Review
Endocrinology & Metabolism
Xu Tian, Shujie Lou, Rengfei Shi
Summary: Sarcopenia, a degenerative muscle condition in older adults, is linked to loss of mitochondrial integrity and decreased sex hormones. Damaged mitochondria, caused by age-related impairments in various mitochondrial quality control processes, contribute to muscle mass decline. Additionally, decreased levels of sex hormones such as 17 beta-estradiol and testosterone also play a role in mitochondrial dysfunction and sarcopenia. This review examines the mechanisms behind mitochondrial dysfunction in sarcopenia and the potential therapeutic approaches.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ching-Chia Wang, Huang-Jen Chen, Ding-Cheng Chan, Chen-Yuan Chiu, Shing-Hwa Liu, Kuo-Cheng Lan
Summary: The study found that acrolein exposure led to increased fasting blood glucose and impaired glucose tolerance in mice. It also showed that acrolein treatment decreased the expression of GLUT4 in both mouse soleus muscles and C2C12 myotubes, as well as suppressed phosphorylation of glucose metabolic signals. Additionally, over-expression of constitutive activation of Akt reversed the inhibitory effects of acrolein on GLUT4 protein expression and glucose uptake in myotubes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Damian Jozef Flis, Emilia Gabriela Bialobrodzka, Ewa Aleksandra Rodziewicz-Flis, Zbigniew Jost, Andzelika Borkowska, Wieslaw Ziolkowski, Jan Jacek Kaczor
Summary: This study investigates the effects of Dex treatment on blood and skeletal muscle metabolites and activity of enzymes related to energy metabolism after long-duration swimming. The results showed that Dex treatment induced body mass loss and increased lipid metabolites in the blood, while prolonged swimming intensified these effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Julio Plaza-Diaz, David Izquierdo, Alvaro Torres-Martos, Aiman Tariq Baig, Concepcion M. Aguilera, Francisco Javier Ruiz-Ojeda
Summary: Exercise and physical activity have beneficial effects on health and chronic disease prevention by inducing physiological responses and adaptations in skeletal muscle. These adaptations are mediated by transcriptional responses and epigenetic modifications, such as DNA methylation and histone modifications. Other emerging epigenetic markers, including epitranscriptomics and modifications mediated by miRNAs, are also being explored. This article provides an overview of the impact of exercise on epigenetic modifications, focusing on skeletal muscle, and discusses the influence of systemic metabolism on these modifications.
Article
Nutrition & Dietetics
Frederic Nicolas Daussin, Alexane Cuillerier, Julianne Touron, Samir Bensaid, Bruno Melo, Ali Al Rewashdy, Goutham Vasam, Keir J. Menzies, Mary-Ellen Harper, Elsa Heyman, Yan Burelle
Summary: The study found that cocoa flavanols supplementation can improve mitochondrial function and whole-body metabolism, particularly by stimulating NAD metabolism and enhancing the function of Sirt3. These findings suggest that cocoa flavanols may help improve metabolic efficiency in the body.
Article
Nutrition & Dietetics
Colleen S. Deane, Ushnah S. U. Din, Tanvir S. Sian, Ken Smith, Amanda Gates, Jonathan N. Lund, John P. Williams, Ricardo Rueda, Suzette L. Pereira, Philip J. Atherton, Bethan E. Phillips
Summary: Acute curcumin supplementation enhances the effect of oral nutritional supplement on microvascular blood flow in healthy older adults, without affecting muscle glucose uptake, vascular function, or blood flow.
Review
Endocrinology & Metabolism
Lijun Yin, Shuo Qi, Zhiqiang Zhu
Summary: An increasing number of studies have shown the crucial roles of androgens and androgen receptors (AR) in regulating glucose and lipid metabolism. Impaired glucose and lipid metabolism and obesity-related diseases have been observed in hypogonadal men and male rodents with androgen deficiency. Exogenous androgens supplementation effectively improves these disorders, but the precise mechanism by which androgens regulate glucose and lipid metabolism remains unclear. Mitochondria, as the powerhouses of cells, play a key role in glucose and lipid metabolism. Existing evidence from pre-clinical and clinical studies suggests that the regulation of glucose and lipid metabolism by androgens/AR is strongly associated with the impact on mitochondrial content and function, but comprehensive reports on the regulatory effect and underlying molecular mechanism are limited. This paper provides a review of the effect of androgens/AR on mitochondrial content, morphology, quality control system, and function, with emphasis on the molecular mechanisms. Additionally, the gender-specific effects of androgens on mitochondria are discussed. This paper lays a theoretical foundation for understanding the influence and mechanism of androgens on glucose and lipid metabolism and highlights the mitochondria-based explanation for the gender-specific effects of androgens on glucose and lipid metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Tanvir S. Sian, Ushnah S. U. Din, Colleen S. Deane, Ken Smith, Amanda Gates, Jonathan N. Lund, John P. Williams, Ricardo Rueda, Suzette L. Pereira, Bethan E. Phillips, Philip J. Atherton
Summary: The study found that acute cocoa flavanol supplementation can increase postprandial muscle microvascular blood volume in older adults, but does not enhance muscle glucose uptake.
