Vascular Endothelial Damage in the Pathogenesis of Organ Injury in Severe COVID-19

Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation

(2020) Jose M. Adrover et al.   NATURE IMMUNOLOGY

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients

(2020) David M. Smadja et al.   ANGIOGENESIS

COVID-19 and its implications for thrombosis and anticoagulation

(2020) Jean Marie Connors et al.   BLOOD

Deep Vein Thrombosis in Hospitalized Patients with Coronavirus Disease 2019 (COVID-19) in Wuhan, China: Prevalence, Risk Factors, and Outcome

(2020) Li Zhang et al.   CIRCULATION

Pulmonary Embolism in COVID-19 Patients: Awareness of an Increased Prevalence

(2020) Julien Poissy et al.   CIRCULATION

The Science Underlying COVID-19: Implications for the Cardiovascular System

(2020) Peter P. Liu et al.   CIRCULATION

Risk of severe illness from COVID-19 in patients with metabolic dysfunction-associated fatty liver disease and increased fibrosis scores

(2020) Giovanni Targher et al.   GUT

Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation

(2020) Daniel E. Leisman et al.   INTENSIVE CARE MEDICINE

High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study

(2020) Julie Helms et al.   INTENSIVE CARE MEDICINE

Management of COVID-19 Respiratory Distress

(2020) John J. Marini et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy

(2020) Giacomo Grasselli et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct Pathophysiology

(2020) Daniel Batlle et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Incidence of venous thromboembolism in hospitalized patients with COVID‐19

(2020) Saskia Middeldorp et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China

(2020) Hua Su et al.   KIDNEY INTERNATIONAL

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Liver injury in COVID-19: management and challenges

(2020) Chao Zhang et al.   Lancet Gastroenterology & Hepatology

Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome

(2020) Elizabeth A Middleton et al.   BLOOD

Immunothrombotic Dysregulation in COVID-19 Pneumonia is Associated with Respiratory Failure and Coagulopathy

(2020) Leo Nicolai et al.   CIRCULATION

Systemic Inflammatory Response Syndrome Is a Major Contributor to COVID-19–Associated Coagulopathy

(2020) Paul Masi et al.   CIRCULATION

Extrapulmonary manifestations of COVID-19

(2020) Aakriti Gupta et al.   NATURE MEDICINE

Incidence of thrombotic complications in critically ill ICU patients with COVID-19

(2020) F.A. Klok et al.   THROMBOSIS RESEARCH

Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study

(2020) George Goshua et al.   Lancet Haematology

Clinical features and risk factors of COVID-19-associated liver injury and function: A retrospective analysis of 830 cases

(2020) Faxiang Chen et al.   Annals of Hepatology

Endotheliopathy is induced by plasma from critically-ill patients and associated with organ failure in severe COVID-19

(2020) Antoine Rauch et al.   CIRCULATION

COVID-19 is, in the end, an endothelial disease

(2020) Peter Libby et al.   EUROPEAN HEART JOURNAL

Hepatic Injury in Patients With COVID-19

(2020) Ravina Kullar et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

(2020) Panagiotis Skendros et al.   JOURNAL OF CLINICAL INVESTIGATION

Histopathological features of multiorgan percutaneous tissue core biopsy in patients with COVID-19

(2020) Xin-xin Wang et al.   JOURNAL OF CLINICAL PATHOLOGY

SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology

(2020) Flavio Protasio Veras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Coagulation biomarkers are independent predictors of increased oxygen requirements in COVID‐19

(2020) Antoine Rauch et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Hypercoagulability and COVID-19 associated hypoxemic respiratory failure

(2020) Calvin H. Yeh et al.   Journal of Trauma and Acute Care Surgery

Immunity, endothelial injury and complement-induced coagulopathy in COVID-19

(2020) Luca Perico et al.   Nature Reviews Nephrology

Neutrophil Extracellular Traps and By-Products Play a Key Role in COVID-19: Pathogenesis, Risk Factors, and Therapy

(2020) Alain R. Thierry et al.   Journal of Clinical Medicine

Vascular neutrophilic inflammation and immunothrombosis distinguish severe COVID‐19 from influenza pneumonia

(2020) Leo Nicolai et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Assessment of Neutrophil Extracellular Traps in Coronary Thrombus of a Case Series of Patients With COVID-19 and Myocardial Infarction

(2020) Ana Blasco et al.   JAMA Cardiology

Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance

(2019) Senna Staessens et al.   HAEMATOLOGICA

Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis after Vessel Injury

(2019) Nicoletta Sorvillo et al.   CIRCULATION RESEARCH

Understanding the Role of Neutrophil Extracellular Traps in Patients With Severe Pneumonia and ARDS

(2019) Inès Bendib et al.   CHEST

Antithrombotic therapy and body mass: an expert position paper of the ESC Working Group on Thrombosis

(2018) Bianca Rocca et al.   EUROPEAN HEART JOURNAL

Human neutrophil peptides inhibit cleavage of von Willebrand factor by ADAMTS13: a potential link of inflammation to TTP

(2016) Vikram G. Pillai et al.   BLOOD

Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature

(2015) Elzbieta Kolaczkowska et al.   Nature Communications

von Willebrand Factor Directly Interacts With DNA From Neutrophil Extracellular Traps

(2014) S. Grassle et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Active von Willebrand factor predicts 28-day mortality in patients with systemic inflammatory response syndrome

(2014) A. Hyseni et al.   BLOOD

Ratio of von Willebrand Factor Propeptide to ADAMTS13 Is Associated With Severity of Sepsis

(2013) Hidetada Fukushima et al.   SHOCK

Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes

(2009) Jin-Kui Yang et al.   ACTA DIABETOLOGICA

Sepsis: the dark side of histones

(2009) Catherine Chaput et al.   NATURE MEDICINE