Review
Public, Environmental & Occupational Health
Rafael Hermelink, Michael F. Leitzmann, Georgios Markozannes, Kostas Tsilidis, Tobias Pukrop, Felix Berger, Hansjoerg Baurecht, Carmen Jochem
Summary: Sedentary behavior is associated with increased risk of several types of cancer and increased risk of cancer mortality.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Review
Endocrinology & Metabolism
Huamin Zeng, Ying Zhang, Sikai Huang, Jinghua Wu, Wenrui Ren, Lingru Zhou, Leneng Huang, Yuyin Ye
Summary: Metformin combined with spironolactone therapy may be more effective in reducing BMI and serum androgen levels in PCOS patients. However, it does not have a significant effect on hirsutism score or gonadotropin hormone levels, and is not associated with an elevation in side-effects. When the treatment course is greater than 6 months, combination therapy can effectively reduce FBG and improve insulin resistance.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Shiyun Chen, Xin Su, Yonghui Feng, Ruojie Li, Minqi Liao, Laina Fan, Jiazi Liu, Shasha Chen, Shiwen Zhang, Jun Cai, Sui Zhu, Jianxiang Niu, Yanbin Ye, Kenneth Lo, Fangfang Zeng
Summary: Ketogenic diets have shown some effects on health, but the current evidence is weak.
Review
Public, Environmental & Occupational Health
Zhu Liduzi Jiesisibieke, Wen-Yi Liu, Yu-Pei Yang, Ching-Wen Chien, Tao-Hsin Tung
Summary: This umbrella meta-analysis provides comprehensive evidence on the effectiveness and safety of COVID-19 vaccinations. Based on the analysis of current studies, mRNA vaccines, adenovirus vector vaccines, subunit vaccines, and inactivated vaccines were found to be effective. However, mRNA vaccines, adenovirus vector vaccines, and subunit vaccines were associated with local and systemic adverse events compared to inactivated vaccines. Conclusion: COVID-19 vaccination is still the preferred way to control the widespread pandemic, but further research is needed to investigate reported adverse events for mass vaccinations.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2023)
Review
Infectious Diseases
Jennifer Curran, Jennifer Lo, Valerie Leung, Kevin Brown, Kevin L. Schwartz, Nick Daneman, Gary Garber, Julie H. C. Wu, Bradley J. Langford
Summary: The study found that each additional day of antibiotic therapy is associated with measurable antibiotic harm, particularly adverse events. These data may provide additional context for clinicians when weighing benefits versus risks of prolonged antibiotic therapy.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Pharmacology & Pharmacy
Vali Musazadeh, Majid Keramati, Faezeh Ghalichi, Zeynab Kavyani, Zohre Ghoreishi, Kamar Allayl Alras, Naryman Albadawi, Abdullah Salem, Mohamed Ismail Albadawi, Raghad Salem, Ahmed Abu-Zaid, Meysam Zarezadeh, Rania A. Mekary
Summary: Meta-analyses on the relationship between vitamin D and depression showed inconsistent results. This umbrella meta-analysis confirms that vitamin D supplementation and higher serum vitamin D levels can significantly reduce the development and symptoms of depression based on the analysis of randomized controlled trials and cohort studies.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Medicine, General & Internal
Karolina Strzebonska, Mateusz Blukacz, Mateusz T. Wasylewski, Maciej Polak, Bishal Gyawali, Marcin Waligora
Summary: This systematic review with meta-analysis evaluated the efficacy and safety profiles of cancer umbrella trials testing targeted drugs or a combination of targeted therapy with chemotherapy. The study found that, on average, one in five cancer patients responded to a given therapy, while one in 125 died due to drug toxicity. The results do not support the expectation of increased patient benefit in cancer umbrella trials, and further studies should be conducted.
Review
Psychology, Clinical
Steven M. Gillespie, Andrew Jones, Carlo Garofalo
Summary: To address the controversial relationship between psychopathy and dangerousness, an umbrella review of all available meta-analyses was conducted. Results showed that psychopathy is significantly correlated with dangerousness, with psychopathy being one of the strongest predictors of dangerousness in the realm of psychopathology.