Article
Geriatrics & Gerontology
Kamar Ghaibour, Melanie Schuh, Sirine Souali-Crespo, Celine Chambon, Anouk Charlot, Joe Rizk, Daniela Rovito, Anna-Isavella Rerra, Qingshuang Cai, Nadia Messaddeq, Joffrey Zoll, Delphine Duteil, Daniel Metzger
Summary: Disrupting the androgen/androgen receptor axis impairs glycolytic activity and promotes the development of type 2 diabetes in male mice, but not in females. It also leads to oxidative stress and necrosis in muscle fibers.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Nutrition & Dietetics
Aaron Persinger, Matthew Butawan, Martina Faietti, Ashley Pryke, Kyley Rose, Marie van der Merwe, Richard J. Bloomer, Melissa J. Puppa
Summary: Time-restricted feeding (TRF) does not significantly impact muscle metabolic flexibility and running performance, especially in young populations consuming a healthy diet and exercising.
Article
Chemistry, Multidisciplinary
Ayano Kato, Iori Sakakibara, Taku Fukushima, Kosuke Sugiura, Tomoya Fukawa, Takeshi Nikawa, Takayuki Uchida
Summary: This study analyzed the effect of different glucose concentrations on protein expression in muscle cells and found that low and medium glucose concentrations can enhance glucose utilization and induce myosin expression.
APPLIED SCIENCES-BASEL
(2022)
Article
Cell Biology
Yajie Hu, Yang Liu, Yuying Yang, Hongming Lv, Shuai Lian, Bin Xu, Shize Li
Summary: The study found that under acute cold exposure conditions, O-GlcNAcylation can enhance the expression of IL-6 in mouse skeletal muscle, promote energy metabolism regulation, and maintain cell survival by enhancing the activity and nuclear translocation of p65.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Jerome Salles, Christelle Guillet, Olivier Le Bacquer, Carmen Malnero-Fernandez, Christophe Giraudet, Veronique Patrac, Alexandre Berry, Philippe Denis, Corinne Pouyet, Marine Gueugneau, Yves Boirie, Heidi Jacobs, Stephane Walrand
Summary: Old rats were found to use pea protein with the same efficiency as casein or whey proteins, with similar effects on body composition, tissue weight, skeletal muscle protein synthesis and degradation. This suggests that using plant-based proteins could help older individuals diversify their protein sources and meet nutritional intake recommendations more easily.
Article
Nutrition & Dietetics
Paul A. Roberson, Gregory N. Kincheloe, Jaclyn E. Welles, Dandan Xu, Mahalia Sam -Clarke, Paul S. MacLean, Charles H. Lang, Leonard S. Jefferson, Scot R. Kimball
Summary: This study confirms the role of Sestrins in glucose-induced mTORC1 activation and reveals the involvement of HK2 in this process in HEK293T cells. The effect of glucose on mTORC1 activation is independent of SESN-GATOR2 interaction and instead associated with alterations in SESNs' association with HK2.
JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Tomaz Mars, Katarina Mis, Marija Meznaric, Sonja Prpar Mihevc, Vid Jan, Fred Haugen, Boris Rogelj, Arild C. Rustan, G. Hege Thoresen, Sergej Pirkmajer, Natasa Nikolic
Summary: Both innervation and EPS promote differentiation into different fiber types in human myotubes, leading to a more oxidative phenotype in terms of metabolism.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Biochemical Research Methods
Naoko Goto-Inoue, Mizuki Morisasa, Kazumasa Machida, Yasuro Furuichi, Nobuharu L. Fujii, Shinji Miura, Tsukasa Mori
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2019)
Article
Biochemistry & Molecular Biology
Satoko Sato, Mitsuru Nomura, Ikko Yamana, Akira Uchiyama, Yasuro Furuichi, Yasuko Manabe, Nobuharu L. Fujii
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Kenichi Sakamoto, Yasuro Furuichi, Masashi Yamamoto, Megumi Takahashi, Yoshihiro Akimoto, Takahiro Ishikawa, Takahiko Shimizu, Masanori Fujimoto, Aki Takada-Watanabe, Aiko Hayashi, Yoshitaka Mita, Yasuko Manabe, Nobuharu L. Fujii, Ryoichi Ishibashi, Yoshiro Maezawa, Christer Betsholtz, Koutaro Yokote, Minoru Takemoto
Article
Multidisciplinary Sciences
Kotaro Tamura, Naoko Goto-Inoue, Kaede Miyata, Yasuro Furuichi, Nobuharu L. Fujii, Yasuko Manabe
Article
Cell Biology
Takumi Wada, Ken-ichi Hironaka, Mitsutaka Wataya, Masashi Fujii, Miki Eto, Shinsuke Uda, Daisuke Hoshino, Katsuyuki Kunida, Haruki Inoue, Hiroyuki Kubota, Tsuguto Takizawa, Yasuaki Karasawa, Hirofumi Nakatomi, Nobuhito Saito, Hiroki Hamaguchi, Yasuro Furuichi, Yasuko Manabe, Nobuharu L. Fujii, Shinya Kuroda
Article
Multidisciplinary Sciences
Daisuke Hoshino, Kentaro Kawata, Katsuyuki Kunida, Atsushi Hatano, Katsuyuki Yugi, Takumi Wada, Masashi Fujii, Takanori Sano, Yuki Ito, Yasuro Furuichi, Yasuko Manabe, Yutaka Suzuki, Nobuharu L. Fujii, Tomoyoshi Soga, Shinya Kuroda
