PPARγ increases HUWE1 to attenuate NF-κB/p65 and sickle cell disease with pulmonary hypertension

Redox Biology of Peroxisome Proliferator-Activated Receptor-γ in Pulmonary Hypertension

(2018) Victor Tseng et al.   ANTIOXIDANTS & REDOX SIGNALING

An overview of the 6th World Symposium on Pulmonary Hypertension

(2018) Nazzareno Galiè et al.   EUROPEAN RESPIRATORY JOURNAL

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

(2018) Gérald Simonneau et al.   EUROPEAN RESPIRATORY JOURNAL

Hypertension-Causing Mutation in Peroxisome Proliferator–Activated Receptor γ Impairs Nuclear Export of Nuclear Factor-κB p65 in Vascular Smooth MuscleNovelty and Significance

(2017) Masashi Mukohda et al.   HYPERTENSION

Peroxisome Proliferator–Activated Receptor γ and microRNA 98 in Hypoxia-Induced Endothelin-1 Signaling

(2016) Bum-Yong Kang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

miR-98 and its host gene Huwe1 target Caspase-3 in Silica nanoparticles-treated male germ cells

(2015) Bo Xu et al.   Scientific Reports

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

Hypoxia downregulates PPARγ via an ERK1/2–NF-κB–Nox4-dependent mechanism in human pulmonary artery smooth muscle cells

(2013) Xianghuai Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypoxia Mediates Mutual Repression between microRNA-27a and PPARγ in the Pulmonary Vasculature

(2013) Bum-Yong Kang et al.   PLoS One

miR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling

(2012) Shanzhong Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension

(2012) Matthias Brock et al.   EUROPEAN HEART JOURNAL

Mortality in Adults With Sickle Cell Disease and Pulmonary Hypertension

(2012) Alem Mehari et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Monocytes from sickle cell disease patients induce differential pulmonary endothelial gene expression via activation of NF-κB signaling pathway

(2012) Surinder Safaya et al.   MOLECULAR IMMUNOLOGY

PPARγ is an E3 ligase that induces the degradation of NFκB/p65

(2012) Yongzhong Hou et al.   Nature Communications

The PPARγ ligand rosiglitazone attenuates hypoxia-induced endothelin signaling in vitro and in vivo

(2011) Bum-Yong Kang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Altered MicroRNA Processing in Heritable Pulmonary Arterial Hypertension

(2011) Kylie M. Drake et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhibition of MicroRNA-17 Improves Lung and Heart Function in Experimental Pulmonary Hypertension

(2011) Soni S. Pullamsetti et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary hypertension diagnosed by right heart catheterisation in sickle cell disease

(2011) G. H. H. Fonseca et al.   EUROPEAN RESPIRATORY JOURNAL

Role for miR-204 in human pulmonary arterial hypertension

(2011) Audrey Courboulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Hemodynamic Study of Pulmonary Hypertension in Sickle Cell Disease

(2011) Florence Parent et al.   NEW ENGLAND JOURNAL OF MEDICINE

Management of Children With Sickle Cell Disease: A Comprehensive Review of the Literature

(2011) P. L. Kavanagh et al.   PEDIATRICS

Global Gene Expression Profiling of Endothelium Exposed to Heme Reveals an Organ-Specific Induction of Cytoprotective Enzymes in Sickle Cell Disease

(2011) Samit Ghosh et al.   PLoS One

Population Estimates of Sickle Cell Disease in the U.S.

(2010) Kathryn L. Hassell   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Dynamic Changes in Lung MicroRNA Profiles During the Development of Pulmonary Hypertension due to Chronic Hypoxia and Monocrotaline

(2010) Paola Caruso et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24-2 cluster and its implication in human diseases

(2010) Ravindresh Chhabra et al.   Molecular Cancer

Rosiglitazone attenuates hypoxia-induced pulmonary arterial hypertension in rats

(2010) Eun Kyung KIM et al.   RESPIROLOGY

Disruption of endothelial peroxisome proliferator-activated receptor-γ reduces vascular nitric oxide production

(2009) Jennifer M. Kleinhenz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Tie2-mediated loss of peroxisome proliferator-activated receptor-γ in mice causes PDGF receptor-β-dependent pulmonary arterial muscularization

(2009) C. Guignabert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Rosiglitazone Attenuates Chronic Hypoxia–Induced Pulmonary Hypertension in a Mouse Model

(2009) Rachel E. Nisbet et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Hematologic, biochemical, and cardiopulmonary effects of l-arginine supplementation or phosphodiesterase 5 inhibition in patients with sickle cell disease who are on hydroxyurea therapy

(2009) Jane A. Little et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

MicroRNA-98 and let-7 Confer Cholangiocyte Expression of Cytokine-Inducible Src Homology 2-Containing Protein in Response to Microbial Challenge

(2009) G. Hu et al.   JOURNAL OF IMMUNOLOGY

Vascular dysfunction in a murine model of severe hemolysis

(2008) A. C. Frei et al.   BLOOD

Placenta growth factor augments endothelin-1 and endothelin-B receptor expression via hypoxia-inducible factor-1 

(2008) N. Patel et al.   BLOOD

An antiproliferative BMP-2/PPARγ/apoE axis in human and murine SMCs and its role in pulmonary hypertension

(2008) Georg Hansmann et al.   JOURNAL OF CLINICAL INVESTIGATION