Nanozyme-based medicine for enzymatic therapy: progress and challenges

Virus-Like Fe3O4@Bi2S3 Nanozymes with Resistance-Free Apoptotic Hyperthermia-Augmented Nanozymitic Activity for Enhanced Synergetic Cancer Therapy

(2020) Yajie Zhao et al.   ACS Applied Materials & Interfaces

An Enzyme-Mimicking Single-Atom Catalyst as an Efficient Multiple Reactive Oxygen and Nitrogen Species Scavenger for Sepsis Management

(2020) Fangfang Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hydrogel-based artificial enzyme for combating bacteria and accelerating wound healing

(2020) Hao Qiu et al.   Nano Research

Efficient elimination of multidrug-resistant bacteria using copper sulfide nanozymes anchored to graphene oxide nanosheets

(2020) Wanshun Wang et al.   Nano Research

Intrinsic Oxidase-like Nanoenzyme Co4S3/Co(OH)2 Hybrid Nanotubes with Broad-Spectrum Antibacterial Activity

(2020) Jin Wang et al.   ACS Applied Materials & Interfaces

Cancer Cell-Targeted Photosensitizer and Therapeutic Protein Co-Delivery Nanoplatform Based on a Metal–Organic Framework for Enhanced Synergistic Photodynamic and Protein Therapy

(2020) Lei Ding et al.   ACS Applied Materials & Interfaces

A mitochondria-targeting magnetothermogenic nanozyme for magnet-induced synergistic cancer therapy

(2020) Jinchao Shen et al.   BIOMATERIALS

Enzyme therapy: a forerunner in catalyzing a healthy society?

(2020) Saptashwa Datta et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases

(2020) Tengfei Liu et al.   Nature Communications

Colloidal Surface Engineering: Growth of Layered Double Hydroxides with Intrinsic Oxidase-Mimicking Activities to Fight Against Bacterial Infection in Wound Healing

(2020) Wendi Zhang et al.   Advanced Healthcare Materials

Mucosal Vaccination for Influenza Protection Enhanced by Catalytic Immune‐Adjuvant

(2020) Tao Qin et al.   Advanced Science

Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy

(2020) Yufeng Liu et al.   Science Advances

MOF-encapsulated nanozyme enhanced siRNA combo: Control neural stem cell differentiation and ameliorate cognitive impairments in Alzheimer's disease model

(2020) Dongqin Yu et al.   BIOMATERIALS

A metal-free nanozyme-activated prodrug strategy for targeted tumor catalytic therapy

(2020) Qian Liang et al.   Nano Today

Intrinsic catalytic activity of rhodium nanoparticles with respect to reactive oxygen species scavenging: implication for diminishing cytotoxicity

(2019) Gao-Juan Cao et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Powering Amyloid Beta Degrading Enzymes: A Possible Therapy for Alzheimer’s Disease

(2019) Nkumbu L. Sikanyika et al.   NEUROCHEMICAL RESEARCH

Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications

(2019) Yanyan Huang et al.   CHEMICAL REVIEWS

Porous platinum nanoparticles as a high-Z and oxygen generating nanozyme for enhanced radiotherapy in vivo

(2019) Yan Li et al.   BIOMATERIALS

Acidic pH and High-H2O2 Dual Tumor Microenvironment-Responsive Nanocatalytic Graphene Oxide for Cancer Selective Therapy and Recognition

(2019) Baoping Lin et al.   ACS Applied Materials & Interfaces

Persistent Regulation of Tumor Microenvironment via Circulating Catalysis of MnFe 2 O 4 @Metal–Organic Frameworks for Enhanced Photodynamic Therapy

(2019) Sheng‐Yan Yin et al.   ADVANCED FUNCTIONAL MATERIALS

Construction of Nanozyme‐Hydrogel for Enhanced Capture and Elimination of Bacteria

(2019) Yanjuan Sang et al.   ADVANCED FUNCTIONAL MATERIALS

Fullerene-like MoS2 Nanoparticles as Cascade Catalysts Improving Lubricant and Antioxidant Abilities of Artificial Synovial Fluid