Article
Cell Biology
Yasuro Furuichi, Yuki Kawabata, Miho Aoki, Yoshitaka Mita, Nobuharu L. Fujii, Yasuko Manabe
Summary: The study demonstrates that high glucose concentrations impede the proliferation of muscle-specific stem cells and affect cell fate, leading to a decrease in reserve cells. Consequently, hyperglycemia may impact the regenerative capability of skeletal muscle fibers and contribute to sarcopenia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hiroki Hamaguchi, Tsubasa S. Matsui, Shinji Deguchi, Yasuro Furuichi, Nobuharu L. Fujii, Yasuko Manabe
Summary: The study utilized a deformable silicone gel substrate to evaluate the contractile force of myotubes, finding that different inducing factors led to different levels of contractile force. This system shows higher sensitivity in assessing the contractile force-related state of myotubes.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Yoshitaka Mita, Haonan Zhu, Yasuro Furuichi, Hiroki Hamaguchi, Yasuko Manabe, Nobuharu L. Fujii
Summary: The ratio of muscle fiber types determines the properties of skeletal muscle tissue, and a myokine called Rspo3 has been found to determine whether satellite cells differentiate into type I fibers. Through induction experiments, it was found that Rspo3 significantly increases the expression of type I fibers, and this effect is mainly mediated through the Wnt/beta-catenin signaling pathway.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Hiroki Hamaguchi, Kitora Dohi, Takaomi Sakai, Masato Taoka, Toshiaki Isobe, Tsubasa S. Matsui, Shinji Deguchi, Yasuro Furuichi, Nobuharu L. Fujii, Yasuko Manabe
Summary: Myokines, such as platelet-derived growth factor sub-unit B (PDGF-B), play a crucial role in regulating muscle mass and function by acting locally on muscle cells or satellite cells. This study found that PDGF-B is continuously secreted by muscle cells and its secretion increases during myoblast to myotube differentiation. Treatment with PDGF-B enhances myoblast proliferation and promotes myotube maturation, as evidenced by increased myotube diameter, myosin heavy chain expression, and contractile force. These findings suggest that PDGF-B acts as a paracrine or autocrine myokine to contribute to skeletal muscle regeneration.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Yasuro Furuichi, Ayana Furutani, Kotaro Tamura, Yasuko Manabe, Nobuharu L. Fujii
Summary: Skeletal muscle undergoes structural and metabolic changes in response to various conditions. The RNA-binding protein Musashi-2 (Msi2) is dominantly expressed in slow-type muscle fibers, and its knockout leads to a decrease in both fiber size and number, as well as a reduction in fast-type fibers and metabolic protein expression. These findings demonstrate the critical role of Msi2 in maintaining fiber type composition and metabolism.
Article
Biochemistry & Molecular Biology
Naoko Goto-Inoue, Mizuki Morisasa, Keisuke Kimura, Tsukasa Mori, Yasuro Furuichi, Yasuko Manabe, Nobuharu L. Fujii
Summary: Muscle atrophy is a significant health problem that requires different treatment approaches for different types of muscle fibers. Chronic exercise promotes muscle hypertrophy and induces metabolic changes, with variations between different fiber types. The study found that chronic exercise primarily caused hypertrophic features in glycolytic myofibers and led to significant changes in protein synthesis and lipid metabolism. Furthermore, the sources of energy, such as glycogen, neutral lipids, and ATP, were sensitive to exercise, with variations between glycolytic and oxidative myofibers.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Sakuka Tsukamoto-Sen, Shinpei Kawakami, Hiroko Maruki-Uchida, Ryouichi Ito, Naoko Matsui, Yuki Komiya, Yoshitaka Mita, Mizuki Morisasa, Naoko Goto-Inoue, Yasuro Furuichi, Yasuko Manabe, Minoru Morita, Nobuharu L. Fujii
Summary: Antioxidant supplementation can alleviate age-related muscle function changes, including increased fat oxidation and locomotor activity, and reduced oxidative stress.
Article
Mathematical & Computational Biology
Naoki Matsuda, Ken-ichi Hironaka, Masashi Fujii, Takumi Wada, Katsuyuki Kunida, Haruki Inoue, Miki Eto, Daisuke Hoshino, Yasuro Furuichi, Yasuko Manabe, Nobuharu L. Fujii, Hiroyuki Noji, Hiromi Imamura, Shinya Kuroda
QUANTITATIVE BIOLOGY
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Satoko Sato, Yusuke Takamura, Ikko Yamana, Mitsuru Nomura, Akira Uchiyama, Yasuro Furuichi, Yasuko Manabe, Nobuharu L. Fujii