Discovery of natural product ellagic acid as a potent CD73 and CD39 dual inhibitor

2-Substituted α,β-Methylene-ADP Derivatives: Potent Competitive Ecto-5′-nucleotidase (CD73) Inhibitors with Variable Binding Modes

(2020) Sanjay Bhattarai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73

(2020) Joel W. Beatty et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of AB680: A Potent and Selective Inhibitor of CD73

(2020) Kenneth V. Lawson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure–Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5′-Nucleotidase (CD73) Inhibitors

(2019) Anna Junker et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Exceptionally Potent Inhibitor of Human CD73

(2019) Christine E. Bowman et al.   BIOCHEMISTRY

Probing the high potency of pyrazolyl pyrimidinetriones and thioxopyrimidinediones as selective and efficient non-nucleotide inhibitors of recombinant human ectonucleotidases

(2019) Hina Andleeb et al.   BIOORGANIC CHEMISTRY

Synthesis of Substituted 5′‐Aminoadenosine Derivatives and Evaluation of Their Inhibitory Potential toward CD73

(2019) Rayane Ghoteimi et al.   ChemMedChem

Virtual Screening Approach for the Identification of Hydroxamic Acids as Novel Human Ecto-5′-Nucleotidase Inhibitors

(2019) Lucas G. Viviani et al.   Journal of Chemical Information and Modeling

CD73 inhibition by purine cytotoxic nucleoside analogue-based diphosphonates

(2018) Charles Dumontet et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Natural products for human health: an historical overview of the drug discovery approaches

(2017) S. Bernardini et al.   NATURAL PRODUCT RESEARCH

Search for New Bioactive Marine Natural Products and Application to Drug Development

(2016) Jun’ichi Kobayashi   CHEMICAL & PHARMACEUTICAL BULLETIN

CD73–adenosine: a next-generation target in immuno-oncology

(2016) David Allard et al.   Immunotherapy

Targeting CD73 in the tumor microenvironment with MEDI9447

(2016) Carl M. Hay et al.   OncoImmunology

α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5′-Nucleotidase (CD73) Inhibitors

(2015) Sanjay Bhattarai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Big opportunities for small molecules in immuno-oncology

(2015) Jerry L. Adams et al.   NATURE REVIEWS DRUG DISCOVERY

Adenosine pathway and cancer: where do we go from here?

(2014) Luca Antonioli et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Crystal structure of NTPDase2 in complex with the sulfoanthraquinone inhibitor PSB-071

(2014) Matthias Zebisch et al.   JOURNAL OF STRUCTURAL BIOLOGY

Targeting Cancer-Derived Adenosine:New Therapeutic Approaches

(2014) A. Young et al.   Cancer Discovery

Identification of sulfonic acids as efficient ecto-5′-nucleotidase inhibitors

(2013) Jamshed Iqbal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Virtual Screening Identifies Novel Sulfonamide Inhibitors of ecto-5′-Nucleotidase

(2012) Peter Ripphausen et al.   JOURNAL OF MEDICINAL CHEMISTRY