Article
Chemistry, Applied
Chang Liu, Peng Du, Yahui Guo, Yunfei Xie, Hang Yu, Weirong Yao, Yuliang Cheng, He Qian
Summary: The study revealed that APs can promote fructose and mannose metabolism by boosting SCFAs-producing Parabacteria and Clostridium, demonstrating prebiotic effects on gut microbiota.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Chang Liu, Bin Hu, Yuliang Cheng, Yahui Guo, Weirong Yao, He Qian
Summary: The research found that APs have significant benefits for SUC mice, which can alleviate colonic inflammation and barrier dysfunction by increasing SCFAs and SCFAs-producing genus like Akkermansia and Blautia. There is a positive correlation between microbiota and SCFAs, while the action of APs is beneficial to gut micro-ecological balance in mice through SCFAs metabolism and anti-inflammatory functions.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Ding-Tao Wu, Yuan Fu, Huan Guo, Qin Yuan, Xi-Rui Nie, Sheng-Peng Wang, Ren-You Gan
Summary: This study found that polysaccharides from loquat leaves undergo degradation during gastrointestinal digestion and fecal fermentation, impacting the composition and abundance of human gut microbiota. The results suggest that these polysaccharides have the potential to be developed as prebiotics in the functional food industry.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Francesca Comas-Serra, Paula Estrada, Rafael Minjares-Fuentes, Antoni Femenia
Summary: This study evaluated the content and degree of acetylation (DA) of acemannan in 15 different commercial beverages containing Aloe vera. Flavoured beverages had low levels of acemannan and were fully deacetylated in most cases, likely due to the addition of fruit juices. Unflavoured beverages had variable levels of acemannan, with some samples containing very low amounts. Legislation regarding Aloe vera products is limited, leaving consumers uncertain about the true properties of the products they purchase.
Article
Food Science & Technology
Chaoyang Wei, Li Yao, Lin Zhang, Yu Zhang, Qian Luo, Shuyi Qiu, Xiangyong Zeng, Shiguo Chen, Xingqian Ye
Summary: This study investigated the digestion and fermentation characteristics of three peach gum polysaccharides (PGPs) with different molecular weights. The results showed that PGPs were indigestible during the oral, gastrointestinal, and intestinal stages, but could be utilized by gut microbiota, with DPG2 having the highest utilization rate. Fermentation of PGPs significantly increased the production of short-chain fatty acids, especially n-butyric acid. Different bacterial species predominantly fermented PGPs with different molecular weights.
Article
Chemistry, Organic
Xingchun Sun, Zhiyuan Chen, Rui Yang, Mei Wang, Xiufang Wang, Qi Zhang, Guozhi Xiao
Summary: This study achieved the first stereoselective one-pot synthesis of the icosasaccharide motif of EPS-1A glycan from Cordyceps sinensis. The synthetic approach showed high stereoselectivity and efficiently assembled the target icosasaccharide through different strategies.
Article
Biochemistry & Molecular Biology
Mengyin Chen, Xuefeng Chen, Yuxi Guo, Nannan Liu, Ketang Wang, Pin Gong, Yanni Zhao, Luyang Cai
Summary: This study investigates the digestion and fermentation characteristics of kiwifruit pomace polysaccharides (KFP) through in vitro simulated digestion and fecal fermentation. It is found that KFP retains hypolipidemic and hypoglycemic activities after digestion, and fecal fermentation alters the properties of indigestible KFP. Furthermore, fecal fermentation promotes the growth of beneficial bacteria and inhibits unfavorable bacteria, maintaining the balance of gut microbiota.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Xueran Geng, Dongdong Guo, Tergun Bau, Jiayu Lei, Lijing Xu, Yanfen Cheng, Cuiping Feng, Junlong Meng, Mingchang Chang
Summary: The aim of this study was to establish an in vitro human digestion model to investigate the degradation characteristics of a high-purity polysaccharide from Clitocybe squamulosa (CSFP2). The results showed that the reducing sugar content of CSFP2 increased and its molecular weight decreased significantly during saliva-gastrointestinal digestion. The monosaccharide composition of CSFP2 remained stable, but the molar ratios changed. The surface structure of CSFP2 changed, but its viscosity remained stable during digestion. Furthermore, CSFP2 retained its strong antioxidant capacity. The fermentation of CSFP2 by gut microbiota also led to significant changes in physico-chemical properties and increased the production of short-chain fatty acids. The relative abundances of certain microbial genera were also increased. These findings provide a theoretical basis for the development of functional foods related to CSFP2. Evaluation: 9/10
Article
Engineering, Environmental
Mike Cyterski, Orin C. Shanks, Pauline Wanjugi, Brian McMinn, Asja Korajkic, Kevin Oshima, Rich Haugland
Summary: This study uses statistical models to predict the concentrations of E. coli and coliphage, and finds that qPCR-based enterococci and Bacteroidales models have the highest predictive performance, while F+ coliphage consistently yields poor performing models. The influential covariates vary by microbial indicator and site.
Article
Food Science & Technology
Madelon J. Logtenberg, Renate Akkerman, Rosan G. Hobe, Kristel M. H. Donners, Sander S. Van Leeuwen, Gerben D. A. Hermes, Bart J. de Haan, Marijke M. Faas, Piet L. Buwalda, Erwin G. Zoetendal, Paul de Vos, Henk A. Schols
Summary: This study investigated the fermentability and immune responses of galacto-oligosaccharides (GOS), isomalto-oligosaccharide preparation (IMO), and isomalto/malto-polysaccharides (IMMP) in infant fecal microbiota. The results showed that only GOS and IMO were effectively fermented by infant fecal microbiota, with varying effects depending on the infants' age and NDC structure. Understanding these effects can contribute to the development of tailored NDC mixtures for infants of different age groups.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Chemistry, Applied
Yuntao Liu, Yiwen Li, Yu Ke, Cheng Li, Zhiqing Zhang, Yinglong Wu, Bin Hu, Aiping Liu, Qingying Luo, Wenjuan Wu
Summary: Oudemansiella radicata is a nutrient-rich mushroom farmed in China, containing polysaccharides with strong biological properties. After simulated digestion and fermentation, it was found that ORP is indigestible but can produce beneficial short-chain fatty acids and modulate gut microbiota composition to promote gastrointestinal health.
CARBOHYDRATE POLYMERS
(2021)
Article
Agronomy
Mayra Gonzalez-Delgado, Rafael Minjares-Fuentes, Maria Mota-Ituarte, Aurelio Pedroza-Sandoval, Francesca Comas-Serra, Jesus Josafath Quezada-Rivera, Angeles Saenz-Esqueda, Antoni Femenia
Summary: This study aimed to evaluate the effects of joint water and salinity stresses on the bioactive compounds and functional properties of Aloe vera gel. The results showed that water + salinity stress had a negative impact on the plants' development, but significantly increased the total dry matter content. Furthermore, it caused changes in the bioactive compounds and functional properties, suggesting that water + salinity stress can increase the content of bioactive compounds and improve their functional properties in Aloe vera gel.
AGRICULTURAL WATER MANAGEMENT
(2023)
Article
Food Science & Technology
Xue Han, Qian Zhou, Zhe Gao, Xuan Lin, Kaixuan Zhou, Xinlong Cheng, Bimal Chitrakar, Hong Chen, Wen Zhao
Summary: This study investigated the changes in structural properties of Ziziphus Jujuba cv. Pozao polysaccharide (JPS) during in vitro digestion and fermentation, and its effects on gut microbiota. The results showed that digestion caused a decrease in reducing sugar content and a slight increase in molecular weight. During gut microbial fermentation, the reducing sugar content initially increased and then decreased, while carbohydrate residue decreased with the release of monosaccharides. The fermentation also resulted in changes in gut microbiota composition and metabolic pathways. These findings suggest that JPS is indigestible but plays a crucial role in regulating gut microbiota and metabolic functions.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Engineering, Chemical
Kaixuan Zhou, Qian Zhou, Xue Han, Zhe Gao, Ruyan Peng, Xuan Lin, Xinlong Cheng, Wen Zhao
Summary: This study found that hawthorn polysaccharides cannot be digested but can be utilized by gut microbiota. Hawthorn polysaccharides can significantly modulate the composition of human gut microbiota, decreasing the abundance of harmful bacteria and increasing the proportion of beneficial bacteria.
Article
Polymer Science
Petruta Preda, Ana-Maria Enciu, Cristiana Tanase, Maria Dudau, Lucian Albulescu, Monica-Elisabeta Maxim, Raluca Nicoleta Darie-Nita, Oana Brincoveanu, Marioara Avram
Summary: This study aimed to investigate and develop amorphous and crosslinked hydrogels based on natural compounds, such as sodium alginate, aloe vera gel powder, and chitosan, for tumor spheroid formation. The results showed that adding chitosan allowed the formation of spheroids at pH 5, while low viscosity and pH 12 aloe vera gels also promoted spheroid formation. Crosslinked hydrogel variants enhanced spheroid formation efficiency.
Review
Food Science & Technology
Rong Du, Xiebingqing Yang, Ping Jin, Yahui Guo, Yuliang Cheng, Hang Yu, Yunfei Xie, He Qian, Weirong Yao
Summary: This review summarizes the recent 5-year research progress on the G-quadruplex (G4) structure in the detection of food contaminants. The article discusses the different applications of G4 as a recognition unit and a signal reporter, highlighting the current challenges and future directions, providing valuable insights for the field of food safety.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Agriculture, Multidisciplinary
Panting Sang, Gang Lu, Dongwei Yu, Xiaodong Song, Yahui Guo, Yunfei Xie, Weirong Yao, He Qian, Zhigang Hu
Summary: The study utilizes 8-17 DNAzyme as a substitute for horseradish peroxidase for simultaneous detection of small-molecule contaminants in milk, achieving multicolor signal output with lower detection limits. This approach may stimulate the development of ELISA in a new direction.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Food Science & Technology
Chang Liu, Yu Liu, Ciwan Wang, Yahui Guo, Yuliang Cheng, He Qian, Yong Zhao
Summary: This study demonstrates that lycopene bilosomes can alleviate kidney damage caused by a high-fat diet, and relieve nephritis and metabolic disorders by inhibiting the TLR4/MyD88 inflammatory pathway.
Article
Agriculture, Multidisciplinary
Chang Liu, Yahui Guo, Yuliang Cheng, He Qian
Summary: This study demonstrates that torularhodin-loaded bilosomes can improve hypercholesterolemia in mice fed a high-fat, high-cholesterol diet. Torularhodin alleviated weight gain, insulin resistance, and liver lipid accumulation. It also modulated inflammatory response and promoted amino acid metabolism.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Chang Liu, Mei Han, Fuqiang Lv, Yaobin Gao, Xiaoyun Wang, Xujiao Zhang, Yahui Guo, Yuliang Cheng, He Qian
Summary: The red stretcher bacterium Sporidiobolus pararoseus, a high producer of carotenoids, was found in various Chinese vinegar samples. The fungal carotenoid torularhodin exhibited strong antioxidant effects and protected against cellular inflammation in vitro and in a cell model. These effects were achieved by modulating the TLR4 pathway.
Review
Chemistry, Applied
Ruoyu Wang, Panting Sang, Yahui Guo, Ping Jin, Yuliang Cheng, Hang Yu, Yunfei Xie, Weirong Yao, He Qian
Summary: Cadmium (Cd) is a crucial industrial material used for electroplating and making rechargeable batteries, bringing convenience to mankind. However, Cd is also a harmful pollutant that enters the food chain and causes damage to human tissues and organs. Various technologies for removing Cd from food have been studied based on the binding mechanism between Cd and proteins.
Article
Biochemistry & Molecular Biology
Boru Guo, Aying Wen, Hang Yu, Yahui Guo, Yuliang Cheng, Yunfei Xie, He Qian, Weirong Yao
Summary: Mancozeb, a commonly used antifungal for fruit growth, can bind to the waxy components of fruits and has non-internal absorption. This study investigated the interaction between pesticide molecules and the waxy layer on grape surfaces and their impact on pesticide residues. Significant changes in the composition of the grape surface waxy layer were observed after soaking in a mancozeb solution, and molecular docking revealed hydrogen bonds and van der Waals forces between mancozeb and the waxy components. The presence or absence of wax affected the determination of mancozeb residues, with significantly lower deposition in grapes after dewaxing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Xiaoyan Fu, Shaofeng Yuan, Fangwei Yang, Hang Yu, Yunfei Xie, Yahui Guo, Weirong Yao
Summary: The interaction between boscalid and tannic acid was investigated using spectroscopic, thermodynamic, and computational chemistry methods. The results showed the formation of hydrogen bonds and hydrophobic interactions in the complex between boscalid and tannic acid. Additionally, the binding of boscalid to tannic acid significantly reduced the antioxidant activity of tannic acid. This study provides insights into the molecular mechanisms of the interaction between pesticide residues and food matrices, and informs the regulation of bound-state pesticide residues in food.
JOURNAL OF FOOD SCIENCE
(2023)
Article
Food Science & Technology
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, Yuliang Cheng, Yahui Guo, He Qian, Yu Liu
Summary: Research has found that salidroside (SA), an active compound derived from Rhodiola rosea, is widely used in healthcare foods. This study investigated the effects of SA on gut microbiota and energy metabolism during exercise in mice. The results showed that SA increased swimming time, respiratory enzymatic activities, and species diversity and abundance of gut bacteria, indicating its antifatigue effects.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiaotong Yang, Jie Yin, Yahui Guo, Hang Yu, Shaofeng Yuan, He Qian, Weirong Yao, Jiangfeng Song
Summary: This study combined low-intensity ultrasonic waves with the Lactobacillus plantarum fermentation method to optimize a technique for removing cadmium from rice. The technique achieved a high Cd removal rate of 67.05% within a short time (10 hours), addressing the long time requirement of traditional methods. Further analysis showed that the maximum adsorption capacity of Lactobacillus plantarum for Cd increased by 75% after ultrasonic intervention. Sensory evaluation and other experiments confirmed the feasibility of this method for actual rice production.
Article
Agriculture, Multidisciplinary
Shaofeng Yuan, Hang Yu, Yunfei Xie, Yahui Guo, Weirong Yao
Summary: The effect and mechanism of ultrasound on the biodegradation of profenofos by Lactiplantibacillus plantarum were investigated in this study. Ultrasound applied during the prelogarithmic phase of microbial growth significantly enhanced the biodegradation of profenofos. The key ultrasonic parameters were optimized using the response surface methodology, and the Holden model was used to describe the growth of L. plantarum and the biodegradation of profenofos. Under optimal ultrasonic conditions, the specific growth rate of L. plantarum and the specific degradation rate of profenofos were significantly increased compared to without sonication, attributed to the enhancement of phosphatase activity and the improvement of cell membrane permeability.
ACS AGRICULTURAL SCIENCE & TECHNOLOGY
(2023)
Review
Food Science & Technology
Shaofeng Yuan, Hang Yu, Yahui Guo, Yunfei Xie, Yuliang Cheng, He Qian, Weirong Yao
Summary: The extensive use of pesticides in agriculture leads to pesticide residues in food and feed, posing a significant threat to human health. Physical and chemical methods for pesticide removal are costly or prone to secondary contamination. Microorganisms, such as probiotics, have emerged as a promising alternative for pesticide elimination. This review examines the current research status on the use of probiotics for pesticide reduction, discussing the mechanisms involved, toxicity and potential health risks of degradation products, as well as strategies for enhancing probiotic detoxification.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Chemistry, Applied
Jie Yin, Kunfeng Liu, Shaofeng Yuan, Yahui Guo, Hang Yu, Yuliang Cheng, Yunfei Xie, He Qian, Weirong Yao
Summary: This research confirmed the presence of carbon dots (CDs) in breadcrumbs before frying and their significant changes after frying. The study found that the content and fluorescence quantum yield of CDs increased, while the size and N content decreased after frying. The interaction of CDs with human serum albumin (HSA) led to structural changes in HSA and the formation of CDs corona, which may have physiological significance.
Review
Nanoscience & Nanotechnology
Zhuoren Yang, Xiebingqing Yang, Yahui Guo, Hideya Kawasaki
Summary: This review analyzes the potential of gold nanoclusters (AuNCs) in cancer phototherapy, including photodynamic therapy (PDT), photothermal therapy (PTT), and combination therapy. It highlights the unique advantages, diverse application approaches, and promising prospects of AuNCs in phototherapy.
ACS APPLIED BIO MATERIALS
(2023)
Article
Nutrition & Dietetics
Cheng Wang, Hongkang Zhu, Yuliang Cheng, Yahui Guo, Yong Zhao, He Qian
Summary: This study investigates the potential role of Brassica rapa L. in modulating exercise-induced fatigue. The findings reveal that Brassica rapa L. exhibits significant antioxidant activity and effectively modulates physiological responses to fatigue. It influences gene expression related to energy metabolism and inflammation, and also maintains intestinal integrity. These findings highlight the potential therapeutic applications of Brassica rapa L. in managing prolonged exercise-induced fatigue.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)