Role of the purinergic signaling network in lung ischemia-reperfusion injury

Glycocalyx degradation in ischemia-reperfusion injury

(2020) Zaid Abassi et al.   AMERICAN JOURNAL OF PATHOLOGY

FIRST IN HUMAN LUNG TRANSPLANTATION: ADENOSINE A2A RECEPTOR AGONIST (REGADENOSON)

(2020) Christine L. Lau et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

TRPV4 Protects the Lung from Bacterial Pneumonia via MAPK Molecular Pathway Switching

(2020) Rachel G. Scheraga et al.   JOURNAL OF IMMUNOLOGY

Purinergic signaling, DAMPs, and inflammation

(2020) Francesco Di Virgilio et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Urgent reconsideration of lung edema as a preventable outcome in COVID-19: Inhibition of TRPV4 represents a promising and feasible approach

(2020) Wolfgang Michael Kuebler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Targeting pulmonary capillary permeability to reduce lung congestion in heart failure: a randomized, controlled pilot trial

(2020) Glenn M. Stewart et al.   EUROPEAN JOURNAL OF HEART FAILURE

TRPV4: A Physio and Pathophysiologically Significant Ion Channel

(2020) Tamara Rosenbaum et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endothelial Pannexin 1 Channels Control Inflammation by Regulating Intracellular Calcium

(2020) Yang Yang et al.   JOURNAL OF IMMUNOLOGY

Mechanisms underlying selective coupling of endothelial Ca 2+ signals with eNOS versus IK/SK channels in systemic and pulmonary arteries

(2020) Matteo Ottolini et al.   JOURNAL OF PHYSIOLOGY-LONDON

Analysis of purine receptor expression and functionality in alveolar epithelial cells

(2020) Cynthia Olotu et al.   Purinergic Signalling

Reduced Post-ischemic Brain Injury in Transient Receptor Potential Vanilloid 4 Knockout Mice

(2020) Koji Tanaka et al.   Frontiers in Neuroscience

Pannexin 1 Channels as a Therapeutic Target: Structure, Inhibition, and Outlook

(2020) Kathleen E. Navis et al.   ACS Chemical Neuroscience

P2X7 Receptor at the Crossroads of T Cell Fate

(2020) Elizabeth Rivas-Yáñez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

P2X7 Receptors as a Therapeutic Target in Cerebrovascular Diseases

(2020) Abraham J. Cisneros-Mejorado et al.   Frontiers in Molecular Neuroscience

The Role of TRPV4 in Regulating Innate Immune Cell Function in Lung Inflammation

(2020) Rachel G. Scheraga et al.   Frontiers in Immunology

PANX1 in inflammation heats up: New mechanistic insights with implications for injury and infection

(2020) Juan C. Sanchez Arias et al.   CELL CALCIUM

TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema

(2020) Jonas Weber et al.   JCI Insight

Potential Therapeutic Role of Purinergic Receptors in Cardiovascular Disease Mediated by SARS-CoV-2

(2020) Fernanda dos Anjos et al.   Journal of Immunology Research

Adenosine from a biologic source regulates neutrophil extracellular traps (NETs)

(2019) Kai Xu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

ATP redirects cytokine trafficking and promotes novel membrane TNF signaling via microvesicles

(2019) Sanooj Soni et al.   FASEB JOURNAL

Targeting CD39 Toward Activated Platelets Reduces Systemic Inflammation and Improves Survival in Sepsis

(2019) Tiago Granja et al.   CRITICAL CARE MEDICINE

Purine Release, Metabolism, and Signaling in the Inflammatory Response

(2019) Joel Linden et al.   Annual Review of Immunology

Pharmacological inhibition of TRPV4 channels protects against ischemia–reperfusion-induced renal insufficiency in neonatal pigs

(2019) Hitesh Soni et al.   CLINICAL SCIENCE

P2Y2R activation by ATP induces oxLDL-mediated inflammasome activation through modulation of mitochondrial damage in human endothelial cells

(2019) Hana Jin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Impaired l-arginine metabolism marks endothelial dysfunction in CD73-deficient mice

