Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production
出版年份 2021 全文链接
标题
Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production
作者
关键词
hematopoietic stem and progenitor cell, Ddx41, zebrafish, R-loops, inflammatory signaling
出版物
DEVELOPMENTAL CELL
Volume 56, Issue 5, Pages 627-640.e5
出版商
Elsevier BV
发表日期
2021-03-01
DOI
10.1016/j.devcel.2021.02.006
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- cGAS-STING–mediated DNA sensing maintains CD8+ T cell stemness and promotes antitumor T cell therapy
- (2020) Wenwen Li et al. Science Translational Medicine
- cGAS-STING pathway in oncogenesis and cancer therapeutics
- (2020) Brandon Yi Da Hoong et al. Oncotarget
- Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming
- (2020) Pengze Yan et al. Cell Reports
- Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production
- (2020) Jenna M. Frame et al. DEVELOPMENTAL CELL
- A novel conditioning-free hematopoietic stem cell transplantation model in zebrafish
- (2020) Ellen Fraint et al. Blood Advances
- The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus
- (2019) Matteo Gentili et al. Cell Reports
- R-Loops as Cellular Regulators and Genomic Threats
- (2019) Madzia P. Crossley et al. MOLECULAR CELL
- Endothelial-to-haematopoietic transition: an update on the process of making blood
- (2019) Katrin Ottersbach BIOCHEMICAL SOCIETY TRANSACTIONS
- Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death
- (2019) Hui Jiang et al. EMBO JOURNAL
- Tight nuclear tethering of cGAS is essential for preventing autoreactivity
- (2019) Hannah E Volkman et al. eLife
- Cyclic di-AMP in host–pathogen interactions
- (2018) Laura Devaux et al. CURRENT OPINION IN MICROBIOLOGY
- Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis
- (2018) Shelly Sorrells et al. Disease Models & Mechanisms
- Hematopoietic development: a gap in our understanding of inherited bone marrow failure
- (2018) Peter Kurre EXPERIMENTAL HEMATOLOGY
- Proinflammatory Signals as Fuel for the Fire of Hematopoietic Stem Cell Emergence
- (2018) Raquel Espin-Palazon et al. TRENDS IN CELL BIOLOGY
- DDX41 Recognizes RNA/DNA Retroviral Reverse Transcripts and Is Critical for In Vivo Control of Murine Leukemia Virus Infection
- (2018) Spyridon Stavrou et al. mBio
- An optimised pipeline for parallel image-based quantification of gene expression and genotyping after in situ hybridisation
- (2018) Tomasz Dobrzycki et al. Biology Open
- Human proteins that interact with RNA/DNA hybrids
- (2018) Isabel X. Wang et al. GENOME RESEARCH
- Nuclear cGAS suppresses DNA repair and promotes tumorigenesis
- (2018) Haipeng Liu et al. NATURE
- Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome
- (2018) Srivarsha Rajshekar et al. eLife
- DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway
- (2017) Juli Bai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- zWEDGI: Wounding and Entrapment Device for Imaging Live Zebrafish Larvae
- (2017) Kayla Huemer et al. Zebrafish
- IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells
- (2015) C. Schinke et al. BLOOD
- Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms
- (2015) Chantana Polprasert et al. CANCER CELL
- Hematopoietic Stem Cell Arrival Triggers Dynamic Remodeling of the Perivascular Niche
- (2015) Owen J. Tamplin et al. CELL
- Conservation of the STING-Mediated Cytosolic DNA Sensing Pathway in Zebrafish
- (2015) Rui Ge et al. JOURNAL OF VIROLOGY
- Breaking bad: R-loops and genome integrity
- (2015) Julie Sollier et al. TRENDS IN CELL BIOLOGY
- Bacterial c-di-GMP Affects Hematopoietic Stem/Progenitors and Their Niches through STING
- (2015) Hiroshi Kobayashi et al. Cell Reports
- Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi–Goutières syndrome
- (2015) Yoong Wearn Lim et al. eLife
- The Molecular Signatures Database Hallmark Gene Set Collection
- (2015) Arthur Liberzon et al. Cell Systems
- Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates
- (2014) Q. He et al. BLOOD
- Proinflammatory Signaling Regulates Hematopoietic Stem Cell Emergence
- (2014) Raquel Espín-Palazón et al. CELL
- The DNA Damage-Regulated Autophagy Modulator DRAM1 Links Mycobacterial Recognition via TLR-MYD88 to Autophagic Defense
- (2014) Michiel van der Vaart et al. Cell Host & Microbe
- Interferon Gamma Signaling Positively Regulates Hematopoietic Stem Cell Emergence
- (2014) Suphansa Sawamiphak et al. DEVELOPMENTAL CELL
- Cytosolic RNA:DNA hybrids activate the cGAS–STING axis
- (2014) Arun K Mankan et al. EMBO JOURNAL
- Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production
- (2014) Yan Li et al. GENES & DEVELOPMENT
- Defective removal of ribonucleotides from DNA promotes systemic autoimmunity
- (2014) Claudia Günther et al. JOURNAL OF CLINICAL INVESTIGATION
- rMATS: Robust and flexible detection of differential alternative splicing from replicate RNA-Seq data
- (2014) Shihao Shen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization
- (2013) Xin Li et al. IMMUNITY
- Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics
- (2013) Linn Fagerberg et al. MOLECULAR & CELLULAR PROTEOMICS
- A systematic genome-wide analysis of zebrafish protein-coding gene function
- (2013) Ross N. W. Kettleborough et al. NATURE
- Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP
- (2013) Andrea Ablasser et al. NATURE
- Zebrafish model for allogeneic hematopoietic cell transplantation not requiring preconditioning
- (2013) Isabell Hess et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Transgenic line with gal4 insertion useful to study morphogenesis of craniofacial perichondrium, vascular endothelium-associated cells, floor plate, and dorsal midline radial glia during zebrafish development
- (2012) Sohei Nakayama et al. DEVELOPMENT GROWTH & DIFFERENTIATION
- The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response
- (2012) Kislay Parvatiyar et al. NATURE IMMUNOLOGY
- The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA
- (2012) Zhiqiang Zhang et al. NATURE IMMUNOLOGY
- Microbial Colonization Induces Dynamic Temporal and Spatial Patterns of NF-κB Activation in the Zebrafish Digestive Tract
- (2011) Michelle Kanther et al. GASTROENTEROLOGY
- The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells
- (2011) Zhiqiang Zhang et al. NATURE IMMUNOLOGY
- Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells
- (2010) A Pellagatti et al. LEUKEMIA
- An Upstream Open Reading Frame and the Context of the Two AUG Codons Affect the Abundance of Mitochondrial and Nuclear RNase H1
- (2010) Y. Suzuki et al. MOLECULAR AND CELLULAR BIOLOGY
- In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium
- (2010) Jean-Charles Boisset et al. NATURE
- Blood stem cells emerge from aortic endothelium by a novel type of cell transition
- (2010) Karima Kissa et al. NATURE
- Haematopoietic stem cells derive directly from aortic endothelium during development
- (2010) Julien Y. Bertrand et al. NATURE
- A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability
- (2009) Renee D. Paulsen et al. MOLECULAR CELL
- High-resolution in situ hybridization to whole-mount zebrafish embryos
- (2007) Christine Thisse et al. Nature Protocols
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now