Evaluating Endosomal Escape of Caspase-3-Containing Nanomaterials Using Split GFP

Anionic Polymers Promote Mitochondrial Targeting of Delocalized Lipophilic Cations

(2020) Ziwen Jiang et al.   BIOCONJUGATE CHEMISTRY

Intracellular Photoactivation of Caspase-3 by Molecular Glues for Spatiotemporal Apoptosis Induction

(2020) Nina B. Hentzen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineered Interactions with Mesoporous Silica Facilitate Intracellular Delivery of Proteins and Gene Editing

(2020) Bin Liu et al.   NANO LETTERS

Imaging small molecule-induced endosomal escape of siRNA

(2020) Hampus Du Rietz et al.   Nature Communications

Tracking exogenous intracellular casp‐3 using split GFP

(2020) Francesca Anson et al.   PROTEIN SCIENCE

Nanocarriers for Protein Delivery to the Cytosol: Assessing the Endosomal Escape of Poly(Lactide-co-Glycolide)-Poly(Ethylene Imine) Nanoparticles

(2019) Marianna Galliani et al.   Nanomaterials

Lipid–peptide bioconjugation through pyridyl disulfide reaction chemistry and its application in cell targeting and drug delivery

(2019) Diego de la Fuente-Herreruela et al.   JOURNAL OF NANOBIOTECHNOLOGY

Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7

(2019) Scott McComb et al.   Science Advances

Cellular Uptake Evaluation of Amphiphilic Polymer Assemblies: Importance of Interplay between Pharmacological and Genetic Approaches

(2019) Ziwen Jiang et al.   BIOMACROMOLECULES

Polymers for cytosolic protein delivery

(2019) Jia Lv et al.   BIOMATERIALS

Endosomal escape enhancing compounds facilitate functional delivery of extracellular vesicle cargo

(2019) Nikki Heath et al.   Nanomedicine

A Coordinative Dendrimer Achieves Excellent Efficiency in Cytosolic Protein and Peptide Delivery

(2019) Lanfang Ren et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent developments in intracellular protein delivery

(2018) Yumiao Zhang et al.   CURRENT OPINION IN BIOTECHNOLOGY

Chloroquine and nanoparticle drug delivery: A promising combination

(2018) Joe Pelt et al.   PHARMACOLOGY & THERAPEUTICS

Efficient cell delivery mediated by lipid-specific endosomal escape of supercharged branched peptides

(2018) Dakota J. Brock et al.   TRAFFIC

The great escape: how cationic polyplexes overcome the endosomal barrier

(2018) Tanja Bus et al.   Journal of Materials Chemistry B

pH-Sensitive Polymers as Dynamic Mediators of Barriers to Nucleic Acid Delivery

(2018) David J. Peeler et al.   BIOCONJUGATE CHEMISTRY

The Endosomal Escape of Nanoparticles: Toward More Efficient Cellular Delivery

(2018) Samuel A. Smith et al.   BIOCONJUGATE CHEMISTRY

Recent Development of pH-Responsive Polymers for Cancer Nanomedicine

(2018) Houliang Tang et al.   MOLECULES

The effects of chemical fixation on the cellular nanostructure

(2017) Yue Li et al.   EXPERIMENTAL CELL RESEARCH

Templated Self-Assembly of a Covalent Polymer Network for Intracellular Protein Delivery and Traceless Release

(2017) Kingshuk Dutta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Utilizing Inverse Emulsion Polymerization To Generate Responsive Nanogels for Cytosolic Protein Delivery

(2017) Kishore Raghupathi et al.   MOLECULAR PHARMACEUTICS

An evaluation of fixation methods: Spatial and compositional cellular changes observed by Raman imaging

(2017) Alison J. Hobro et al.   VIBRATIONAL SPECTROSCOPY

Distinct effects of endosomal escape and inhibition of endosomal trafficking on gene delivery via electrotransfection

(2017) Lisa D. Cervia et al.   PLoS One

Labeling nanoparticles: Dye leakage and altered cellular uptake

(2016) Sofie Snipstad et al.   CYTOMETRY PART A

Versatile protein tagging in cells with split fluorescent protein

(2016) Daichi Kamiyama et al.   Nature Communications

Influence of Block versus Random Monomer Distribution on the Cellular Uptake of Hydrophilic Copolymers

(2016) John Moraes et al.   ACS Macro Letters

Critical importance of appropriate fixation conditions for faithful imaging of receptor microclusters

(2016) Tess A. Stanly et al.   Biology Open

Enhancing Endosomal Escape for Intracellular Delivery of Macromolecular Biologic Therapeutics

(2016) Peter Lönn et al.   Scientific Reports

Quantitative Imaging of Glutathione in Live Cells Using a Reversible Reaction-Based Ratiometric Fluorescent Probe

(2015) Xiqian Jiang et al.   ACS Chemical Biology

Detecting Cytosolic Peptide Delivery with the GFP Complementation Assay in the Low Micromolar Range

(2015) Samuel Schmidt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Quantitative assessment of cellular uptake and cytosolic access of antibody in living cells by an enhanced split GFP complementation assay

(2015) Ji-sun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Co-Delivery of Protein and Small Molecule Therapeutics Using Nanoparticle-Stabilized Nanocapsules

(2015) Chang Soo Kim et al.   BIOCONJUGATE CHEMISTRY

Fluorophore:Dendrimer Ratio Impacts Cellular Uptake and Intracellular Fluorescence Lifetime

(2015) Casey A. Dougherty et al.   BIOCONJUGATE CHEMISTRY

Reactive Self-Assembly of Polymers and Proteins to Reversibly Silence a Killer Protein

(2015) Judy Ventura et al.   BIOMACROMOLECULES

Intracellular Delivery of Functional Proteins and Native Drugs by Cell-Penetrating Poly(disulfide)s

(2015) Jiaqi Fu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

GFP-complementation assay to detect functional CPP and protein delivery into living cells

(2015) Nadia Milech et al.   Scientific Reports

Promises and Pitfalls of Intracellular Delivery of Proteins

(2014) Ailing Fu et al.   BIOCONJUGATE CHEMISTRY

Stimuli-responsive nanomaterials for therapeutic protein delivery

(2014) Yue Lu et al.   JOURNAL OF CONTROLLED RELEASE

Endosomal Escape: A Bottleneck in Intracellular Delivery

(2014) Harshad K. Shete et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

A display of pH-sensitive fusogenic GALA peptide facilitates endosomal escape from a Bio-nanocapsule via an endocytic uptake pathway

(2014) Yuya Nishimura et al.   JOURNAL OF NANOBIOTECHNOLOGY

Direct Delivery of Functional Proteins and Enzymes to the Cytosol Using Nanoparticle-Stabilized Nanocapsules

(2013) Rui Tang et al.   ACS Nano

Hydrophobic Fluorescent Probes Introduce Artifacts into Single Molecule Tracking Experiments Due to Non-Specific Binding

(2013) Laura C. Zanetti-Domingues et al.   PLoS One

Surface charge generation in nanogels for activated cellular uptake at tumor-relevant pH

(2013) Longyu Li et al.   Chemical Science

Amphiphilic block co-polymers: Preparation and application in nanodrug and gene delivery

(2012) Xiao-Bing Xiong et al.   Acta Biomaterialia

Ligand-Decorated Nanogels: Fast One-Pot Synthesis and Cellular Targeting

(2012) Ja-Hyoung Ryu et al.   BIOMACROMOLECULES

Cellular Uptake Mechanisms and Endosomal Trafficking of Supercharged Proteins

(2012) David B. Thompson et al.   CHEMISTRY & BIOLOGY

Modeling the proton sponge hypothesis: examining proton sponge effectiveness for enhancing intracellular gene delivery through multiscale modeling

(2012) Eric C. Freeman et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Concurrent Binding and Delivery of Proteins and Lipophilic Small Molecules Using Polymeric Nanogels

(2012) Daniella C. González-Toro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tailoring nanocarriers for intracellular protein delivery

(2011) Zhen Gu et al.   CHEMICAL SOCIETY REVIEWS

Proton Sponge Trick for pH-Sensitive Disassembly of Polyethylenimine-Based siRNA Delivery Systems

(2010) Gaelle Creusat et al.   BIOCONJUGATE CHEMISTRY

A GFP complementation system for monitoring and directing nanomaterial mediated protein delivery to human cellular organelles

(2010) Shyam Sundhar Bale et al.   BIOTECHNOLOGY AND BIOENGINEERING

Delivery of Therapeutic Proteins

(2010) Dipak S. Pisal et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Surface-Functionalizable Polymer Nanogels with Facile Hydrophobic Guest Encapsulation Capabilities

(2010) Ja-Hyoung Ryu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Noncovalent Encapsulation Stabilities in Supramolecular Nanoassemblies

(2010) Siriporn Jiwpanich et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Truncated HGP Peptide Sequence That Retains Endosomolytic Activity and Improves Gene Delivery Efficiencies

(2010) Ester J. Kwon et al.   MOLECULAR PHARMACEUTICS

Delivery of Macromolecules Using Arginine-Rich Cell-Penetrating Peptides: Ways to Overcome Endosomal Entrapment

(2009) Ayman El-Sayed et al.   AAPS Journal

Human Caspases: Activation, Specificity, and Regulation

(2009) Cristina Pop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Application of an HIV gp41-Derived Peptide for Enhanced Intracellular Trafficking of Synthetic Gene and siRNA Delivery Vehicles

(2008) Ester J. Kwon et al.   BIOCONJUGATE CHEMISTRY

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE

Executioner caspase-3 and caspase-7 are functionally distinct proteases

(2008) J. G. Walsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein therapeutics: a summary and pharmacological classification

(2007) Benjamin Leader et al.   NATURE REVIEWS DRUG DISCOVERY