Journal
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
Volume 30, Issue 6, Pages 937-940Publisher
HIGHER EDUCATION PRESS
DOI: 10.1007/s40242-014-4240-6
Keywords
Tetrandrine; Fangchinoline; Derivative; Cytotoxicity
Categories
Funding
- National Natural Science Foundation of China [81360479]
- Ministry of Science and Technology of China [2012CB722601]
- Science and Technology Department of Guizhou Province, China [QKHZYZ[2011] 5085, QKHRZ[2011] 33]
Ask authors/readers for more resources
series of derivatives of tetrandrine and fangchinoline was designed and synthesized to find more active anti-cancer compounds. Their anti-cancer activities were tested against human hepatocellular carcinoma BEL-7402 and PLC/PRF/5 cells, human lung adenocarcinoma A549 cells as well as human leukaemia K562 cells, and the structure-activity relationship(SAR) was also studied. All the compounds except B1 exhibited superior inhibitory activities against PLC/PRF/5 cells with half maximal inhibitory concentration(IC50) values of less than 15 mu mol/L, and compounds A2, A4, B2 and B4 showed IC50 values of less than 9 mu mol/L. Compounds A2, A6, B2 and B4 showed potent anti-cancer activities against all the tested cells with IC50 values of less than 10 mu mol/L. The results show that terandrine and fangchinoline derivatives are potential suppressors to human cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available