Biomarkers to Personalize the Treatment of Rheumatoid Arthritis: Focus on Autoantibodies and Pharmacogenetics

EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update

(2020) Josef S Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

The potential value of blood monitoring of biologic drugs used in the treatment of rheumatoid arthritis

(2020) Martin Perry et al.   Therapeutic Advances in Musculoskeletal Disease

What Is the Clinical Relevance of TNF Inhibitor Immunogenicity in the Management of Patients With Rheumatoid Arthritis?

(2020) Puja Mehta et al.   Frontiers in Immunology

Current Understanding of an Emerging Role of HLA-DRB1 Gene in Rheumatoid Arthritis–From Research to Clinical Practice

(2020) Tomasz Wysocki et al.   Cells

The need of a multicomponent guiding approach to personalize clopidogrel treatment

(2020) Conti Valeria et al.   PHARMACOGENOMICS JOURNAL

A Genotyping/Phenotyping Approach with Careful Clinical Monitoring to Manage the Fluoropyrimidines-Based Therapy: Clinical Cases and Systematic Review of the Literature

(2020) Valeria Conti et al.   Journal of Personalized Medicine

Gene expression profiling identifies classifier of methotrexate non-response in patients with rheumatoid arthritis

(2019) Darren Plant et al.   Arthritis & Rheumatology

Association between ABCB1 C3435T polymorphism and methotrexate treatment outcomes in rheumatoid arthritis patients: a meta-analysis

(2019) Xiao He et al.   PHARMACOGENOMICS

Association of female sex and positive rheumatoid factor with low serum infliximab and anti-drug antibodies, related to treatment failure in early rheumatoid arthritis: results from the SWEFOT trial population

(2019) K Hambardzumyan et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Pharmacogenetics of statins treatment: Efficacy and safety

(2019) Zi‐Wan Guan et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Methotrexate an Old Drug with New Tricks

(2019) Yosra Bedoui et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Methotrexate pharmacogenetics in the treatment of rheumatoid arthritis

(2019) Biljana Jekic et al.   PHARMACOGENOMICS

Pharmacogenetics: A strategy for personalized medicine for autoimmune diseases

(2018) S. Tavakolpour et al.   CLINICAL GENETICS

Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients

(2018) John C. Taylor et al.   PHARMACOGENOMICS JOURNAL

The combination of three autoantibodies, ACPA, RF and anti-CarP antibodies is highly specific for rheumatoid arthritis: implications for very early identification of individuals at risk to develop rheumatoid arthritis

(2018) Marije K. Verheul et al.   Arthritis & Rheumatology

Methotrexate mechanism in treatment of rheumatoid arthritis

(2018) Benjamin Friedman et al.   JOINT BONE SPINE

Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction

(2018) V. Michael Holers et al.   Nature Reviews Rheumatology

Genetic markers in methotrexate treatments

(2018) Andrea Giletti et al.   PHARMACOGENOMICS JOURNAL

Arthritis in primary Sjögren's syndrome: Characteristics, outcome and treatment from French multicenter retrospective study

(2018) Adrien Mirouse et al.   AUTOIMMUNITY REVIEWS

MicroRNA-132, miR-146a, and miR-155 as potential biomarkers of methotrexate response in patients with rheumatoid arthritis

(2018) Ankita Singh et al.   CLINICAL RHEUMATOLOGY

FCGR2A/FCGR3A Gene Polymorphisms and Clinical Variables as Predictors of Response to Tocilizumab and Rituximab in Patients With Rheumatoid Arthritis

(2018) Alberto Jiménez Morales et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Incidence and risk factors for adalimumab and infliximab anti-drug antibodies in rheumatoid arthritis: A European retrospective multicohort analysis

(2018) Jocelyn Quistrebert et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Plasma MicroRNA Profiles in Patients with Early Rheumatoid Arthritis Responding to Adalimumab plus Methotrexate vs Methotrexate Alone: A Placebo-controlled Clinical Trial

(2017) Jacob Sode et al.   JOURNAL OF RHEUMATOLOGY

Polymorphisms and pharmacogenomics for the toxicity of methotrexate monotherapy in patients with rheumatoid arthritis

(2017) Qi Qiu et al.   MEDICINE

Beyond citrullination: other post-translational protein modifications in rheumatoid arthritis

(2017) Leendert A. Trouw et al.   Nature Reviews Rheumatology

Systematic review and meta-analysis: pharmacogenetics of anti-TNF treatment response in rheumatoid arthritis

(2017) S Bek et al.   PHARMACOGENOMICS JOURNAL

The impact of anti-drug antibodies on drug concentrations and clinical outcomes in rheumatoid arthritis patients treated with adalimumab, etanercept, or infliximab: Results from a multinational, real-world clinical practice, non-interventional study

(2017) Robert J. Moots et al.   PLoS One

Pharmacogenomics of Methotrexate: Current Status and Future Outlook

(2017) Mengda Cao et al.   CURRENT DRUG METABOLISM

The association between reduced folate carrier-1 gene 80G/A polymorphism and methotrexate efficacy or methotrexate related-toxicity in rheumatoid arthritis: A meta-analysis

(2016) XiaoBing Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

IgA Complexes in Plasma and Synovial Fluid of Patients with Rheumatoid Arthritis Induce Neutrophil Extracellular Traps via FcαRI

(2016) Esil Aleyd et al.   JOURNAL OF IMMUNOLOGY

Rheumatoid arthritis

(2016) Josef S Smolen et al.   LANCET

Mechanism of action of methotrexate in rheumatoid arthritis and the search for biomarkers

(2016) Philip M. Brown et al.   Nature Reviews Rheumatology

ABC transporter polymorphisms are associated with irinotecan pharmacokinetics and neutropenia

(2016) M Li et al.   PHARMACOGENOMICS JOURNAL

Association of the ATIC 347 C/G polymorphism with responsiveness to and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis

(2016) Young Ho Lee et al.   RHEUMATOLOGY INTERNATIONAL

Anti-citrullinated peptide antibodies and their value for predicting responses to biologic agents: a review

(2016) Emilio Martin-Mola et al.   RHEUMATOLOGY INTERNATIONAL

Elevated IgA Plasmablast Levels in Subjects at Risk of Developing Rheumatoid Arthritis

(2016) Jennifer D. Kinslow et al.   Arthritis & Rheumatology

Genetic polymorphism ofCYP1A2but not total or free teriflunomide concentrations is associated with leflunomide cessation in rheumatoid arthritis

(2015) Ashley M. Hopkins et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Biomarkers for rheumatoid and psoriatic arthritis

(2015) M.K. Verheul et al.   CLINICAL IMMUNOLOGY

Fcγand Complement Receptors and Complement Proteins in Neutrophil Activation in Rheumatoid Arthritis: Contribution to Pathogenesis and Progression and Modulation by Natural Products

(2015) Adriana Balbina Paoliello-Paschoalato et al.   Evidence-based Complementary and Alternative Medicine

The tumor necrosis factor receptor superfamily member 1B polymorphisms predict response to anti-TNF therapy in patients with autoimmune disease: A meta-analysis

(2015) Wenjuan Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Analysis of associations between polymorphisms within genes coding for tumour necrosis factor (TNF)-alpha and TNF receptors and responsiveness to TNF-alpha blockers in patients with rheumatoid arthritis

(2015) Jerzy Swierkot et al.   JOINT BONE SPINE

Anti-carbamylated Protein Antibodies Are Present Prior to Rheumatoid Arthritis and Are Associated with Its Future Diagnosis

(2015) R. W. Gan et al.   JOURNAL OF RHEUMATOLOGY

Genetic variants within the TNFRSF1B gene and susceptibility to rheumatoid arthritis and response to anti-TNF drugs

(2015) Luz M. Canet et al.   Pharmacogenetics and Genomics

Association of the ABCB1 C3435T polymorphism with responsiveness to and toxicity of DMARDs in rheumatoid arthritis

(2015) Y.H. Lee et al.   ZEITSCHRIFT FUR RHEUMATOLOGIE

2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis

(2015) Jasvinder A. Singh et al.   ARTHRITIS CARE & RESEARCH

IgG Subclass Specificity Discriminates Restricted IgM Rheumatoid Factor Responses From More Mature Anti-Citrullinated Protein Antibody-Associated or Isotype-Switched IgA Responses

(2015) Willem J. J. Falkenburg et al.   Arthritis & Rheumatology

Variation at FCGR2A and Functionally Related Genes Is Associated with the Response to Anti-TNF Therapy in Rheumatoid Arthritis

(2015) Gabriela Avila-Pedretti et al.   PLoS One

Association of the MTHFR C677T and A1298C polymorphisms with methotrexate toxicity in rheumatoid arthritis: a meta-analysis

(2014) Gwan Gyu Song et al.   CLINICAL RHEUMATOLOGY

Gender differences in autoimmune disease

(2014) S.T. Ngo et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Association between tumor necrosis factor-α (TNF-α) promoter −308 G/A and response to TNF-α blockers in rheumatoid arthritis: a meta-analysis

(2014) Zhen Zeng et al.   Modern Rheumatology

Genome-wide analysis of methotrexate pharmacogenomics in rheumatoid arthritis shows multiple novel risk variants and leads for TYMS regulation

(2014) Sabyasachi Senapati et al.   Pharmacogenetics and Genomics

Association of FCGR2A with the response to infliximab treatment of patients with rheumatoid arthritis

(2014) Ariana Montes et al.   Pharmacogenetics and Genomics

Pharmacogenomics of NAT2 and ABCG2 influence the toxicity and efficacy of sulphasalazine containing DMARD regimens in early rheumatoid arthritis

(2014) M D Wiese et al.   PHARMACOGENOMICS JOURNAL

SLC19A1, SLC46A1 and SLCO1B1 Polymorphisms as Predictors of Methotrexate-Related Toxicity in Portuguese Rheumatoid Arthritis Patients

(2014) Aurea Lima et al.   TOXICOLOGICAL SCIENCES

A preliminary algorithm introducing immunogenicity assessment in the management of patients with RA receiving tumour necrosis factor inhibitor therapies

(2013) Sandra Garcês et al.   ANNALS OF THE RHEUMATIC DISEASES

Familial Risks and Heritability of Rheumatoid Arthritis: Role of Rheumatoid Factor/Anti-Citrullinated Protein Antibody Status, Number and Type of Affected Relatives, Sex, and Age

(2013) Thomas Frisell et al.   ARTHRITIS AND RHEUMATISM

Peptidylarginine deiminases in citrullination, gene regulation, health and pathogenesis

(2013) Shu Wang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Rheumatoid Factors: Clinical Applications

(2013) Francesca Ingegnoli et al.   DISEASE MARKERS

A Single Nucleotide Polymorphism of Reduced Folate Carrier 1 Predicts Methotrexate Efficacy in Japanese Patients with Rheumatoid Arthritis

(2013) Hideki Hayashi et al.   Drug Metabolism and Pharmacokinetics

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Immunogenicity of anti-TNF biologic therapies for rheumatoid arthritis

(2013) Pauline A. van Schouwenburg et al.   Nature Reviews Rheumatology

Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis

(2013) Jing Cui et al.   PLoS Genetics

Structural Changes and Antibody Enrichment in the Lungs Are Early Features of Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis

(2013) Gudrun Reynisdottir et al.   Arthritis & Rheumatology

A prediction rule for the development of arthritis in seropositive arthralgia patients

(2012) Lotte Arwen van de Stadt et al.   ANNALS OF THE RHEUMATIC DISEASES

The immunogenicity of anti-TNF therapy in immune-mediated inflammatory diseases: a systematic review of the literature with a meta-analysis

(2012) Sandra Garcês et al.   ANNALS OF THE RHEUMATIC DISEASES

Elevated rheumatoid factor and long term risk of rheumatoid arthritis: a prospective cohort study

(2012) S. F. Nielsen et al.   BMJ-British Medical Journal

Lack of association between CAG repeat polymorphism in the androgen receptor gene and the outcome of rheumatoid arthritis treatment with leflunomide

(2011) Violetta Dziedziejko et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Development of Antidrug Antibodies Against Adalimumab and Association With Disease Activity and Treatment Failure During Long-term Follow-up

(2011) Geertje M. Bartelds   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Complement activation by (auto-) antibodies

(2011) Nina A. Daha et al.   MOLECULAR IMMUNOLOGY

PharmGKB summary

(2011) Torben S. Mikkelsen et al.   Pharmacogenetics and Genomics

Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage

(2011) J. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of immunogenicity on the efficacy of long-term treatment with infliximab in rheumatoid arthritis

(2011) D. Pascual-Salcedo et al.   RHEUMATOLOGY

Indirect comparisons of the efficacy of biological antirheumatic agents in rheumatoid arthritis in patients with an inadequate response to conventional disease-modifying antirheumatic drugs or to an anti-tumour necrosis factor agent: a meta-analysis

(2010) C. Salliot et al.   ANNALS OF THE RHEUMATIC DISEASES

2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative

(2010) D. Aletaha et al.   ANNALS OF THE RHEUMATIC DISEASES

Genome-wide association study of genetic predictors of anti-tumor necrosis factor treatment efficacy in rheumatoid arthritis identifies associations with polymorphisms at seven loci

(2010) Darren Plant et al.   ARTHRITIS AND RHEUMATISM

Associations between the C677T and A1298C Polymorphisms of MTHFR and the Efficacy and Toxicity of Methotrexate in Rheumatoid Arthritis

(2010) Young Ho Lee et al.   CLINICAL DRUG INVESTIGATION

Contribution of HLA-DRB1*04 alleles and anti-cyclic citrullinated antibodies to development of resistance to disease-modifying antirheumatic drugs in early rheumatoid arthritis

(2010) Shunsuke Mori et al.   CLINICAL RHEUMATOLOGY

The effect ofESR1andESR2gene polymorphisms on the outcome of rheumatoid arthritis treatment with leflunomide

(2010) Violetta Dziedziejko et al.   PHARMACOGENOMICS

Regulation of IFN response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment

(2010) Lisa GM van Baarsen et al.   ARTHRITIS RESEARCH & THERAPY

Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis

(2009) Diane van der Woude et al.   ARTHRITIS AND RHEUMATISM

Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways

(2009) L. A. Trouw et al.   ARTHRITIS AND RHEUMATISM

Sex hormones modulate the effects of Leflunomide on cytokine production by cultures of differentiated monocyte/macrophages and synovial macrophages from rheumatoid arthritis patients

(2009) Maurizio Cutolo et al.   JOURNAL OF AUTOIMMUNITY

Metaanalysis of Methylenetetrahydrofolate Reductase (MTHFR) Polymorphisms Affecting Methotrexate Toxicity

(2009) M. C. FISHER et al.   JOURNAL OF RHEUMATOLOGY

The effect of exon (19C>A) dihydroorotate dehydrogenase gene polymorphism on rheumatoid arthritis treatment with leflunomide

(2009) Andrzej Pawlik et al.   PHARMACOGENOMICS

Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus

(2009) Yi Li et al.   ARTHRITIS RESEARCH & THERAPY

Influence of variants of Fc  receptors IIA and IIIA on the American College of Rheumatology and European League Against Rheumatism responses to anti-tumour necrosis factor   therapy in rheumatoid arthritis

(2008) J D Canete et al.   ANNALS OF THE RHEUMATIC DISEASES

Genetic polymorphism of CYP1A2 and the toxicity of leflunomide treatment in rheumatoid arthritis patients

(2008) Petra Bohanec Grabar et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Genetic determinants of methotrexate toxicity in rheumatoid arthritis patients: a study of polymorphisms affecting methotrexate transport and folate metabolism

(2008) Petra Bohanec Grabar et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Association of the tumour necrosis factor-308 variant with differential response to anti-TNF agents in the treatment of rheumatoid arthritis

(2008) James R. Maxwell et al.   HUMAN MOLECULAR GENETICS

Can tumor necrosis factor receptor II gene 676T>G polymorphism predict the response grading to anti-TNFα therapy in rheumatoid arthritis?

(2008) Alessia Ongaro et al.   RHEUMATOLOGY INTERNATIONAL