Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition

Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity

(2020) Machteld Sillen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Age-Dependent Approach to Search for Genetic Variants Associated with Myocardial Infarction

(2020) G. J. Osmak et al.   MOLECULAR BIOLOGY

Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1

(2019) Katherine A. Vousden et al.   Scientific Reports

Genetic association between plasminogen activator inhibitor‐1 rs1799889 polymorphism and venous thromboembolism: Evidence from a comprehensive meta‐analysis

(2019) Guangbin Huang et al.   CLINICAL CARDIOLOGY

Functional plasminogen activator inhibitor 1 is retained on the activated platelet membrane following platelet activation

(2019) Gael B. Morrow et al.   HAEMATOLOGICA

Molecular mechanism of two nanobodies that inhibit PAI‐1 activity reveals a modulation at distinct stages of the PAI‐1/plasminogen activator interaction

(2019) Machteld Sillen et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Targeting plasminogen activator inhibitor-1 in tetracycline-induced pleural injury in rabbits

(2018) Galina Florova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Identification of novel plasminogen activator inhibitor-1 inhibitors with improved oral bioavailability: Structure optimization of N -acylanthranilic acid derivatives

(2018) Nagahisa Yamaoka et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The roles of PAI-1 gene polymorphisms in atherosclerotic diseases: A systematic review and meta-analysis involving 149,908 subjects

(2018) Yu Liu et al.   GENE

Plasminogen activator inhibitor-1: a risk factor for deep vein thrombosis after total hip arthroplasty

(2018) Ju Tang et al.   Journal of Orthopaedic Surgery and Research

Resolving distinct molecular origins for copper effects on PAI-1

(2017) Joel C. Bucci et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Plasminogen Activator Inhibitor Type-1 as a Regulator of Fibrosis

(2017) Reyhaneh Rabieian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

PAI-1 levels are related to insulin resistance and carotid atherosclerosis in subjects with familial combined hyperlipidemia

(2017) Arturo Carratala et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Imaging analyses of coagulation-dependent initiation of fibrinolysis on activated platelets and its modification by thrombin-activatable fibrinolysis inhibitor

(2017) Tomasz Brzoska et al.   THROMBOSIS AND HAEMOSTASIS

Latency transition of plasminogen activator inhibitor type 1 is evolutionarily conserved

(2017) Agnieszka Jendroszek et al.   THROMBOSIS AND HAEMOSTASIS

Mutation in a highly conserved glycine residue in strand 5B of plasminogen activator inhibitor 1 causes polymerisation

(2017) Kotomi Nagahashi et al.   THROMBOSIS AND HAEMOSTASIS

Pharmacological Targeting of Plasminogen Activator Inhibitor-1 Decreases Vascular Smooth Muscle Cell Migration and Neointima FormationHighlights

(2016) Yan Ji et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance

(2016) P. G. W. Gettins et al.   BIOCHEMICAL JOURNAL

Copper(II) Ions Increase Plasminogen Activator Inhibitor Type 1 Dynamics in Key Structural Regions That Govern Stability

(2016) Joel C. Bucci et al.   BIOCHEMISTRY

Inhibition of Thrombin-Activatable Fibrinolysis Inhibitor and Plasminogen Activator Inhibitor-1 Reduces Ischemic Brain Damage in Mice

(2016) Frederik Denorme et al.   STROKE

Generation and in vitro characterisation of inhibitory nanobodies towards plasminogen activator inhibitor 1

(2016) Xiaohua Zhou et al.   THROMBOSIS AND HAEMOSTASIS

Plasminogen activator inhibitor and the risk of cardiovascular disease: The Framingham Heart Study

(2016) G.H. Tofler et al.   THROMBOSIS RESEARCH

Intracellular Expression of PAI-1 Specific Aptamers Alters Breast Cancer Cell Migration, Invasion and Angiogenesis

