Article
Cell Biology
Xiaoxuan Duan, Yihuan Chen, Kai Zhang, Wei Chen, Jun Zhao, Xiaoshuo Dai, Wenbo Cao, Ziming Dong, Saijun Mo, Jing Lu
Summary: This study found that phosphoglycerate dehydrogenase (PHGDH) was highly expressed in esophageal squamous carcinoma (ESCC), and high expression was associated with poor prognosis. In vitro and in vivo experiments demonstrated that PHGDH knockdown inhibited ESCC progression by suppressing Wnt/beta-catenin signaling pathway. These results indicate that PHGDH may be a potential therapeutic target for ESCC.
CELLULAR SIGNALLING
(2023)
Article
Plant Sciences
Cai-Wen Fan, Juan Tang, Jing-Chen Jiang, Mei-Mei Zhou, Mei-Shan Li, Heng-Shan Wang
Summary: This study demonstrated that PGG can inhibit proliferation, induce apoptosis and autophagy, and decrease metastatic capacity of NPC cells. Mechanistically, PGG exerts its effects through the p38 MAPK/mTOR and Wnt/beta-catenin pathways, providing evidence for PGG as a potential therapeutic option for NPC.
Article
Geriatrics & Gerontology
Y. Li, W. Cui, B. Song, X. Ye, Z. Li, C. Lu
Summary: This study found that SIRT1 activator has a negative regulatory effect on weight, blood lipid levels, and lesion conditions in AS mice, and reduces the CD34+/VEGFR2+ density in aortic tissues. In in vitro experiments, the SIRT1 activator promotes the proliferation and migration of EPCs and acts through the wnt/beta-catenin/GSK3 beta signaling pathway.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Environmental Sciences
Saifang Fu, Rongbang Tan, Yufei Feng, Ping Yu, Yuqian Mo, Wei Xiao, Shouyu Wang, Jingjing Zhang
Summary: This study revealed that N-methyl-N-nitrosourea (MNU) induced aberrant angiogenesis through the modulation of the rspo1/Wnt/β-catenin/vegfaa axis. Furthermore, it was found that the pro-angiogenic effect of MNU on developing zebrafish embryos could be controlled through pharmacological manipulation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biotechnology & Applied Microbiology
Jie Gao, Jiayuan Zhang, Lianheng Xia, Xuewei Liang, Wukun Ding, Meiyu Song, Linggen Li, Zhen Jia
Summary: Chitosan up-regulates CAV1 expression and promotes canonical Wnt signaling pathway activity, providing pharmacological effects on wound healing and angiogenesis.
Article
Microbiology
Chongyang Wang, Ruochen Hu, Liuyuan Duan, Qili Hou, Mengqing Yang, Ting Wang, Haijin Liu, Sa Xiao, Ruyi Dang, Juan Wang, Xinglong Wang, Shuxia Zhang, Zengqi Yang
Summary: This study showed that pseudorabies virus (PRV) infection activates the Wnt/beta-catenin signaling pathway, leading to enhanced virus proliferation and regulation of virus-induced autophagy. Inhibitors of this pathway can reduce PRV titers, while stimulation of the pathway can enhance PRV proliferation. These findings provide potential targets for the development of antiviral agents against PRV.
VETERINARY MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuri Lee, Hai-long Piao, Jongchan Kim
Summary: The Wnt signaling pathway is crucial for regulating various cellular processes, and dysregulation of this pathway has been linked to human diseases, including cancer. In this study, researchers aimed to identify the deubiquitinases (DUBs) that regulate the pathway through the essential component LEF1. They discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to increased interaction with beta-catenin. This study suggests that OTUD7B may serve as a potential therapeutic target in diseases where Wnt signaling is dysregulated, such as cancer.
