COVID-19—The Potential Beneficial Therapeutic Effects of Spironolactone during SARS-CoV-2 Infection

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

COVID-19, ACE2, and the cardiovascular consequences

(2020) Andrew M. South et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

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What does androgenetic alopecia have to do with COVID-19? An insight into a potential new therapy

(2020) Andy Goren et al.   Dermatologic Therapy

Androgenetic Alopecia Present in the Majority of Hospitalized COVID-19 Patients – the “Gabrin sign”

(2020) Carlos Gustavo Wambier et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Excess mortality in men and women in Massachusetts during the COVID-19 pandemic

(2020) Nancy Krieger et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

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COVID-19: consider cytokine storm syndromes and immunosuppression

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Controversies of renin–angiotensin system inhibition during the COVID-19 pandemic

(2020) Andrew M. South et al.   Nature Reviews Nephrology

A preliminary observation: Male pattern hair loss among hospitalized COVID‐19 patients in Spain – A potential clue to the role of androgens in COVID‐19 severity

(2020) Andy Goren et al.   Journal of Cosmetic Dermatology

Racial Variations in COVID‐19 Deaths May Be Due to Androgen Receptor Genetic Variants Associated with Prostate Cancer and Androgenetic Alopecia. Are Anti‐Androgens a Potential Treatment for COVID‐19?

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Gender Differences in Patients With COVID-19: Focus on Severity and Mortality

(2020) Jian-Min Jin et al.   Frontiers in Public Health

Mineralocorticoid Receptors

(2020) Achim Lother   CIRCULATION RESEARCH

The pivotal role of TMPRSS2 in coronavirus disease 2019 and prostate cancer

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SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications

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Severe obesity, increasing age and male sex are independently associated with worse in-hospital outcomes, and higher in-hospital mortality, in a cohort of patients with COVID-19 in the Bronx, New York

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Global, regional, and national estimates of the population at increased risk of severe COVID-19 due to underlying health conditions in 2020: a modelling study

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COVID-19: The Potential Treatment of Pulmonary Fibrosis Associated with SARS-CoV-2 Infection

(2020) Kacper Lechowicz et al.   Journal of Clinical Medicine

Spironolactone: An Anti-androgenic and Anti-hypertensive Drug That May Provide Protection Against the Novel Coronavirus (SARS-CoV-2) Induced Acute Respiratory Distress Syndrome (ARDS) in COVID-19

(2020) Flavio A. Cadegiani et al.   Frontiers in Medicine

A novel treatment for skin repair using a combination of spironolactone and vitamin D3

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Spironolactone may provide protection from SARS-CoV-2: Targeting androgens, angiotensin converting enzyme 2 (ACE2), and renin-angiotensin-aldosterone system (RAAS)

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Cytokine profile and disease severity in patients with COVID-19

(2020) Ali Ghazavi et al.   CYTOKINE

Spironolactone inhibits endothelial-mesenchymal transition via the adenosine A2A receptor to reduce cardiorenal fibrosis in rats

(2019) Xingxing Chen et al.   LIFE SCIENCES

Spironolactone inhibits the growth of cancer stem cells by impairing DNA damage response

(2019) Ayala Gold et al.   ONCOGENE

The renin‐angiotensin‐aldosterone system and its suppression

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Flaviviridae Viruses and Oxidative Stress: Implications for Viral Pathogenesis

(2019) Zhenzhen Zhang et al.   Oxidative Medicine and Cellular Longevity

Impact of spironolactone on markers of myocardial oxidative status, inflammation and remodeling in hyperthyroid rats.

(2019) Fadia A Mayyas et al.   Current Molecular Pharmacology

Myocardial Effects of Aldosterone Antagonism in Heart Failure With Preserved Ejection Fraction

(2019) Adam K. McDiarmid et al.   Journal of the American Heart Association

2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure

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Implications of oxidative stress on viral pathogenesis

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Wytyczne ESC dotyczące diagnostyki i leczenia ostrej i przewlekłej niewydolności serca w 2016 roku

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Spirolactone provides protection from renal fibrosis by inhibiting the endothelial–mesenchymal transition in isoprenaline-induced heart failure in rats

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Spironolactone for Heart Failure with Preserved Ejection Fraction

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Mineralocorticoid receptor in adipocytes and macrophages: A promising target to fight metabolic syndrome

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Role of the endothelial-to-mesenchymal transition in renal fibrosis of chronic kidney disease

(2013) Jianhua He et al.   Clinical and Experimental Nephrology

Mineralocorticoid receptor antagonists attenuate pulmonary inflammation and bleomycin-evoked fibrosis in rodent models

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2013 ESH/ESC Guidelines for the management of arterial hypertension

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Androgen Regulation of the TMPRSS2 Gene and the Effect of a SNP in an Androgen Response Element

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Spironolactone Attenuates Bleomycin-Induced Pulmonary Injury Partially via Modulating Mononuclear Phagocyte Phenotype Switching in Circulating and Alveolar Compartments

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Mineralocorticoid receptor antagonists for heart failure with reduced ejection fraction: integrating evidence into clinical practice

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Methylene Blue Protects Liver Oxidative Capacity after Gut Ischaemia–Reperfusion in the Rat

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Aldosterone Promotes Autoimmune Damage by Enhancing Th17-Mediated Immunity

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Androgen receptor and androgen-dependent gene expression in lung

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Effects of spironolactone on human blood mononuclear cells: mineralocorticoid receptor independent effects on gene expression and late apoptosis induction

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