CLINICAL PSYCHOLOGY REVIEW
(2023)
Review
Food Science & Technology
Vali Musazadeh, Meysam Zarezadeh, Amir Hossein Faghfouri, Majid Keramati, Parmida Jamilian, Parsa Jamilian, Arash Mohagheghi, Alireza Farnam
Summary: A meta-analysis was conducted to investigate the impact of probiotic supplementation on depressive symptoms. The results showed that consuming probiotics can significantly reduce depression symptoms, especially with intervention duration >8 weeks and dosage >10 x 10(9) CFU.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Orthopedics
Luis Suso-Marti, Roy La Touche, Aida Herranz-Gomez, Santiago Angulo-Diaz-Parreno, Alba Paris-Alemany, Ferran Cuenca-Martinez
Summary: Telerehabilitation shows positive clinical results, particularly in patients with neurological conditions, which could justify its implementation in clinical settings due to lower cost and less interference in patients' daily life during the era of coronavirus disease 2019.
Review
Endocrinology & Metabolism
Alvin Kuate Defo, Veselko Bakula, Alessandro Pisaturo, Christopher Labos, Simon S. Wing, Stella S. Daskalopoulou
Summary: The aim of this umbrella review and meta-analysis was to evaluate the impact of diabetes on the risk of dementia and the effectiveness of antidiabetic treatments. The study found that metformin, thiazolidinediones, pioglitazone, GLP1RAs, and SGLT2is were associated with a reduced risk of dementia. However, further longitudinal studies are needed to determine their relative benefits in different populations.
DIABETES OBESITY & METABOLISM
(2023)
Review
Cardiac & Cardiovascular Systems
Wenqiang Niu, Juan Shao, Benxiang Yu, Guolong Liu, Ran Wang, Hengyang Dong, Haijie Che, Lubin Li
Summary: The study found that metformin can limit the expansion of abdominal aortic aneurysm (AAA) and reduce mortality related to AAA repair or rupture. However, further biological experiments and clinical trials are still needed to support these findings.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Immunology
Zeynab Kavyani, Vali Musazadeh, Soroor Fathi, Amir Hossein Faghfouri, Parvin Dehghan, Bahareh Sarmadi
Summary: This umbrella meta-analysis found that supplementation of n-3 PUFAs can significantly improve CRP, TNF-alpha, and IL-6 concentrations in adults with various health conditions, suggesting their potential as adjuvant anti-inflammatory agents.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Rebecca W. Zeng, Jie Ning Yong, Darren J. H. Tan, Clarissa E. Fu, Wen Hui Lim, Jieling Xiao, Kai En Chan, Caitlyn Tan, Xin Lei Goh, Douglas Chee, Nicholas Syn, Eunice X. Tan, Mark D. Muthiah, Cheng Han Ng, Nobuharu Tamaki, Sung Won Lee, Beom Kyung Kim, Mindie H. Nguyen, Rohit Loomba, Daniel Q. Huang
Summary: An updated meta-analysis suggests that the use of statins and aspirin is associated with a reduced risk of hepatocellular carcinoma, while the use of metformin is not. These findings have implications for future clinical trial design.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Orthopedics
Ferran Cuenca-Martinez, Roy La Touche, Clovis Varangot-Reille, Maeva Sardinoux, Jade Bahier, Luis Suso-Marti, Josue Fernandez-Carnero
Summary: This study assessed the effects of neural mobilization (NM) treatments through umbrella reviews with meta-meta-analyses. The results indicated that NM treatment had a moderate to large beneficial clinical effect on pain intensity and disability in people with musculoskeletal disorders and on mechanosensitivity in individuals who were asymptomatic. However, the quality of evidence was limited.
Article
Allergy
Louis Jacob, Jae Il Shin, Guillermo F. Lopez-Sanchez, Josep Maria Haro, Ai Koyanagi, Karel Kostev, Laurie Butler, Yvonne Barnett, Hans Oh, Lee Smith
Summary: This study aimed to investigate the association between asthma and work absence in a large sample of US working adults, while controlling for several sociodemographic and health characteristics. The results showed that individuals with asthma were more likely to report at least one or three days of absence from work in the past 12 months than those without asthma. Furthermore, after adjusting for all control variables, asthma was positively and significantly associated with work absence.
