Sequentially Targeting Cancer‐Associated Fibroblast and Mitochondria Alleviates Tumor Hypoxia and Inhibits Cancer Metastasis by Preventing “Soil” Formation and “Seed” Dissemination

Remodeling extracellular matrix based on functional covalent organic framework to enhance tumor photodynamic therapy

(2020) Shi-Bo Wang et al.   BIOMATERIALS

Photothermal Depletion of Cancer-Associated Fibroblasts Normalizes Tumor Stiffness in Desmoplastic Cholangiocarcinoma

(2020) Alba Nicolás-Boluda et al.   ACS Nano

Targeting cancer-associated fibroblasts by dual-responsive lipid-albumin nanoparticles to enhance drug perfusion for pancreatic tumor therapy

(2020) Qianwen Yu et al.   JOURNAL OF CONTROLLED RELEASE

Mitochondrial metabolism and cancer metastasis

(2020) Dandan Yu et al.   Annals of Translational Medicine

Prognosis and targeting of pre-metastatic niche

(2020) Yi Zhou et al.   JOURNAL OF CONTROLLED RELEASE

A novel mitochondrial targeted hybrid peptide modified HPMA copolymers for breast cancer metastasis suppression

(2020) Qiuyi Li et al.   JOURNAL OF CONTROLLED RELEASE

Dual Functional Immunostimulatory Polymeric Prodrug Carrier with Pendent Indoximod for Enhanced Cancer Immunochemotherapy

(2019) Zhuoya Wan et al.   Acta Biomaterialia

Sequential Targeting TGF‐β Signaling and KRAS Mutation Increases Therapeutic Efficacy in Pancreatic Cancer

(2019) Yuanyuan Pei et al.   Small

TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis

(2019) Yang Hao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Knockdown of hypoxia-inducible factor-1 alpha by tumor targeted delivery of CRISPR/Cas9 system suppressed the metastasis of pancreatic cancer

(2019) Man Li et al.   JOURNAL OF CONTROLLED RELEASE

Eradication of unresectable liver metastasis through induction of tumour specific energy depletion

(2019) Da Huo et al.   Nature Communications

Reshaping Prostate Tumor Microenvironment To Suppress Metastasis via Cancer-Associated Fibroblast Inactivation with Peptide-Assembly-Based Nanosystem

(2019) Jiayan Lang et al.   ACS Nano

Tumor-Associated Fibroblast-Targeted Regulation and Deep Tumor Delivery of Chemotherapeutic Drugs with a Multifunctional Size-Switchable Nanoparticle

(2019) Xingli Cun et al.   ACS Applied Materials & Interfaces

Integration of immunogenic activation and immunosuppressive reversion using mitochondrial-respiration-inhibited platelet-mimicking nanoparticles

(2019) Xiaoli Mai et al.   BIOMATERIALS

Self-Delivery Micellar Nanoparticles Prevent Premetastatic Niche Formation by Interfering with the Early Recruitment and Vascular Destruction of Granulocytic Myeloid-Derived Suppressor Cells

(2019) Yang Long et al.   NANO LETTERS

Amplification of CD20 Cross-Linking in Rituximab-Resistant B-Lymphoma Cells Enhances Apoptosis Induction by Drug-Free Macromolecular Therapeutics

(2018) Lian Li et al.   ACS Nano

Bioinspired Hybrid Protein Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-tumor Immunity and Abscopal Effect

(2018) Zhikuan Chen et al.   ACS Nano

Oxygen-boosted immunogenic photodynamic therapy with gold nanocages@manganese dioxide to inhibit tumor growth and metastases

(2018) Ruijing Liang et al.   BIOMATERIALS

Inhibition of tumor-promoting stroma to enforce subsequently targeting AT 1 R on tumor cells by pathological inspired micelles

(2018) Yun Zhu et al.   BIOMATERIALS

Pro-apoptotic Bax promotes mesenchymal-epithelial transition by binding to respiratory complex-I and antagonizing the malignant actions of pro-survival Bcl-2 proteins

(2018) Eun Mi Kim et al.   CANCER LETTERS

IL-6 mediates cross-talk between activated fibroblasts and tumor cells in the tumor microenvironment

(2018) Tatiana A Karakasheva et al.   CANCER RESEARCH

Investigation on Physicochemical Characteristics of a Nanoliposome-Based System for Dual Drug Delivery

