New Insight Into Metformin-Induced Cholesterol-Lowering Effect Crosstalk Between Glucose and Cholesterol Homeostasis via ChREBP (Carbohydrate-Responsive Element-Binding Protein)-Mediated PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Regulation
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
New Insight Into Metformin-Induced Cholesterol-Lowering Effect Crosstalk Between Glucose and Cholesterol Homeostasis via ChREBP (Carbohydrate-Responsive Element-Binding Protein)-Mediated PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Regulation
Authors
Keywords
-
Journal
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Volume -, Issue -, Pages -
Publisher
Ovid Technologies (Wolters Kluwer Health)
Online
2021-02-04
DOI
10.1161/atvbaha.120.315708
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Hepatic Glucagon Signaling Regulates PCSK9 and Low-Density Lipoprotein Cholesterol
- (2019) Stefano Spolitu et al. CIRCULATION RESEARCH
- Metformin in 2019
- (2019) James Flory et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Low LDL Cholesterol by PCSK9 Variation Reduces Cardiovascular Mortality
- (2019) Marianne Benn et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy
- (2019) Rosina Pryor et al. CELL
- Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial
- (2019) Kausik K Ray et al. Lancet Diabetes & Endocrinology
- Impact of proprotein convertase subtilisin/kexin type 9 inhibition with evolocumab on the postprandial responses of triglyceride-rich lipoproteins in type II diabetic subjects
- (2019) Marja-Riitta Taskinen et al. Journal of Clinical Lipidology
- Triglyceride-Rich Lipoprotein Cholesterol and Risk of Cardiovascular Events Among Patients Receiving Statin Therapy in the Treating to New Targets (TNT) Trial
- (2018) Antonio J. Vallejo-Vaz et al. CIRCULATION
- Circulating PCSK9 levels and 2-hPG are positively correlated in metabolic diseases in a Chinese Han population
- (2018) Wen Guo et al. Lipids in Health and Disease
- Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo
- (2018) Anila K. Madiraju et al. NATURE MEDICINE
- Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice
- (2018) Cheng-Yang Wu et al. Molecular Metabolism
- Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase
- (2018) Roger W. Hunter et al. NATURE MEDICINE
- The interrelations between PCSK9 metabolism and cholesterol synthesis and absorption
- (2018) Günther Silbernagel et al. JOURNAL OF LIPID RESEARCH
- Inhibiting PCSK9 — biology beyond LDL control
- (2018) Robert M. Stoekenbroek et al. Nature Reviews Endocrinology
- Reduction of low density lipoprotein-cholesterol and cardiovascular events with proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors and statins: an analysis of FOURIER, SPIRE, and the Cholesterol Treatment Trialists Collaboration
- (2017) Brian A Ference et al. EUROPEAN HEART JOURNAL
- Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity
- (2017) Deqiang Zhang et al. JOURNAL OF CLINICAL INVESTIGATION
- Cardiovascular safety and efficacy of the PCSK9 inhibitor evolocumab in patients with and without diabetes and the effect of evolocumab on glycaemia and risk of new-onset diabetes: a prespecified analysis of the FOURIER randomised controlled trial
- (2017) Marc S Sabatine et al. Lancet Diabetes & Endocrinology
- Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial
- (2017) John R Petrie et al. Lancet Diabetes & Endocrinology
- Metformin treatment of antipsychotic-induced dyslipidemia: an analysis of two randomized, placebo-controlled trials
- (2016) R-R Wu et al. MOLECULAR PSYCHIATRY
- Role of Insulin in the Regulation of Proprotein Convertase Subtilisin/Kexin Type 9Significance
- (2015) Ji Miao et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins
- (2015) Joseph L. Goldstein et al. CELL
- Effects of Metformin on Metabolite Profiles and LDL Cholesterol in Patients With Type 2 Diabetes
