From the origin of NASH to the future of metabolic fatty liver disease

Proportion of NAFLD patients with normal ALT value in overall NAFLD patients: a systematic review and meta-analysis

(2020) Xuefeng Ma et al.   BMC GASTROENTEROLOGY

Towards genetic prediction of non-alcoholic fatty liver disease trajectories: PNPLA3 and beyond

(2020) Marcin Krawczyk et al.   GASTROENTEROLOGY

Association Between Fibrosis Stage and Outcomes of Patients with Non-Alcoholic Fatty Liver Disease: a Systematic Review and Meta-Analysis

(2020) Rod S. Taylor et al.   GASTROENTEROLOGY

Genetic Risk Factors and Disease Modifiers of Nonalcoholic Steatohepatitis

(2020) Julia Kozlitina   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

FibroScan-AST (FAST) score for the non-invasive identification of patients with non-alcoholic steatohepatitis with significant activity and fibrosis: a prospective derivation and global validation study

(2020) Philip N Newsome et al.   Lancet Gastroenterology & Hepatology

Non-invasive diagnosis of patients with ‘at-risk’ NAFLD : only fibrosis counts?

(2020) Andreas Geier et al.   GUT

Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically-characterised cohort

(2020) Quentin M. Anstee et al.   JOURNAL OF HEPATOLOGY

A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement

(2020) Mohammed Eslam et al.   JOURNAL OF HEPATOLOGY

Multiple Parallel Hits Hypothesis in NAFLD – Revisited After a Decade

(2020) Herbert Tilg et al.   HEPATOLOGY

A blood-based biomarker panel (NIS4) for non-invasive diagnosis of non-alcoholic steatohepatitis and liver fibrosis: a prospective derivation and global validation study

(2020) Stephen A Harrison et al.   Lancet Gastroenterology & Hepatology

Benefits and Risks of Bariatric Surgery in Adults

(2020) David E. Arterburn et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

NAFLD : Reporting Histologic Findings in Clinical Practice

(2020) Elizabeth M. Brunt et al.   HEPATOLOGY

The Natural History of Advanced Fibrosis Due to Nonalcoholic Steatohepatitis: Data From the Simtuzumab Trials

(2019) Arun J. Sanyal et al.   HEPATOLOGY

New sequential combinations of noninvasive fibrosis tests provide an accurate diagnosis of advanced fibrosis in NAFLD

(2019) Jérôme Boursier et al.   JOURNAL OF HEPATOLOGY

Development and Validation of Hepamet Fibrosis Scoring System A Simple, Noninvasive Test to Identify Patients With Nonalcoholic Fatty Liver Disease With Advanced Fibrosis

(2019) Javier Ampuero et al.   Clinical Gastroenterology and Hepatology

The role of senescence in the development of non-alcoholic fatty liver disease and progression to non-alcoholic steatohepatitis

(2019) Alkistis-Maria Papatheodoridi et al.   HEPATOLOGY

Noninvasive tests accurately identify advanced fibrosis due to NASH : Baseline data from the STELLAR trials

(2019) Quentin M. Anstee et al.   HEPATOLOGY

qFIBS: A Novel Automated Technique for Quantitative Evaluation of Fibrosis, Inflammation, Ballooning, and Steatosis in Patients With Nonalcoholic Steatohepatitis

(2019) Feng Liu et al.   HEPATOLOGY

High-Throughput, Machine Learning-based Quantification of Steatosis, Inflammation, Ballooning, and Fibrosis in Biopsies From Patients with Nonalcoholic Fatty Liver Disease

(2019) Roberta Forlano et al.   Clinical Gastroenterology and Hepatology

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

(2019) Zobair M Younossi et al.   LANCET

Screening for therapeutic trials and treatment indication in clinical practice: MACK-3, a new blood test for the diagnosis of fibrotic NASH

(2018) J. Boursier et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Animal models of NAFLD from the pathologist's point of view

(2018) Helmut Denk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Animal models of NAFLD from a hepatologist's point of view

(2018) Daniel Jahn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Fibrosis Severity as a Determinant of Cause-Specific Mortality in Patients With Advanced Nonalcoholic Fatty Liver Disease

(2018) Eduardo Vilar-Gomez et al.   GASTROENTEROLOGY

Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030

(2018) Chris Estes et al.   JOURNAL OF HEPATOLOGY

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease

(2018) Thomas Jensen et al.   JOURNAL OF HEPATOLOGY

Could inherited predisposition drive non-obese fatty liver disease? Results from German tertiary referral centers

(2018) Marcin Krawczyk et al.   JOURNAL OF HUMAN GENETICS

Serum biomarkers of fibrosis and extracellular matrix remodeling in patients with nonalcoholic fatty liver disease

(2018) Yusuf Yilmaz et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Non-alcoholic fatty liver disease – A global public health perspective

(2018) Zobair M. Younossi   JOURNAL OF HEPATOLOGY

Trends in hepatocellular carcinoma due to non-alcoholic fatty liver disease

(2018) Luis Calzadilla Bertot et al.   Expert Review of Gastroenterology & Hepatology

Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta-analysis

(2017) Parambir S. Dulai et al.   HEPATOLOGY

A stepwise algorithm using an at-a-glance first-line test for the non-invasive diagnosis of advanced liver fibrosis and cirrhosis

(2017) Jérôme Boursier et al.   JOURNAL OF HEPATOLOGY

Fibrosis stage but not NASH predicts mortality and time to development of severe liver disease in biopsy-proven NAFLD

(2017) Hannes Hagström et al.   JOURNAL OF HEPATOLOGY

Genetic Factors That Affect Risk of Alcoholic and Nonalcoholic Fatty Liver Disease

(2016) Quentin M. Anstee et al.   GASTROENTEROLOGY

The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Clinical patterns of hepatocellular carcinoma in nonalcoholic fatty liver disease: A multicenter prospective study

(2016) Fabio Piscaglia et al.   HEPATOLOGY

Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease

(2016) Jérôme Boursier et al.   JOURNAL OF HEPATOLOGY

Combined effects of thePNPLA3rs738409,TM6SF2rs58542926, andMBOAT7rs641738 variants on NAFLD severity: a multicenter biopsy-based study

(2016) Marcin Krawczyk et al.   JOURNAL OF LIPID RESEARCH

The ability of Hepascore to predict liver fibrosis in chronic liver disease: a meta-analysis

(2016) Yi Huang et al.   LIVER INTERNATIONAL

SAF score and mortality in NAFLD after up to 41 years of follow-up

(2016) Hannes Hagström et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Serum YKL-40 as a marker of liver fibrosis in patients with non-alcoholic fatty liver disease

(2016) Erina Kumagai et al.   Scientific Reports

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease

(2015) Paul Angulo et al.   GASTROENTEROLOGY

Bariatric Surgery Reduces Features of Nonalcoholic Steatohepatitis in Morbidly Obese Patients

(2015) Guillaume Lassailly et al.   GASTROENTEROLOGY

Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up

(2015) Mattias Ekstedt et al.   HEPATOLOGY

Reply to: HCC and liver disease risk in homozygous PNPLA3 p.I148M carriers approach monogenic inheritance

(2015) Quentin M. Anstee et al.   JOURNAL OF HEPATOLOGY

HCC and liver disease risks in homozygous PNPLA3 p.I148M carriers approach monogenic inheritance

(2015) Marcin Krawczyk et al.   JOURNAL OF HEPATOLOGY

Epigenetic-Mediated Downregulation of μ-Protocadherin in Colorectal Tumours

(2015) Bujko Mateusz et al.   Gastroenterology Research and Practice

On the Evolutionary Origins of Obesity: A New Hypothesis

(2014) Dyan Sellayah et al.   ENDOCRINOLOGY

Utility and appropriateness of the fatty liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease

(2014) Pierre Bedossa et al.   HEPATOLOGY

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

(2014) Julia Kozlitina et al.   NATURE GENETICS

A comparison of FibroMeter™ NAFLD Score, NAFLD fibrosis score, and transient elastography as noninvasive diagnostic tools for hepatic fibrosis in patients with biopsy-proven non-alcoholic fatty liver disease

(2014) Umut Emre Aykut et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Simple Noninvasive Systems Predict Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease

(2013) Paul Angulo et al.   GASTROENTEROLOGY

Current histological classification of NAFLD: strength and limitations

(2013) Pierre Bedossa   Hepatology International

Heterogeneity of fibrosis patterns in non-alcoholic fatty liver disease supports the presence of multiple fibrogenic pathways

(2013) Richard Skoien et al.   LIVER INTERNATIONAL

Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients

(2012) Pierre Bedossa et al.   HEPATOLOGY

Noninvasive Parameters and hepatic fibrosis scores in children with nonalcoholic fatty liver disease

(2012) Hye Ran Yang   WORLD JOURNAL OF GASTROENTEROLOGY

Endpoints and clinical trial design for nonalcoholic steatohepatitis

(2011) Arun J. Sanyal et al.   HEPATOLOGY

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

(2011) Elizabeth K. Speliotes et al.   PLoS Genetics

Simple non-invasive fibrosis scoring systems can reliably exclude advanced fibrosis in patients with non-alcoholic fatty liver disease

(2010) S. McPherson et al.   GUT

Noninvasive assessment of liver fibrosis

(2010) Stella M. Martínez et al.   HEPATOLOGY

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings

(2010) Elizabeth M. Brunt et al.   HEPATOLOGY

Nonalcoholic steatohepatitis in children: A multicenter clinicopathological study

(2009) Christine Carter-Kent et al.   HEPATOLOGY

Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: A multicenter validation study

(2009) Ariel E. Feldstein et al.   HEPATOLOGY

Serum levels of hyaluronic acid and tissue metalloproteinase inhibitor-1 combined with age predict the presence of nonalcoholic steatohepatitis in a pilot cohort of subjects with nonalcoholic fatty liver disease

(2009) Luca Miele et al.   Translational Research

Mallory–Denk-bodies: Lessons from keratin-containing hepatic inclusion bodies

(2008) P. Strnad et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Development and validation of a simple NAFLD clinical scoring system for identifying patients without advanced disease

(2008) S A Harrison et al.   GUT

Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: A role for insulin resistance and diabetes

(2008) Anna Ludovica Fracanzani et al.   HEPATOLOGY

Susruta of India, an unrecognized contributor to the history of exercise physiology

(2008) Charles M. Tipton   JOURNAL OF APPLIED PHYSIOLOGY

Ballooned hepatocytes in steatohepatitis: The value of keratin immunohistochemistry for diagnosis

(2008) Carolin Lackner et al.   JOURNAL OF HEPATOLOGY

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS