akt pathway and inhibited cell apoptosis by modulating miR-181a-5p/PTEN. The findings suggest that circ-ERBB2 could serve as a valuable biomarker for the diagnosis and treatment of CRC.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Oncology
Mingyue Zhou, Zehua Bian, Bingxin Liu, Yi Zhang, Yulin Cao, Kaisa Cui, Shengbai Sun, Jiuming Li, Jia Zhang, Xue Wang, Chaoqun Li, Surui Yao, Yuan Yin, Bojian Fei, Zhaohui Huang
Summary: In this study, we found that MCM3AP-AS1 expression was higher in CRC tissues than in noncancerous tissues, and increased expression was associated with poor outcomes. Functional experiments revealed that silencing MCM3AP-AS1 could inhibit the proliferation, colony formation, migratory, and invasive abilities of CRC cells. In vivo experiments confirmed that silencing MCM3AP-AS1 significantly inhibited the growth and metastasis of CRC.
Article
Oncology
Hui Sun, Jihong Yan, Guangyu Tian, Xiaojun Chen, Wenbo Song
Summary: The study confirmed the impact of LINC01224 on the biological behavior of gastric cancer by mediating miR-193a-5p to regulate CDK8.
Article
Cell Biology
Ming-Yii Huang, Yi-Jung Huang, Tian-Lu Cheng, Wun-Ya Jhang, Chien-Chih Ke, Yi-Ting Chen, Shih-Hsun Kuo, I-Ling Lin, Yu-Hsiang Huang, Chih-Hung Chuang
Summary: This study investigated the effects of XPF-ERCC1 blockers on chemotherapy and chemoradiotherapy using 5-FU or oxaliplatin in colorectal cancer. The results showed that XPF-ERCC1 blockers reduced the cytotoxicity of chemotherapy drugs and enhanced the efficacy of chemoradiotherapy. These findings suggest that XPF-ERCC1 blockers may improve the effectiveness of 5-FU and oxaliplatin-based chemoradiotherapy.
Article
Oncology
Shengli Pan, Yingying Deng, Jun Fu, Yuhao Zhang, Zhijin Zhang, Xianju Qin
Summary: This study found that exosomal miR-181d-5p inhibits the sensitivity of colorectal cancer cells to 5-FU by targeting NCALD. This suggests that exosomal miR-181d-5p may serve as a potential prognostic marker for CRC.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Fanfan Liu, Ruijia Li, Rui Zhang, Meng He, Yueli Zhang
Summary: The study revealed that upregulation of circNRIP1 in colorectal cancer promotes cancer progression by enhancing proliferation, invasion, and migration, while inhibiting apoptosis. Knockdown of circNRIP1 sensitizes CRC cells to 5-FU through sponging miR-532-3p, potentially improving chemotherapy efficacy.
Article
Oncology
Linlin Qu, Yan Chen, Fan Zhang, Liang He
Summary: The study found that DLGAP1-AS1 plays a crucial role in the progression of colorectal carcinoma and 5-FU resistance through the miR-149-5p/TGFB2 regulatory axis. Silencing DLGAP1-AS1 inhibited cell proliferation and invasiveness, while enhancing the sensitivity of CRC cells to 5-FU chemotherapy.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Biochemistry & Molecular Biology
Huiya Wang, Xia Wang, Haiyang Zhang, Ting Deng, Rui Liu, Ying Liu, Hongli Li, Ming Bai, Tao Ning, Junyi Wang, Shaohua Ge, Yi Ba
Summary: The study revealed that miR-135b-5p is significantly increased in oxaliplatin-resistant colorectal cancer cells and may induce protective autophagy through the MUL1/ULK1 signaling pathway, promoting oxaliplatin resistance.
Article
Cell Biology
Xingyue Weng, Hao Liu, Jian Ruan, Miaoyan Du, Lingjie Wang, Jiayan Mao, Ying Cai, Xuemei Lu, Wei Chen, Yaqing Huang, Xiao Zhi, Jianzhen Shan
Summary: This study discovered that HOTAIR, a long non-coding RNA, is upregulated in hypoxia-treated colorectal cancer (CRC) cells and tumors. Knockdown of HOTAIR reversed the hypoxia-induced resistance to the chemotherapy drug oxaliplatin in CRC cells by inhibiting the expression of ZEB1 through negative regulation of miR-1277-5p. In mouse models, HOTAIR knockdown significantly inhibited tumor growth when treated with oxaliplatin. These findings suggest that the HOTAIR/miR-1277-5p/ZEB1 axis may serve as a potential therapeutic target for improving oxaliplatin efficacy in CRC.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Dong Wang, Xiaohui Wang, Yujia Song, Mahan Si, Yuqi Sun, Xiaohui Liu, Shuxiang Cui, Xianjun Qu, Xinfeng Yu
Summary: This study found a significant positive correlation between CXCR7 expression and CAF activation markers in colonic tissues and transgenic mice. RNA sequencing revealed an increase in miR-146a-5p and miR-155-5p levels in CXCR7-overexpressing CRC cells and their exosomes. Furthermore, these CRC cell-derived miRNAs could be uptaken by CAFs via exosomes and promote their activation, leading to enhanced invasive capacity of CRC cells and pro-metastatic switch. The activation of CAFs by miR-146a-5p and miR-155-5p also facilitated tumor formation and lung metastasis of CRC in vivo. Therefore, these findings provide new insights into CXCR7-mediated CRC metastasis and suggest potential biomarkers and therapeutic targets for inhibiting CRC metastasis.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Zhuhe Luo, Ruijun Chen, Shen Hu, Xibin Huang, Zhenyi Huang
Summary: The study reveals that PVT1 promotes resistance of colon cancer cells to 5-FU by regulating the miR-486-5p/CDK4 axis. This could provide a potential target for overcoming 5-FU resistance in colon cancer therapy.
Article
Oncology
Rilei Jiang, Xiaolei Chen, Shaohua Ge, Qin Wang, Yichang Liu, Haijun Chen, Jiatuo Xu, Jiang Wu
Summary: The study revealed that miR-21-5p induces pyroptosis in colorectal cancer through TGFBI regulation, providing important mechanistic insights and expanding its potential for clinical applications.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Yousef Yousefzadeh, Mohammad Sadegh Soltani-Zangbar, Maryam Hemmatzadeh, Navid Shomali, Ata Mahmoodpoor, Javad Ahmadian Heris, Mehdi Yousefi
Summary: The question of how the maternal immune system tolerates the foreign fetus has long been a mystery, with various cells and molecules playing important roles in fetomaternal tolerance. Understanding the complex mechanisms of fetomaternal tolerance is crucial for preventing spontaneous abortion and inducing immunological tolerance in high-risk populations.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Review
Oncology
Faezeh Sharafi, Sadegh Abaei Hasani, Samira Alesaeidi, Mohammad Saeed Kahrizi, Ali Adili, Shadi Ghoreishizadeh, Navid Shomali, Rozita Tamjidifar, Ramin Aslaminabad, Morteza Akbari
Summary: ICIs have been developed and shown potential advantages in treating HCC. ICIs targeting PD-1, PD-L1, and CTLA-4 have made significant advances in HCC treatment. Several ICIs are currently being tested in clinical trials, and the field is rapidly developing. Up-to-date management guidelines are crucial for the safety profile of ICIs as immunotherapy-related adverse events expand.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Samaneh Ramezani, Fatemeh Ezzatifar, Tahereh Hojjatipour, Maryam Hemmatzadeh, Arezoo Gowhari Shabgah, Jamshid Gholizadeh Navashenaq, Saeed Aslani, Navid Shomali, Mohsen Arabi, Farhad Babaie, Farhad Jadidi-Niaragh, Ramin Hosseinzadeh, Fahimeh Feizisani, Sara Khodayar, Roghaiyeh Safari, Hamed Mohammadi
