Spironolactone inhibits the growth of cancer stem cells by impairing DNA damage response

Spironolactone and the risk of urinary tract cancer in patients with hypertension

(2017) Ya-Wen Chuang et al.   JOURNAL OF HYPERTENSION

Cancer stem cells: The root of tumor recurrence and metastases

(2017) Claudia Peitzsch et al.   SEMINARS IN CANCER BIOLOGY

Novel approach to target cancer stem cells for therapy

(2016) Ajumeera Rajanna   MEDICAL HYPOTHESES

Balancing efficacy of and host immune responses to cancer therapy: the yin and yang effects

(2016) Yuval Shaked   Nature Reviews Clinical Oncology

DNA repair targeted therapy: The past or future of cancer treatment?

(2016) Navnath S. Gavande et al.   PHARMACOLOGY & THERAPEUTICS

The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity

(2016) C. M. Torres et al.   SCIENCE

Increased global transcription activity as a mechanism of replication stress in cancer

(2016) Panagiotis Kotsantis et al.   Nature Communications

Cancer stem cells: a metastasizing menace!

(2016) Saurabh Bandhavkar   Cancer Medicine

Mineralocorticoid receptors are present in skeletal muscle and represent a potential therapeutic target

(2015) Jessica A. Chadwick et al.   FASEB JOURNAL

Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition

(2015) Lynnette R. Ferguson et al.   SEMINARS IN CANCER BIOLOGY

Mammary Stem Cells and Tumor-Initiating Cells Are More Resistant to Apoptosis and Exhibit Increased DNA Repair Activity in Response to DNA Damage

(2015) Chi-Hsuan Chang et al.   Stem Cell Reports

A Small Molecule Screen Identifies an Inhibitor of DNA Repair Inducing the Degradation of TFIIH and the Chemosensitization of Tumor Cells to Platinum

(2014) Sergey Alekseev et al.   CHEMISTRY & BIOLOGY

A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair

(2014) Or David Shahar et al.   NUCLEIC ACIDS RESEARCH

DNA-Damaging Agents in Cancer Chemotherapy: Serendipity and Chemical Biology

(2013) Kahlin Cheung-Ong et al.   CHEMISTRY & BIOLOGY

Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRγ activation

(2013) Wai-Hang Leung et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of G2/M arrest, caspase activation and apoptosis by α-santonin derivatives in HL-60 cells

(2013) José Roberto Oliveira Ferreira et al.   TOXICOLOGY IN VITRO

Quiescence and attenuated DNA damage response promote survival of esophageal cancer stem cells

(2012) Yulin Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

In vitro generation of human cells with cancer stem cell properties

(2011) Paola Scaffidi et al.   NATURE CELL BIOLOGY

Differentiation Therapy Exerts Antitumor Effects on Stem-like Glioma Cells

(2010) B. Campos et al.   CLINICAL CANCER RESEARCH

A Comparison of the Aldosterone-blocking Agents Eplerenone and Spironolactone

(2008) Allan Struthers et al.   CLINICAL CARDIOLOGY