(2019) P. Mierzejewska et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome

(2019) Ramadan A. Ali et al.   Nature Communications

PAR2-Mediated cAMP Generation Suppresses TRPV4-Dependent Ca2+ Signaling in Alveolar Macrophages to Resolve TLR4-Induced Inflammation

(2019) Sheikh Rayees et al.   Cell Reports

Therapeutic Potential of Agonists and Antagonists of A1, A2a, A2b And A3 Adenosine Receptors

(2019) Sumit Jamwal et al.   CURRENT PHARMACEUTICAL DESIGN

Blockade of Transient Receptor Potential Vanilloid 4 Enhances Antioxidation after Myocardial Ischemia/Reperfusion

(2019) Qiongfeng Wu et al.   Oxidative Medicine and Cellular Longevity

Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4)

(2019) Carl A. Brooks et al.   ACS Medicinal Chemistry Letters

Purinergic Signaling in Pulmonary Inflammation

(2019) Thanh-Thuy T. Le et al.   Frontiers in Immunology

Cell type- and tissue-specific functions of ecto-5'-nucleotidase (CD73)

(2019) Marquet Minor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Pannexin‐1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation

(2019) Kaiwen W. Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

P2X7 Interactions and Signaling – Making Head or Tail of It

(2019) Robin Kopp et al.   Frontiers in Molecular Neuroscience

Role of macrophage TRPV4 in inflammation

(2019) Bidisha Dutta et al.   LABORATORY INVESTIGATION

ATP amplifies NADPH-dependent and -independent neutrophil extracellular trap formation

(2019) Aderonke Sofoluwe et al.   Scientific Reports

Propofol Induces Cardioprotection Against Ischemia-Reperfusion Injury via Suppression of Transient Receptor Potential Vanilloid 4 Channel

(2019) Binbin Wang et al.   Frontiers in Pharmacology

Pannexin 1 channels on endothelial cells mediate vascular inflammation during lung ischemia-reperfusion injury

(2018) Ashish K. Sharma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TRPV4 Stimulation Releases ATP via Pannexin Channels in Human Pulmonary Fibroblasts

(2018) Mozibur Rahman et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

P2X7 receptor is involved in lung injuries induced by ischemia-reperfusion in pulmonary arterial hypertension rats

(2018) Lian Duan et al.   MOLECULAR IMMUNOLOGY

Nitric Oxide–Dependent Feedback Loop Regulates Transient Receptor Potential Vanilloid 4 (TRPV4) Channel Cooperativity and Endothelial Function in Small Pulmonary Arteries

(2017) Corina Marziano et al.   Journal of the American Heart Association

NOX2 Activation of Natural Killer T Cells Is Blocked by the Adenosine A2AReceptor to Inhibit Lung Ischemia–Reperfusion Injury

(2016) Ashish K. Sharma et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Ex vivo lung perfusion with adenosine A2A receptor agonist allows prolonged cold preservation of lungs donated after cardiac death

(2016) Cynthia E. Wagner et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Neutrophil Extracellular Traps Are Pathogenic in Primary Graft Dysfunction after Lung Transplantation

(2015) David M. Sayah et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation

(2015) Alexander W. Lohman et al.   Nature Communications

NADPH oxidase mediates synergistic effects of IL-17 and TNF-α on CXCL1 expression by epithelial cells after lung ischemia-reperfusion

(2013) Ashish K. Sharma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Adenosine A 2A Agonist Improves Lung Function During Ex Vivo Lung Perfusion

(2011) Abbas Emaminia et al.   ANNALS OF THORACIC SURGERY

Pretreatment strategy with adenosine A2A receptor agonist attenuates reperfusion injury in a preclinical porcine lung transplantation model

(2011) Damien J. LaPar et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Targeting of adenosine receptors in ischemia–reperfusion injury

(2010) Victor E Laubach et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Additive protection against lung ischemia-reperfusion injury by adenosine A2A receptor activation before procurement and during reperfusion

(2007) Leo M. Gazoni et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY