Bee Venom—A Potential Complementary Medicine Candidate for SARS-CoV-2 Infections

The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak

(2020) Hussin A. Rothan et al.   JOURNAL OF AUTOIMMUNITY

COVID-19 and the cardiovascular system

(2020) Ying-Ying Zheng et al.   Nature Reviews Cardiology

Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection

(2020) Emmie de Wit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential association between COVID-19 mortality and health-care resource availability

(2020) Yunpeng Ji et al.   Lancet Global Health

Remdesivir for Treatment of COVID-19: Combination of Pulmonary and IV Administration May Offer Aditional Benefit

(2020) Duxin Sun   AAPS Journal

Handling of allergen immunotherapy in the COVID‐19 pandemic: An ARIA‐EAACI statement

(2020) Ludger Klimek et al.   ALLERGY

COVID-19, ACE2, and the cardiovascular consequences

(2020) Andrew M. South et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Of chloroquine and COVID-19

(2020) Franck Touret et al.   ANTIVIRAL RESEARCH

COVID-19 and Cardiovascular Disease

(2020) Kevin J. Clerkin et al.   CIRCULATION

The prospects for the SARS ‐CoV‐2 pandemic in Africa

(2020) Virginia Quaresima et al.   EMBO Molecular Medicine

Pathogenesis of COVID-19 from a cell biology perspective

(2020) Robert J. Mason   EUROPEAN RESPIRATORY JOURNAL

Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020

(2020) Kenji Mizumoto et al.   Eurosurveillance

Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis

(2020) Jing Yang et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19

(2020) Guoping Li et al.   JOURNAL OF AUTOIMMUNITY

Genotype and phenotype of COVID-19: Their roles in pathogenesis

(2020) Leila Mousavizadeh et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

(2020) Yeming Wang et al.   LANCET

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19

(2020) Mandeep R. Mehra et al.   NEW ENGLAND JOURNAL OF MEDICINE

Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19

(2020) Yan Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reply to Kesici et al. and Zeng et al.: Blocking the virus and reducing the inflammatory damage in COVID-19

(2020) Kai Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Effects of Apamin as a Bee Venom Component for Non-Neoplastic Disease

(2020) Hyemin Gu et al.   Toxins

In vitro activity of lopinavir/ritonavir and hydroxychloroquine against severe acute respiratory syndrome coronavirus 2 at concentrations achievable by usual doses

(2020) Chang Kyung Kang et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

The Honeybee Venom Major Allergen Api m 10 (Icarapin) and Its Role in Diagnostics and Treatment of Hymenoptera Venom Allergy

(2020) Thilo Jakob et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Pharmaco-Immunomodulatory Therapy in COVID-19

(2020) John G. Rizk et al.   DRUGS

A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19

(2020) Andrea Cortegiani et al.   JOURNAL OF CRITICAL CARE

Famotidine Against SARS-CoV2: A Hope or Hype?

(2020) Ritwik Ghosh et al.   MAYO CLINIC PROCEEDINGS

The role of Neutrophil Extracellular Traps in Covid-19: Only an hypothesis or a potential new field of research?

(2020) Chiara Mozzini et al.   THROMBOSIS RESEARCH

Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis

(2020) F.A. Klok et al.   THROMBOSIS RESEARCH

Bee venom and SARS-CoV-2

(2020) Wei Yang et al.   TOXICON

Potential adjuvants for the development of a SARS-CoV-2 vaccine based on experimental results from similar coronaviruses

(2020) Tania Gupta et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The kiss of (cell) death: can venom-induced immune response contribute to dermal necrosis following arthropod envenomations?

(2019) John P. Dunbar et al.   CLINICAL TOXICOLOGY

Safety and efficacy of rifabutin among HIV/TB-coinfected children on lopinavir/ritonavir-based ART

(2019) Holly E Rawizza et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

How Melittin Inserts into Cell Membrane: Conformational Changes, Inter-Peptide Cooperation, and Disturbance on the Membrane

(2019) Hong et al.   MOLECULES

Risk factors and indicators of severe systemic insect sting reactions

(2019) Johanna Stoevesandt et al.   ALLERGY

Bee Venom Immunotherapy: Current Status and Future Directions

(2019) Abida Zahirović et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Automatic ECG Artefact Removal from EEG Signals

(2019) Mohamed F. Issa et al.   Measurement Science Review

Hypotensive Snake Venom Components—A Mini-Review

(2019) Orsolya Péterfi et al.   MOLECULES

Melittin: a venom-derived peptide with promising anti-viral properties

(2019) Hamed Memariani et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Bee Venom: Overview of Main Compounds and Bioactivities for Therapeutic Interests

(2019) Rim Wehbe et al.   MOLECULES

Bee Updated: Current Knowledge on Bee Venom and Bee Envenoming Therapy

(2019) Manuela B. Pucca et al.   Frontiers in Immunology

The membrane effects of melittin on gastric and colorectal cancer

(2019) Caroline Soliman et al.   PLoS One

Mechanistic Pathway on Human α-Glucosidase Maltase-Glucoamylase Unveiled by QM/MM Calculations

(2018) Natércia F. Brás et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Anti-hypertensive and cardioprotective effects of a novel apitherapy formulation via upregulation of peroxisome proliferator-activated receptor-α and -γ in spontaneous hypertensive rats

(2018) Yanru Sun et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Therapeutic effects of bee venom on experimental atopic dermatitis