Article
Psychiatry
Wolfgang Marx, Sam H. Manger, Mark Blencowe, Greg Murray, Fiona Yan-Yee Ho, Sharon Lawn, James A. Blumenthal, Felipe Schuch, Brendon Stubbs, Anu Ruusunen, Hanna Demelash Desyibelew, Timothy G. Dinan, Felice Jacka, Arun Ravindran, Michael Berk, Adrienne O'Neil
Summary: This study aims to provide clinicians with evidence-based recommendations and implementation considerations for lifestyle-based mental health care for adults with Major Depressive Disorder (MDD). The study conducted systematic literature searches and formed nine recommendations, including physical activity, relaxation techniques, work-directed interventions, sleep, and mindfulness-based therapies. The study also emphasized the importance of implementing this approach with input from allied health professionals and support networks, and delivering interventions using a biopsychosocial-cultural framework.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Yeon Jae Jeong, Seoyeon Park, Dong Keon Yon, Seung Won Lee, Kalthoum Tizaoui, Ai Koyanagi, Louis Jacob, Karel Kostev, Elena Dragioti, Joaquim Radua, Andrew Stickley, Hans Oh, Jae Il Shin, Lee Smith
Summary: Gout, a common rheumatic disease, has been understudied in non-industrialized countries. This study aimed to investigate the global burden of gout, including its associations with various factors. The findings revealed an increasing trend in the total number of gout patients and age-standardized prevalence rate from 1990 to 2019. Gout was most prevalent in Australasia and high-income North America, and higher sociodemographic index was associated with higher prevalence, incidence, and YLDs. High BMI and kidney dysfunction were identified as risk factors for gout, and gout showed correlations with other kidney diseases.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Virology
Rosie Kwon, Min Ji Koo, Seung Won Lee, Yong Sung Choi, Youn Ho Shin, Jung U. Shin, Ai Koyanagi, Louis Jacob, Lee Smith, Sang Youl Rhee, Hyug-Gi Kim, Chanyang Min, Seong Ho Cho, Abdullah Ozgur Yeniova, So Young Kim, Jinseok Lee, Seung Geun Yeo, Jae Il Shin, Dong Keon Yon
Summary: During the COVID-19 pandemic, physical activity among Korean youth, especially aerobic and muscle-strengthening activities, decreased. However, there was a recovery in these activities during the pandemic. Therefore, it is important to enhance public health policies and promote physical activity among young people.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Sport Sciences
R. Lopez-Bueno, G. F. Lopez-Sanchez, L. Smith, E. Sundstrup, L. L. Andersen, J. A. Casajus
Summary: Prevention of disability is a major public health challenge, and promoting a healthy lifestyle with sufficient physical activity may be a solution. According to a survey, workers who engage in less than 600 MET-minutes/week of physical activity have a higher risk of activity limitation, especially within specific age ranges.
Article
Psychiatry
Christoph U. Correll, Marco Solmi, Samuele Cortese, Maurizio Fava, Mikkel Hojlund, Helena C. Kraemer, Roger S. McIntyre, Daniel S. Pine, Lon S. Schneider, John M. Kane
Summary: Despite progress in pharmacotherapy, many mental disorders remain insufficiently treated due to limited knowledge of pathophysiology, lack of biological markers, and challenges in drug development and testing. This paper discusses promising drugs and innovative mechanisms of action undergoing testing for various psychiatric disorders, as well as the clinical trial parameters that need to be considered for successful drug development. It also highlights the hurdles and perils in new drug development and testing and emphasizes the importance of considering these factors for increased chances of success.
Article
Psychiatry
Hans Oh, Jinyu Du, Lee Smith, Ai Koyanagi
Summary: This study examined the disparities in mental health issues among multiracial young adult college students. The findings indicated that multiracial students had higher rates of mental and behavioral health problems, self-injurious behaviors, and lifetime psychiatric disorders compared to monoracial students.
