Article
Biology
Kou-Toung Chung, Li-Wen Chen, Hung-Wei Tseng, Chung-Hsin Wu
Summary: This study evaluated the effects of acute and chronic exposure to the neonicotinoid imidacloprid on the social behavior of adult zebrafish. The results showed that imidacloprid exposure significantly reduced the swimming speed, distance traveled, acceleration, and deceleration of the zebrafish. Furthermore, it also decreased heterosexual attractive behavior and defensive alert behavior among males. Histomorphology and immunohistochemistry evidence suggested that imidacloprid exposure may lead to oxidative stress, inflammation, apoptosis, and damage in the telencephalon of adult zebrafish.
Article
Environmental Sciences
Saurabh Shukla, Reena C. Jhamtani, Rakhi Agarwal
Summary: In this study, the effect of individual and combined exposure to different pesticides on antioxidant enzyme responses in zebrafish was investigated. The results showed that the activity of all antioxidant enzymes was significantly enhanced in the individual exposure group, which was further amplified in the combined exposure group. mRNA expression levels of SOD, CAT, GPx, and MT-II were significantly down-regulated in the liver and kidney, while significant up-regulation was observed in the brain, except for GPx, in the DIC and IMD groups. The findings suggest a synergistic toxic manifestation in the combined exposure group.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Garam An, Junho Park, Whasun Lim, Gwonhwa Song
Summary: Thiobencarb, a widely used herbicide on rice paddies, has been found to have toxic effects on aquatic organisms. This study investigated the mechanism of toxicity in zebrafish embryos and found that thiobencarb caused decreased viability, phenotypic abnormalities, and defects in the cardiovascular system. The toxicity was mediated by pro-inflammatory cytokines and excessive reactive oxygen species generation due to the downregulation of antioxidant enzyme genes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
S. P. Ramya Ranjan Nayak, L. S. Dhivya, R. Reshma, Bader O. Almutairi, Selvaraj Arokiyaraj, M. K. Kathiravan, Jesu Arockiaraj
Summary: This study investigates the anti-inflammatory effects of synthesized chalcone DKO7 in a zebrafish model of intestinal inflammation. The results demonstrate that DKO7 possesses anti-inflammatory and antioxidant properties, and protects zebrafish against oxidative stress and inflammation. The study provides evidence for the potential of DKO7 in alleviating DSS-induced gut inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Environmental Sciences
Weike Shaoyong, Wanrong Zhang, Chenyang Wang, Zhongyun Kou, Wenlong Yong, Junheng Jiao, Wenyong Yan, Weijun Pang
Summary: The study found that exposure to BDE-209 resulted in reduced body weight, intestinal oxidative stress, apoptosis, autophagy, and inflammation in mice, as well as decreased intestinal mucus barrier and increased gut permeability. Furthermore, BDE-209 lowered levels of intestinal short-chain fatty acids. NAC attenuated the effects of BDE-209 on gut toxicity through the oxidative stress pathway.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Karoline Felisbino, Nathalia Kirsten, Shayane da Silva Milhorini, Isabela Saragioto Marcal, Karina Bernert, Rafaela Schiessl, Leticia Nominato-Oliveira, Izonete Cristina Guiloski
Summary: This study evaluated the acute toxicity, teratogenic effects, oxidative stress, and neurotoxicity of Dicamba in zebrafish embryos. The results showed that Dicamba could cause developmental delay, teratogenic effects, and oxidative stress. These findings highlight the potential risks of Dicamba exposure during embryonic development and the need for further studies.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Eman Hassanen, Ahmed M. Hussien, Sally Mehanna, Marwa A. Ibrahim, Neven H. Hassan
Summary: Pesticides are considered a major source of ecological contamination and pose serious risks to humans and animals. This study explored the mechanisms of liver and kidney toxicity caused by the insecticides IM and HFM in rats. It was found that both insecticides induced organ damage through excessive production of reactive oxygen species, activation of NF-B-K signaling pathways, and mitochondrial/JNK-dependent apoptosis pathway.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Yunlong Meng, Keyuan Zhong, Suping Chen, Yong Huang, You Wei, Juan Wu, Juan Liu, Zhaopeng Xu, Jing Guo, Fasheng Liu, Huiqiang Lu
Summary: The study revealed that exposure to Pendimethalin can reduce heart rate, survival rate, and body length of zebrafish embryos, causing various malformations and affecting antioxidant enzyme activity and the expression of genes related to cardiac development.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Engineering, Environmental
Haiyun Zhang, Julia Vidonish Aspinall, Weiguang Lv, Xianqing Zheng, Hanlin Zhang, Shuangxi Li, Juanqin Zhang, Naling Bai, Yue Zhang, Xilong Wang
Summary: The study systematically revealed the compound/time/exposure scenario-dependent effects of trace neonicotinoids on earthworm metabolomics and advanced the understanding of their action modes. Neonicotinoid transformation was closely related to worms' metabolic profiles, providing important insights in contaminant fate in soil ecosystems.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Agronomy
Jin Yang, Yiming Chang, Yanning Zhang, Lizhen Zhu, Liangang Mao, Lan Zhang, Xingang Liu, Hongyun Jiang
Summary: This study found that the mixture of commonly used pesticides imidacloprid, acetochlor, and tebuconazole in rice fields had a more pronounced effect on the reproductive outcomes of zebrafish, resulting in reduced number of F1 embryos, increased developmental defects, and disruption in reproductive hormones and gene expression.
Article
Chemistry, Applied
Tao Wang, Shuxuan Wang, Shuchen Dong, Yu Zhang, Mohamedelfatieh Ismael, Shuang Wang, Caihong Shi, Jie Yang, Xin Wang, Xin Lue
Summary: The study found that CCDB can alleviate colitis by strengthening the gut barrier, reducing oxidative stress and inflammation, and regulating the composition of gut microbiota.
Article
Environmental Sciences
Lulu Ran, Ya Yang, Xia Zhou, Xiaoxia Jiang, Deyu Hu, Ping Lu
Summary: The study demonstrates that R-(-)-dinotefuran has a greater toxic effect on zebrafish, affecting their development, and shows selective effects on oxidative stress. Metabolomics method reveals disturbances of endogenous metabolites caused by R-(-)-dinotefuran. Only phenylalanine metabolic pathways are involved in zebrafish exposed to R-(-)-dinotefuran, while in fish exposed to S(+)-dinotefuran, phenylalanine, tyrosine, and tryptophan biosynthesis are involved.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Siyu Xia, Xinhong Zhu, Yuepei Yan, Tao Zhang, Guoliang Chen, Daoxi Lei, Guixue Wang
Summary: This study revealed the neurotoxic and developmental toxicity of antimony on zebrafish embryos, primarily affecting neurotransmitter systems and oxidative stress, thereby altering behavior. The findings advance the understanding of antimony-induced neurotoxicity, environmental issues, and health hazards.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Marine & Freshwater Biology
Xin Chen, Tiantong Qiu, Peng Xiao, Wenhua Li
Summary: Isoflucypram has been found to have teratogenic effects on retinogenesis in zebrafish, causing abnormalities in retinal development and increased retinal cell apoptosis. This SDHI fungicide also demonstrates toxic effects on non-target aquatic organisms, highlighting the need for further investigation.
