The prospective Hemophilia Inhibitor PUP Study reveals distinct antibody signatures prior to FVIII inhibitor development

Tolerating Factor VIII: Recent Progress

(2020) Sebastien Lacroix-Desmazes et al.   Frontiers in Immunology

NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting

(2020) Corey Tan et al.   NATURE IMMUNOLOGY

New players in the gene regulatory network controlling late B cell differentiation

(2019) Simon N Willis et al.   CURRENT OPINION IN IMMUNOLOGY

Bleeding events and safety outcomes in persons with haemophilia A with inhibitors: A prospective, multi-centre, non-interventional study

(2018) Johnny Mahlangu et al.   HAEMOPHILIA

The Aryl Hydrocarbon Receptor: Connecting Immunity to the Microenvironment

(2018) Rahul Shinde et al.   TRENDS IN IMMUNOLOGY

High-affinity, noninhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors

(2016) G. Batsuli et al.   BLOOD

Nonneutralizing antibodies against factor VIII and risk of inhibitor development in severe hemophilia A

(2016) Antonino Cannavò et al.   BLOOD

The aryl hydrocarbon receptor controls cell-fate decisions in B cells

(2016) Bharat Vaidyanathan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Randomized Trial of Factor VIII and Neutralizing Antibodies in Hemophilia A

(2016) Flora Peyvandi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Affinity of FVIII-specific antibodies reveals major differences between neutralizing and nonneutralizing antibodies in humans

(2014) C. J. Hofbauer et al.   BLOOD

The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation

(2014) Sebastian Carotta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

Distinct characteristics of antibody responses against factor VIII in healthy individuals and in different cohorts of hemophilia A patients

(2012) S. F. J. Whelan et al.   BLOOD

F8 gene mutation type and inhibitor development in patients with severe hemophilia A: systematic review and meta-analysis

(2012) S. C. Gouw et al.   BLOOD

Increased prevalence of inhibitors in Hispanic patients with severe haemophilia A enrolled in the Universal Data Collection database

(2012) S. L. CARPENTER et al.   HAEMOPHILIA

Experience of Advate rAHF-PFM in previously untreated patients and minimally treated patients with haemophilia A

(2012) A. Alexis Thompson et al.   THROMBOSIS AND HAEMOSTASIS

Impact of polymorphisms of the major histocompatibility complex class II, interleukin-10, tumor necrosis factor-α and cytotoxic T-lymphocyte antigen-4 genes on inhibitor development in severe hemophilia A

(2009) A. PAVLOVA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Plasma cell development: From B-cell subsets to long-term survival niches

(2008) Kirsten A. Fairfax et al.   SEMINARS IN IMMUNOLOGY