期刊
BIOMEDICAL MATERIALS
卷 16, 期 4, 页码 -出版社
IOP Publishing Ltd
DOI: 10.1088/1748-605X/abe7b4
关键词
nanozymes; enzymatic therapy; tumor catalytic therapy; antimicrobial; antioxidant; anti-inflammation
资金
- National Key R&D Program of China [2019YFA0709200, 2018YFC1003500]
- National Natural Science Foundation of China [81930050, 81671810]
Nanozymes are nanomaterials with enzyme-like characteristics that can overcome the limitations of natural enzymes in enzymatic therapy. They have various activities that can either protect cells or kill harmful cells, showing great potential in medical applications.
Nanozymes are nanomaterials with enzyme-like characteristics. As a new generation of artificial enzymes, nanozymes have the advantages of low cost, good stability, simple preparation, and easy storage, allowing them to overcome many of the limitations of natural enzymes in enzymatic therapy. Currently, most reported nanozymes exhibit oxidoreductase-like activities and can regulate redox balance in cells. Nanozymes with superoxide dismutase and catalase activity can be used to scavenge reactive oxygen species (ROS) for cell protection, while those with peroxidase and oxidase activity can generate ROS to kill harmful cells, such as tumor cells and bacteria. In this review, we summarize recent progress in nanozyme-based medicine for enzymatic therapy and highlight the opportunities and challenges in this field for future study.
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