AQUATIC TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yasmina M. Abd-Elhakim, Taghred M. Saber, Mohamed M. M. Metwally, Noura A. Abd-Allah, Rasha M. S. M. Mohamed, Gehan A. Ahmed
Summary: Thymol has a potential protective effect against the harmful effects of IMID on the brain, which is achieved through its antioxidant, anti-inflammatory, and anti-apoptotic activities.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Environmental Sciences
Xia Wang, Lai Wei, Jianbo Zhu, Bingnan He, Baida Kong, Yuanxiang Jin, Zhengwei Fu
ENVIRONMENTAL TOXICOLOGY
(2020)
Article
Environmental Sciences
Xianling Yuan, Jiayan Shen, Xinyue Zhang, Wenqing Tu, Zhengwei Fu, Yuanxiang Jin
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Engineering, Environmental
Cuiyuan Jin, Xianling Yuan, Caiyun Wang, Zhengwei Fu, Yuanxiang Jin
Summary: The study found that exposure to Imazalil (IMZ) can cause significant changes in mucus secretion and ion transport in the intestine, disrupt the expression of antimicrobial peptides, affect bile acid metabolism, alter the expression levels of critical genes, and lead to remarkable increase in IL-22 expression. Immune cell-produced cytokines also exhibited extraordinary changes after exposure to IMZ. This indicates that IMZ exposure is perceived as a major stress by the intestinal epithelium, strongly impacting intestinal barrier function.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Huilin Yang, Hong Lai, Jing Huang, Liwei Sun, Jan Alexander Mennigen, Qiyu Wang, Yu Liu, Yuanxiang Jin, Wenqing Tu
Article
Environmental Sciences
Zhiwei Bao, Yao Zhao, Anyi Wu, Ze Lou, Huahui Lu, Qianxuan Yu, Zhengwei Fu, Yuanxiang Jin
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Environmental Sciences
Qinglian Hu, Hui Wang, Chao He, Yuanxiang Jin, Zhengwei Fu
Summary: The study revealed that PS NPs induced oxidative damage and inflammatory response in zebrafish larvae and macrophage cells, activating the p38 MAPK signal pathway and leading to cell apoptosis.
ENVIRONMENTAL POLLUTION
(2021)
Article
Engineering, Environmental
Guiling Yang, Yanhua Wang, Jian Li, Dou Wang, Zhiwei Bao, Qiang Wang, Yuanxiang Jin
Summary: The fungicides CTL, CBZ, and PCZ and their mixtures affect zebrafish by altering hundreds of metabolites, particularly impacting glycolysis metabolism and amino acid metabolism. The increased levels of 2-aminoadipic acid (2-AAA) across all groups suggest it as a potential biomarker for fungicide toxicity evaluation. Joint effects of CTL+PCZ on zebrafish embryos and larvae are weaker on amino acid metabolism compared to other groups, but do not influence individual fungicidal activity. Metabolomics data provides important insights into the mechanism of fungicides or their mixtures on zebrafish.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Engineering, Environmental
Yanhua Wang, Cuiyuan Jin, Dou Wang, Jiajie Zhou, Guiling Yang, Kan Shao, Qiang Wang, Yuanxiang Jin
Summary: The study found that exposure to chlorothalonil, procymidone, or a combination of both may cause liver injury, significant changes in glucose, triglyceride levels, and related gene expression, inhibition of fatty acids β-oxidation, alteration of gut microbiota structure, and disruption of intestinal barrier function integrity. Additionally, an additive effect between chlorothalonil and procymidone in mice was observed.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Ting Luo, You Weng, Zhuizui Huang, Yao Zhao, Yuanxiang Jin
Summary: The study found that even low concentrations of combined exposure to microplastics and pesticides could lead to more severe hepatotoxicity in zebrafish and produce more significant changes at the gene expression level. More combined toxicity studies are essential for a more accurate risk assessment of microplastics and pesticides.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Environmental Sciences
Yao Zhao, Zhen Qin, Zhuizui Huang, Zhiwei Bao, Ting Luo, Yuanxiang Jin
Summary: This study demonstrates that polyethylene microplastics have significant effects on the microbiome and metabolism of larval zebrafish, including changes in microbial community, alterations in metabolites levels, and variations in gene transcription levels.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
You Weng, Zhuizui Huang, Anyi Wu, Qianxuan Yu, Huahui Lu, Ze Lou, Longxi Lu, Zhiwei Bao, Yuanxiang Jin
Summary: The study found that EPX has toxic effects on zebrafish embryos and larvae, affecting development, biochemical parameters, and gene transcription, especially glucose and lipid metabolism. This indicates that triazole fungicides have toxic effects on non-target organisms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
You Weng, Ting Xu, Caihong Wang, Yuanxiang Jin
Summary: Epoxiconazole, a triazole fungicide widely used in agriculture, has been found to increase health risks and potentially harm mammals. In a study on mice, exposure to EPX resulted in altered liver and colon function, changes in gut microbiota composition, and disruption of lipid metabolism.
Article
Biochemistry & Molecular Biology
Bingnan He, Xia Wang, Xini Jin, Zimeng Xue, Jianbo Zhu, Caiyun Wang, Yuanxiang Jin, Zhengwei Fu
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2020)
Article
Environmental Sciences
Guiling Yang, Xianling Yuan, Cuiyuan Jin, Dou Wang, Yanhua Wang, Wenyu Miao, Yuanxiang Jin
ENVIRONMENTAL POLLUTION
(2020)
Article
Biochemistry & Molecular Biology
Gabriela Maressa Machado Baesso, Amanda Vitoria Venancio, Livia Costa Varela Barca, Pepita Fernanda Peppi, Caique Aparecido Faria, Joao Pedro Cosmo Machado, Luiz David Solis Murgas, Alvaro Jose de Almeida Bicudo, Eduardo Mauricio Mendes de Lima, Andre Rodrigues da Cunha Barreto-Vianna
Summary: This study evaluated the effects of eugenol, menthol, and lidocaine as anesthetics on glucose levels and recovery times in zebrafish. The results showed that eugenol and menthol did not affect glucose levels, while lidocaine caused non-concentration-dependent hyperglycemia. Recovery times were similar for eugenol and menthol, but concentration-dependent for lidocaine. Eugenol and menthol were deemed safe and satisfactory for glucose analysis in zebrafish research, while lidocaine could introduce biases and safety concerns. Researchers should carefully consider the selection of anesthetics for reliable results in zebrafish assessments.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Xiaoxue Li, Tangsong Feng, Weiqun Lu
Summary: This study reveals that exposure to VPA induces ASD-like phenotypes and behaviors, including gene transcription changes, social interaction deficit, decreased aggression, increased anxiety behavior, and elevated cortisol levels. The aggression behavior assay is a better predictor of neurotoxicology behavior of VPA.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Garam An, Junho Park, Whasun Lim, Gwonhwa Song
Summary: In this study, we investigated the hepatotoxicity and mechanism of action of pyridaben using zebrafish and ZFL cells. Pyridaben caused liver size reduction and apoptosis, and these effects were associated with uncontrolled intracellular calcium flow and downregulation of the PI3K/Akt signaling cascade.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Md Alamgir Kabir, Md. Golam Rabbane, Marco R. Hernandez, Md Aftab Ali Shaikh, Mohammad Moniruzzaman, Xuexiu Chang
Summary: This study investigated the toxicity of high concentrations of cadmium (Cd) on intestinal immunity and microbial diversity in common carp. The results showed that high Cd concentration caused intestinal inflammation, immunosuppression, and changes in the gut microbiome, leading to detrimental effects on the intestinal homeostasis and health status of the fish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Anuradha Batabyal, Veronica Rivi, Cristina Benatti, Johanna M. C. Blom, Fabio Tascedda, Ken Lukowiak
Summary: This study found that exposure to heat shock stressors and bacterial lipopolysaccharide can induce the Garcia effect in pond snails. Additionally, aspirin can prevent the formation of the Garcia effect. However, unexpectedly, exposure to crushed aspirin and heat shock stressors together leads to long-lasting feeding suppression and molecular changes in the snails' serotoninergic system and neuroplasticity genes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Li-Yih Lin, Chieh-An Cheng, Sian-Tai Liu, Jiun-Lin Horng
Summary: This study reveals that ammonia exposure impairs ion regulation in zebrafish embryos by inducing oxidative stress, mitochondrial dysfunction, and cell death. The findings suggest that ammonia is toxic to aquatic animals and can lead to the death of embryos.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Antonio Durate Pagano, Natieli Machado Goncalves, William Borges Domingues, Tony Leandro Rezende da Silveira, Mateus Tavares Kutter, Antonio Sergio Varela Jr, Carine Dahl Corcini, Mariana Cavalcanti Nascimento, Luana Ferreira Viana dos Reis, Patricia Gomes Costa, Adalto Bianchini, Matheus Vieira Volcan, Mariana Harter Remia, Vinicius Farias Campos