(2019) Tongming Chen et al.   ACS Biomaterials-Science & Engineering

Synthesis of Pegylated Manganese Protoporphyrin as a Catalase Mimic and Its Therapeutic Application to Acetaminophen-Induced Acute Liver Failure

(2019) Tianli Zhang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Carbogenic Nanozyme with Ultrahigh Reactive Nitrogen Species Selectivity for Traumatic Brain Injury

(2019) Xiaoyu Mu et al.   NANO LETTERS

Superoxide dismutase mimetic nanoceria restrains cerulein induced acute pancreatitis

(2019) Amit Khurana et al.   Nanomedicine

O2-Generating Metal–Organic Framework-Based Hydrophobic Photosensitizer Delivery System for Enhanced Photodynamic Therapy

(2019) Qianqian Sun et al.   ACS Applied Materials & Interfaces

The antitoxic effects of quercetin and quercetin-conjugated iron oxide nanoparticles (QNPs) against H2O2-induced toxicity in PC12 cells

(2019) Zahra Yarjanli et al.   International Journal of Nanomedicine

Bienzymatic synergism of vanadium oxide nanodots to efficiently eradicate drug-resistant bacteria during wound healing in vivo

(2019) Weishuai Ma et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Nanozyme-Based Bandage with Single-Atom Catalysis for Brain Trauma

(2019) Ruijuan Yan et al.   ACS Nano

A Nanozyme with Photo-Enhanced Dual Enzyme-Like Activities for Deep Pancreatic Cancer Therapy

(2019) Shanshan Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper/Carbon Hybrid Nanozyme: Tuning Catalytic Activity by the Copper State for Antibacterial Therapy

(2019) Juqun Xi et al.   NANO LETTERS

Reactive Oxygen Species-Induced Aggregation of Nanozymes for Neuron Injury

(2019) Hua He et al.   ACS Applied Materials & Interfaces

Mitochondria-targeted TPP-MoS2 with dual enzyme activity provides efficient neuroprotection through M1/M2 microglial polarization in an Alzheimer's disease model

(2019) Chaoxiu Ren et al.   BIOMATERIALS

Biodegradation-Mediated Enzymatic Activity-Tunable Molybdenum Oxide Nanourchins for Tumor-Specific Cascade Catalytic Therapy

(2019) Xi Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tumor Catalytic–Photothermal Therapy with Yolk–Shell Gold@Carbon Nanozymes

(2018) Lei Fan et al.   ACS Applied Materials & Interfaces

Nanozyme Decorated Metal–Organic Frameworks for Enhanced Photodynamic Therapy

(2018) Yan Zhang et al.   ACS Nano

A Novel Theranostic Nanoplatform Based on Pd@Pt-PEG-Ce6 for Enhanced Photodynamic Therapy by Modulating Tumor Hypoxia Microenvironment

(2018) Jingping Wei et al.   ADVANCED FUNCTIONAL MATERIALS

Selenium-Based Nanozyme as Biomimetic Antioxidant Machinery

(2018) Yanyan Huang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Olipudase alfa for treatment of acid sphingomyelinase deficiency (ASMD): safety and efficacy in adults treated for 30 months

(2018) Melissa P. Wasserstein et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Green synthesis of catalytic gold/bismuth oxyiodide nanocomposites with oxygen vacancies for treatment of bacterial infections

(2018) Chia-Lun Hsu et al.   Nanoscale

ROS scavenging Mn3O4 nanozymes for in vivo anti-inflammation

(2018) Jia Yao et al.   Chemical Science

In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy

(2018) Kelong Fan et al.   Nature Communications

Neuropathic Pain: Delving into the Oxidative Origin and the Possible Implication of Transient Receptor Potential Channels

(2018) Cristina Carrasco et al.   Frontiers in Physiology

Iridium nanocrystals encapsulated liposomes as near-infrared light controllable nanozymes for enhanced cancer radiotherapy

(2018) Liangzhu Feng et al.   BIOMATERIALS

Mn-Fe layered double hydroxides nanosheets: a new photothermal nanocarrier for O2-evolving phototherapy

(2018) Yudi Ruan et al.   CHEMICAL COMMUNICATIONS

Enzyme therapy for functional bowel disease-like post-prandial distress

(2018) David Y. Graham et al.   Journal of Digestive Diseases

Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors

(2018) Zhenzhen Wang et al.   Nature Communications

Converting organosulfur compounds to inorganic polysulfides against resistant bacterial infections

(2018) Zhuobin Xu et al.   Nature Communications

Photomodulated Nanozyme Used for a Gram-Selective Antimicrobial

(2018) Jingsheng Niu et al.   CHEMISTRY OF MATERIALS

Chiral Molecule-mediated Porous CuxO Nanoparticle Clusters with Antioxidation Activity for Ameliorating Parkinson’s Disease

(2018) Changlong Hao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Silver-gold-apoferritin nanozyme for suppressing oxidative stress during cryopreservation

(2018) Fariba Dashtestani et al.   Materials Science & Engineering C-Materials for Biological Applications

Nanocatalytic Tumor Therapy by Biomimetic Dual Inorganic Nanozyme-Catalyzed Cascade Reaction

(2018) Shanshan Gao et al.   Advanced Science

Redox-dependent catalase mimetic cerium oxide-based nanozyme protect human hepatic cells from 3-AT induced acatalasemia

(2018) Ragini Singh et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Molecular Imprinting on Inorganic Nanozymes for Hundred-fold Enzyme Specificity

(2017) Zijie Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-Supplying O2 through the Catalase-Like Activity of Gold Nanoclusters for Photodynamic Therapy against Hypoxic Cancer Cells

(2017) Ching-Ping Liu et al.   Small

Self-Assembly of Multi-nanozymes to Mimic an Intracellular Antioxidant Defense System

(2016) Yanyan Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ceria/POMs hybrid nanoparticles as a mimicking metallopeptidase for treatment of neurotoxicity of amyloid-β peptide

(2016) Yijia Guan et al.   BIOMATERIALS

Integration of Upconversion Nanoparticles and Ultrathin Black Phosphorus for Efficient Photodynamic Theranostics under 808 nm Near-Infrared Light Irradiation

(2016) Ruichan Lv et al.   CHEMISTRY OF MATERIALS

Polyoxometalate-based nanozyme: Design of a multifunctional enzyme for multi-faceted treatment of Alzheimer’s disease

(2016) Nan Gao et al.   Nano Research

Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy

(2016) Jundong Shao et al.   Nature Communications

Elevated levels of matrix metalloproteinases and chronic wound healing: an updated review of clinical evidence

(2016) J.L. Lazaro et al.   Journal of Wound Care

Inflammation and cancer: advances and new agents

(2015) Shanthini M. Crusz et al.   Nature Reviews Clinical Oncology

Antioxidant nanozyme: a facile synthesis and evaluation of the reactive oxygen species scavenging potential of nanoceria encapsulated albumin nanoparticles

(2015) Bharat Bhushan et al.   Journal of Materials Chemistry B

Metalloproteinases and Wound Healing

(2015) Matthew P. Caley et al.   Advances in Wound Care

An antioxidant nanozyme that uncovers the cytoprotective potential of vanadia nanowires

(2014) Amit A. Vernekar et al.   Nature Communications

Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes

(2013) Hui Wei et al.   CHEMICAL SOCIETY REVIEWS

Cerium oxide caged metal chelator: anti-aggregation and anti-oxidation integrated H2O2-responsive controlled drug release for potential Alzheimer's disease treatment

(2013) Meng Li et al.   Chemical Science

Anti-bacterial and in vivo tumor treatment by reactive oxygen species generated by magnetic nanoparticles

(2013) Di Zhang et al.   Journal of Materials Chemistry B

Sensitization of pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS production

(2012) Melissa S. Wason et al.   Nanomedicine-Nanotechnology Biology and Medicine

The reversal of cisplatin-induced nephrotoxicity by selenium nanoparticles functionalized with 11-mercapto-1-undecanol by inhibition of ROS-mediated apoptosis

(2011) Yinghua Li et al.   BIOMATERIALS

Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer’s disease?

(2011) Natalia N. Nalivaeva et al.   JOURNAL OF NEUROCHEMISTRY