Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 58, Issue -, Pages 68-74Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2019.04.007
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Funding
- National Health and Medical Research Council (NHMRC) of Australia [1054925, 1058238, 1144905]
- Cancer Council Victoria [1102662]
- Walter and Eliza Hall Trust Centenary Fellowship
- National Health and Medical Research Council of Australia [1144905] Funding Source: NHMRC
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The differentiation of B cells into antibody-secreting plasma cells is associated with profound changes in morphology, lifespan, and cellular metabolism that are needed to support high rates of antibody production. These processes are driven by dramatic alterations to the transcriptional program and to the organization of the nucleus itself that in turn are regulated by the activity of a select group of transcription factors and epigenetic regulators. Although the core differentiation program is conserved in all mature B cells, subset-specific regulators, such as those found in B1 or memory B cells, provide additional complexity. Here, we review the key components of the gene regulatory network controlling B-cell terminal differentiation, with an emphasis on the new players and processes that have emerged in recent years.
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