Article
Agricultural Engineering
Jing Wang, Tianyi Dai, Yankun Lin, Hongbing Jia, Qingmin Ji, Guoliang Yuan
Summary: In this study, intelligent ionic hydrogels based on oxide sodium alginate, poly (acrylamide-co-acrylic acid), and FeCl3 were synthesized. The hydrogels showed excellent elongation at break, strong tensile strength, and high self-healing efficiency. They also demonstrated accurate and stable detection of human movement and physiological stimuli.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Chemistry, Multidisciplinary
Zhi Zhao, Yurong Li, Haibin Wang, Yupeng Shan, Xuemei Liu, Mengfei Wu, Xinping Zhang, Xiaoyan Song
Summary: Due to the high water content and homogeneous texture, conventional hydrogels have poor mechanical performance. However, this study shows that ultra-tough hydrogels can be obtained through a unique hierarchical architecture composed of chemically coupled self-assembly units. The results demonstrate a universal strategy to prepare desired ultra-tough hydrogels in predictable and controllable manners, surpassing the best known records in terms of tensile strength, fracture strain, and toughness.
Article
Materials Science, Composites
Panlei Liu, Na Sun, Yuanyuan Mi, Xiaohang Luo, Xiaoxiao Dong, Jiaye Cai, Xilai Jia, Melvin A. Ramos, Travis Shihao Hu, Quan Xu
Summary: This study introduces a high-performance hydrogel-based self-healing triboelectric nanogenerator that can quickly self-heal in a short period of time and has superior output performance, suitable for wearable electronic devices.
COMPOSITES SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chun Chen, Xuelei Pang, Yajuan Li, Xudong Yu
Summary: This paper demonstrates seven enhanced mechanical behaviors of polymer-cluster based hydrogels with small molecule additives. The results show that the multiple and hierarchical non-covalent interactions of polymer clusters contribute to the excellent performance of the hydrogel.
Article
Construction & Building Technology
Niranjan Prabhu Kannikachalam, Paula Sofia Marin Peralta, Didier Snoeck, Nele De Belie, Liberato Ferrara
Summary: This paper investigates the effects of stimulated autogenous self-healing on the performance recovery of UHPC under impact loadings. Experimental results show that specimens healed continuously under submerged conditions exhibit the highest healing efficiency, with complete closure of surface cracks and over 80% recovery in natural frequency. After four months of healing, there is a significant increase in stiffness and energy dissipation capacity.
CEMENT & CONCRETE COMPOSITES
(2023)
Article
Chemistry, Physical
Kai Chen, Yunping Hu, Feng Wang, Mingxiang Liu, Pei Liu, Cong Li, Yongsheng Yu, Xiufeng Xiao, Qian Feng
Summary: In this study, a multifunctional MXene/polyampholytes nanocomposite hydrogel was proposed, which simultaneously achieved stretchability, toughness, self-healing, and adhesiveness through the crosslinking of strong and weak ionic bonds. The introduction of MXene further enhanced the mechanical properties and conductivity of the hydrogel. The wearable epidermal sensor based on this hydrogel exhibited durable accuracy and sensitivity in detecting human motions, and could be used as a detector in the daily activity monitor of ADHD patients.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Engineering, Environmental
Zhenwei Yi, Fangke Zhan, Yijia Chen, Ran Zhang, Haodong Lin, Liming Zhao
Summary: A water-soluble conductive material was synthesized by grafting polyaniline onto carboxymethyl chitosan, and dual cross-linked hydrogels with injectable, self-healing, and conductive properties were created. The hydrogel showed good biocompatibility, elastic modulus, and electrical conductivity, promoting the proliferation and migration of Schwann cells and enhancing nerve conduction velocity in sciatic nerve injury.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Yinghui Ma, Kuo Liu, Li Lao, Xing Li, Zuocai Zhang, Shaorong Lu, Yuqi Li, Ziwei Li
Summary: This study reports a sandwich-structure sensor based on biomucopolysaccharide hydrogel, which exhibits excellent stretchability, self-healing ability, high sensitivity, short response time, and good working stability. It provides innovative ideas for the development of biopolysaccharide hydrogels for sensor applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Wenda Wang, Zicheng Zeng, Li Xiang, Cong Liu, Diana Diaz-Dussan, Zunguo Du, Anika B. Asha, Wenshuai Yang, Yi-Yang Peng, Mingfei Pan, Ravin Narain, Jifang Liu, Hongbo Zeng
Summary: An injectable self-healing hydrogel based on gastric environment-adaptive supramolecular assembly has been developed for gastric perforation healing. The hydrogel dressing possesses sensitive thermo-responsibility, injectability, antibiofouling property, simplifying surgical procedures, reducing postoperative complications, and enhancing the healing process. This work provides valuable insights for the development of biological environment-adaptive functional materials for biomedical applications.
