Review
Pharmacology & Pharmacy
Yannis Simos, Konstantinos Spyrou, Michaela Patila, Niki Karouta, Haralambos Stamatis, Dimitrios Gournis, Evangelia Dounousi, Dimitrios Peschos
Summary: Current oral modalities for treating type 2 diabetes mellitus have drawbacks such as low bioavailability, immediate release of the drug necessitating increased dosing frequency, and potential adverse effects. Advances in nanotechnology offer the potential to improve drug bioavailability, prolong release, reduce dosing frequency, and enhance patient compliance and quality of life.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Taiwo P. Adesoba, Clare C. Brown
Summary: The objective of this study was to examine trends and prevalence of lean diabetes among adults in the U.S. from 2015 to 2020. The study found that the prevalence of lean diabetes has been increasing during this period, with larger increases among women and populations of color.
Article
Endocrinology & Metabolism
Mariangela Gaudio, Nicoletta Dozio, Michael Feher, Marina Scavini, Amelia Caretto, Mark Joy, Jeremy Van Vlymer, William Hinton, Simon de Lusignan
Summary: The study aimed to describe trends in modifiable and non-modifiable unfavorable factors affecting pregnancy outcomes in women with diabetes of childbearing age from an English primary care perspective. Despite improvements in general diabetes care, the majority of women with Type 1 or Type 2 diabetes still have unfavorable, mostly modifiable factors for the start of pregnancy. Good diabetes care for women of childbearing age should consider the possibility of pregnancy.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
A. G. Unnikrishnan, R. K. Sahay, Uday Phadke, S. K. Sharma, Parag Shah, Rishi Shukla, Vijay Viswanathan, S. K. Wangnoo, Santosh Singhal, Mathew John, Ajay Kumar, Mala Dharmalingam, Subodh Jain, Shehla Shaikh, Willem J. Verberk
Summary: Through studying newly diagnosed T2DM patients in India, it is found that they have high cardiovascular disease risk. This indicates the need for further extension of ASCVD risk identification programs and prevention strategies to reduce the occurrence of cardiovascular diseases.
Article
Public, Environmental & Occupational Health
Jack Wang, Sarah H. Wild
Summary: The study revealed that socioeconomic inequalities in the prevalence of type 2 diabetes in Scotland have increased between 2001-2007 and 2021. Further research is needed to investigate potential medium-term effects of the COVID-19 pandemic.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2022)
Review
Nutrition & Dietetics
Anna Izzo, Elena Massimino, Gabriele Riccardi, Giuseppe Della Pepa
Summary: Type 2 diabetes mellitus is a major health burden for the elderly, affecting approximately 25% of those over 65 years old. Sarcopenia, characterized by loss of skeletal muscle mass and function, has been identified as a new complication in elderly individuals with T2DM. It is important for researchers and clinicians to understand the risk factors and associations of sarcopenia in T2DM patients in order to provide appropriate therapeutic interventions.
Article
Endocrinology & Metabolism
C. Baechle, A. Stahl-Pehe, N. Prinz, T. Meissner, C. Kamrath, R. W. Holl, J. Rosenbauer, cooperation German Paediat Surveillance Unit ESPED, DPV initiative German Ctr Diabet Res DZD
Summary: This study estimated the prevalence and temporal trends of type 1 and type 2 diabetes mellitus in children and adolescents in North Rhine-Westphalia, Germany. The results showed that the prevalence of diabetes has increased significantly but at a lower rate in recent years. Continued surveillance of the prevalence is essential.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Multidisciplinary Sciences
Boonsub Sakboonyarat, Warabhorn Pima, Channarong Chokbumrungsuk, Taksin Pimpak, Sirikorn Khunsri, Supak Ukritchon, Worarachanee Imjaijitt, Mathirut Mungthin, Wisit Kaewput, Bhophkrit Bhopdhornangkul, Nattapol Sathavarodom, Pyatat Tatsanavivat, Ram Rangsin
Summary: Diabetes is a major global health issue with increasing prevalence, and the study in Thailand found that the rate of adequate glycemic control among patients with type 2 diabetes was on the rise. Factors associated with poor glycemic control included gender, age, region, level of care, health insurance scheme, duration of diabetes, body mass index, and presence of hypertension comorbidity.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Annika Vestergaard Kvist, Mohamad I. Nasser, Peter Vestergaard, Morten Frost, Andrea M. Burden
Summary: A study in Denmark from 1997 to 2017 found that the incidence rates of fractures were higher in patients with type 1 and type 2 diabetes compared to those without diabetes, except for foot fractures. The incidence of hip fractures decreased by 35.2%, 47.0%, and 23.4% in patients with type 1 diabetes, type 2 diabetes, and without diabetes, respectively, over the last 5 years. However, vertebral fractures increased by 14.8%, 18.5%, and 38.9% in the same groups. After age adjustment, patients with type 1 diabetes still had a higher risk of fractures compared to those without diabetes, while patients with type 2 diabetes had a risk similar to those without diabetes.