(2016) Yolanda M. Fortenberry et al.   PLoS One

Fibrinolysis and the control of blood coagulation

(2015) John C. Chapin et al.   BLOOD REVIEWS

The -844 G>A PAI-1 Polymorphism Is Associated with Acute Coronary Syndrome in Mexican Population

(2015) Ilian Janet García-González et al.   DISEASE MARKERS

Small molecules inhibitors of plasminogen activator inhibitor-1 – An overview

(2015) Anne Rouch et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structure of the Michaelis Complex between Tissue-type Plasminogen Activator and Plasminogen Activators Inhibitor-1

(2015) Lihu Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab

(2015) Giovanna Scapin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distinct encounter complexes of PAI-1 with plasminogen activators and vitronectin revealed by changes in the conformation and dynamics of the reactive center loop

(2015) Tihami Qureshi et al.   PROTEIN SCIENCE

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab

(2015) Giovanna Scapin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Innovative thrombolytic strategy using a heterodimer diabody against TAFI and PAI-1 in mouse models of thrombosis and stroke

(2014) T. Wyseure et al.   BLOOD

Serpin latency transition at atomic resolution

(2014) G. Cazzolli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and function of plasminogen/plasmin system

(2014) R. B. Aisina et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

Inhibition of PAI-1 Antiproteolytic Activity Against tPA by RNA Aptamers

(2014) Jared Damare et al.   Nucleic Acid Therapeutics

Plasmin Promotes Foam Cell Formation by Increasing Macrophage Catabolism of Aggregated Low-Density Lipoprotein

(2013) Abigail S. Haka et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Structural Insight into Inactivation of Plasminogen Activator Inhibitor-1 by a Small-Molecule Antagonist

(2013) Zhonghui Lin et al.   CHEMISTRY & BIOLOGY

Plasminogen activator inhibitor-1 inhibitors: a patent review (2006 – present)

(2013) Yolanda M Fortenberry   EXPERT OPINION ON THERAPEUTIC PATENTS

The obstetric, gynaecological and fertility implications of homozygous PAI-1 deficiency: single-centre experience

(2013) M. Heiman et al.   HAEMOPHILIA

Evaluation of the profibrinolytic properties of a bispecific antibody-based inhibitor against human and mouse thrombin-activatable fibrinolysis inhibitor and plasminogen activator inhibitor-1

(2013) T. Wyseure et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1

(2013) S.-H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three Decades of Research on Plasminogen Activator Inhibitor-1: A Multifaceted Serpin

(2013) Ann Gils et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Hydrogen/Deuterium Exchange Mass Spectrometry Reveals Specific Changes in the Local Flexibility of Plasminogen Activator Inhibitor 1 upon Binding to the Somatomedin B Domain of Vitronectin

(2012) Morten Beck Trelle et al.   BIOCHEMISTRY

A peptide mimicking the C-terminal part of the reactive center loop induces the transition to the latent form of plasminogen activator inhibitor type-1

(2012) Salvino D'Amico et al.   FEBS LETTERS

Characterization of a Small Molecule Inhibitor of Plasminogen Activator Inhibitor Type 1 That Accelerates the Transition into the Latent Conformation

(2012) Ola Fjellström et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Altered Plasminogen Activator Inhibitor-1 Expression on Cardiovascular Disease

(2011) Victoria A. Ploplis   CURRENT DRUG TARGETS

Remarkable extension of PAI-1 half-life surprisingly brings no changes to its structure

(2011) Jerzy Jankun   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Crystal Structure of Plasminogen Activator Inhibitor-1 in an Active Conformation with Normal Thermodynamic Stability

(2011) Jan K. Jensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Recognition of Urokinase-type Plasminogen Activator by Plasminogen Activator Inhibitor-1

(2011) Zhonghui Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelets Retain High Levels of Active Plasminogen Activator Inhibitor 1

(2011) Helén Brogren et al.   PLoS One

Maximal PAI-1 inhibition in vivo requires neutralizing antibodies that recognize and inhibit glycosylated PAI-1

(2011) Britt Van De Craen et al.   THROMBOSIS RESEARCH

The first report of uncontrollable subchorionic and retroplacental haemorrhage inducing preterm labour in complete PAI-1 deficiency in a human

(2011) Takayuki Iwaki et al.   THROMBOSIS RESEARCH

A Case Of Convergence: Why Did a Simple Alternative to Canonical Antibodies Arise in Sharks and Camels?

(2011) Martin F. Flajnik et al.   PLOS BIOLOGY

Two Latent and Two Hyperstable Polymeric Forms of Human Neuroserpin

(2010) Stefano Ricagno et al.   BIOPHYSICAL JOURNAL

Venous thrombosis risk associated with plasma hypofibrinolysis is explained by elevated plasma levels of TAFI and PAI-1

(2010) M. E. Meltzer et al.   BLOOD

Structure–Activity Relationships of New 2-Acylamino-3-thiophenecarboxylic Acid Dimers as Plasminogen Activator Inhibitor-1 Inhibitors

(2010) Nagahisa Yamaoka et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Characterization of a Novel Class of Polyphenolic Inhibitors of Plasminogen Activator Inhibitor-1

(2010) Jacqueline M. Cale et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metals affect the structure and activity of human plasminogen activator inhibitor-1. II. Binding affinity and conformational changes

(2010) Lawrence C. Thompson et al.   PROTEIN SCIENCE

Metals affect the structure and activity of human plasminogen activator inhibitor-1. I. Modulation of stability and protease inhibition

(2010) Lawrence C. Thompson et al.   PROTEIN SCIENCE

Association of PAI-1 4G/5G and -844G/A Gene Polymorphisms and Changes in PAI-1/Tissue Plasminogen Activator Levels in Myocardial Infarction: A Case–Control Study

(2009) Nesrine Abboud et al.   Genetic Testing and Molecular Biomarkers

Antimetastatic Potential of PAI-1–Specific RNA Aptamers

(2009) Charlene M. Blake et al.   OLIGONUCLEOTIDES

Species-dependent molecular drug targets in plasminogen activator inhibitor-1 (PAI-1)

(2009) Lester M. Meissenheimer et al.   THROMBOSIS AND HAEMOSTASIS

Inhibition of Plasminogen Activator Inhibitor-1

(2008) Yuko Izuhara et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The effects of pharmacological PAI-1 inhibition on thrombus formation and neointima formation after arterial injury

(2008) Jun-ichi Suzuki et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A Deletion Mutant of Vitronectin Lacking the Somatomedin B Domain Exhibits Residual Plasminogen Activator Inhibitor-1-binding Activity

(2008) Christine R. Schar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of a Site on PAI-1 That Binds to Vitronectin Outside of the Somatomedin B Domain

(2008) Christine R. Schar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High quality structure of cleaved PAI-1-stab

(2008) M. Dewilde et al.   JOURNAL OF STRUCTURAL BIOLOGY

New insights into the molecular mechanisms of the fibrinolytic system

(2008) D. C. RIJKEN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A Peptide Accelerating the Conversion of Plasminogen Activator Inhibitor-1 to an Inactive Latent State

(2008) L. Mathiasen et al.   MOLECULAR PHARMACOLOGY

Plasminogen mediates the atherogenic effects of macrophage-expressed urokinase and accelerates atherosclerosis in apoE-knockout mice

(2008) M. Kremen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution structure of the stable plasminogen activator inhibitor type-1 variant 14-1B in its proteinase-cleaved form: A new tool for detailed interaction studies and modeling

(2008) Jan K. Jensen et al.   PROTEIN SCIENCE

Heterogeneous glycosylation patterns of human PAI-1 may reveal its cellular origin

(2008) Helén Brogren et al.   THROMBOSIS RESEARCH

Transgenic overexpression of a stable Plasminogen Activator Inhibitor-1 variant

(2008) Abigail T. Fahim et al.   THROMBOSIS RESEARCH

Single-domain antibody fragments with high conformational stability

(2002) Mireille Dumoulin et al.   PROTEIN SCIENCE