(2018) Hyemin Gu et al.   Molecular Medicine Reports

Multiple bee stings, multiple organs involved: a case report

(2018) Luana Ferreira Martins de Toledo et al.   Revista da Sociedade Brasileira de Medicina Tropical

To bee or not to bee: The potential efficacy and safety of bee venom acupuncture in humans

(2018) E. Paul Cherniack et al.   TOXICON

Anti-cancer effect of bee venom on human MDA-MB-231 breast cancer cells using Raman spectroscopy

(2018) Gyeong Bok Jung et al.   Biomedical Optics Express

The pathophysiology of anaphylaxis

(2017) Laurent L. Reber et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches

(2017) Nisreen MA Okba et al.   Current Opinion in Virology

Efficacy of Bee Venom Acupuncture for Chronic Low Back Pain: A Randomized, Double-Blinded, Sham-Controlled Trial

(2017) Byung-Kwan Seo et al.   Toxins

Suppressive Effects of Bee Venom Acupuncture on Paclitaxel-Induced Neuropathic Pain in Rats: Mediation by Spinal α2-Adrenergic Receptor

(2017) Jiho Choi et al.   Toxins

Melittin, a Potential Natural Toxin of Crude Bee Venom: Probable Future Arsenal in the Treatment of Diabetes Mellitus

(2017) Md. Sakib Hossen et al.   Journal of Chemistry

Inhibitory effects of bee venom and its components against viruses in vitro and in vivo

(2016) Md Bashir Uddin et al.   JOURNAL OF MICROBIOLOGY

Melittin, the Major Pain-Producing Substance of Bee Venom

(2016) Jun Chen et al.   Neuroscience Bulletin

Bee Venom Phospholipase A2: Yesterday’s Enemy Becomes Today’s Friend

(2016) Gihyun Lee et al.   Toxins

Bee venom enhances the differentiation of human regulatory T cells

(2015) I. Caramalho et al.   ALLERGY

Antimicrobial activity of apitoxin, melittin and phospholipase A2 of honey bee (Apis mellifera) venom against oral pathogens

(2015) Luís F. Leandro et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

Critical role of phospholipase A2group IID in age-related susceptibility to severe acute respiratory syndrome–CoV infection

(2015) Rahul Vijay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Three Valuable Peptides from Bee and Wasp Venoms for Therapeutic and Biotechnological Use: Melittin, Apamin and Mastoparan

(2015) Miguel Moreno et al.   Toxins

Inhibitory effects of bee venom on Propionibacterium acnes-induced inflammatory skin disease in an animal model

(2014) HYUN-JIN AN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Human 60-kDa Lysophospholipase Contains an N-terminal l-Asparaginase Domain That Is Allosterically Regulated by l-Asparagine

(2014) Christos S. Karamitros et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bee Venom Phospholipase A2 Protects against Acetaminophen-Induced Acute Liver Injury by Modulating Regulatory T Cells and IL-10 in Mice

(2014) Hyunseong Kim et al.   PLoS One

A Beneficial Role for Immunoglobulin E in Host Defense against Honeybee Venom

(2013) Thomas Marichal et al.   IMMUNITY

Bee Venom Phospholipase A2 Induces a Primary Type 2 Response that Is Dependent on the Receptor ST2 and Confers Protective Immunity

(2013) Noah W. Palm et al.   IMMUNITY

Green synthesis of silver nanoparticles using Ganoderma neo-japonicum Imazeki: a potential cytotoxic agent against breast cancer cells

(2013) Vikineswary Sabaratnam et al.   International Journal of Nanomedicine

Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2–DP1 receptor paracrine axis

(2013) Yoshitaka Taketomi et al.   NATURE IMMUNOLOGY

Bee Venom and Its Component Apamin as Neuroprotective Agents in a Parkinson Disease Mouse Model

(2013) Daniel Alvarez-Fischer et al.   PLoS One

Bee Venom Phospholipase A2, a Good “Chauffeur” for Delivering Tumor Antigen to the MHC I and MHC II Peptide-Loading Compartments of the Dendritic Cells: The Case of NY-ESO-1

(2013) Christine Almunia et al.   PLoS One

Basophil response and the induction of a tolerance in venom immunotherapy: a long-term sting challenge study

(2012) R. Eržen et al.   ALLERGY

Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen

(2012) Nagihan Bostanci et al.   FEMS MICROBIOLOGY LETTERS

Allergic host defences

(2012) Noah W. Palm et al.   NATURE

Complex cocktails: the evolutionary novelty of venoms

(2012) Nicholas R. Casewell et al.   TRENDS IN ECOLOGY & EVOLUTION

IgE, mast cells, basophils, and eosinophils

(2010) Kelly D. Stone et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

In vitroBiphasic Effect of Honey Bee Venom on Basophils from Screened Healthy Blood Donors

(2010) Salvatore Chirumbolo et al.   Allergy Asthma & Immunology Research

The natural history and epidemiology of insect venom allergy: clinical implications

(2009) M. B. Bilò et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Molecularly targeted nanocarriers deliver the cytolytic peptide melittin specifically to tumor cells in mice, reducing tumor growth

(2009) Neelesh R. Soman et al.   JOURNAL OF CLINICAL INVESTIGATION

Bee venom suppresses PMA-mediated MMP-9 gene activation via JNK/p38 and NF-κB-dependent mechanisms

(2009) Hyun-Ji Cho et al.   JOURNAL OF ETHNOPHARMACOLOGY

Melittin prevents liver cancer cell metastasis through inhibition of the Rac1-dependent pathway

(2008) Shujing Liu et al.   HEPATOLOGY