USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-β2 transcription

CDK5 activates Hippo signaling to confer resistance to radiotherapy via upregulating TAZ in lung cancer

(2020) Yulan Zeng et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Direct Targeting of CREB1 with Imperatorin Inhibits TGF β 2‐ERK Signaling to Suppress Esophageal Cancer Metastasis

(2020) Wen Wen Xu et al.   Advanced Science

Transforming Growth Factor-β Signaling in Immunity and Cancer

(2019) Eduard Batlle et al.   IMMUNITY

USP9X deubiquitinates ALDH1A3 and maintains mesenchymal identity in glioblastoma stem cells

(2019) Zhengxin Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses

(2019) Yuhang Jiang et al.   Nature Communications

TGF-β signaling in cell fate control and cancer

(2019) Yi Yu et al.   CURRENT OPINION IN CELL BIOLOGY

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

(2018) Yong Yu et al.   CANCER CELL

β-Trcp ubiquitin ligase and RSK2 kinase-mediated degradation of FOXN2 promotes tumorigenesis and radioresistance in lung cancer

(2018) Jia Ma et al.   CELL DEATH AND DIFFERENTIATION

S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer

(2018) Yumei Huang et al.   Theranostics

A novel USP9X substrate TTK contributes to tumorigenesis in non-small-cell lung cancer

(2018) Xiangling Chen et al.   Theranostics

Clinical epigenetics: seizing opportunities for translation

(2018) María Berdasco et al.   NATURE REVIEWS GENETICS

CDK20 interacts with KEAP1 to activate NRF2 and promotes radiochemoresistance in lung cancer cells

(2017) Q Wang et al.   ONCOGENE

Epigenetic plasticity and the hallmarks of cancer

(2017) William A. Flavahan et al.   SCIENCE

USP9X regulates centrosome duplication and promotes breast carcinogenesis

(2017) Xin Li et al.   Nature Communications

Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia

(2016) Ngai Cheung et al.   CANCER CELL

The Deubiquitinase USP9X Maintains DNA Replication Fork Stability and DNA Damage Checkpoint Responses by Regulating CLASPIN during S-Phase

(2016) Edel McGarry et al.   CANCER RESEARCH

Jmjd2/Kdm4 demethylases are required for expression ofIl3raand survival of acute myeloid leukemia cells

(2016) Karl Agger et al.   GENES & DEVELOPMENT

The unravelling of the ubiquitin system

(2015) Aaron Ciechanover   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Proteomic Analysis of the Human Cyclin-dependent Kinase Family Reveals a Novel CDK5 Complex Involved in Cell Growth and Migration

(2014) Shuangbing Xu et al.   MOLECULAR & CELLULAR PROTEOMICS

The Demethylase JMJD2C Localizes to H3K4me3-Positive Transcription Start Sites and Is Dispensable for Embryonic Development

(2014) M. T. Pedersen et al.   MOLECULAR AND CELLULAR BIOLOGY

Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens

(2014) C. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin

(2014) M. K. Ayrapetov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New tricks for an old fox: Impact of TGF  on the DNA damage response and genomic stability

(2014) M. H. Barcellos-Hoff et al.   Science Signaling

KDM4/JMJD2 Histone Demethylases: Epigenetic Regulators in Cancer Cells

(2013) W. L. Berry et al.   CANCER RESEARCH

Natural variation in the histone demethylase, KDM4C, influences expression levels of specific genes including those that affect cell growth

(2013) B. L. Gregory et al.   GENOME RESEARCH

Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA Replication

(2013) Monica M. Olcina et al.   MOLECULAR CELL

The emerging role of histone lysine demethylases in prostate cancer

(2012) Francesco Crea et al.   Molecular Cancer

Novel Smad proteins localize to IR-induced double-strand breaks: interplay between TGFβ and ATM pathways

(2012) Minli Wang et al.   NUCLEIC ACIDS RESEARCH

Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression

(2012) W. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blockade of TGF-  Signaling by the TGF R-I Kinase Inhibitor LY2109761 Enhances Radiation Response and Prolongs Survival in Glioblastoma

(2011) M. Zhang et al.   CANCER RESEARCH

TGF 1 Inhibition Increases the Radiosensitivity of Breast Cancer Cells In Vitro and Promotes Tumor Control by Radiation In Vivo

(2011) F. Bouquet et al.   CLINICAL CANCER RESEARCH

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

(2009) Martin Schwickart et al.   NATURE