Review
Biochemistry & Molecular Biology
Pu Yang, Zhen Li, Bairong Fang, Liangle Liu
Summary: This paper reviews recent advances in the design of self-healing hydrogels based on natural polymers for skin wound healing applications. It outlines various natural polymers that can be used to construct self-healing hydrogel systems and discusses the advantages and disadvantages of different natural polymers. The principle of self-healing hydrogels, based on physical and chemical crosslinking mechanisms, is described and analyzed in terms of their performance characteristics for skin trauma applications. The biological mechanisms involved in skin wound healing are outlined, and the current application strategies for self-healing hydrogels based on these mechanisms are described. Challenges and prospects of natural-material-based self-healing hydrogels for skin applications are also analyzed and summarized.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Ye Wang, Changyuan He, Chong Chen, Wentao Dong, Xuekun Yang, Ye Wu, Qingquan Kong, Bin Yan
Summary: In this study, an injectable zwitterionic hydrogel with excellent self-healing property, good cytocompatibility, and antibacterial adhesion was developed. The hydrogel showed a distinct thermal-induced sol-gel transition and could be easily applied to complex wounds. It possessed rapid self-healing ability and low cytotoxicity, and effectively prevented bacterial adhesion, promoting wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Chemistry, Multidisciplinary
Miao Qi, Ruiqi Yang, Zhe Wang, Yanting Liu, Qichong Zhang, Bing He, Kaiwei Li, Qing Yang, Lei Wei, Caofeng Pan, Mengxiao Chen
Summary: Inspired by nature, self-healing materials have been developed for improving durability and integrating intriguing properties into electronic devices. This review presents a detailed discussion on bioinspired self-healing soft electronics, including healing mechanisms, materials categories, functions, applications, and inspirations from humans and animals. It is believed that this field will accelerate the development of applications in various areas.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Polymer Science
Chuchu Cheng, Kang Ding, Wenhao Du, Dong Wang, Xi Zhang
Summary: In this study, a self-healing ionic hydrogel based on copolymers of acrylic acid and acrylamide is reported, which possesses excellent mechanical properties, dual self-healing ability, and ultra-high electrical sensitivity, showing great potential in wearable sensor applications.
Article
Biotechnology & Applied Microbiology
Xue Xu, Yulong Zhang, Pin Ha, Yao Chen, Chenshuang Li, Emily Yen, Yuxing Bai, Renji Chen, Benjamin M. Wu, Andrew Da Lio, Kang Ting, Chia Soo, Zhong Zheng
Summary: Tendons are commonly injured tissues in the musculoskeletal system, and current treatments for enhancing tendon healing have not achieved significant clinical improvements. In this study, a novel FMOD/gHA-hydrogel was developed to deliver FMOD and enhance tendon healing. The hydrogel exhibited desired characteristics, such as microinvasive application and a two-phase release of FMOD. The hydrogel significantly improved tendon healing in a rat model.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Physical
Bin Kong, Rui Liu, Yi Cheng, Xiaodong Cai, Junying Liu, Dagan Zhang, Hui Tan, Yuanjin Zhao
Summary: Developing a biocompatible and multifunctional adhesive hydrogel for wound healing is a highly anticipated clinical application. In this paper, a novel natural biopolymer-derived hydrogel based on aldehyde-modified oxidized guar gum (OGG) and carboxymethyl chitosan (CMCS) is presented. The hydrogel has excellent self-healing ability and shear thinning behavior, and can be injected conveniently through a needle. The physiochemical properties of the hydrogel can be controlled by regulating the concentrations of OGG. In addition, the hydrogel can adhere tightly to tissues and promote wound repair by encapsulating vascular endothelial growth factor (VEGF).
Article
Chemistry, Physical
Peipei Guo, Jiaqi Liang, Yangyang Li, Xueting Lu, Hai Fu, Houchao Jing, Shuang Guan, Dongxue Han, Li Niu
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2019)
Article
Chemistry, Physical
Houchao Jing, Jianping Shi, Peipei Guoab, Shuang Guan, Hai Fu, Wei Cui
Summary: The hydrogels prepared in this work exhibit excellent mechanical properties and fatigue resistance due to the synergistic effect of physical cross-linkers. They can be recast multiple times at high temperature, showing potential for application in flexible sensors.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Nanoscience & Nanotechnology
Lin Xu, Ying Pan, Xuanqi Wang, Zhijun Xu, Huasheng Tian, Yue Liu, Xiaodan Bu, Houchao Jing, Tianyu Wang, Yaqing Liu, Minghua Liu
Summary: In this study, a lithium ion-triggered gelation strategy was designed to produce a molecular hydrogel with thixotropy, which can be mechanically recycled or reconfigured at room temperature. The hydrogel utilizes lithium ions to construct supramolecular nanoassemblies and charge carriers for ionic conductivity. Additionally, polymer additives were used to improve the mechanical flexibility of the hydrogel for daily use in touch panels. This work sheds light on enhancing the functionalities of hydrogel-based ionotronics through a supramolecular approach.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Multidisciplinary Sciences
Huasheng Tian, Chen Wang, Yuwei Chen, Liping Zheng, Houchao Jing, Lin Xu, Xuanqi Wang, Yaqing Liu, Jingcheng Hao
Summary: This study develops a hybrid hydrogel with optically modulated ionic conductivity to emulate the functions of a biological synapse. The hydrogel can be used as an information processing unit to perceive different optical stimuli and regulate the grasping motion of a robotic hand, performing logical motion feedback with learning-experience function.
Article
Chemistry, Physical
Houch Jing, Lin Xu, Xuanqi Wang, Yaqing Liu, Jingcheng Hao
Summary: A novel phase-change-gel-based pressure sensor was designed with tunable sensitivity and sensing ranges by adjusting the Young's modulus of the gel through a phase change. The sensor was integrated into a robotic gripper to enable artificial tactile feedback system and autonomous grasping force adjustment for various objects with different stiffness. This work provides a new strategy for functional pressure sensors and advances intelligent robotic technologies.
JOURNAL OF MATERIALS CHEMISTRY A
(2021)
Article
Chemistry, Physical
Houchao Jing, Lin He, Jinyang Feng, Hai Fu, Shuang Guan, Peipei Guo
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)