Current Evidence on the Protective Effects of Recombinant Human Erythropoietin and Its Molecular Variants against Pathological Hallmarks of Alzheimer’s Disease

Neuroprotective and Neurestorative Effects of Epo and VEGF: Perspectives for New Therapeutic Approaches to Neurological Diseases

(2020) Mónica E. Ureña-Guerrero et al.   CURRENT PHARMACEUTICAL DESIGN

Adalimumab improves cognitive impairment, exerts neuroprotective effects and attenuates neuroinflammation in an Aβ1-40-injected mouse model of Alzheimer's disease

(2019) JIAE Park et al.   CYTOTHERAPY

Neuroprotective effects of EpoL against oxidative stress induced by soluble oligomers of Aβ peptide

(2019) C. Castillo et al.   Redox Biology

Correlation between abnormal GSK3β, β Amyloid, total Tau, p-Tau 181 levels and neuropsychological assessment total scores in CKD patients with cognitive dysfunction: Impact of rHuEPO therapy

(2019) G. Vinothkumar et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Therapeutic impact of rHuEPO on abnormal platelet APP, BACE 1, presenilin 1, ADAM 10 and Aβ expressions in chronic kidney disease patients with cognitive dysfunction like Alzheimer’s disease: A pilot study

(2018) Vinothkumar G. et al.   BIOMEDICINE & PHARMACOTHERAPY

The technical reliability and biotemporal stability of cerebrospinal fluid biomarkers for profiling multiple pathophysiologies in Alzheimer’s disease

(2018) Bianca A. Trombetta et al.   PLoS One

Neuroprotective effect of a new variant of Epo nonhematopoietic against oxidative stress

(2018) C. Castillo et al.   Redox Biology

Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems

(2018) Varunvenkatesh Balaji et al.   Autophagy

Streptozotocin-Induced Sporadic Alzheimer's Disease: Selection of Appropriate Dose

(2018) Jogender Mehla et al.   JOURNAL OF ALZHEIMERS DISEASE

NeuroEPO Preserves Neurons from Glutamate-Induced Excitotoxicity

(2018) Fernando Garzón et al.   JOURNAL OF ALZHEIMERS DISEASE

A Brain Penetrating Bifunctional Erythropoietin-Transferrin Receptor Antibody Fusion Protein for Alzheimer’s Disease

(2018) Rudy Chang et al.   MOLECULAR PHARMACEUTICS

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Effect of erythropoietin combined with hypothermia on serum tau protein levels and neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy

(2017) Lian-xiang Li et al.   Neural Regeneration Research

Neuroprotective effects of erythropoietin on Alzheimer’s dementia model in rats

(2017) Betul Cevik et al.   Advances in Clinical and Experimental Medicine

Calcium and Mitochondrial Reactive Oxygen Species Generation: How to Read the Facts

(2017) Vera Adam-Vizi et al.   JOURNAL OF ALZHEIMERS DISEASE

An Intranasal Formulation of Erythropoietin (Neuro-EPO) Prevents Memory Deficits and Amyloid Toxicity in the APPSwe Transgenic Mouse Model of Alzheimer’s Disease

(2016) Yamila Rodríguez Cruz et al.   JOURNAL OF ALZHEIMERS DISEASE

ATP leakage induces P2XR activation and contributes to acute synaptic excitotoxicity induced by soluble oligomers of β-amyloid peptide in hippocampal neurons

(2016) F. Sáez-Orellana et al.   NEUROPHARMACOLOGY

EPO induces changes in synaptic transmission and plasticity in the dentate gyrus of rats

(2016) William Almaguer-Melian et al.   SYNAPSE

Pharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosis

(2016) Izhar Livne-Bar et al.   Cell Death & Disease

Inflammatory Cytokines and Alzheimer’s Disease: A Review from the Perspective of Genetic Polymorphisms

(2016) Fan Su et al.   Neuroscience Bulletin

Aβ Induces Excitotoxicity Mediated by APC/C-Cdh1 Depletion That Can Be Prevented by Glutaminase Inhibition Promoting Neuronal Survival

(2016) T. Fuchsberger et al.   Scientific Reports

Mechanisms of Neuronal Protection against Excitotoxicity, Endoplasmic Reticulum Stress, and Mitochondrial Dysfunction in Stroke and Neurodegenerative Diseases

(2015) Howard Prentice et al.   Oxidative Medicine and Cellular Longevity

A review on Alzheimer's disease pathophysiology and its management: an update

(2015) Anil Kumar et al.   Pharmacological Reports

On the antioxidant properties of erythropoietin and its association with the oxidative-nitrosative stress response to hypoxia in humans

(2014) D. M. Bailey et al.   Acta Physiologica

JAK2/STAT5/Bcl-xL signalling is essential for erythropoietin-mediated protection against apoptosis induced in PC12 cells by the amyloid β−peptide Aβ25-35

(2014) Rong Ma et al.   BRITISH JOURNAL OF PHARMACOLOGY

High-dose erythropoietin for tissue protection

(2014) Anton Lund et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis

(2014) Urte Neniskyte et al.   FEBS LETTERS

Recombinant Human Erythropoietin to Target Cognitive Dysfunction in Bipolar Disorder

(2014) Kamilla W. Miskowiak et al.   JOURNAL OF CLINICAL PSYCHIATRY

Erythropoietin modulates the immune-inflammatory response of a SOD1G93A transgenic mouse model of amyotrophic lateral sclerosis (ALS)

(2014) Min Young Noh et al.   NEUROSCIENCE LETTERS

Biomarker-Driven Therapeutic Management of Alzheimer’s Disease: Establishing the Foundations

(2013) J Cummings et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Erythropoietin: A Neuroprotective Agent in Cerebral Hypoxia, Neurodegeneration, and Epilepsy

(2013) Amalia Merelli et al.   CURRENT PHARMACEUTICAL DESIGN

Intranasal formulation of erythropoietin (EPO) showed potent protective activity against amyloid toxicity in the Aβ25-35 non-transgenic mouse model of Alzheimer’s disease

(2013) Tangui Maurice et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Inhibition of amyloid beta-induced synaptotoxicity by a pentapeptide derived from the glycine zipper region of the neurotoxic peptide

(2013) Christian Peters et al.   NEUROBIOLOGY OF AGING

Nature of the neurotoxic membrane actions of amyloid-β on hippocampal neurons in Alzheimer's disease

(2013) Fernando J. Sepúlveda et al.   NEUROBIOLOGY OF AGING

Erythropoietin prevents cognitive impairment and oxidative parameters in Wistar rats subjected to pneumococcal meningitis

(2013) Tatiana Barichello et al.   Translational Research

What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer’s disease, about the therapeutic strategies in Alzheimer’s research

(2012) Melita Salkovic-Petrisic et al.   JOURNAL OF NEURAL TRANSMISSION

Erythropoietin: still on the neuroprotection road

(2012) Nelvys Subirós et al.   Therapeutic Advances in Neurological Disorders

Erythropoietin prevents PC12 cells from beta-amyloid-induced apoptosis via PI3K⁄Akt pathway

(2012) Sun Zhi-Kun et al.   Translational Neurodegeneration

Ablation of TNF-RI/RII Expression in Alzheimer's Disease Mice Leads to an Unexpected Enhancement of Pathology

(2011) Sara L. Montgomery et al.   AMERICAN JOURNAL OF PATHOLOGY

Identification of peripheral inflammatory markers between normal control and Alzheimer's disease

(2011) Sam-Moon Kim et al.   BMC Neurology

Tetrandrine suppresses amyloid-β-induced inflammatory cytokines by inhibiting NF-κB pathway in murine BV2 microglial cells

(2011) Fu Qian He et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Erythropoietin improves memory function with reducing endothelial dysfunction and amyloid-beta burden in Alzheimer’s disease models

(2011) Soon-Tae Lee et al.   JOURNAL OF NEUROCHEMISTRY

Tumor Necrosis Factor-alpha and the Roles it Plays in Homeostatic and Degenerative Processes Within the Central Nervous System

(2011) Sara L. Montgomery et al.   Journal of Neuroimmune Pharmacology

CC Chemokine Receptor 2 Deficiency Aggravates Cognitive Impairments and Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease

(2011) G. Naert et al.   JOURNAL OF NEUROSCIENCE

The Nasal Route as a Potential Pathway for Delivery of Erythropoietin in the Treatment of Acute Ischemic Stroke in Humans

(2011) Julio Cesar García-Rodríguez et al.   TheScientificWorldJOURNAL

Treatment with Nasal Neuro-EPO Improves the Neurological, Cognitive, and Histological State in a Gerbil Model of Focal Ischemia

(2011) Yamila Rodríguez Cruz et al.   TheScientificWorldJOURNAL

Anti-TNF-α reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains

(2010) Jian-Quan Shi et al.   BRAIN RESEARCH

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

Effects of Erythropoietin on Memory Deficits and Brain Oxidative Stress in the Mouse Models of Dementia

(2010) Rohit Kumar et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Let’’s try erythropoietin in Alzheimer’s disease

(2010) Amirhossein Modabbernia et al.   MEDICAL HYPOTHESES

Erythropoietin promotes hippocampal neurogenesis in in vitro models of neonatal stroke

(2010) Damjan Osredkar et al.   NEUROBIOLOGY OF DISEASE

New Strategies for Alzheimer Disease and Cognitive Impairment

(2010) Kenneth Maiese et al.   Oxidative Medicine and Cellular Longevity

Erythropoietin 2nd cerebral protection after acute injuries: A double-edged sword?

(2010) L. Velly et al.   PHARMACOLOGY & THERAPEUTICS

Synaptotoxicity of Alzheimer Beta Amyloid Can Be Explained by Its Membrane Perforating Property

(2010) Fernando J. Sepulveda et al.   PLoS One

Transmembrane TNF- : structure, function and interaction with anti-TNF agents

(2010) T. Horiuchi et al.   RHEUMATOLOGY

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

(2009) Xiao-xia Dong et al.   ACTA PHARMACOLOGICA SINICA

Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects

(2009) Leslie M. Shaw et al.   ANNALS OF NEUROLOGY

Effects of Pycnogenol and vitamin E on cognitive deficits and oxidative damage induced by intracerebroventricular streptozotocin in rats

(2009) Tauheed Ishrat et al.   BEHAVIOURAL PHARMACOLOGY

Mitochondrial calcium function and dysfunction in the central nervous system

(2009) David G. Nicholls   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The Forkhead Transcription Factor FOXO3a Controls Microglial Inflammatory Activation and Eventual Apoptotic Injury through Caspase 3

(2009) Yan Shang et al.   CURRENT NEUROVASCULAR RESEARCH

Accumulation of Aspartic Acid421- and Glutamic Acid391-Cleaved Tau in Neurofibrillary Tangles Correlates With Progression in Alzheimer Disease

(2009) Gustavo Basurto-Islas et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Erythropoietin protects PC12 cells from β-amyloid25–35-induced apoptosis via PI3K/Akt signaling pathway

(2009) Rong Ma et al.   NEUROPHARMACOLOGY

Effects of treadmill running on spatial learning and memory in streptozotocin-induced diabetic rats

(2009) Parham Reisi et al.   NEUROSCIENCE LETTERS

Erythropoietin modulation of astrocyte water permeability as a component of neuroprotection

(2009) E. Gunnarson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity

(2009) R. I. Stanika et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of erythropoietin on emotional processing biases in patients with major depression: an exploratory fMRI study

(2009) Kamilla W. Miskowiak et al.   PSYCHOPHARMACOLOGY

The Erythropoietin NeuroProtective Effect: Assessment in CABG Surgery (TENPEAKS)

(2009) Gregory Haljan et al.   STROKE

Recombinant Human Erythropoietin in the Treatment of Acute Ischemic Stroke

(2009) Hannelore Ehrenreich et al.   STROKE

Erythropoietin reduces lipopolysaccharide-induced cell Damage and midkine secretion in U937 human histiocytic lymphoma cells

(2008) Nuray Yazihan et al.   ADVANCES IN THERAPY

Chronic Neuron-Specific Tumor Necrosis Factor-Alpha Expression Enhances the Local Inflammatory Environment Ultimately Leading to Neuronal Death in 3xTg-AD Mice

(2008) Michelle C. Janelsins et al.   AMERICAN JOURNAL OF PATHOLOGY

Erythropoietin enhances hippocampal long-term potentiation and memory

(2008) Bartosz Adamcio et al.   BMC BIOLOGY

Oxidative Stress Signaling in Alzheimers Disease

(2008) B. Su et al.   Current Alzheimer Research

TNF-alpha-induced apoptosis is prevented by erythropoietin treatment on SH-SY5Y cells

(2008) Nicolás Pregi et al.   EXPERIMENTAL CELL RESEARCH

Protective effects of erythropoietin on tau phosphorylation induced by β-amyloid

(2008) Zhi-kun Sun et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Recombinant human erythropoietin increases survival and reduces neuronal apoptosis in a murine model of cerebral malaria

(2008) Lothar Wiese et al.   MALARIA JOURNAL

Protective effect of erythropoietin on β-amyloid-induced PC12 cell death through antioxidant mechanisms

(2008) Gang Li et al.   NEUROSCIENCE LETTERS

Combination of deferoxamine and erythropoietin: Therapy for hypoxia–ischemia-induced brain injury in the neonatal rat?

(2008) Michael A. van der Kooij et al.   NEUROSCIENCE LETTERS

Erythropoietin and its carbamylated derivative prevent the development of experimental diabetic autonomic neuropathy in STZ-induced diabetic NOD-SCID mice

(2007) Robert E. Schmidt et al.   EXPERIMENTAL NEUROLOGY

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

(2007) Fernanda G. De Felice et al.   NEUROBIOLOGY OF AGING