Neutrophil specific granule and NETosis defects in gray platelet syndrome

The endoplasmic reticulum protein SEC22B interacts with NBEAL2 and is required for megakaryocyte α-granule biogenesis

(2020) Richard Lo et al.   BLOOD

Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome

(2020) Matthew C. Sims et al.   BLOOD

The Neutrophil Life Cycle

(2019) Andrés Hidalgo et al.   TRENDS IN IMMUNOLOGY

Biological Roles of Neutrophil-Derived Granule Proteins and Cytokines

(2019) Marco Antonio Cassatella et al.   TRENDS IN IMMUNOLOGY

Gain-of-function CEBPE mutation causes non-canonical autoinflammatory inflammasomopathy

(2019) Helka Göös et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dynamic Transcriptome-Proteome Correlation Networks Reveal Human Myeloid Differentiation and Neutrophil-Specific Programming

(2019) Arie J. Hoogendijk et al.   Cell Reports

CEBPE-Mutant Specific Granule Deficiency Correlates With Aberrant Granule Organization and Substantial Proteome Alterations in Neutrophils

(2018) Nina K. Serwas et al.   Frontiers in Immunology

NBEAL2 (Neurobeachin-Like 2) Is Required for Retention of Cargo Proteins by α-Granules During Their Production by Megakaryocytes

(2018) Richard W. Lo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Chromatin swelling drives neutrophil extracellular trap release

(2018) Elsa Neubert et al.   Nature Communications

Dynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils

(2018) Luigi Grassi et al.   Cell Reports

Hermansky-Pudlak syndrome type 2: Aberrant pre-mRNA splicing and mislocalization of granule proteins in neutrophils

(2017) Martin de Boer et al.   HUMAN MUTATION

NBEAL2 is required for neutrophil and NK cell function and pathogen defense

(2017) John M. Sowerby et al.   JOURNAL OF CLINICAL INVESTIGATION

Diverse stimuli engage different neutrophil extracellular trap pathways

(2017) Elaine F Kenny et al.   eLife

Differential Signalling and Kinetics of Neutrophil Extracellular Trap Release Revealed by Quantitative Live Imaging

(2017) Maarten van der Linden et al.   Scientific Reports

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Gray platelet syndrome can mimic autoimmune lymphoproliferative syndrome

(2015) A. Rensing-Ehl et al.   BLOOD

A Novel In-Frame Deletion in the Leucine Zipper Domain of C/EBPε Leads to Neutrophil-Specific Granule Deficiency

(2015) Taizo Wada et al.   JOURNAL OF IMMUNOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Gray platelet syndrome: proinflammatory megakaryocytes and  -granule loss cause myelofibrosis and confer metastasis resistance in mice

(2014) J. A. Guerrero et al.   BLOOD

Two independent killing mechanisms of Candida albicans by human neutrophils: evidence from innate immunity defects

(2014) R. P. Gazendam et al.   BLOOD

Papillon-Lefèvre syndrome patient reveals species-dependent requirements for neutrophil defenses

(2014) Ole E. Sørensen et al.   JOURNAL OF CLINICAL INVESTIGATION

Rab27a Regulates Exocytosis of Tertiary and Specific Granules in Human Neutrophils

(2014) M. J. Herrero-Turrion et al.   JOURNAL OF IMMUNOLOGY

Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens

(2014) Nora Branzk et al.   NATURE IMMUNOLOGY

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

(2014) Christine Schauer et al.   NATURE MEDICINE

Transcriptional diversity during lineage commitment of human blood progenitors

(2014) L. Chen et al.   SCIENCE

Abnormal megakaryocyte development and platelet function in Nbeal2-/- mice

(2013) W. H. A. Kahr et al.   BLOOD

Defects in neutrophil granule mobilization and bactericidal activity in familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) syndrome caused by STXBP2/Munc18-2 mutations

(2013) X. W. Zhao et al.   BLOOD

NETosis: how vital is it?

(2013) B. G. Yipp et al.   BLOOD

Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors

(2013) Sara Rørvig et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The BEACH Is Hot: A LYST of Emerging Roles for BEACH-Domain Containing Proteins in Human Disease

(2013) Andrew R. Cullinane et al.   TRAFFIC

Innate Antifungal Immunity: The Key Role of Phagocytes

(2011) Gordon D. Brown   Annual Review of Immunology

Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome

(2011) Walter HA Kahr et al.   NATURE GENETICS

Exome sequencing identifies NBEAL2 as the causative gene for gray platelet syndrome

(2011) Cornelis A Albers et al.   NATURE GENETICS

Gray platelet syndrome: natural history of a large patient cohort and locus assignment to chromosome 3p

(2010) M. Gunay-Aygun et al.   BLOOD

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

The α-granule proteome: novel proteins in normal and ghost granules in gray platelet syndrome

(2010) D. M. MAYNARD et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Restoration of NET formation by gene therapy in CGD controls aspergillosis

(2009) M. Bianchi et al.   BLOOD

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY