Sex-specific transcriptional signatures in human depression

Identification of 15 genetic loci associated with risk of major depression in individuals of European descent

(2016) Craig L Hyde et al.   NATURE GENETICS

Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility

(2016) Rosemary C. Bagot et al.   NEURON

Pervasive and opposing effects of Unpredictable Chronic Mild Stress (UCMS) on hippocampal gene expression in BALB/cJ and C57BL/6J mouse strains

(2015) Karim Malki et al.   BMC GENOMICS

Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress

(2015) G. E. Hodes et al.   JOURNAL OF NEUROSCIENCE

Erratum: Sex differences in glutamate receptor gene expression in major depression and suicide

(2015) A L Gray et al.   MOLECULAR PSYCHIATRY

Somatostatin, neuronal vulnerability and behavioral emotionality

(2015) L C Lin et al.   MOLECULAR PSYCHIATRY

Sparse whole-genome sequencing identifies two loci for major depressive disorder

(2015) Na Cai et al.   NATURE

Laminar and cellular analyses of reduced somatostatin gene expression in the subgenual anterior cingulate cortex in major depression

(2015) Marianne L. Seney et al.   NEUROBIOLOGY OF DISEASE

Quantification of the Serotonin 1A Receptor Using PET: Identification of a Potential Biomarker of Major Depression in Males

(2015) Joshua Kaufman et al.   NEUROPSYCHOPHARMACOLOGY

A Systems Approach Identifies Networks and Genes Linking Sleep and Stress: Implications for Neuropsychiatric Disorders

(2015) Peng Jiang et al.   Cell Reports

Sex differences in stress-related psychiatric disorders: Neurobiological perspectives

(2014) Debra A. Bangasser et al.   FRONTIERS IN NEUROENDOCRINOLOGY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

RNA-sequencing of the brain transcriptome implicates dysregulation of neuroplasticity, circadian rhythms and GTPase binding in bipolar disorder

(2014) N Akula et al.   MOLECULAR PSYCHIATRY

Normalization of RNA-seq data using factor analysis of control genes or samples

(2014) Davide Risso et al.   NATURE BIOTECHNOLOGY

A Quantitative Framework to Evaluate Modeling of Cortical Development by Neural Stem Cells

(2014) Jason L. Stein et al.   NEURON

The Genetics of Major Depression

(2014) Jonathan Flint et al.   NEURON

Integrative Functional Genomic Analyses Implicate Specific Molecular Pathways and Circuits in Autism

(2013) Neelroop N. Parikshak et al.   CELL

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Sex differences of gray matter morphology in cortico-limbic-striatal neural system in major depressive disorder

(2013) Lingtao Kong et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The brain reward circuitry in mood disorders

(2013) Scott J. Russo et al.   NATURE REVIEWS NEUROSCIENCE

Circadian patterns of gene expression in the human brain and disruption in major depressive disorder

(2013) J. Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Genetic Sex in Affect Regulation and Expression of GABA-Related Genes Across Species

(2013) Marianne L. Seney et al.   Frontiers in Psychiatry

Brain-Derived Neurotrophic Factor Signaling and Subgenual Anterior Cingulate Cortex Dysfunction in Major Depressive Disorder

(2012) Adam Tripp et al.   AMERICAN JOURNAL OF PSYCHIATRY

Revisiting Global Gene Expression Analysis

(2012) Jakob Lovén et al.   CELL

Gene Expression Changes in the Prefrontal Cortex, Anterior Cingulate Cortex and Nucleus Accumbens of Mood Disorders Subjects That Committed Suicide

(2012) Adolfo Sequeira et al.   PLoS One

Epigenetic Mechanisms of Depression and Antidepressant Action

(2011) Vincent Vialou et al.   Annual Review of Pharmacology and Toxicology

Neuron density and serotonin receptor binding in prefrontal cortex in suicide

(2011) Mark D. Underwood et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression

(2011) J-P Guilloux et al.   MOLECULAR PSYCHIATRY

Possible antidepressant effects and mechanisms of memantine in behaviors and synaptic plasticity of a depression rat model

(2011) M.-N. Quan et al.   NEUROSCIENCE

A human-mouse conserved sex bias in amygdala gene expression related to circadian clock and energy metabolism

(2011) Li-Chun Lin et al.   Molecular Brain

Is My Network Module Preserved and Reproducible?

(2011) Peter Langfelder et al.   PLoS Computational Biology

Effect of chronic mild stress on hippocampal transcriptome in mice selected for high and low stress-induced analgesia and displaying different emotional behaviors

(2010) Pawel Lisowski et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex

(2010) H. E. Covington et al.   JOURNAL OF NEUROSCIENCE

Rank–rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures

(2010) Seema B. Plaisier et al.   NUCLEIC ACIDS RESEARCH

Gender differences in α-[11C]MTrp brain trapping, an index of serotonin synthesis, in medication-free individuals with major depressive disorder: A positron emission tomography study

(2010) Benicio N. Frey et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Gene Expression Studies in Major Depression

(2010) Divya Mehta et al.   Current Psychiatry Reports

Role of Nuclear Factor κB in Ovarian Hormone-Mediated Stress Hypersensitivity in Female Mice

(2009) Quincey LaPlant et al.   BIOLOGICAL PSYCHIATRY

Altered expression of lipid metabolism and immune response genes in the frontal cortex of suicide completers

(2009) Aleksandra Lalovic et al.   JOURNAL OF AFFECTIVE DISORDERS

Transcriptional expression of serotonergic regulators in laser-captured microdissected dorsal raphe neurons of subjects with major depressive disorder: sex-specific differences

(2009) Dharmendra B. Goswami et al.   JOURNAL OF NEUROCHEMISTRY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Global Brain Gene Expression Analysis Links Glutamatergic and GABAergic Alterations to Suicide and Major Depression

(2009) Adolfo Sequeira et al.   PLoS One

Sex differences in hormonal responses to a social stressor in chronic major depression

(2009) Kevin K. Chopra et al.   PSYCHONEUROENDOCRINOLOGY

Eigen-R2 for dissecting variation in high-dimensional studies

(2008) Lin S. Chen et al.   BIOINFORMATICS

Protection of stress-induced impairment of hippocampal/prefrontal LTP through blockade of glucocorticoid receptors

(2008) François Mailliet et al.   EXPERIMENTAL NEUROLOGY

Gender-specific decrease in NUDR and 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder

(2008) Bernadeta Szewczyk et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY