Modulating macrophage activities to promote endogenous bone regeneration: Biological mechanisms and engineering approaches

Macrophages enhance mesenchymal stem cell osteogenesis via down-regulation of reactive oxygen species

(2020) Meng-lin Luo et al.   JOURNAL OF DENTISTRY

An “all-in-one” scaffold targeting macrophages to direct endogenous bone repair in situ

(2020) Yiming Niu et al.   Acta Biomaterialia

Unsaturated polyurethane films grafted with enantiomeric polylysine promotes macrophage polarization to a M2 phenotype through PI3K/Akt1/mTOR axis

(2020) Yiyuan Duan et al.   BIOMATERIALS

Strontium modulates osteogenic activity of bone cement composed of bioactive borosilicate glass particles by activating Wnt/β-catenin signaling pathway

(2020) Xu Cui et al.   Bioactive Materials

Osteoblastic and anti-osteoclastic activities of strontium-substituted silicocarnotite ceramics: In vitro and in vivo studies

(2020) Junkai Zeng et al.   Bioactive Materials

Gene-activated dermal equivalents to accelerate healing of diabetic chronic wounds by regulating inflammation and promoting angiogenesis

(2020) Dong Lou et al.   Bioactive Materials

Biofunctional magnesium coated Ti6Al4V scaffold enhances osteogenesis and angiogenesis in vitro and in vivo for orthopedic application

(2020) Peng Gao et al.   Bioactive Materials

Engineered three-dimensional scaffolds for enhanced bone regeneration in osteonecrosis

(2020) Tongtong Zhu et al.   Bioactive Materials

A Biomimetic Hierarchical Nanointerface Orchestrates Macrophage Polarization and Mesenchymal Stem Cell Recruitment to Promote Endogenous Bone Regeneration

(2019) Shan-Shan Jin et al.   ACS Nano

Building capacity for macrophage modulation and stem cell recruitment in high-stiffness hydrogels for complex periodontal regeneration: Experimental studies in vitro and in rats

(2019) Xiao-Tao He et al.   Acta Biomaterialia

Macrophage-lineage TRAP+ cells recruit periosteum-derived cells for periosteal osteogenesis and regeneration

(2019) Bo Gao et al.   JOURNAL OF CLINICAL INVESTIGATION

Biodegradable Magnesium-Incorporated Poly(l-lactic acid) Microspheres for Manipulation of Drug Release and Alleviation of Inflammatory Response

(2019) Fenghe Yang et al.   ACS Applied Materials & Interfaces

Strontium chondroitin sulfate/silk fibroin blend membrane containing microporous structure modulates macrophage responses for guided bone regeneration

(2019) Ma Fenbo et al.   CARBOHYDRATE POLYMERS

Pore size-mediated macrophage M1-to-M2 transition influences new vessel formation within the compartment of a scaffold

(2019) Yuan Yin et al.   Applied Materials Today

Near-Infrared-Triggered Dynamic Surface Topography for Sequential Modulation of Macrophage Phenotypes

(2019) Xiaowen Zheng et al.   ACS Applied Materials & Interfaces

Biomimetic anti-inflammatory nano-capsule serves as a cytokine blocker and M2 polarization inducer for bone tissue repair

(2019) Chengcheng Yin et al.   Acta Biomaterialia

Compromised Bone Healing in Aged Rats Is Associated With Impaired M2 Macrophage Function

(2019) Julia Löffler et al.   Frontiers in Immunology

Periosteal matrix-derived hydrogel promotes bone repair through an early immune regulation coupled with enhanced angio- and osteogenesis

(2019) Pengcheng Qiu et al.   BIOMATERIALS

Immunomodulatory ECM-like Microspheres for Accelerated Bone Regeneration in Diabetes Mellitus

(2018) Zhiai Hu et al.   ACS Applied Materials & Interfaces

Macrophage involvement affects matrix stiffness-related influences on cell osteogenesis under three-dimensional culture conditions

(2018) Xiao-Tao He et al.   Acta Biomaterialia

3D-printed IFN-γ-loading calcium silicate-β-tricalcium phosphate scaffold sequentially activates M1 and M2 polarization of macrophages to promote vascularization of tissue engineering bone

(2018) Tao Li et al.   Acta Biomaterialia

Regulation of immune response by bioactive ions released from silicate bioceramics for bone regeneration

(2018) Yan Huang et al.   Acta Biomaterialia

Controlled M1-to-M2 transition of aged macrophages by calcium phosphate coatings

(2018) Jumana R. Alhamdi et al.   BIOMATERIALS

MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity

(2018) Shipin Zhang et al.   BIOMATERIALS

Promoting in vivo early angiogenesis with sub-micrometer strontium-contained bioactive microspheres through modulating macrophage phenotypes

(2018) Fujian Zhao et al.   BIOMATERIALS

Mesenchymal stem cell-macrophage crosstalk and bone healing

(2018) Jukka Pajarinen et al.   BIOMATERIALS

Macrophages in bone fracture healing: Their essential role in endochondral ossification

(2018) Claudia Schlundt et al.   BONE

Dual-inflammatory cytokines on TiO2 nanotube-coated surfaces used for regulating macrophage polarization in bone implants

(2018) Lili Gao et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Copper-Modified Ti6Al4 V Suppresses Inflammatory Response and Osteoclastogenesis while Enhancing Extracellular Matrix Formation for Osteoporotic Bone Regeneration

(2018) Xiongcheng Xu et al.   ACS Biomaterials-Science & Engineering

Zinc-Modified Sulfonated Polyetheretherketone Surface with Immunomodulatory Function for Guiding Cell Fate and Bone Regeneration

(2018) Wei Liu et al.   Advanced Science

Combinatorial Surface Roughness Effects on Osteoclastogenesis and Osteogenesis

(2018) Yang Zhang et al.   ACS Applied Materials & Interfaces

Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice

(2018) Linda Vi et al.   Nature Communications

The effect of strontium incorporation into sol-gel biomaterials on their protein adsorption and cell interactions

(2018) F. Romero-Gavilán et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Deconvolution of heterogeneous wound tissue samples into relative macrophage phenotype composition via models based on gene expression

(2017) Nicole M. Ferraro et al.   Integrative Biology

Pro-inflammatory M1 macrophages promote Osteogenesis by mesenchymal stem cells via the COX-2-prostaglandin E2 pathway

(2017) Laura Y. Lu et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity

(2017) Kely Campos Navegantes et al.   Journal of Translational Medicine

Nanoporous microstructures mediate osteogenesis by modulating the osteo-immune response of macrophages

(2017) Zetao Chen et al.   Nanoscale

Mesenchymal Stem Cell-Derived Extracellular Vesicles as Mediators of Anti-Inflammatory Effects: Endorsement of Macrophage Polarization

(2017) Claudia Lo Sicco et al.   Stem Cells Translational Medicine

The influence of surface modified poly(l-lactic acid) films on the differentiation of human monocytes into macrophages

(2017) Clara R. Correia et al.   Biomaterials Science

CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair

(2017) Lena Batoon et al.   BIOMATERIALS

Strontium-Substituted Submicrometer Bioactive Glasses Modulate Macrophage Responses for Improved Bone Regeneration

(2016) Wen Zhang et al.   ACS Applied Materials & Interfaces

The proangiogenic potential of a novel calcium releasing biomaterial: Impact on cell recruitment

(2016) Hugo Oliveira et al.   Acta Biomaterialia

Titanium surface characteristics, including topography and wettability, alter macrophage activation

(2016) Kelly M. Hotchkiss et al.   Acta Biomaterialia

Copper-doped mesoporous silica nanospheres, a promising immunomodulatory agent for inducing osteogenesis

(2016) Mengchao Shi et al.   Acta Biomaterialia

Fibrinogen scaffolds with immunomodulatory properties promote in vivo bone regeneration

(2016) Daniel M. Vasconcelos et al.   BIOMATERIALS

Spatially localized recruitment of anti-inflammatory monocytes by SDF-1α-releasing hydrogels enhances microvascular network remodeling

(2016) J.R. Krieger et al.   BIOMATERIALS

Recruitment of mesenchymal stem cells and macrophages by dual release of stromal cell-derived factor-1 and a macrophage recruitment agent enhances wound closure

(2016) Yang-Hee Kim et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair

(2016) Kai Hu et al.   JOURNAL OF CLINICAL INVESTIGATION

In vitroresponse of macrophages to ceramic scaffolds used for bone regeneration

(2016) Pamela L. Graney et al.   Journal of the Royal Society Interface

Carbon nanohorns allow acceleration of osteoblast differentiation via macrophage activation

(2016) Eri Hirata et al.   Nanoscale

IL-4 administration exerts preventive effects via suppression of underlying inflammation and TNF-α-induced apoptosis in steroid-induced osteonecrosis

(2016) X. Wu et al.   OSTEOPOROSIS INTERNATIONAL

Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response

(2016) Ajaykumar Vishwakarma et al.   TRENDS IN BIOTECHNOLOGY

Macrophages form functional vascular mimicry channels in vivo

(2016) Faith H. Barnett et al.   Scientific Reports

Improved osteogenesis and angiogenesis of magnesium-doped calcium phosphate cement via macrophage immunomodulation