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
(2023)
Article
Pathology
Ji Hyun Park, Claudio Luchini, Alessia Nottegar, Kalthoum Tizaoui, Ai Koyanagi, Shuji Ogino, Jae Il Shin, Beom Jin Lim, Lee Smith
Summary: This study aims to investigate the prognostic role of CD274 (PD-L1) overexpression in malignant tumors. The meta-analysis of eligible studies suggests that CD274 (PD-L1) overexpression is a potential biomarker for multiple types of cancers and is associated with worse prognosis. However, further studies are needed to confirm these findings and reduce heterogeneity.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Geriatrics & Gerontology
Nicola Veronese, Laura Maniscalco, Domenica Matranga, Guido Lacca, Ligia J. Dominguez, Mario Barbagallo
Summary: This study aimed to investigate the potential association between air and noise pollution and frailty and prefrailty in older adults. The cross-sectional study of UK Biobank participants aged 60 and older found that increased exposure to nitrogen oxides (NOx) and particulate matter (PM2.5, PM2.5-10, PM10) was associated with a higher probability of being in the prefrail and frail category. These findings suggest that air pollution may contribute to frailty and highlight the importance of considering the impact of air pollutants in frailty prevention and intervention strategies.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Review
Psychiatry
Andrea De Micheli, Umberto Provenzani, Marco Solmi, Albertine Van Lawick Van Pabst, Enas Youssef, Philip McGuire, Paolo Fusar-Poli
Summary: This systematic review and meta-analysis examined the association between tobacco smoking and Clinical High Risk for Psychosis (CHR-P) status. The analysis showed that CHR-P individuals had a higher prevalence of smoking compared to healthy controls, but no causal association was found between smoking and the incidence of psychosis. Further research is needed.
SCHIZOPHRENIA RESEARCH
(2023)
Review
Psychiatry
Alessandro Miola, Konstantinos N. Fountoulakis, Ross J. Baldessarini, Marin Veldic, Marco Solmi, Natalie Rasgon, Aysegul Ozerdem, Giulio Perugi, Mark A. Frye, Antonio Preti
Summary: This systematic review examines the definitions, prevalence, and clinical characteristics of rapid-cycling bipolar disorder (RC-BD). The results indicate that RC-BD has a high prevalence (22.3%-35.5% of BD cases) and is associated with inferior treatment response, suicide attempts, and unsatisfactory response to mood stabilizers. Factors such as childhood maltreatment, mixed features, female sex, and type-II BD also show associations with RC-BD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Nutrition & Dietetics
Ritanna Curci, Antonella Bianco, Isabella Franco, Caterina Bonfiglio, Angelo Campanella, Antonella Mirizzi, Vito Giannuzzi, Raffaele Cozzolongo, Nicola Veronese, Alberto Ruben Osella
Summary: This study aimed to estimate the main effect of two different physical activity (PA) programs, and a Low-Glycemic-Index Mediterranean Diet (LGIMD), or their combined effect on liver fibrosis parameters in subjects with NAFLD. The results showed that only subjects following LGIMD or LGIMD plus PA program experienced a significant reduction in liver fibrosis at 90 days.
Article
Urology & Nephrology
Serkan Yildiz, Cihan Heybeli, Lee Smith, Pinar Soysal, Rumeyza Kazancioglu
Summary: This study aimed to determine predictors of loss of appetite among older adults with chronic kidney disease (CKD). Logistic regression analysis was performed using demographic and clinical data to identify the predictors of loss of appetite. The results showed that loss of appetite is common in older adults with CKD and is associated with insomnia and depressive mood.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Geriatrics & Gerontology
Agnese Di Prazza, Baldassare Canino, Mario Barbagallo, Nicola Veronese
Summary: Brief MPI and CFS demonstrate good accuracy and precision in predicting mortality in older patients attending the ED. Their quick application makes them potentially valuable tools for ED clinical practice.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Meeting Abstract
Psychiatry
A. Gonzalez-Rodriguez, J. A. Monreal, M. Solmi, M. Balestrieri, M. Fornaro, A. L. Panfil, F. Duval, M. V. Seeman
EUROPEAN PSYCHIATRY
(2023)