Article
Environmental Sciences
Karla Rangel-Moreno, Brenda Gamboa-Loira, Lizbeth Lopez-Carrillo, Mariano E. Cebrian
Summary: This study found that the metabolism of inorganic arsenic (iAs) in urine is associated with the prevalence of type 2 diabetes mellitus (T2DM), but not with the urinary arsenic levels. This suggests a link between iAs metabolism and T2DM, but further research is needed to explore the interplay among iAs metabolism, T2DM, and hypertension.
ENVIRONMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Stefano Ciardullo, Tommaso Monti, Gianluca Perseghin
Summary: The prevalence of liver steatosis and fibrosis is high in patients with T2DM from the United States, with obesity being a major risk factor. Screening for these conditions among patients with diabetes is recommended based on the study results.
Article
Endocrinology & Metabolism
Zijing Wang, Yao Wu, Junhui Wu, Mengying Wang, Xiaowen Wang, Jiating Wang, Tao Wu, Yiqun Wu, Yonghua Hu
Summary: In Beijing, China, the prevalence of diagnosed type 2 diabetes increased steadily over 10 years, while the incidence decreased overall except in individuals under 40 years old. Efforts to prevent diabetes in China should be continuous.
Article
Endocrinology & Metabolism
Thorsten Otto, Joanna Diesing, Julia Borchert, Elke Heitmann, Nanette C. Schloot, Jeremie Lebrec, Dirk Mueller-Wieland, Dennis Haeckl
Summary: This study assessed the prevalence of type 2 diabetes mellitus (T2DM) in Germany, particularly in patients at risk for or with established cardiovascular disease (CVD), and their treatments. Using claims data, T2DM prevalence was estimated at 11.9%, higher in older patients. The majority of T2DM patients had at least one cardiovascular risk factor, and about half had established CVD. Early prevention of CVD in T2DM patients, especially in older individuals, is crucial. Furthermore, the use of insulin in older T2DM patients needs further evaluation.
DIABETES OBESITY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Irena Patsan, Amanda Tapley, Peter Davoren, Alison Fielding, Elizabeth Holliday, Jean Ball, Andrew Davey, Mieke van Driel, Rachel Turner, Katie Mulquiney, Neil Spike, Kristen FitzGerald, Parker Magin
Summary: This study aimed to describe the temporal trends and associations of Australian general practitioner registrars' prescription and initiation of "new" second-line oral agents compared to sulphonylureas. The results showed a significant increase in the prescription and initiation of "new" medications compared to sulphonylureas over time, with less prescribing for non-English-speaking patients and regional variation.
Article
Endocrinology & Metabolism
Saba S. Memon, Anurag Lila, Rohit Barnabas, Manjunath Goroshi, Vijaya Sarathi, Vyankatesh Shivane, Virendra Patil, Nalini Shah, Tushar Bandgar
Summary: The study aims to assess the prevalence of primary aldosteronism (PA) in Asian Indian patients with Type 2 diabetes mellitus (T2DM) and hypertension, revealing that a significant number of patients tested positive for PA, showing higher levels of uncontrolled blood pressure and more severe disease conditions compared to those without PA. Further research is needed to evaluate the cost-effectiveness of routine screening for PA in this population.
CLINICAL ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Priyanga Diloshini Ranasinghe, Subhash Pokhrel, Nana Kwame Anokye
Summary: This study is the first review aiming to summarize the evidence on the economics of physical activity in low-income and middle-income countries, identifying potential target variables for policy, and conducting a descriptive synthesis of data.
Review
Nutrition & Dietetics
Priyanga Ranasinghe, Ranil Jayawardena, Nishadi Gamage, V. Pujitha Wickramasinghe, Andrew P. Hills
Summary: Obesity is defined as excessive accumulation of body fat with health consequences. This study evaluated non-traditional anthropometric measurements of overweight and obesity in children, identifying various parameters used in different countries. Further research is needed to determine the accuracy and precision of these measurements.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2021)
Review
Pharmacology & Pharmacy
Priyanga Ranasinghe, Melisande L. Addison, James W. Dear, David J. Webb
Summary: Post-transcriptional gene silencing can be achieved through siRNA therapy, which uses synthetic short double-stranded RNA molecules to specifically target and degrade mRNA transcripts. This technology offers advantages such as broad targeting capabilities and long-lasting effects. However, challenges in terms of pharmacokinetics and pharmacodynamics have been addressed through chemical modification and delivery systems. Several siRNA therapies have been approved for clinical use, but further advancements are needed to target organs beyond the liver and reach special sites.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Priyanga Ranasinghe, Nirmala Sirisena, Vidarsha Senadeera, Gayani Anandagoda, Vajira Hw Dissanayake
Summary: This study aimed to describe the diversity of pharmacogenomic variants affecting warfarin metabolism in Sri Lankans. The findings showed that the frequencies of certain variants in CYP2C9, VKORC1, and CYP4F2 genes were significantly different in Sri Lankans compared to other populations, suggesting that these variants may contribute to the variability in warfarin dosage requirements among Sri Lankan individuals.
Editorial Material
Cardiac & Cardiovascular Systems
Priyanga Ranasinghe, Melisande L. Addison, David J. Webb
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Peripheral Vascular Disease
Melisande L. Addison, Priyanga Ranasinghe, David J. Webb
Summary: Hypertension, affecting half of US adults, is the leading cause of cardiovascular disease and premature death globally. Novel pharmacological strategies that silences liver angiotensinogen have shown impressive and durable effects on blood pressure control.
Article
Pharmacology & Pharmacy
Priyanga Ranasinghe, Nirmala Sirisena, Jeremy N. Ariadurai, Thuwaragesh Vishnukanthan, Sathsarani Thilakarathne, Gayani Anandagoda, Vajira H. W. Dissanayake
Summary: This study describes the diversity of pharmacogenetic variants of statins among Sri Lankans. They found that variants that affect the efficacy of statins and increase the risk of statin-induced myotoxicity are prevalent in higher frequencies among Sri Lankans compared with western populations.
Article
Pharmacology & Pharmacy
Melisande L. Addison, Priyanga Ranasinghe, David J. Webb
Summary: Hypertension is a major risk factor for cardiovascular disease worldwide. Nonadherence to medication is a significant issue in hypertension treatment. Small interfering RNA therapy targeting hepatic angiotensinogen offers durability and liver-specificity, making it a potential precision medicine approach for hypertension.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2023)
Article
Health Care Sciences & Services
P. Ranasinghe, C. K. Liyanage, J. Meegoda, R. L. Jayakody, P. Galappatthy
Summary: This study investigated the availability of medicines and drug use in outpatient department (OPD) pharmacies in government hospitals in Sri Lanka. The findings revealed that irrational prescribing and excessive use of antibiotics were the major issues. However, prescribing by generic name, use of injectable preparations, and adherence to the essential medicine list (EML) were in line with WHO recommendations.
JOURNAL OF PHARMACEUTICAL HEALTH SERVICES RESEARCH
(2022)
Article
Health Care Sciences & Services
Fathima Rufaideen, Chiranthi K. Liyanage, Chathuranga Ranasinghe, Priyanga Ranasinghe
Summary: This study evaluated the content and frequency of ayurvedic and herbal product advertisements in electronic and print media in Sri Lanka. The findings showed that there were variations in the content and format of the advertisements, with many of them lacking important information and making unsubstantiated therapeutic claims. The study highlights the need for stringent guidelines to protect the health and safety of the population.
JOURNAL OF PHARMACEUTICAL HEALTH SERVICES RESEARCH
(2022)
Article
Biology
Priyanga Ranasinghe, Julian Monge-Najera, Chiranthi K. Liyanagel, Yuh-Shan Ho
Summary: This study provides a comprehensive bibliometric analysis of research in Sri Lanka, revealing that Sri Lankan authors often play minor roles in international mega projects. The study suggests that Sri Lankan authors should expand their research fields, strengthen their local journals for better visibility and impact, and improve their positions in international projects published in larger journals.
REVISTA DE BIOLOGIA TROPICAL
(2022)
Article
Nutrition & Dietetics
Hasinthi Swarnamali, Ranil Jayawardena, Michail Chourdakis, Priyanga Ranasinghe
Summary: This study quantifies the association between per capita fat supply and the prevalence of overweight and obesity worldwide, and further examines the impact of Gross National Income (GNI) on this association.
Article
Integrative & Complementary Medicine
Ranil Jayawardena, Tormalli Francis, Sachith Abhayaratna, Priyanga Ranasinghe
Summary: A systematic review of clinical trials evaluating the effects of C. fimbriata as an appetite suppressant and weight loss supplement found that while the plant extract showed some reduction in waist circumference and waist-hip ratio, it did not significantly affect body weight, BMI, hip circumference, biochemical factors, or appetite parameters. Additionally, few studies reported mild side effects such as constipation, diarrhea, nausea, and rashes among individuals who consumed the extract.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
