Chronic stress induces sex-specific functional and morphological alterations in cortico-accumbal and cortico-tegmental pathways

Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects

(2019) Brendan D. Hare et al.   Nature Communications

A whole-brain atlas of monosynaptic input targeting four different cell types in the medial prefrontal cortex of the mouse

(2019) Sofie Ährlund-Richter et al.   NATURE NEUROSCIENCE

Biology and Bias in Cell Type-Specific RNAseq of Nucleus Accumbens Medium Spiny Neurons

(2019) Hope Kronman et al.   Scientific Reports

Social defeat stress causes selective attenuation of neuronal activity in the ventromedial prefrontal cortex

(2019) Reimi Abe et al.   Scientific Reports

Chronic social defeat stress induces sustained synaptic structural changes in the prefrontal cortex and amygdala

(2019) L. Colyn et al.   BEHAVIOURAL BRAIN RESEARCH

Opposite Molecular Signatures of Depression in Men and Women

(2018) Marianne L. Seney et al.   BIOLOGICAL PSYCHIATRY

Prefrontal alterations in GABAergic and glutamatergic gene expression in relation to depression and suicide

(2018) J. Zhao et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Chronic stress dysregulates amygdalar output to the prefrontal cortex

(2018) Emily G. Lowery-Gionta et al.   NEUROPHARMACOLOGY

Sex Differences in the Neuroadaptations of Reward-related Circuits in Response to Subchronic Variable Stress

(2018) Song Zhang et al.   NEUROSCIENCE

Reduced Synapse and Axon Numbers in the Prefrontal Cortex of Rats Subjected to a Chronic Stress Model for Depression

(2018) Dávid Csabai et al.   Frontiers in Cellular Neuroscience

Long-Term Stress Disrupts the Structural and Functional Integrity of GABAergic Neuronal Networks in the Medial Prefrontal Cortex of Rats

(2018) Boldizsár Czéh et al.   Frontiers in Cellular Neuroscience

PV Interneurons: Critical Regulators of E/I Balance for Prefrontal Cortex-Dependent Behavior and Psychiatric Disorders

(2018) Brielle R. Ferguson et al.   Frontiers in Neural Circuits

Optogenetic and chemogenetic approaches to manipulate attention, impulsivity and behavioural flexibility in rodents

(2018) Madison R. Carr et al.   BEHAVIOURAL PHARMACOLOGY

Glutamine has antidepressive effects through increments of glutamate and glutamine levels and glutamatergic activity in the medial prefrontal cortex

(2018) Hyeonwi Son et al.   NEUROPHARMACOLOGY

Dopamine enhances signal-to-noise ratio in cortical-brainstem encoding of aversive stimuli

(2018) Caitlin M. Vander Weele et al.   NATURE

Mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors

(2018) Sebastian P. Fernandez et al.   Nature Communications

Homer1a protein expression in schizophrenia, bipolar disorder, and major depression

(2017) Stefan L. Leber et al.   JOURNAL OF NEURAL TRANSMISSION

Tonic or phasic stimulation of dopaminergic projections to prefrontal cortex causes mice to maintain or deviate from previously learned behavioral strategies

(2017) Ian T. Ellwood et al.   JOURNAL OF NEUROSCIENCE

Prefrontal cortex output circuits guide reward seeking through divergent cue encoding

(2017) James M. Otis et al.   NATURE

Sex-specific transcriptional signatures in human depression

(2017) Benoit Labonté et al.   NATURE MEDICINE

Bidirectional Control of Anxiety-Related Behaviors in Mice: Role of Inputs Arising from the Ventral Hippocampus to the Lateral Septum and Medial Prefrontal Cortex

(2017) Gustavo Morrone Parfitt et al.   NEUROPSYCHOPHARMACOLOGY

Sub-chronic variable stress induces sex-specific effects on glutamatergic synapses in the nucleus accumbens

(2017) Anna Brancato et al.   NEUROSCIENCE

Regional differences in dendritic spine density confer resilience to chronic social defeat stress

(2017) Youge Qu et al.   ACTA NEUROPSYCHIATRICA

Ventral tegmental area subcircuits process rewarding and aversive experiences

(2016) Sebastiano Bariselli et al.   JOURNAL OF NEUROCHEMISTRY

Somatostatin-expressing neurons in cortical networks

(2016) Joanna Urban-Ciecko et al.   NATURE REVIEWS NEUROSCIENCE

Direct Ventral Hippocampal-Prefrontal Input Is Required for Anxiety-Related Neural Activity and Behavior

