BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways

Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes

(2019) Li-Ming Gan et al.   Nature Communications

Arsenic trioxide inhibits EMT in hepatocellular carcinoma by promoting lncRNA MEG3 via PKM2

(2019) Zhuoyang Fan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cell-mediated delivery of VEGF modified mRNA enhances blood vessel regeneration and ameliorates murine critical limb ischemia

(2019) Ziyou Yu et al.   JOURNAL OF CONTROLLED RELEASE

Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells

(2019) Marco Maugeri et al.   Nature Communications

Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

(2018) Marianna Yanez Arteta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Immunomodulatory Role of BMP-2 on Macrophages to Accelerate Osteogenesis

(2018) Fei Wei et al.   TISSUE ENGINEERING PART A

An improved, chemically modified RNA encoding BMP-2 enhances osteogenesis in vitro and in vivo

(2018) Wen Zhang et al.   TISSUE ENGINEERING PART A

Biocompatible, Purified VEGF-A mRNA Improves Cardiac Function after Intracardiac Injection 1 Week Post-myocardial Infarction in Swine

(2018) Leif Carlsson et al.   Molecular Therapy-Methods & Clinical Development

VEGF/BMP-2 loaded three-dimensional model for enhanced angiogenic and odontogenic potential of dental pulp stem cells

(2017) H. Aksel et al.   INTERNATIONAL ENDODONTIC JOURNAL

Evaluation of synergistic osteogenesis between icariin and BMP2 through a micro/meso hierarchical porous delivery system

(2017) Qian Wang et al.   International Journal of Nanomedicine

Innovative biodegradable poly(L-lactide)/collagen/hydroxyapatite composite fibrous scaffolds promote osteoblastic proliferation and differentiation

(2017) Guoqiang Zhou et al.   International Journal of Nanomedicine

Comparative study of porous hydroxyapatite/chitosan and whitlockite/chitosan scaffolds for bone regeneration in calvarial defects

(2017) Ding Zhou et al.   International Journal of Nanomedicine

Optimizing combination of vascular endothelial growth factor and mesenchymal stem cells on ectopic bone formation in SCID mice

(2017) Chris H. Dreyer et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Functionalizing titanium surface with PAMAM dendrimer and human BMP2 gene via layer-by-layer assembly for enhanced osteogenesis

(2017) Weizhen Chen et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Local delivery of strontium ranelate promotes regeneration of critical size bone defects filled with collagen sponge

(2017) Bárbara Furtado Masalskas et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Chemically modified RNA induces osteogenesis of stem cells and human tissue explants as well as accelerates bone healing in rats

(2016) Elizabeth R. Balmayor et al.   BIOMATERIALS

Healing of osteoporotic bone defects by baculovirus-engineered bone marrow-derived MSCs expressing MicroRNA sponges

(2016) Kuei-Chang Li et al.   BIOMATERIALS

Cell Proliferation and Cytotoxicity Assays

(2016) Aysun Adan et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair

(2016) Kai Hu et al.   JOURNAL OF CLINICAL INVESTIGATION

Biomimetically Ornamented Rapid Prototyping Fabrication of an Apatite–Collagen–Polycaprolactone Composite Construct with Nano–Micro–Macro Hierarchical Structure for Large Bone Defect Treatment

(2015) Jinbing Wang et al.   ACS Applied Materials & Interfaces

Chemically modified RNA activated matrices enhance bone regeneration

(2015) Satheesh Elangovan et al.   JOURNAL OF CONTROLLED RELEASE

Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals

(2015) Andreas Thess et al.   MOLECULAR THERAPY

The Treatment Efficacy of Bone Tissue Engineering Strategy for Repairing Segmental Bone Defects Under Osteoporotic Conditions

(2015) Zhen Xing Wang et al.   TISSUE ENGINEERING PART A

Osteogenic differentiation of adipose-derived stem cells and calvarial defect repair using baculovirus-mediated co-expression of BMP-2 and miR-148b

(2014) Ya-Hsin Liao et al.   BIOMATERIALS

Complications with the use of bone morphogenetic protein 2 (BMP-2) in spine surgery

(2014) Chadi A. Tannoury et al.   Spine Journal

Synthetic Chemically Modified mRNA (modRNA): Toward a New Technology Platform for Cardiovascular Biology and Medicine

(2014) K. R. Chien et al.   Cold Spring Harbor Perspectives in Medicine

Effect of bioactive borate glass microstructure on bone regeneration, angiogenesis, and hydroxyapatite conversion in a rat calvarial defect model

(2013) Lianxiang Bi et al.   Acta Biomaterialia

Non-viral gene therapy for bone tissue engineering

(2013) Fiona Wegman et al.   Biotechnology & Genetic Engineering Reviews

Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA

(2013) Kathy O Lui et al.   CELL RESEARCH

Role of mesenchymal stem cells in bone regeneration and fracture repair: a review

(2013) Xin Wang et al.   INTERNATIONAL ORTHOPAEDICS

Nonviral gene transfer strategies to promote bone regeneration

(2013) Gun-Il Im   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Cancer Risk After Use of Recombinant Bone Morphogenetic Protein-2 for Spinal Arthrodesis

(2013) Eugene J Carragee et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

(2013) Lior Zangi et al.   NATURE BIOTECHNOLOGY

The potential of human fetal mesenchymal stem cells for off-the-shelf bone tissue engineering application

(2012) Zhi-Yong Zhang et al.   BIOMATERIALS

Evaluation of isolation methods and culture conditions for rat bone marrow mesenchymal stem cells

(2012) Xueyuan Li et al.   CYTOTECHNOLOGY

Increased Erythropoiesis in Mice Injected With Submicrogram Quantities of Pseudouridine-containing mRNA Encoding Erythropoietin

(2012) Katalin Karikó et al.   MOLECULAR THERAPY

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

(2011) Michael S D Kormann et al.   NATURE BIOTECHNOLOGY

A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned

(2011) Eugene J. Carragee et al.   Spine Journal

A Comparative Analysis of the Osteogenic Effects of BMP-2, FGF-2, and VEGFA in a Calvarial Defect Model

(2011) Björn Behr et al.   TISSUE ENGINEERING PART A

Neo-vascularization and bone formation mediated by fetal mesenchymal stem cell tissue-engineered bone grafts in critical-size femoral defects

(2009) Zhi-Yong Zhang et al.   BIOMATERIALS

Recombinant human VEGF165b protein is an effective anti-cancer agent in mice

(2008) Emma S. Rennel et al.   EUROPEAN JOURNAL OF CANCER

Superior Osteogenic Capacity for Bone Tissue Engineering of Fetal Compared with Perinatal and Adult Mesenchymal Stem Cells

(2008) Zhi-Yong Zhang et al.   STEM CELLS