Summary: This study analyzed the toxic effects of Roundup Transorb (R) on the endangered Neotropical annual killifish Austrolebias charrua by evaluating molecular and biochemical biomarkers. The findings showed that exposure to Roundup significantly increased the production of reactive oxygen species, lipid peroxidation, and DNA damage in the fish's blood cells. It also decreased membrane fluidity. Gene expression analysis revealed alterations in genes associated with oxidative stress and antioxidant defense. This study provides new insights into adaptive mechanisms of A. charrua in response to Roundup, and it has important implications for environmental monitoring and aquatic toxicology assessment.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Xiaochan Gao, Hongtao Ren, Yong Huang, Yimin Li, Jiaqi Shen
Summary: The influence of multi-walled carbon nanotubes (MWCNTs) on the toxicity of zinc oxide nanoparticles (ZnONPs) in the intestine of common carp was investigated. The study found that the concentration and concentration ratio of the mixture played a role in the toxicity of ZnONPs. The presence of MWCNTs significantly decreased intercellular zinc accumulation and altered the microbial community diversity and composition of the gut microbiota.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Guangchao Yang, Qian Yang, Trust Beta, Qin Liu, Zhenzhu Zhu, Fei Shen
Summary: The study found that black garlic MLDs have alleviative effects on ZEN-induced toxicity, and exert their effects through antioxidative, anti-apoptotic, and inhibitory mechanisms on ZEN absorption.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Tuul Sepp, Ciara Baines, Randel Kreitsberg, Joern Peter Scharsack, Pedro Nogueira, Thomas Lang, Jerome Fort, Elin Sild, John T. Clarke, Arvo Tuvikene, Richard Meitern
Summary: Environmental factors can cause cancer in both wild animals and humans. The use of polluted habitats provides opportunities to study cancer defense mechanisms, which can be influenced by genetic variation and natural selection. Flatfish species, specifically flounders, show higher resistance to pollution-induced cancer compared to dabs, with elevated pollutant metabolism and stronger tumor suppression mechanisms in their liver tissue. This suggests a potential hormetic upregulation of tumor suppression or stronger natural selection pressure for cancer resistance in flounders. Wild species offer valuable insights into understanding the nature and evolution of natural cancer defense mechanisms.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Regan A. Moss, Kaitlyn M. Murphy, Steven T. Gardner, Madison M. Watkins, John W. Finger Finger Jr, Meghan D. Kelley, Ruth M. Elsey, Daniel A. Warner, Mary T. Mendonca
Summary: The study explored the impact of environmentally relevant concentrations of E2 on the immune system and hormone levels of hatchling American alligators. Results showed that exposure to environmental estrogen can alter plasma hormone concentrations but have little to no impact on morphology and immune responses.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ye Liang, Zihao Li, Jing Yuan, Yiwen Zhou, Meng Li, Haifeng Gu
Summary: This study investigated the toxicity mechanism of homo-YTX and NH3-N on the survival of abalone. The results showed that homo-YTX and NH3-N enhanced oxidative stress and lipid peroxidation reactions, inhibited energy supply, disrupted metabolic and immune physiological functions, and activated apoptosis in the gills of abalone.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2024)
