Germ Granules Allow Transmission of Small RNA-Based Parental Responses in the “Germ Plasm”

Small-RNA-mediated transgenerational silencing of histone genes impairs fertility in piRNA mutants

(2020) Giorgia Barucci et al.   NATURE CELL BIOLOGY

poly(UG)-tailed RNAs in genome protection and epigenetic inheritance

(2020) Aditi Shukla et al.   NATURE

RNAi pathways repress reprogramming of C. elegans germ cells during heat stress

(2020) Alicia K Rogers et al.   NUCLEIC ACIDS RESEARCH

Natural cryptic variation in epigenetic modulation of an embryonic gene regulatory network

(2020) Chee Kiang Ewe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans

(2020) Kevin I Manage et al.   eLife

Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans

(2020) Leah Houri-Zeevi et al.   CELL

DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans

(2020) Kin Man Suen et al.   Nature Communications

A Small-RNA-Mediated Feedback Loop Maintains Proper Levels of 22G-RNAs in C. elegans

(2020) Alicia K. Rogers et al.   Cell Reports

Maternal and zygotic gene regulatory effects of endogenous RNAi pathways

(2019) Miguel Vasconcelos Almeida et al.   PLoS Genetics

A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos

(2019) Andrea Putnam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis

(2019) Junzhong Liu et al.   CELL RESEARCH

Environmentally-induced epigenetic conversion of a piRNA cluster

(2019) Karine Casier et al.   eLife

H3K9me3 is required for inheritance of small RNAs that target a unique subset of newly evolved genes

(2019) Itamar Lev et al.   eLife

Piwi/PRG-1 Argonaute and TGF-β Mediate Transgenerational Learned Pathogenic Avoidance

(2019) Rebecca S. Moore et al.   CELL

Neuronal Small RNAs Control Behavior Transgenerationally

(2019) Rachel Posner et al.   CELL

Germ Granules Govern Small RNA Inheritance

(2019) Itamar Lev et al.   CURRENT BIOLOGY

Germ Granules Coordinate RNA-Based Epigenetic Inheritance Pathways

(2019) Anne E. Dodson et al.   DEVELOPMENTAL CELL

P Granules Protect RNA Interference Genes from Silencing by piRNAs

(2019) John Paul T. Ouyang et al.   DEVELOPMENTAL CELL

ZNFX-1 Functions within Perinuclear Nuage to Balance Epigenetic Signals

(2018) Takao Ishidate et al.   MOLECULAR CELL

Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs

(2018) Yunfang Zhang et al.   NATURE CELL BIOLOGY

A Cytoplasmic Argonaute Protein Promotes the Inheritance of RNAi

(2018) Fei Xu et al.   Cell Reports

The piRNA pathway responds to environmental signals to establish intergenerational adaptation to stress

(2018) Tony Belicard et al.   BMC BIOLOGY

The P Granules of C. elegans: A Genetic Model for the Study of RNA–Protein Condensates

(2018) Geraldine Seydoux   JOURNAL OF MOLECULAR BIOLOGY

Spatiotemporal regulation of liquid-like condensates in epigenetic inheritance

(2018) Gang Wan et al.   NATURE

Distinct regions of the intrinsically disordered protein MUT-16 mediate assembly of a small RNA amplification complex and promote phase separation of Mutator foci

(2018) Celja J. Uebel et al.   PLoS Genetics

Intergenerational and transgenerational epigenetic inheritance in animals

(2018) Marcos Francisco Perez et al.   NATURE CELL BIOLOGY

C. elegans Heterochromatin Factor SET-32 Plays an Essential Role in Transgenerational Establishment of Nuclear RNAi-Mediated Epigenetic Silencing

(2018) Natallia Kalinava et al.   Cell Reports

Germ Granules Prevent Accumulation of Somatic Transcripts in the AdultCaenorhabditis elegansGermline

(2017) Andrew Kekūpa’a Knutson et al.   GENETICS

ALG-5 is a miRNA-associated Argonaute required for proper developmental timing in the Caenorhabditis elegans germline

(2017) Kristen C. Brown et al.   NUCLEIC ACIDS RESEARCH

Transgenerational transmission of environmental information in C. elegans

(2017) Adam Klosin et al.   SCIENCE

Transgenerational Diapause as an Avoidance Strategy against Bacterial Pathogens in Caenorhabditis elegans

(2017) M. Fernanda Palominos et al.   mBio

Decoupling the downstream effects of germline nuclear RNAi reveals that H3K9me3 is dispensable for heritable RNAi and the maintenance of endogenous siRNA-mediated transcriptional silencing in Caenorhabditis elegans

(2017) Natallia Kalinava et al.   Epigenetics & Chromatin

Germ Granules Prevent Accumulation of Somatic Transcripts in the AdultCaenorhabditis elegansGermline

(2017) Andrew Kekūpa’a Knutson et al.   GENETICS

A Tunable Mechanism Determines the Duration of the Transgenerational Small RNA Inheritance in C. elegans

(2016) Leah Houri-Ze’evi et al.   CELL

A transgenerational role of the germline nuclear RNAi pathway in repressing heat stress-induced transcriptional activation in C. elegans

(2016) Julie Zhouli Ni et al.   Epigenetics & Chromatin

A Stress-Activated Transposon in Arabidopsis Induces Transgenerational Abscisic Acid Insensitivity

(2016) Hidetaka Ito et al.   Scientific Reports

A Ribonuclease Coordinates siRNA Amplification and mRNA Cleavage during RNAi

(2015) Hsin-Yue Tsai et al.   CELL

The Nrde Pathway Mediates Small-RNA-Directed Histone H3 Lysine 27 Trimethylation in Caenorhabditis elegans

(2015) Hui Mao et al.   CURRENT BIOLOGY

CSR-1 and P granules suppress sperm-specific transcription in the C. elegans germline

(2015) A. C. Campbell et al.   DEVELOPMENT

Maternal piRNAs Are Essential for Germline Development following De Novo Establishment of Endo-siRNAs in Caenorhabditis elegans

(2015) Bruno F.M. de Albuquerque et al.   DEVELOPMENTAL CELL

piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi Pathway

(2015) Carolyn M. Phillips et al.   DEVELOPMENTAL CELL

Paramutation in Drosophila Requires Both Nuclear and Cytoplasmic Actors of the piRNA Pathway and Induces Cis-spreading of piRNA Production

(2015) C. Hermant et al.   GENETICS

Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress

(2015) Ali B. Rodgers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

(2015) Q. Chen et al.   SCIENCE

Natural RNA interference directs a heritable response to the environment

(2015) Daniel Schott et al.   Scientific Reports

RNA-mediated paternal heredity of diet-induced obesity and metabolic disorders

(2015) Valérie Grandjean et al.   Scientific Reports

Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans

(2014) Oded Rechavi et al.   CELL

Germ-Granule Components Prevent Somatic Development in the C. elegans Germline

(2014) Dustin L. Updike et al.   CURRENT BIOLOGY

The Vasa Homolog RDE-12 Engages Target mRNA and Multiple Argonaute Proteins to Promote RNAi in C. elegans

(2014) Masaki Shirayama et al.   CURRENT BIOLOGY

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

(2014) Katharina Gapp et al.   NATURE NEUROSCIENCE

Reduced Insulin/IGF-1 Signaling Restores Germ Cell Immortality to Caenorhabditis elegans Piwi Mutants

(2014) Matt Simon et al.   Cell Reports

Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans

(2014) Jennifer T Wang et al.   eLife

Argonautes Promote Male Fertility and Provide a Paternal Memory of Germline Gene Expression in C. elegans

(2013) Colin C. Conine et al.   CELL

Warm temperatures induce transgenerational epigenetic release of RNA silencing by inhibiting siRNA biogenesis in Arabidopsis

(2013) S.-H. Zhong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans

(2012) Alyson Ashe et al.   CELL

piRNAs Initiate an Epigenetic Memory of Nonself RNA in the C. elegans Germline

(2012) Masaki Shirayama et al.   CELL

Protection from Feed-Forward Amplification in an Amplified RNAi Mechanism

(2012) Julia Pak et al.   CELL

The Caenorhabditis elegans RDE-10/RDE-11 Complex Regulates RNAi by Promoting Secondary siRNA Amplification

(2012) Chi Zhang et al.   CURRENT BIOLOGY

Extremely stable Piwi-induced gene silencing inCaenorhabditis elegans

(2012) Maartje J Luteijn et al.   EMBO JOURNAL

MUT-16 promotes formation of perinuclear Mutator foci required for RNA silencing in the C. elegans germline

(2012) C. M. Phillips et al.   GENES & DEVELOPMENT

The RDE-10/RDE-11 complex triggers RNAi-induced mRNA degradation by association with target mRNA in C. elegans

(2012) H. Yang et al.   GENES & DEVELOPMENT

A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality

(2012) Bethany A. Buckley et al.   NATURE

Transgenerational Inheritance of an Acquired Small RNA-Based Antiviral Response in C. elegans

(2011) Oded Rechavi et al.   CELL

P granules extend the nuclear pore complex environment in theC. elegansgerm line

(2011) Dustin L. Updike et al.   JOURNAL OF CELL BIOLOGY

PGL proteins self associate and bind RNPs to mediate germ granule assembly inC. elegans

(2011) Momoyo Hanazawa et al.   JOURNAL OF CELL BIOLOGY

An siRNA pathway prevents transgenerational retrotransposition in plants subjected to stress

(2011) Hidetaka Ito et al.   NATURE

Nuclear RNAi maintains heritable gene silencing in Caenorhabditis elegans

(2011) N. O. Burton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perinuclear P granules are the principal sites of mRNA export in adult C. elegans germ cells

(2010) U. Sheth et al.   DEVELOPMENT

C. elegans Dicer interacts with the P-granule component GLH-1 and both regulate germline RNPs

(2010) Erica L. Beshore et al.   DEVELOPMENTAL BIOLOGY

Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans

(2010) Colin C. Conine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway

(2010) Jessica J. Vasale et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dicer's helicase domain is required for accumulation of some, but not all, C. elegans endogenous siRNAs

(2010) N. C. Welker et al.   RNA

Cytoplasmic Partitioning of P Granule Components Is Not Required to Specify the Germline in C. elegans

(2010) C. M. Gallo et al.   SCIENCE

The Argonaute CSR-1 and Its 22G-RNA Cofactors Are Required for Holocentric Chromosome Segregation

(2009) Julie M. Claycomb et al.   CELL

CDE-1 Affects Chromosome Segregation through Uridylation of CSR-1-Bound siRNAs

(2009) Josien C. van Wolfswinkel et al.   CELL

A Genomewide RNAi Screen for Genes That Affect the Stability, Distribution and Function of P Granules in Caenorhabditis elegans

(2009) Dustin L. Updike et al.   GENETICS

Requirement for the ERI/DICER Complex in Endogenous RNA Interference and Sperm Development in Caenorhabditis elegans

(2009) Derek M. Pavelec et al.   GENETICS

Distinct Argonaute-Mediated 22G-RNA Pathways Direct Genome Surveillance in the C. elegans Germline

(2009) Weifeng Gu et al.   MOLECULAR CELL

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

A C. elegans Piwi, PRG-1, Regulates 21U-RNAs during Spermatogenesis

(2008) Guilin Wang et al.   CURRENT BIOLOGY

DEPS-1 promotes P-granule assembly and RNA interference in C. elegans germ cells

(2008) C. A. Spike et al.   DEVELOPMENT

Genetic Analysis of the Caenorhabditis elegans GLH Family of P-Granule Proteins

(2008) C. Spike et al.   GENETICS

Transmission Dynamics of Heritable Silencing Induced by Double-Stranded RNA in Caenorhabditis elegans

(2008) Rosa M. Alcazar et al.   GENETICS

PRG-1 and 21U-RNAs Interact to Form the piRNA Complex Required for Fertility in C. elegans

(2008) Pedro J. Batista et al.   MOLECULAR CELL