Summary: The study found that MMP9 and MMP3 gene polymorphisms are associated with increased susceptibility to COVID-19 and COVID-19 with neurological syndrome, with higher serum levels of MMP-9 and MMP-3 in COVID-19 cases compared to healthy controls. However, the polymorphisms in MMP genes do not appear to regulate serum levels of MMPs.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Pathology
Shahrooz Amin Mozaffari, Ali Salehi, Elnaz Mousavi, Burhan Abdullah Zaman, Ali Eslambol Nassaj, Farnoosh Ebrahimzadeh, Hadi Nasiri, Zahra Valedkarimi, Ali Adili, Ghazaleh Asemani, Morteza Akbari
Summary: This article reviews the evidence that gut microbiota plays an important role in health and is linked to colorectal cancer development, and proposes SARS-CoV-2 as a potential contributor to CRC pathogenesis.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Mohammadsaleh Jahangir, Mohammad Saeed Kahrizi, Mohammad Natami, Raziyeh Moaref Pour, Shadi Ghoreishizadeh, Maryam Hemmatzadeh, Hamed Mohammadi, Navid Shomali, Siamak Sandoghchian Shotorbani
Summary: This study investigated the role of miR-155 and its targeted factors in the pathogenesis of ankylosing spondylitis (AS). The results showed that the up-regulation of miR-155 led to the down-regulation of SOCS3 and increased expression of IL-21 and STAT3. In addition, the inhibitor Brefeldin A affected the expression and secretion of IL-21. Furthermore, a significant correlation between miR-155 and pathological features of AS patients was found.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Clinical Neurology
Nasim Saeidi, Hadi Goudarzvand, Hamed Mohammadi, Amirhossein Mardi, Shadi Ghoreishizadeh, Navid Shomali, Mahdi Goudarzvand
Summary: This study aims to find a simple, non-invasive, valuable biomarker for early detection and potential treatment of multiple sclerosis (MS). The results showed that the down-regulation of miR-193a was associated with increased CRP levels, CSF IgG positivity, and MSSS, suggesting that miR-193a may be a potential diagnostic and prognostic indicator for MS.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Mahsa Mashayekhi, Milad Asadi, Shahriar Hashemzadeh, Amir Vahedi, Dariush Shanehbandi, Ahmad Faris Al-Omar, Morteza Akbari, Mortaza Raeisi
Summary: The study aimed to evaluate the role of methylation status in the promoter of RASSF1 and ATIC genes in Iranian lung cancer patients. Methylation of the RASSF1 gene promoter was significantly higher in lung tumor tissues, while promoter methylation levels of the ATIC gene were significantly lower. These findings were further validated by analysis of the TCGA dataset. Promoter methylation of both RASSF1 and ATIC genes was significantly associated with lymph node metastasis and clinical stage of lung cancer, suggesting their potential as diagnostic biomarkers.
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
(2023)
Review
Biotechnology & Applied Microbiology
Hesam Shahabifard, Mahdi Zarei, Keihan Kookli, Nazgol Esmalian Afyouni, Narges Soltani, Sairan Maghsoodi, Ali Adili, Javad Mahmoudi, Navid Shomali, Siamak Sandoghchian Shotorbani
Summary: Genetically modified immune cells, especially CAR-T cells, have gained significant attention in the past decade. They play a crucial role in the treatment of hematological cancers, autoimmune disorders, and cancers. This study aims to explore the therapeutic targets and potential applications of CAR-T cells in neurological disorders, including cancer and neurodegenerative diseases.
BIOTECHNOLOGY PROGRESS
(2023)
Review
Pathology
Sina Rahimpour, Hadi Jabbari, Hajar Yousofi, Arian Fathi, Shiva Mahmoodi, Mohammad Javad Jafarian, Navid Shomali, Siamak Sandoghchian Shotorbani
Summary: Sericin protein, derived from silk cocoons, possesses unique medicinal and cosmetic properties, making it widely used in the pharmaceutical and cosmetic industries. Its applications include wound healing, anti-diabetic, anti-cholesterol, and antioxidant effects.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biotechnology & Applied Microbiology
Hamed Aghazadeh, Parastoo Taheri, Sobhan Aboulhassanzadeh, Samin Aboulhassanzadeh, Tahereh Sangchooli, Behnaz Hazrati Dorigh, Esmaeil Farmani Gheshlaghi
Summary: Niosomes, as analogous to cellular biomembranes, are being increasingly utilized as biopolymeric drug carriers due to their biocompatibility. In this research, PEGylated cationic nano-niosomes (CUR) were used to enhance therapeutic effectiveness in the MCF-7 cell line. By utilizing nan-niosomes as carriers, curcumin, the active ingredient in turmeric, can be effectively delivered to cancer cells while stabilizing the medication. This combination has wide-ranging applications in pharmaceuticals, medicine, health, environment, nanotherapy, cancer detection and treatment, gene delivery, cosmetics, food industry, and agriculture.
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2023)
Review
Medicine, Research & Experimental
Alireza Isazadeh, Javad Ahmadian Heris, Parviz Shahabi, Reza Mohammadinasab, Navid Shomali, Hadi Nasiri, Zahra Valedkarimi, Ahmad Jamei Khosroshahi, Saba Hajazimian, Morteza Akbari, Shahram Sadeghvand
Summary: Pattern recognition receptors (PRRs) are specific sensors that recognize molecules derived from pathogens and damaged cells. PRRs play a crucial role in the immune response to SARS-CoV-2 infection and other microbial infections. This review provides an overview of PRRs and their signaling pathways in response to SARS-CoV-2, highlighting their potential as therapeutic targets.
Review
Biochemistry & Molecular Biology
Houman Isazadeh, Farshid Oruji, Shima Shabani, Javad Behroozi, Hadi Nasiri, Alireza Isazadeh, Morteza Akbari
Summary: Advancements in siRNA technology offer new possibilities for precision cancer therapy. By incorporating siRNAs into nanoparticles, their effectiveness can be optimized in various types of carcinomas. Despite challenges such as off-target effects and degradation, ongoing progress demonstrates the potential of siRNA-loaded nanoparticles for cancer treatment.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Pathology
Navid Shomali, Amin Kamrani, Javad Ahmadian Heris, Parviz Shahabi, Hadi Nasiri, Shahram Sadeghvand, Kazem Ghahremanzadeh, Morteza Akbari
Summary: Breast cancer is a prevalent cancer in women worldwide, and the function of the p53 gene has drawn significant attention. Mutations in this gene can result in loss of function, leading to uncontrolled cell division and the onset of breast cancer. Focusing on p53 mutations holds promise for developing individualized treatments for breast cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Clinical Neurology
Mirhadi Mussavi, Shokoufeh Khanzadeh, Shahram Sadeghvand, Eslam Hasanpour, Morteza Akbari, Shahram Nasiri, Fateme Valaei
Summary: This study aimed to assess the frequency and causes of abnormal brain findings in neonates with seizures using brain computed tomography scan (CT scan) and ultrasonography (US) and multichannel-electroencephalography (EEG). The results showed that EEG is a highly accurate method for detecting brain pathologies in neonates with seizures. In terms of detecting the underlying causes of seizures, brain CT scan showed higher capacity compared to US.
IRANIAN JOURNAL OF CHILD NEUROLOGY
(2022)
Correction
Oncology
Xiaoyu Yang, Yan Wang, Heshu Sulaiman Rahman, Talar A. M. Mohammad, Stanislav Evgenievich Korsakov, Lakshmi Thangavelu, Ali Adili, Rozita Tamjidi Far, Hossein Saeedi, Ramin Aslaminabad, Saeed Tarzi, Morteza Akbari
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)