- (2015) Tao Xu et al. DIABETES CARE
- Genome-Wide Analysis of ChREBP Binding Sites on Male Mouse Liver and White Adipose Chromatin
- (2015) Naravat Poungvarin et al. ENDOCRINOLOGY
- Metabolic abnormalities in Williams–Beuren syndrome
- (2015) María Gabriela Palacios-Verdú et al. JOURNAL OF MEDICAL GENETICS
- Metformin: From Mechanisms of Action to Therapies
- (2014) Marc Foretz et al. Cell Metabolism
- Proprotein Convertase Subtilisin Kexin Type 9 Promotes Intestinal Overproduction of Triglyceride-Rich Apolipoprotein B Lipoproteins Through Both Low-Density Lipoprotein Receptor–Dependent and –Independent Mechanisms
- (2014) Shirya Rashid et al. CIRCULATION
- PCSK9
- (2014) Nabil G. Seidah et al. CIRCULATION RESEARCH
- The effect of insulin on circulating PCSK9 in postmenopausal obese women
- (2014) Zuhier Awan et al. CLINICAL BIOCHEMISTRY
- FoxO3 Transcription Factor and Sirt6 Deacetylase Regulate Low Density Lipoprotein (LDL)-cholesterol Homeostasis via Control of the Proprotein Convertase Subtilisin/Kexin Type 9 (Pcsk9) Gene Expression
- (2013) Rongya Tao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets
- (2013) Bertrand Cariou et al. Nutrition & Metabolism
- Novel insights into ChREBP regulation and function
- (2013) Gaëlle Filhoulaud et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice
- (2012) Ding Ai et al. JOURNAL OF CLINICAL INVESTIGATION
- Blockade of cholesterol absorption by ezetimibe reveals a complex homeostatic network in enterocytes
- (2012) Luke J. Engelking et al. JOURNAL OF LIPID RESEARCH
- A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism
- (2012) Mark A. Herman et al. NATURE
- Hepatic FoxO1 Integrates Glucose Utilization and Lipid Synthesis through Regulation of Chrebp O-Glycosylation
- (2012) Yukari Ido-Kitamura et al. PLoS One
- Insulin Resistance, Hyperglycemia, and Atherosclerosis
- (2011) Karin E. Bornfeldt et al. Cell Metabolism
- O-GlcNAcylation Increases ChREBP Protein Content and Transcriptional Activity in the Liver
- (2011) C. Guinez et al. DIABETES
- Inhibition of Gluconeogenic Genes by Calcium-regulated Heat-stable Protein 1 via Repression of Peroxisome Proliferator-activated Receptor α
- (2011) Yanbo Fan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Strong induction of PCSK9 gene expression through HNF1α and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters
- (2010) Bin Dong et al. JOURNAL OF LIPID RESEARCH
- Williams–Beuren Syndrome
- (2010) Barbara R. Pober NEW ENGLAND JOURNAL OF MEDICINE
- Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus
- (2010) NEW ENGLAND JOURNAL OF MEDICINE
- Trends in Cardiovascular Disease Risk Factors in Individuals With and Without Diabetes Mellitus in the Framingham Heart Study
- (2009) Sarah Rosner Preis et al. CIRCULATION
- Major Lipids, Apolipoproteins, and Risk of Vascular Disease
- (2009) The Emerging Risk Factors Collaboration* JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Hepatocyte Nuclear Factor 1α Plays a Critical Role inPCSK9Gene Transcription and Regulation by the Natural Hypocholesterolemic Compound Berberine
- (2009) Hai Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genetic and Metabolic Determinants of Plasma PCSK9 Levels
- (2009) Susan G. Lakoski et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Selective versus Total Insulin Resistance: A Pathogenic Paradox
- (2008) Michael S. Brown et al. Cell Metabolism
- Dual Mechanisms for the Fibrate-mediated Repression of Proprotein Convertase Subtilisin/Kexin Type 9
- (2008) Sanae Kourimate et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Newly identified loci that influence lipid concentrations and risk of coronary artery disease
- (2008) Cristen J Willer et al. NATURE GENETICS
- Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
- (2008) Jaspal S Kooner et al. NATURE GENETICS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now