(2016) Meng Wang et al.   Biomaterials Science

Biomimetic collagenous scaffold to tune inflammation by targeting macrophages

(2016) Francesca Taraballi et al.   Journal of Tissue Engineering

Bioactive lipid coating of bone allografts directs engraftment and fate determination of bone marrow-derived cells in rat GFP chimeras

(2015) Anusuya Das et al.   BIOMATERIALS

Immunomodulation by mesenchymal stem cells combats the foreign body response to cell-laden synthetic hydrogels

(2015) Mark D. Swartzlander et al.   BIOMATERIALS

Clinoenstatite coatings have high bonding strength, bioactive ion release, and osteoimmunomodulatory effects that enhance in vivo osseointegration

(2015) Chengtie Wu et al.   BIOMATERIALS

Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds

(2015) Kara L. Spiller et al.   BIOMATERIALS

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Low-dose TNF augments fracture healing in normal and osteoporotic bone by up-regulating the innate immune response

(2015) J. K. Chan et al.   EMBO Molecular Medicine

The Effect of Interferon-γ and Zoledronate Treatment on Alpha-Tricalcium Phosphate/Collagen Sponge-Mediated Bone-Tissue Engineering

(2015) Peiqi Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Incorporation of Mg particles into PDLLA regulates mesenchymal stem cell and macrophage responses

(2015) Sandra C. Cifuentes et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Bioeffects of micron-size magnesium particles on inflammatory cells and bone turnoverin vivoandin vitro

(2015) Chengzhi Guo et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Macrophages Promote Osteoblastic Differentiation In Vivo: Implications in Fracture Repair and Bone Homeostasis

(2015) Linda Vi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Enhanced osseous integration of human trabecular allografts following surface modification with bioactive lipids

(2015) Tiffany Wang et al.   Drug Delivery and Translational Research

Controlled release of sphingosine-1-phosphate agonist with gelatin hydrogels for macrophage recruitment

(2014) Masahiro Murakami et al.   Acta Biomaterialia

Mesenchymal stroma cells trigger early attraction of M1 macrophages and endothelial cells into fibrin hydrogels, stimulating long bone healing without long-term engraftment

(2014) Elisabeth Seebach et al.   Acta Biomaterialia

Fracture Healing via Periosteal Callus Formation Requires Macrophages for Both Initiation and Progression of Early Endochondral Ossification

(2014) Liza J. Raggatt et al.   AMERICAN JOURNAL OF PATHOLOGY

Therapeutic angiogenesis by autologous adipose-derived regenerative cells: comparison with bone marrow mononuclear cells

(2014) Changning Hao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Bone tissue remodeling and development: Focus on matrix metalloproteinase functions

(2014) Katiucia Batista Silva Paiva et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Bone tissue formation with human mesenchymal stem cells and biphasic calcium phosphate ceramics: The local implication of osteoclasts and macrophages

(2014) Anne-Laure Gamblin et al.   BIOMATERIALS

The role of macrophage phenotype in vascularization of tissue engineering scaffolds

(2014) Kara L. Spiller et al.   BIOMATERIALS

A review of the effects of dietary silicon intake on bone homeostasis and regeneration

(2014) Luigi Fabrizio Rodella et al.   Journal of Nutrition Health & Aging

Osteogenesis differentiation of human periodontal ligament cells by CO2 laser-treatment stimulating macrophages via BMP2 signalling pathway

(2014) Wen-Hui Hsieh et al.   LASER PHYSICS

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

(2014) Anjali P. Kusumbe et al.   NATURE

Evaluation of the Therapeutic Potential of Bone Marrow-Derived Myeloid Suppressor Cell (MDSC) Adoptive Transfer in Mouse Models of Autoimmunity and Allograft Rejection

(2014) Lucile Drujont et al.   PLoS One

Wound Administration of M2-Polarized Macrophages Does Not Improve Murine Cutaneous Healing Responses

(2014) Nadine Jetten et al.   PLoS One

Osteal macrophages support physiologic skeletal remodeling and anabolic actions of parathyroid hormone in bone

(2014) S. W. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone: a new endocrine organ at the heart of chronic kidney disease and mineral and bone disorders

(2014) Marc G Vervloet et al.   Lancet Diabetes & Endocrinology

The promotion of mandibular defect healing by the targeting of S1P receptors and the recruitment of alternatively activated macrophages

(2013) Anusuya Das et al.   BIOMATERIALS

Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds

(2013) Koyal Garg et al.   BIOMATERIALS

Enhancement of bone regeneration by dual release of a macrophage recruitment agent and platelet-rich plasma from gelatin hydrogels

(2013) Yang-Hee Kim et al.   BIOMATERIALS

Osteogenic differentiation of bone marrow MSCs by β-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway

(2013) Zetao Chen et al.   BIOMATERIALS

Modulation of macrophage phenotype by cell shape

(2013) F. Y. McWhorter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical Practice Guideline for the Management of Chronic Kidney Disease-Mineral and Bone Disorder

