Large genome-wide association study identifies three novel risk variants for restless legs syndrome

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

(2019) Richard Karlsson Linnér et al.   NATURE GENETICS

Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci

(2019) Joel Gelernter et al.   BIOLOGICAL PSYCHIATRY

Update on Restless Legs Syndrome: from Mechanisms to Treatment

(2019) Paulina Gonzalez-Latapi et al.   Current Neurology and Neuroscience Reports

RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues

(2019) Keren Yizhak et al.   SCIENCE

DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors

(2019) Thomas Folkmann Hansen et al.   BMJ Open

Contribution of genetics to visceral adiposity and its relation to cardiovascular and metabolic disease

(2019) Torgny Karlsson et al.   NATURE MEDICINE

Longer-term efficiency and safety of increasing the frequency of whole blood donation (INTERVAL): extension study of a randomised trial of 20 757 blood donors

(2019) Stephen Kaptoge et al.   Lancet Haematology

Treatment of restless legs syndrome: Evidence-based review and implications for clinical practice (Revised 2017)§

(2018) Juliane Winkelmann et al.   MOVEMENT DISORDERS

Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors

(2018) Maria Didriksen et al.   SLEEP MEDICINE

Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry

(2018) Loic Yengo et al.   HUMAN MOLECULAR GENETICS

Blood, sweat, and tears: Red Blood Cell-Omics study objectives, design, and recruitment activities

(2018) Stacy M. Endres-Dighe et al.   TRANSFUSION

A direct interaction between two Restless Legs Syndrome predisposing genes: MEIS1 and SKOR1

(2018) Helene Catoire et al.   Scientific Reports

Leveraging Polygenic Functional Enrichment to Improve GWAS Power

(2018) Gleb Kichaev et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Restless Legs Syndrome and Other Movement Disorders of Sleep—Treatment Update

(2018) Aaro V. Salminen et al.   Current Treatment Options in Neurology

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program

(2018) Derek Klarin et al.   NATURE GENETICS

The UK Biobank

(2018) Nicole Rusk   NATURE METHODS

Donor InSight: characteristics and representativeness of a Dutch cohort study on blood and plasma donors

(2018) Tiffany C. Timmer et al.   VOX SANGUINIS

Efficiency and safety of varying the frequency of whole blood donation (INTERVAL): a randomised trial of 45 000 donors

(2017) Emanuele Di Angelantonio et al.   LANCET

Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis

(2017) Barbara Schormair et al.   LANCET NEUROLOGY

Genome-wide association study identifies 112 new loci for body mass index in the Japanese population

(2017) Masato Akiyama et al.   NATURE GENETICS

Prevalence of restless legs syndrome and associated factors in an otherwise healthy population: results from the Danish Blood Donor Study

(2017) Maria Didriksen et al.   SLEEP MEDICINE

Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity

(2016) Anubha Mahajan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Lifestyle Factors and Risk of Restless Legs Syndrome: Prospective Cohort Study

(2016) Salma Batool-Anwar et al.   Journal of Clinical Sleep Medicine

Weighting sequence variants based on their annotation increases power of whole-genome association studies

(2016) Gardar Sveinbjornsson et al.   NATURE GENETICS

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

(2016) Cristian Pattaro et al.   Nature Communications

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

(2015) Bjarni J. Vilhjálmsson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

MAGMA: Generalized Gene-Set Analysis of GWAS Data

(2015) Christiaan A. de Leeuw et al.   PLoS Computational Biology

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Periodic Leg Movements during Sleep Are Associated with Polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD

(2014) Hyatt Moore et al.   SLEEP

Restless legs syndrome/Willis–Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria – history, rationale, description, and significance

(2014) Richard P. Allen et al.   SLEEP MEDICINE

Low brain iron content in idiopathic restless legs syndrome patients detected by phase imaging

(2013) Giovanni Rizzo et al.   MOVEMENT DISORDERS

Restless Legs Syndrome: A Review of Diagnosis and Management in Primary Care

(2013) Richard K. Bogan et al.   POSTGRADUATE MEDICINE

Restless legs syndrome, pica, and iron status in blood donors

(2013) Bryan R. Spencer et al.   TRANSFUSION

Prevalence of restless legs syndrome in female blood donors 1 week after blood donation

(2013) B. Pedrazzini et al.   VOX SANGUINIS

A delicate balance: Iron metabolism and diseases of the brain

(2013) Dominic Hare et al.   Frontiers in Aging Neuroscience

Replication of GWAS-identified neuroblastoma risk loci strengthens the role of BARD1 and affirms the cumulative effect of genetic variations on disease susceptibility

(2012) Mario Capasso et al.   CARCINOGENESIS

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

The transcription factor Uncx4.1 acts in a short window of midbrain dopaminergic neuron differentiation

(2012) Tamara I Rabe et al.   Neural Development

Restless legs syndrome: a comprehensive overview on its epidemiology, risk factors, and treatment

(2011) Paul Yeh et al.   Sleep and Breathing

Association studies of variants in MEIS1, BTBD9, and MAP2K5/SKOR1 with restless legs syndrome in a US population

(2011) Qinbo Yang et al.   SLEEP MEDICINE

The Danish Blood Donor Study: a large, prospective cohort and biobank for medical research

(2011) O. B. Pedersen et al.   VOX SANGUINIS

Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1

(2011) Juliane Winkelmann et al.   PLoS Genetics

Prevalence and disease burden of primary restless legs syndrome: Results of a general population survey in the United States

(2010) Richard P. Allen et al.   MOVEMENT DISORDERS

Integrative genomics identifies LMO1 as a neuroblastoma oncogene

(2010) Kai Wang et al.   NATURE

Replication of restless legs syndrome loci in three European populations

(2009) D Kemlink et al.   JOURNAL OF MEDICAL GENETICS

RLS and blood donation

(2009) Brendan J. Burchell et al.   SLEEP MEDICINE

Physician-diagnosed restless legs syndrome in a large sample of primary medical care patients in western Europe: Prevalence and characteristics

(2009) Richard P. Allen et al.   SLEEP MEDICINE

PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome

(2008) Barbara Schormair et al.   NATURE GENETICS