Article
Oncology
Yajing Cui, Yingbin Luo, Qiaohong Qian, Jianhui Tian, Zhihong Fang, Xi Wang, Yaoying Zeng, Jianchun Wu, Yan Li
Summary: This study found that Sang can inhibit tumor angiogenesis by regulating the polarization of M2 macrophages, and the underlying mechanism may involve the WNT/β-Catenin signaling pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Ruili Guo, Xue Wang, Yani Fang, Xiongjian Chen, Kun Chen, Wenting Huang, Jun Chen, Jian Hu, Fei Liang, Jingting Du, Confidence Dordoe, Xianxi Tian, Li Lin
Summary: In this study, it was found that rhFGF20 can reduce brain edema, Evans blue penetration, and upregulate the expression of BBB-related tight junction proteins after TBI. rhFGF20 promotes angiogenesis and contributes to neurological and cognitive function recovery in the TBI repair phase. Through the Wnt/beta-catenin pathway, rhFGF20 may prevent vascular repair and angiogenesis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Clinical Neurology
Byung Woo Kang, Fred Kim, Joon-Yong Cho, SangYun Kim, Jinseol Rhee, Jai Jun Choung
Summary: Mirodenafil, a blood-brain barrier penetrating phosphodiesterase 5 (PDE5) inhibitor with polypharmacological properties, has the potential to improve cognitive behavior in an Alzheimer's disease (AD) mouse model and ameliorate AD pathology by modulating multiple key signaling pathways.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Qiang Zhang, Qi Zhang, Xiao Yan, Liping Wang, Xiao Yuan
Summary: This study evaluated the effects of different dimensional wrinkled topography on the osteogenic differentiation of MC3T3-E1 cells and explored the underlying mechanisms. The results showed that wrinkled topographies activated the autophagy-mediated Wnt/β-catenin signaling pathway and affected the osteogenic differentiation of MC3T3-E1 cells.
ARCHIVES OF ORAL BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Zheng Qin, Yupei Li, Jiameng Li, Luojia Jiang, Zhuyun Zhang, Kaixi Chang, Qinbo Yang, Shanshan Chen, Ruoxi Liao, Baihai Su
Summary: This study found that exosomal STAT1 derived from HP-treated HUVECs can promote VSMC calcification. Activation of the Wnt/beta-catenin pathway may be a potential mechanism of exosome-promoted VSMC calcification.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Oncology
Wei Xie, Huijie Zhao, Fengxian Wang, Yiyun Wang, Yuan He, Tong Wang, Kunchi Zhang, Hao Yang, Zhaoli Zhou, Haibin Shi, Jin Wang, Gang Huang
Summary: A novel humanized antibody targeting Fzd7, named SHH002-hu1, was developed and demonstrated potential anti-tumor activity. It showed high affinity with Fzd7, specifically targeted Fzd7(+) cells and tumor tissues, and enhanced the anti-TNBC capacity of Bevacizumab through inhibiting Wnt/beta-catenin signaling. SHH002-hu1 could be a promising candidate for synergistic therapy with Bevacizumab in preventing TNBC recurrence.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Endocrinology & Metabolism
Li-Ping Wang, Jiaji Pan, Yongfang Li, Jieli Geng, Chang Liu, Lin-Yuan Zhang, Panting Zhou, Yao-Hui Tang, Yongting Wang, Zhijun Zhang, Guo-Yuan Yang
Summary: Transplantation of oligodendrocyte precursor cells promotes angiogenesis and remyelination after ischemic stroke, improving motor and cognitive function and alleviating brain atrophy.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Article
Orthopedics
Sean V. Cahill, Hyuk-Kwon Kwon, Jungho Back, Inkyu Lee, Saelim Lee, Kareme D. Alder, Zichen Hao, Kristin E. Yu, Christopher M. Dussik, Themis R. Kyriakides, Francis Y. Lee
Summary: Local rifampin-loaded hydrogel effectively combats MRSA infection, reduces bacterial load, prevents implant colonization, and improves fracture healing outcomes in a murine model. Systemic rifampin is more effective at eliminating infection and promoting fracture healing. Further studies are needed to validate these findings in clinical settings.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Review
Engineering, Biomedical
Themis R. Kyriakides, Arindam Raj, Tiffany H. Tseng, Hugh Xiao, Ryan Nguyen, Farrah S. Mohammed, Saiti Halder, Mengqing Xu, Michelle J. Wu, Shuozhen Bao, Wendy C. Sheu
Summary: Nanomaterials have revolutionized medicine by enabling new sensing, diagnostic, and therapeutic approaches, but concerns about their biocompatibility and toxicity have been raised. Research on the interactions between nanomaterials and host cells can provide insights into their effects on the human body.
BIOMEDICAL MATERIALS
(2021)
Article
Engineering, Biomedical
Ayomiposi M. Loye, Hyuk-Kwon Kwon, David Dellal, Rodrigo Ojeda, Sangmin Lee, Rose Davis, Natalie Nagle, Panagiotis G. Doukas, Jan Schroers, Francis Y. Lee, Themis R. Kyriakides
Summary: The research suggests that nanopatterned Pt-BMGs have the potential to serve as an alternative to conventional metallic implants with simultaneous induction of osteoblasts and inhibition of osteoclasts. In vivo studies comparing Pt-BMG and titanium showed similar biocompatibility, indicating that further processing at the nanoscale could improve outcomes.
BIOMEDICAL MATERIALS
(2021)
Article
Multidisciplinary Sciences
Swayam Prakash Srivastava, Han Zhou, Ocean Setia, Bing Liu, Keizo Kanasaki, Daisuke Koya, Alan Dardik, Carlos Fernandez-Hernando, Julie Goodwin
Summary: The endothelial glucocorticoid receptor plays a crucial role in regulating diseases, with its loss associated with accelerated renal fibrosis and heightened inflammation. Proper regulation of endothelial cell homeostasis is essential in preventing diseases from progressing to organ fibrosis.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Swayam Prakash Srivastava, Julie E. Goodwin, Pratima Tripathi, Keizo Kanasaki, Daisuke Koya
Summary: Long noncoding RNAs (lncRNAs) play central roles in diabetes and cancer, regulating diverse targets and interacting with microRNAs bidirectionally. Their potential as therapeutic targets is promising, emphasizing their significance in the pathogenesis of diabetes and diabetic kidney disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Swayam Prakash Srivastava, Han Zhou, Ocean Setia, Alan Dardik, Carlos Fernandez-Hernando, Julie Goodwin
Summary: The study found that the loss of glucocorticoid receptor in podocytes leads to upregulation of the Wnt signaling pathway and disruption in fatty acid metabolism, resulting in the development of diabetic nephropathy. The crosstalk between podocytes and endothelial cells is crucial for maintaining glomerular homeostasis, and its disruption may contribute to diabetic nephropathy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
Hyuk-Kwon Kwon, Inkyu Lee, Kristin E. Yu, Sean Cahill, Kareme D. Alder, Saelim Lee, Christopher M. Dussik, JungHo Back, Jeongjoon Choi, Lee Song, Themis R. Kyriakides, Francis Y. Lee
Summary: The text discusses the challenge of treating joint infections and presents a new treatment modality involving locally delivered cell-penetrating antibiotics to eradicate bacteria and targeting inflammation to protect articular cartilage, offering a promising new therapeutic strategy for septic arthritis.
Review
Chemistry, Medicinal
Swayam Prakash Srivastava, Rohit Srivastava, Subhash Chand, Julie E. Goodwin
Summary: The review discusses the severity of COVID-19 in patients with diabetes and diabetic kidney disease, highlighting various mechanisms that may lead to organ damage and emphasizing the importance of comprehensive treatment for patients with diabetic COVID-19.
Review
Engineering, Biomedical
Themis R. Kyriakides, Hyun-Je Kim, Christy Zheng, Lauren Harkins, Wanyun Tao, Emily Deschenes
Summary: Implanted biomaterials elicit a foreign body reaction (FBR) involving macrophages and encapsulation with collagenous capsules. Specific macrophage subsets have been linked to different outcomes, and adaptive immunity cells may play a role in the FBR to synthetic polymers, although their exact participation remains unclear. This suggests a complex interplay between innate and adaptive immune cells in response to different types of implants.
BIOMEDICAL MATERIALS
(2022)
Article
Immunology
Hyuk-Kwon Kwon, Christopher M. Dussik, Sang-Hun Kim, Themis R. Kyriakides, Irvin Oh, Francis Y. Lee
Summary: This study proposes a new therapeutic approach for treating bacterial infection within the synovial joint by combining antimicrobial therapy with inflammation mitigation. Through experiments in a murine model, the researchers found that the combination of antibiotics and anti-inflammatory drugs can protect articular cartilage and reduce inflammatory damage.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Hao Xing, Yaqing Huang, Britta H. Kunkemoeller, Peter J. Dahl, Ohvia Muraleetharan, Nikhil S. Malvankar, Michael P. Murrell, Themis R. Kyriakides
Summary: Fibroblasts in diabetes show altered morphology, migration, extracellular matrix production, traction force, 3D contraction, and cell stiffness, which are associated with decreased active Rac1 and lack of co-localization between F-actin and WAVE2. Deletion of thrombospondin-2 rescues these phenotypes and restores normal levels of active Rac1 and WAVE2-F-actin co-localization.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Mohammad Shohel Akhter, Julie Elizabeth Goodwin
Summary: The endothelium plays a crucial role in controlling vascular inflammation and function. The glucocorticoid receptor (GR) in endothelial cells negatively regulates vascular inflammation through the suppression of Wnt signaling. GR also affects fibrosis in various organs by modulating the fatty acid oxidation pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Swayam Prakash Srivastava, Julie E. Goodwin
Summary: This study shows that the absence of endothelial glucocorticoid receptor (GR) leads to accelerated organ fibrosis in a mouse model of diabetes, through upregulation of Wnt signaling. Additionally, the study demonstrates that the fibrosis can be improved with a Wnt inhibitor or metformin. The findings highlight the importance of the synergistic effects of Wnt signaling and inflammation in the pathogenesis of organ fibrosis.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)