(2013) Masafumi Fukagawa et al.   THERAPEUTIC APHERESIS AND DIALYSIS

Adsorbed Fibrinogen Enhances Production of Bone- and Angiogenic-Related Factors by Monocytes/Macrophages

(2013) Joana Maciel et al.   TISSUE ENGINEERING PART A

Interleukin-1β induces differentiation of human mesenchymal stem cells into osteoblasts via the Wnt-5a/receptor tyrosine kinase-like orphan receptor 2 pathway

(2012) Koshiro Sonomoto et al.   ARTHRITIS AND RHEUMATISM

CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair

(2012) S. Willenborg et al.   BLOOD

MMP9 regulates the cellular response to inflammation after skeletal injury

(2012) Xiaodong Wang et al.   BONE

Pathophysiology of Bone Remodelling and Current Therapeutic Approaches

(2012) I. Juhasz-Böss et al.   GEBURTSHILFE UND FRAUENHEILKUNDE

Classically Activated Macrophages Use Stable Microtubules for Matrix Metalloproteinase-9 (MMP-9) Secretion

(2012) Raed Hanania et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bone marrow stromal cells enhance the osteogenic properties of hydroxyapatite scaffolds by modulating the foreign body reaction

(2012) Gregory Tour et al.   Journal of Tissue Engineering and Regenerative Medicine

Fracture healing under healthy and inflammatory conditions

(2012) Lutz Claes et al.   Nature Reviews Rheumatology

Monocytes Induce STAT3 Activation in Human Mesenchymal Stem Cells to Promote Osteoblast Formation

(2012) Vicky Nicolaidou et al.   PLoS One

Induction of Osteogenesis in Mesenchymal Stem Cells by Activated Monocytes/Macrophages Depends on Oncostatin M Signaling

(2012) Pierre Guihard et al.   STEM CELLS

Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function

(2011) James A. Thomas et al.   HEPATOLOGY

Interferon-γ plays a role in bone formation in vivo and rescues osteoporosis in ovariectomized mice

(2011) Gustavo Duque et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model

(2011) Kylie A Alexander et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A potential therapeutic approach to overload-induced bone loss around implant: Parathyroid hormone (PTH)

(2011) Xiaohua Zeng et al.   MEDICAL HYPOTHESES

Therapeutic approaches to bone pathology in Gaucher disease: Past, present and future

(2011) Ozlem Goker-Alpan   MOLECULAR GENETICS AND METABOLISM

TNF-  promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells

(2011) G. E. Glass et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice

(2010) Emma C. Walker et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanical stress induces Interleukin-11 expression to stimulate osteoblast differentiation

(2009) Shinsuke Kido et al.   BONE

Reduction of particle-induced osteolysis by interleukin-6 involves anti-inflammatory effect and inhibition of early osteoclast precursor differentiation

(2009) Michael Darowish et al.   BONE

Molecular Mechanisms Controlling Bone Formation during Fracture Healing and Distraction Osteogenesis

(2009) Z.S. AI-Aql et al.   JOURNAL OF DENTAL RESEARCH

Inhibition of RANK Expression and Osteoclastogenesis by TLRs and IFN-  in Human Osteoclast Precursors

(2009) J.-D. Ji et al.   JOURNAL OF IMMUNOLOGY

Elevated levels of macrophage colony-stimulating factor in human fracture healing

(2009) Kambiz Sarahrudi et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Wound healing essentials: Let there be oxygen

(2009) Chandan K. Sen   WOUND REPAIR AND REGENERATION

Self-setting bioactive calcium–magnesium phosphate cement with high strength and degradability for bone regeneration

(2008) Fan Wu et al.   Acta Biomaterialia

Osteoclast–osteoblast communication

(2008) Koichi Matsuo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Sphingosine-1-Phosphate Induces an Antiinflammatory Phenotype in Macrophages

(2008) Jeniter E. Hughes et al.   CIRCULATION RESEARCH

COMPARISON OF CONDITIONING REGIMENS FOR ALVEOLAR MACROPHAGE RECONSTITUTION AND INNATE IMMUNE FUNCTION POST BONE MARROW TRANSPLANT

(2008) Leah L. N. Hubbard et al.   EXPERIMENTAL LUNG RESEARCH

Interferon-γ Targets Cancer Cells and Osteoclasts to Prevent Tumor-associated Bone Loss and Bone Metastases

(2008) Zhiqiang Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for VEGF as a negative regulator of pericyte function and vessel maturation

(2008) Joshua I. Greenberg et al.   NATURE

Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate

(2008) L. Pederson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone remodeling during fracture repair: The cellular picture

(2008) Aaron Schindeler et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY