Article
Behavioral Sciences
Yu Hu, Haixia Li, Cheng Zhou, Ying Liu, Zhen Ma
Summary: The study investigated the effects of different concentrations of the serotonin receptor agonist on aggressive behavior in juvenile pufferfish, showing that activation of the serotonergic system can suppress both aggressive behavior and locomotor activity in the fish.
AGGRESSIVE BEHAVIOR
(2022)
Article
Medicine, General & Internal
Xujiao Zhou, Yiqin Dai, Zimeng Zhai, Jiaxu Hong
Summary: The study revealed that 5-HT1A receptors play a role in inflammation and autophagy in a dry eye disease (DED) mouse model, influencing corneal fluorescein sodium staining spots and potentially contributing to the pathogenesis of DED. The activation of the 5-HT1A receptor-ROS-autophagy axis is critically involved in DED development.
FRONTIERS IN MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Sergio Vegas-Suarez, Asier Aristieta, Catalina Requejo, Harkaitz Bengoetxea, Jose Vicente Lafuente, Cristina Miguelez, Luisa Ugedo
Summary: The study found that systemic activation of the 5-HT1A receptor has different effects on the electrophysiological properties of the entopeduncular nucleus depending on the integrity of the nigrostriatal pathway, and does not alter the relationship between subthalamic nucleus and entopeduncular nucleus neuron activity.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Behavioral Sciences
Jillian H. Broadbear, Ronan Y. Depoortere, Kristina Vacy, David Ralph, Brendan J. Tunstall, Adrian Newman-Tancredi
Summary: NLX-101 and F13714 are selective, full efficacy, biased agonists of the serotonin (5-HT1A) receptor with distinct profiles in behavioral models. F13714 fully substitutes for the training dose of 8-OH-DPAT with high potency, while NLX-101 achieves full substitution at a higher dose and also activates presynaptic 5-HT1A receptors. The discriminative cue produced by 0.1 mg/kg i.p. 8-OH-DPAT results from activation of presynaptic 5-HT1A receptors.
BEHAVIOURAL PHARMACOLOGY
(2021)
Article
Behavioral Sciences
Susanne Nikolaus, Hans-Jorg Wittsack, Markus Beu, Hubertus Hautzel, Christina Antke, Eduards Mamlins, Jens Cardinale, Cvetana Decheva, Joseph P. Huston, Gerald Antoch, Frederik L. Giesel, Hans-Wilhelm Mueller
Summary: In this study, the effects of the 5-HT1A receptor antagonist, WAY-100635, on the dopaminergic system in the rat brain were assessed. It was found that WAY-100635 reduced D2/3R binding and resulted in decreased motor activity and increased grooming behavior. These effects were region-specific and time-dependent.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Neurosciences
Ria Gupta, Sidharth Mehan, Pranshul Sethi, Aradhana Prajapati, Abdulrahman Alshammari, Metab Alharbi, Haneen A. Al-Mazroua, Acharan S. Narula
Summary: This study investigated the neuroprotective effects of Purmorphamine, a smoothened-sonic-hedgehog agonist, in a rat model of obsessive-compulsive disorder (OCD). The results demonstrated that Purmorphamine attenuated OCD-like behaviors, oxidative stress, inflammation, apoptosis, and neurotransmitter imbalance induced by 8-hydroxy-2-(di-n-propylamino)-tetralin injection. The neuroprotective effect of Purmorphamine was comparable to the standard drug for OCD, fluvoxamine, and the combination of Purmorphamine and fluvoxamine showed a more significant restoration of these pathological changes.
Article
Chemistry, Multidisciplinary
Barbara A. Bricker, Chandrashekhar Voshavar, Edem K. Onyameh, Uma M. Gonela, Xinsong Lin, Tracy L. Swanson, Laura B. Kozell, Jennifer L. Schmachtenberg, Shelley H. Bloom, Aaron J. Janowsky, Seth Y. Ablordeppey
Summary: In this study, we synthesized and separated the enantiomers of SYA0340, identified their absolute configurations, and evaluated their binding affinities and functional characteristics at the 5-HT1A and 5-HT7A receptors. The results showed that both enantiomers have similar agonist properties at the 5-HT1A receptor and antagonist properties at the 5-HT7A receptor, with SYA0340-P1 displaying higher potency as a 5-HT1A receptor antagonist. Therefore, SYA0340-P1 is considered the eutomer and these enantiomers may serve as new pharmacological probes for the 5-HT1A and 5-HT7A receptors.
Article
Dermatology
Claudia Cervantes-Duran, Miguel Avalos-Viveros, Luz Torner, Sandra-Guadalupe Sanchez-Ceja, Alain-Raimundo Rodriguez-Orozco, Hector-Eduardo Martinez-Flores, Martha-Estrella Garcia-Perez
Summary: The study found that in the IMQ-induced psoriasis mice model, the development of secondary chronic allodynia and hyperalgesia could be modulated by anti-inflammatory agents and compound 48/80, and the activation of 5-HT1A receptor might regulate these nociceptive behaviours. Additionally, it was observed that the long-lasting pain resulting from psoriasis inflammation is associated with the serotonergic system, indicating that the 5-HT1A receptor could be a potential therapeutic target for psoriasis pain modulation.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Clinical Neurology
Rafael Pazinatto de Aguiar, Adrian Newman-Tancredi, Jos Prickaerts, Rubia Maria Weffort de Oliveira
Summary: This review focuses on the roles and mechanisms of 5-HT1A receptors in neuroprotection in experimental models of cerebral ischemia, with experimental evidence suggesting that 5-HT1A receptor agonists can prevent neuronal damage and promote functional recovery induced by ischemia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Neha Munawar, Milad S. Bitar, Willias Masocha
Summary: This study investigates the role of serotoninergic nervous system in diabetic neuropathic pain (DNP) and suggests that treatment with 8-OH-DPAT, a selective 5-HT1AR agonist, could be effective in alleviating DNP symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Martina Janikova, Karolina Mainerova, Iveta Vojtechova, Tomas Petrasek, Jan Svoboda, Ales Stuchlik
Summary: The study examined the impact of using 8-OH-DPAT to simulate OCD behavior on spatial learning, as well as the effects of memantine and riluzole in this model. The results showed that monotherapy with glutamate-modulating agents in the model group did not reduce cognitive symptoms but may exacerbate them.
Review
Biochemistry & Molecular Biology
Irina P. Voronova
Summary: This review discusses the influence of serotonin receptors on body temperature regulation in warm-blooded animals, covering different receptor types and their activation effects on temperature.
Article
Pharmacology & Pharmacy
Hirohito Esaki, Yuki Sasaki, Naoya Nishitani, Hikari Kamada, Satoko Mukai, Yoshitaka Ohshima, Sao Nakada, Xiyan Ni, Satoshi Deyama, Katsuyuki Kaneda
Summary: This study examined whether the prosocial effects induced by MDMA are mediated by 5-HT neurotransmission in the medial prefrontal cortex (mPFC) and the basolateral nucleus of amygdala (BLA). The results showed that selective inhibition of 5-HT transporters before MDMA administration did not suppress the prosocial effects. However, the 5-HT1A receptor antagonist WAY100635 significantly suppressed the prosocial effects of MDMA. Furthermore, local administration of WAY100635 into the BLA, but not the mPFC, suppressed the MDMA-induced prosocial effects. These findings suggest that MDMA induces prosocial effects through the stimulation of 5-HT1A receptors in the BLA.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Behavioral Sciences
A. Ezequiel Pereyra, Camilo J. Mininni, B. Silvano Zanutto
Summary: The study demonstrates that serotonin modulates reward-driven learning, and 5-HT1A receptors in the BLA play a crucial role in extinction. Fluoxetine treatment accelerates extinction learning, while BLA lesions partially revert this effect.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Matthieu Colom, Benjamin Vidal, Sylvain Fieux, Jerome Redoute, Nicolas Costes, Franck Lavenne, Ines Merida, Zacharie Irace, Thibaud Iecker, Caroline Bouillot, Thierry Billard, Adrian Newman-Tancredi, Luc Zimmer
Summary: The study evaluated the sensitivity of the radiopharmaceutical [F-18]F13640 to endogenous serotonin release, demonstrating its effectiveness in measuring neurotransmitter fluctuations but highlighting the importance of longer PET scans for accurate displacement measurements.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Claudia Kasper, Francois Olivier Hebert, Nadia Aubin-Horth, Barbara Taborsky
Article
Biology
Maria Reyes-Contreras, Gaetan Glauser, Diana J. Rennison, Barbara Taborsky
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2019)
Article
Ecology
Claudia Kasper, Tanja Schreier, Barbara Taborsky
JOURNAL OF EVOLUTIONARY BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Cecilia Nyman, Francois Olivier Hebert, Mathilde Bessert-Nettelbeck, Nadia Aubin-Horth, Barbara Taborsky
Article
Multidisciplinary Sciences
Mukta Watve, Sebastian Prati, Barbara Taborsky
Article
Multidisciplinary Sciences
Diogo F. Antunes, Barbara Taborsky
SCIENTIFIC REPORTS
(2020)
Review
Ecology
Barbara Taborsky, Sinead English, Tim W. Fawcett, Bram Kuijper, Olof Leimar, John M. McNamara, Suvi Ruuskanen, Carmen Sandi
Summary: All organisms have different stress response systems to cope with environmental threats, with environmental predictability and physiological constraints being key factors shaping stress response evolution. An integrated research programme combining theory, experimental evolution, and comparative analysis is needed to advance scientific understanding of how this core physiological system has evolved.
TRENDS IN ECOLOGY & EVOLUTION
(2021)
Article
Behavioral Sciences
Diogo F. Antunes, Maria Reyes-Contreras, Gaetan Glauser, Barbara Taborsky
Summary: Research shows that in cooperatively breeding cichlid fish, the early social environment has lifelong effects on the physiological stress system, including differences in baseline cortisol levels, of the offspring.
HORMONES AND BEHAVIOR
(2021)
Article
Behavioral Sciences
Dona A. M. Lerena, Diogo F. Antunes, Barbara Taborsky
Summary: The study found that winner and loser effects exist in cooperatively breeding cichlid fish, but these effects are not modulated by social rank. Winners are more likely to win subsequent contests, escalate the contest, and show more overt aggression, while losers exhibit more restrained aggression. This indicates that fighting experience and social rank may play complementary roles in conflict resolution.
Article
Biochemistry & Molecular Biology
Diogo F. Antunes, Magda C. Teles, Matthew Zuelling, Caitlin N. Friesen, Rui F. Oliveira, Nadia Aubin-Horth, Barbara Taborsky
Summary: The early social environment can have long-term effects on animal behavior, potentially altering the neurogenomic profile of brain nuclei. In cooperatively breeding fish, differences in social upbringing, such as being raised with parents and siblings or only same-clutch siblings, can lead to developmental differences in neurophysiological systems.
Article
Cell Biology
Diogo F. Antunes, Marta C. Soares, Michael Taborsky
Summary: Dopamine plays an important role in social behavior, especially in cooperative breeding animals. The modulation of aggressive, submissive, and affiliative behaviors can be influenced by blocking or stimulating dopamine receptors. The environmental context has a crucial impact on the role of dopamine receptors in social encounters.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Behavioral Sciences
Farrah N. Madison, Verner P. Bingman, Tom Smulders, Christine R. Lattin
Summary: Although research on the avian hippocampus has been limited, it is crucial for understanding its evolution and changes over time. The avian hippocampus plays important roles in spatial cognition as well as regulating anxiety, approach-avoidance behavior, and stress responses. Future research should focus on elucidating the cellular and molecular mechanisms, including endocrinology, to resolve outstanding questions about avian hippocampal function and organization.
HORMONES AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Judith A. H. Smit, Riet Vooijs, Peter Lindenburg, Alexander T. Baugh, Wouter Halfwerk
Summary: This study investigates the effects of urbanization on hormone levels in tungara frogs and found that urban frogs and forest frogs have different endocrine phenotypes. Exposure to urban noise and light pollution led to an increase in testosterone and a decrease in corticosterone in urban frogs, while forest frogs showed no endocrine response to sensory pollutants. These results suggest that urbanization can modulate hormone levels and influence behavior in frogs.
HORMONES AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Hannah D. Fulenwider, Yangmiao Zhang, Andrey E. Ryabinin
Summary: Social hierarchies have significant effects on overall health of individuals in animal groups, particularly the lowest-ranking individuals. Tube test can be used to determine social rank in male and female mice, and the complex interactions between social rank, sex, environment, and testing length influence peptide levels.
HORMONES AND BEHAVIOR
(2024)