(2016) Nancy Padilla-Coreano et al.   NEURON

Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex

(2016) A.C. Felix-Ortiz et al.   NEUROSCIENCE

Ventral tegmental area muscarinic receptors modulate depression and anxiety-related behaviors in rats

(2016) Keri M. Small et al.   NEUROSCIENCE LETTERS

The Nucleus Accumbens: An Interface Between Cognition, Emotion, and Action

(2015) Stan B. Floresco   Annual Review of Psychology

Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress

(2015) G. E. Hodes et al.   JOURNAL OF NEUROSCIENCE

Sex differences in glutamate receptor gene expression in major depression and suicide

(2015) A L Gray et al.   MOLECULAR PSYCHIATRY

Basomedial amygdala mediates top-down control of anxiety and fear

(2015) Avishek Adhikari et al.   NATURE

PSD-95 family MAGUKs are essential for anchoring AMPA and NMDA receptor complexes at the postsynaptic density

(2015) Xiaobing Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior

(2015) E. A. Ferenczi et al.   SCIENCE

Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression

(2015) Rosemary C. Bagot et al.   Nature Communications

Prefrontal Cortical Circuit for Depression- and Anxiety-Related Behaviors Mediated by Cholecystokinin: Role of  FosB

(2014) V. Vialou et al.   JOURNAL OF NEUROSCIENCE

Child Abuse, Depression, and Methylation in Genes Involved With Stress, Neural Plasticity, and Brain Circuitry

(2014) Natalie Weder et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Circuit dynamics of adaptive and maladaptive behaviour

(2014) Karl Deisseroth   NATURE

Homer1/mGluR5 Activity Moderates Vulnerability to Chronic Social Stress

(2014) Klaus V Wagner et al.   NEUROPSYCHOPHARMACOLOGY

Opposing Effects of Acute versus Chronic Blockade of Frontal Cortex Somatostatin-Positive Inhibitory Neurons on Behavioral Emotionality in Mice

(2014) Amelie Soumier et al.   NEUROPSYCHOPHARMACOLOGY

Activity-dependent FUS dysregulation disrupts synaptic homeostasis

(2014) C. F. Sephton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cortical Control of Affective Networks

(2013) S. Kumar et al.   JOURNAL OF NEUROSCIENCE

The brain reward circuitry in mood disorders

(2013) Scott J. Russo et al.   NATURE REVIEWS NEUROSCIENCE

Reward and aversion in a heterogeneous midbrain dopamine system

(2013) Stephan Lammel et al.   NEUROPHARMACOLOGY

Burden of Depressive Disorders by Country, Sex, Age, and Year: Findings from the Global Burden of Disease Study 2010

(2013) Alize J. Ferrari et al.   PLOS MEDICINE

Chronic stress alters inhibitory networks in the medial prefrontal cortex of adult mice

(2012) Javier Gilabert-Juan et al.   Brain Structure & Function

Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

(2012) Dipesh Chaudhury et al.   NATURE

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

(2012) Hyo Jung Kang et al.   NATURE MEDICINE

Scaffold protein Homer 1: Implications for neurological diseases

(2012) Peng Luo et al.   NEUROCHEMISTRY INTERNATIONAL

α2-containing GABAA receptors: A target for the development of novel treatment strategies for CNS disorders

(2012) Elif Engin et al.   PHARMACOLOGY & THERAPEUTICS

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

(2011) Michael J. Krashes et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrated behavioral z-scoring increases the sensitivity and reliability of behavioral phenotyping in mice: Relevance to emotionality and sex

(2011) Jean-Philippe Guilloux et al.   JOURNAL OF NEUROSCIENCE METHODS

The role of the nucleus accumbens in knowing when to respond

(2011) T. Singh et al.   LEARNING & MEMORY

Neural circuits underlying the pathophysiology of mood disorders

(2011) Joseph L. Price et al.   TRENDS IN COGNITIVE SCIENCES

Antidepressant-like properties of α2-containing GABAA receptors

(2010) Isabel Vollenweider et al.   BEHAVIOURAL BRAIN RESEARCH

Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex

(2010) H. E. Covington et al.   JOURNAL OF NEUROSCIENCE

Antidepressant-Like Effects of Medial Prefrontal Cortex Deep Brain Stimulation in Rats

(2009) Clement Hamani et al.   BIOLOGICAL PSYCHIATRY

Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression

(2008) Wayne C. Drevets et al.   Brain Structure & Function

Differential trafficking of AMPA and NMDA receptors by SAP102 and PSD-95 underlies synapse development

(2008) G. M. Elias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex

(2007) Jason J. Radley et al.   JOURNAL OF COMPARATIVE NEUROLOGY