Article
Environmental Sciences
Byeong-Gon Kim, Pureun-Haneul Lee, Jisu Hong, An-Soo Jang
Summary: This study used PCR array and proteomics analysis to identify changes in gene and protein expression in NHBE cells exposed to diesel exhaust particles (DEPs). It found that DEPs can induce airway inflammation and lead to lung fibrosis. These findings contribute to the identification of biomarkers and therapeutic targets for pollutant-related respiratory diseases.
Article
Medicine, Research & Experimental
Byung Hyuk Han, Se Hoon Jang, Youn Jae Jang, Se Won Na, Jung Joo Yoon, Hi Gyu Moon, Soo Yeon Kim, Chang Seob Seo, Ho Sub Lee, Young Mi Lee, Dae Gill Kang, Yun Jung Lee
Summary: The study investigated the protective effect of Securiniga suffruticosa against respiratory exposure to particulate matter (PM) and diesel exhaust particulate (DEP) induced lung and cardiovascular diseases. The results showed that S. suffruiticosa reduced the expression of inflammatory markers in the lungs and inhibited the NLRP3 signaling pathway. Additionally, S. suffruiticosa inhibited the production of reactive oxygen species and the translocation of NF-kappa B p65 in endothelial cells. These findings suggest that S. suffruiticosa may have therapeutic potential against air pollution-mediated lung and cardiovascular diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Environmental Sciences
Naresh Singh, Naveen Arora
Summary: The study found that exposure to diesel exhaust in mice led to lung injury and pulmonary fibrosis, as evidenced by impaired lung function, cellular infiltration, inflammation, thickening of the alveolar wall, and tissue remodeling. The involvement of the TGF-beta/SMAD3 pathway and activation of EMT in diesel exhaust-exposed mice was demonstrated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Sang Yeon Kim, Sunjoo Park, Ronglan Cui, Hajeong Lee, Hojung Choi, Mohamed El-Agamy Farh, Hai In Jo, Jae Hee Lee, Hyo Jeong Song, Yoon-Jin Lee, Yun-Sil Lee, Bong Yong Lee, Jaeho Cho
Summary: This study suggests that NXC736 is an effective therapeutic agent against radiation-induced lung fibrosis. It inhibits collagen deposition, inflammatory cell infiltration, and epithelial-mesenchymal transition. It also reduces lung volume damage and improves lung function parameters by interfering with the NLRP3-ASC-caspase-1 interaction and blocking the Smad signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Energy & Fuels
Xin Su, Hao Chen, Nan Gao, Meijuan Ding, Xiaochen Wang, Hongming Xu, Peng Zhang
Summary: This study investigates the use of cyclohexanol-diesel blends in diesel engines. The results show that the blends have a longer ignition delay and a shorter combustion duration, and increase NOx emissions. However, with the appropriate blending ratio and injection timing, the blended fuel can reduce particulate emissions.
Article
Biochemistry & Molecular Biology
Edyta Dzialo, Marcin Czepiel, Karolina Tkacz, Maciej Siedlar, Gabriela Kania, Przemyslaw Blyszczuk
Summary: The study revealed that WNT/beta-catenin signaling promotes the transition of cardiac fibroblasts to myofibroblasts by enhancing IL-11 production in TGF-beta-mediated pathways, while non-canonical WNT5a co-activation suppressed TGF-beta-induced collagen I production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Anissa Fries, Fanny Saidoune, Francois Kuonen, Isabelle Dupanloup, Nadine Fournier, Ana Cristina Guerra de Souza, Muzlifah Haniffa, Feiyang Ma, Johann E. Gudjonsson, Lennart Roesner, Yang Li, Thomas Werfel, Curdin Conrad, Raphael Gottardo, Robert L. Modlin, Jeremy Di Domizio, Michel Gilliet
Summary: This study establishes the role of interleukin 26 (IL-26) in the generation of IL-17A producing Th17 CD4(+) T cells, indicating its involvement in the pathogenic response of psoriasis. IL-26-producing cells infiltrate psoriatic skin and promote their own differentiation into IL17A-producing T(H)17 cells through epithelial crosstalk involving paracrine production of TGF-& beta;1.
NATURE COMMUNICATIONS
(2023)
Article
Environmental Sciences
Yang Zhao, Mingdi Li, Guangju Xu, Shuai Liu, Yinnan Yuan, Zhong Wang
Summary: The study investigates the evolution of particles during diesel exhaust transport process and the effects of transport distance on particulate microstructure. Results show that as transport distance increases, particles exhibit longer chains, increased accumulation, and stacking, larger average diameter, and more disorderly carbon layers. Additionally, interlayer spacing and curvature of carbon particles increase with transport distance, leading to greater oxidative activity and decreased graphitization.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Chun-Jung Chang, Chiou-Feng Lin, Chih-Hsin Lee, Hsiao-Chi Chuang, Fu-Chia Shih, Shu-Wen Wan, Chi Tai, Chia-Ling Chen
Summary: Abnormal activation of transforming growth factor (TGF)-beta leads to the upregulation of various signaling molecules, contributing to pulmonary lesions and collagen deposition in lung fibrosis. Interferon (IFN)-gamma signaling is significantly reduced in myofibroblasts, while treatments like BIBF 1120 can effectively inhibit TGF-beta-induced activation of myofibroblasts and attenuate fibrosis. Blockade of SHP2 enhances the anti-fibrotic efficacy of IFN-gamma in myofibroblasts.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Joong Won Lee, Hee Jae Lee, Young-Joo Lee, Yong-beom Lim, Woo Jong Sim, Ji-Hye Jang, Hye-Ryeon Heo, Hyun Joung Lim, Ji-Won Jung, Jin Sik Kim
Summary: Studies have found that exposure to diesel exhaust particles (DEP) can lead to chromosomal DNA damage in normal human lung cells, indicating a potential genotoxic effect of DEP.
Article
Environmental Sciences
Ibrahim Yildiz, Hakan Caliskan, Kazutoshi Mori
Summary: The study demonstrates the effectiveness of a cordierite-based diesel particulate filter (CPF) in reducing total particle concentration, soot concentration, CO and HC emissions from a diesel engine. However, the utilization of CPF also leads to an increase in CO2 and NOx emissions due to oxidation processes within the filter.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Article
Environmental Sciences
Yingxue Geng, Yan Cao, Qun Zhao, Yingjie Li, Senlin Tian
Summary: Long-term exposure to diesel exhaust particulate matter (DEPM) can have adverse effects on respiratory health. The interaction between DEPM and pulmonary surfactant (PS) was investigated, revealing important insights into the potential hazards of airborne particles on lung health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Editorial Material
Hematology
Jonas S. Jutzi, Ann Mullally
Summary: In this article, Melo-Cardenas et al investigate the role of IL-13/IL-4 signaling in myelofibrosis and suggest that it plays a crucial role in driving fibrotic progression through megakaryocyte expansion and increased TGF-beta production.
Review
Biochemistry & Molecular Biology
Jeff Yat-Fai Chung, Max Kam-Kwan Chan, Jane Siu-Fan Li, Alex Siu-Wing Chan, Philip Chiu-Tsun Tang, Kam-Tong Leung, Ka-Fai To, Hui-Yao Lan, Patrick Ming-Kuen Tang
Summary: TGF-beta signaling plays crucial roles in inflammatory diseases by regulating immunocytes in tissue fibrosis and accelerating tumor development in cancer. The pleiotropic nature of TGF-beta signaling in generating fibrotic TME, containing CAFs and matrix proteins, remains largely unclear, despite recent studies demonstrating its clinical implications in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Energy & Fuels
Federico Millo, Theodoros Vlachos, Andrea Piano
Summary: This paper provides a comprehensive characterization of diesel Particulate Matter (PM) in terms of various factors, including mass, chemical composition, particles number, size distribution, and mutagenic potential. The study found that different fuel blends in a diesel engine can result in variations in the chemical composition and toxicity of PM. Biofuel blends showed negligible differences in particles number distributions compared to standard diesel, but had an impact on the mutagenic potential of PM samples.