(2018) Jae Hyun Nam et al.   Nanoscale Research Letters

Fibroblast-derived CXCL12 promotes breast cancer metastasis by facilitating tumor cell intravasation

(2018) Dinesh K. Ahirwar et al.   ONCOGENE

Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer

(2018) Tian Fang et al.   Nature Communications

Investigation on Physicochemical Characteristics of a Nanoliposome-Based System for Dual Drug Delivery

(2018) Jae Hyun Nam et al.   Nanoscale Research Letters

Hypoxia-tropic Protein Nanocages for Modulation of Tumor- and Chemotherapy-Associated Hypoxia

(2018) Xinglu Huang et al.   ACS Nano

Cancer-associated fibroblasts as key regulators of the breast cancer tumor microenvironment

(2018) J. M. Houthuijzen et al.   CANCER AND METASTASIS REVIEWS

Platelet-Derived Growth Factor-D Enables Liver Myofibroblasts to Promote Tumor Lymphangiogenesis in Cholangiocarcinoma

(2018) Massimiliano Cadamuro et al.   JOURNAL OF HEPATOLOGY

Turning foes to friends: targeting cancer-associated fibroblasts

(2018) Xueman Chen et al.   NATURE REVIEWS DRUG DISCOVERY

Overcoming chemotherapy resistance via simultaneous drug-efflux circumvention and mitochondrial targeting

(2018) Minglu Zhou et al.   Acta Pharmaceutica Sinica B

Intratumoral injection of gels containing losartan microspheres and (PLG-g-mPEG)-cisplatin nanoparticles improves drug penetration, retention and anti-tumor activity

(2018) Meiling Yu et al.   CANCER LETTERS

The Binding Site Barrier Elicited by Tumor-Associated Fibroblasts Interferes Disposition of Nanoparticles in Stroma-Vessel Type Tumors

(2016) Lei Miao et al.   ACS Nano

Development of a multi-target peptide for potentiating chemotherapy by modulating tumor microenvironment

(2016) Xu Song et al.   BIOMATERIALS

Pre-Metastatic Niche Formation Has Taken Its TOLL

(2016) Candia M. Kenific et al.   CANCER CELL

An in vitro investigation of a detachable fork-like structure as efficient nuclear-targeted sub-unit in A2780 cell cultures

(2016) Shan Guan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Time-staggered delivery of docetaxel and H1-S6A,F8A peptide for sequential dual-strike chemotherapy through tumor priming and nuclear targeting

(2016) Lian Li et al.   JOURNAL OF CONTROLLED RELEASE

Selective Activation of Anticancer Chemotherapy by Cancer-Associated Fibroblasts in the Tumor Microenvironment

(2016) Mi-Gyeong Kim et al.   JNCI-Journal of the National Cancer Institute

Selective Activation of Anticancer Chemotherapy by Cancer-Associated Fibroblasts in the Tumor Microenvironment

(2016) Mi-Gyeong Kim et al.   JNCI-Journal of the National Cancer Institute

Transformable Peptide Nanocarriers for Expeditious Drug Release and Effective Cancer Therapy via Cancer-Associated Fibroblast Activation

(2015) Tianjiao Ji et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting tumor metastases: Drug delivery mechanisms and technologies

(2015) Vidya Ganapathy et al.   JOURNAL OF CONTROLLED RELEASE

The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

(2015) Thomas R. Cox et al.   NATURE

Doxorubicin-loaded, charge reversible, folate modified HPMA copolymer conjugates for active cancer cell targeting

(2014) Lian Li et al.   BIOMATERIALS

Inorganic nanomaterials for bioimaging, targeted drug delivery and therapeutics

(2014) Ruizheng Liang et al.   CHEMICAL COMMUNICATIONS

Expansion of CD11b+Ly6G+Ly6Cint cells driven by medroxyprogesterone acetate in mice bearing breast tumors restrains NK cell effector functions

(2013) Raúl Germán Spallanzani et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

(2011) C. C.-L. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guanidine-Containing Methacrylamide (Co)polymers via aRAFT: Toward a Cell-Penetrating Peptide Mimic

(2011) Nicolas J. Treat et al.   ACS Macro Letters

Hypoxia and Hypoxia-Inducible Factors: Master Regulators of Metastasis

(2010) X. Lu et al.   CLINICAL CANCER RESEARCH

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

(2009) Janine T. Erler et al.   CANCER CELL